Weinreb Amides as Directing Groups for Transition Metal-Catalyzed C-H Functionalizations

The European 1,2-Dichloroethane Ban Should Liberate not Limit C-H Activation Research and Development

(2018) James Sherwood   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoredox Catalysis for Building C–C Bonds from C(sp2)–H Bonds

(2018) Chang-Sheng Wang et al.   CHEMICAL REVIEWS

Green and Sustainable Solvents in Chemical Processes

(2018) Coby J. Clarke et al.   CHEMICAL REVIEWS

Cp*Co(III)-Catalyzed Coupling of Benzamides with α,β-Unsaturated Carbonyl Compounds: Preparation of Aliphatic Ketones and Azepinones

(2018) Paula G. Chirila et al.   CHEMISTRY-A EUROPEAN JOURNAL

Weinreb Amide Directed Versatile C−H Bond Functionalization under (η5 -Pentamethylcyclopentadienyl)cobalt(III) Catalysis

(2018) Kentaro Kawai et al.   CHEMISTRY-A EUROPEAN JOURNAL

Ligand-Enabled γ-C(sp3)–H Activation of Ketones

(2018) Ru-Yi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Enantioselective C(sp3)‒H bond activation by chiral transition metal catalysts

(2018) Tyler G. Saint-Denis et al.   SCIENCE

Base- and Additive-Free Ir-Catalyzed ortho-Iodination of Benzoic Acids: Scope and Mechanistic Investigations

(2018) Elis Erbing et al.   ACS Catalysis

Palladium-Catalyzed C–H Amination of C(sp2) and C(sp3)–H Bonds: Mechanism and Scope for N-Based Molecule Synthesis

(2018) Yam N. Timsina et al.   ACS Catalysis

Achieving High Ortho Selectivity in Aniline C–H Borylations by Modifying Boron Substituents

(2018) Milton R. Smith et al.   ACS Catalysis

Transition-Metal-Catalyzed Site-Selective C−H Halogenation Reactions

(2018) Riki Das et al.   Asian Journal of Organic Chemistry

Rhodium(iii)-catalyzed Oxidative Coupling of N-Methoxybenzamides and Ethenesulfonyl fluoride: a C–H Bond Activation Strategy for the Preparation of 2-Aryl ethenesulfonyl fluorides and Sulfonyl fluoride Substituted γ-Lactams

(2018) Shi-Meng Wang et al.   Organic Chemistry Frontiers

Transient Directing Groups for Transformative C–H Activation by Synergistic Metal Catalysis

(2018) Parthasarathy Gandeepan et al.   Chem

Towards the generalized iterative synthesis of small molecules

(2018) Jonathan W. Lehmann et al.   Nature Reviews Chemistry

A comprehensive overview of directing groups applied in metal-catalysed C–H functionalisation chemistry

(2018) Carlo Sambiagio et al.   CHEMICAL SOCIETY REVIEWS

Ligand-Enabled, Palladium-Catalyzed β-C(sp3)–H Arylation of Weinreb Amides

(2018) Hojoon Park et al.   ACS Catalysis

Rh-Catalyzed Removable Directing Group Assisted sp2 or sp3-C-H Bond Functionalization

(2018) Naoto Chatani et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

3d Transition Metals for C–H Activation

(2018) Parthasarathy Gandeepan et al.   CHEMICAL REVIEWS

A Pharmaceutical Industry Perspective on Sustainable Metal Catalysis

(2018) John D. Hayler et al.   ORGANOMETALLICS

Approach to Comparing the Functional Group Tolerance of Reactions

(2017) Tobias Gensch et al.   JOURNAL OF ORGANIC CHEMISTRY

Ruthenium-Catalyzed C–H Benzoxylation of tert-Benzamides with Aromatic Acids by Weak Coordination

(2017) Nagnath Yadav More et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed, ortho-Selective C–H Halogenation of Benzyl Nitriles, Aryl Weinreb Amides, and Anilides

(2017) Riki Das et al.   JOURNAL OF ORGANIC CHEMISTRY

Ir-Catalyzed ortho-Borylation of Phenols Directed by Substrate–Ligand Electrostatic Interactions: A Combined Experimental/in Silico Strategy for Optimizing Weak Interactions

(2017) Buddhadeb Chattopadhyay et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Noncovalent Interactions in Ir-Catalyzed C–H Activation: L-Shaped Ligand for Para-Selective Borylation of Aromatic Esters

(2017) Md Emdadul Hoque et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regioselective Synthesis of o-Benzenediboronic Acids via Ir-Catalyzed o-C–H Borylation Directed by a Pyrazolylaniline-Modified Boronyl Group

(2017) Takeshi Yamamoto et al.   ORGANIC LETTERS

Iridium/Bipyridine-Catalyzed ortho-Selective C–H Borylation of Phenol and Aniline Derivatives

(2017) Hong-Liang Li et al.   ORGANIC LETTERS

The Transient Directing Group Strategy: A New Trend in Transition-Metal-Catalyzed C–H Bond Functionalization

(2017) Tatiana Besset et al.   SYNTHESIS-STUTTGART

Plausible Rh(V) Intermediates in Catalytic C–H Activation Reactions

(2017) Suhelen Vásquez-Céspedes et al.   ACS Catalysis

Connecting the Dots: Method Development Using Sustainable Solvents

(2017) Kirsty L. Wilson et al.   Chem

Recent Developments in Organoboron Chemistry: Old Dogs, New Tricks

(2017) James W.B. Fyfe et al.   Chem

Well-defined nickel and palladium precatalysts for cross-coupling

(2017) Nilay Hazari et al.   Nature Reviews Chemistry

Hexafluoroisopropanol as a highly versatile solvent

(2017) Ignacio Colomer et al.   Nature Reviews Chemistry

Merging Visible Light Photoredox Catalysis with Metal Catalyzed C–H Activations: On the Role of Oxygen and Superoxide Ions as Oxidants

(2016) David C. Fabry et al.   ACCOUNTS OF CHEMICAL RESEARCH

Which Metals are Green for Catalysis? Comparison of the Toxicities of Ni, Cu, Fe, Pd, Pt, Rh, and Au Salts

(2016) Ksenia S. Egorova et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Simple and Versatile Amide Directing Group for C−H Functionalizations

(2016) Ru-Yi Zhu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Reaching the south: metal-catalyzed transformation of the aromatic para-position

(2016) Aniruddha Dey et al.   CHEMICAL COMMUNICATIONS

Applications of Palladium-Catalyzed C–N Cross-Coupling Reactions

(2016) Paula Ruiz-Castillo et al.   CHEMICAL REVIEWS

Organic Photoredox Catalysis

(2016) Nathan A. Romero et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Transformations of Alkyl C–H Bonds

(2016) Jian He et al.   CHEMICAL REVIEWS

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

Cooperative photoredox catalysis

(2016) Xianjun Lang et al.   CHEMICAL SOCIETY REVIEWS

Product Control using Substrate Design: Ruthenium-Catalysed Oxidative C−H Olefinations of Cyclic Weinreb Amides

(2016) Riki Das et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Deaminative Phenanthridinone Synthesis from Aniline via C–H Bond Activation

(2016) Subhash L. Yedage et al.   JOURNAL OF ORGANIC CHEMISTRY

Photoredox Catalysis in Organic Chemistry

(2016) Megan H. Shaw et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium catalysed meta-C–H functionalization reactions

(2016) Aniruddha Dey et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Cp*CoIII-Catalyzed Dehydrative C–H Allylation of 6-Arylpurines and Aromatic Amides Using Allyl Alcohols in Fluorinated Alcohols

(2016) Youka Bunno et al.   ORGANIC LETTERS

A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams

(2016) Darren Willcox et al.   SCIENCE

Ru-catalysed C–H functionalisations as a tool for selective organic synthesis

(2016) Sara Ruiz et al.   TETRAHEDRON LETTERS

A remarkable solvent effect of fluorinated alcohols on transition metal catalysed C–H functionalizations

(2016) J. Wencel-Delord et al.   Organic Chemistry Frontiers

Undirected, Homogeneous C–H Bond Functionalization: Challenges and Opportunities

(2016) John F. Hartwig et al.   ACS Central Science

From Synthesis to Function via Iterative Assembly of N-Methyliminodiacetic Acid Boronate Building Blocks

(2015) Junqi Li et al.   ACCOUNTS OF CHEMICAL RESEARCH

Transition Metal-Catalyzed CH Activation of Indoles

(2015) Alexander H. Sandtorv   ADVANCED SYNTHESIS & CATALYSIS

Cationic Iridium/S-Me-BIPAM-Catalyzed Direct Asymmetric Intermolecular Hydroarylation of Bicycloalkenes

(2015) Tomohiko Shirai et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Boron-selective reactions as powerful tools for modular synthesis of diverse complex molecules

(2015) Liang Xu et al.   CHEMICAL SOCIETY REVIEWS

Fujiwara-Moritani Reaction of Weinreb Amides using a Ruthenium-Catalyzed C−H Functionalization Reaction

(2015) Riki Das et al.   Chemistry-An Asian Journal

DFT Studies on the Mechanism of the Rhodium(III)-Catalyzed C–H Activation of N-Phenoxyacetamide

(2015) Juan Li et al.   JOURNAL OF ORGANIC CHEMISTRY

Pd(II)-Catalyzed C–H Functionalizations Directed by Distal Weakly Coordinating Functional Groups

(2015) Gang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Experimental and DFT Studies Explain Solvent Control of C–H Activation and Product Selectivity in the Rh(III)-Catalyzed Formation of Neutral and Cationic Heterocycles

(2015) David L. Davies et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Pd(ii)-catalyzed C–H arylation of aryl and benzyl Weinreb amides

(2015) Yan Wang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solvents and sustainable chemistry

(2015) Tom Welton   PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Synthesis of many different types of organic small molecules using one automated process

(2015) J. Li et al.   SCIENCE

Weinreb Amides

(2015) Monika Nowak   SYNLETT

Carbon–hydrogen (C–H) bond activation at PdIV: a Frontier in C–H functionalization catalysis

(2015) Joseph J. Topczewski et al.   Chemical Science

Cobalt-Catalyzed C–H Activation

(2015) Marc Moselage et al.   ACS Catalysis

Reusable and Removable Directing Groups for C(sp2)−H Bond Functionalization of Arenes

(2015) M. Ramu Yadav et al.   Asian Journal of Organic Chemistry

An ortho-directed C–H borylation/Suzuki coupling sequence in the formation of biphenylbenzylic amines

(2015) Lillian V. A. Hale et al.   Organic Chemistry Frontiers

Low-Valent Cobalt Catalysis: New Opportunities for C–H Functionalization

(2014) Ke Gao et al.   ACCOUNTS OF CHEMICAL RESEARCH

Air-Stable Carbonyl(pentamethylcyclopentadienyl)cobalt Diiodide Complex as a Precursor for Cationic (Pentamethylcyclopentadienyl)cobalt(III) Catalysis: Application for Directed C-2 Selective CH Amidation of Indoles

(2014) Bo Sun et al.   ADVANCED SYNTHESIS & CATALYSIS

Weakly Coordinating Directing Groups for Ruthenium(II)- Catalyzed CH Activation

(2014) Suman De Sarkar et al.   ADVANCED SYNTHESIS & CATALYSIS

Phosphine-Directed CH Borylation Reactions: Facile and Selective Access to Ambiphilic Phosphine Boronate Esters

(2014) Kristina M. Crawford et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Combining Rhodium and Photoredox Catalysis for CH Functionalizations of Arenes: Oxidative Heck Reactions with Visible Light

(2014) David C. Fabry et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of Cobalt-Catalyzed C–H Bond Functionalization Reactions

(2014) Naohiko Yoshikai   BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN

Arene C–H functionalisation using a removable/modifiable or a traceless directing group strategy

(2014) Fengzhi Zhang et al.   CHEMICAL SOCIETY REVIEWS

Experiment and computation: a combined approach to study the reactivity of palladium complexes in oxidation states 0 toiv

(2014) Karl J. Bonney et al.   CHEMICAL SOCIETY REVIEWS

Iridium-Catalyzed C–H Borylation of Heteroarenes: Scope, Regioselectivity, Application to Late-Stage Functionalization, and Mechanism

(2014) Matthew A. Larsen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Promoted Alkylation of C(sp3)–H and C(sp2)–H Bonds

(2014) Ru-Yi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silyl Phosphorus and Nitrogen Donor Chelates for Homogeneous Ortho Borylation Catalysis

(2014) Behnaz Ghaffari et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of most polyene natural product motifs using just 12 building blocks and one coupling reaction

(2014) Eric M. Woerly et al.   Nature Chemistry

Rhodium-Catalyzed CH Olefination of Aryl Weinreb Amides

(2013) Yan Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

A Cationic High-Valent Cp*CoIIIComplex for the Catalytic Generation of Nucleophilic Organometallic Species: Directed CH Bond Activation

(2013) Tatsuhiko Yoshino et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Rhodium(III)-Catalyzed Intramolecular Hydroarylation, Amidoarylation, and Heck-type Reaction: Three Distinct Pathways Determined by an Amide Directing Group

(2013) Tyler A. Davis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Visible Light Photoredox Catalysis with Transition Metal Complexes: Applications in Organic Synthesis

(2013) Christopher K. Prier et al.   CHEMICAL REVIEWS

Selection of boron reagents for Suzuki–Miyaura coupling

(2013) Alastair J. J. Lennox et al.   CHEMICAL SOCIETY REVIEWS

Cp*CoIII-Catalyzed C2-Selective Addition of Indoles to Imines

(2013) Tatsuhiko Yoshino et al.   CHEMISTRY-A EUROPEAN JOURNAL

A robustness screen for the rapid assessment of chemical reactions

(2013) Karl D. Collins et al.   Nature Chemistry

Rh(III)-Catalyzed Halogenation of Vinylic C–H Bonds: Rapid and General Access to Z-Halo Acrylamides

(2013) Nadine Kuhl et al.   ORGANIC LETTERS

Ruthenium-Catalyzed C–H Oxygenation on Aryl Weinreb Amides

(2013) Fanzhi Yang et al.   ORGANIC LETTERS

On the Interpretation of Deuterium Kinetic Isotope Effects in CH Bond Functionalizations by Transition-Metal Complexes

(2012) Eric M. Simmons et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Development of Bulky Palladium NHC Complexes for the Most-Challenging Cross-Coupling Reactions

(2012) Cory Valente et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Cross-Coupling: A Historical Contextual Perspective to the 2010 Nobel Prize

(2012) Carin C. C. Johansson Seechurn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium(II)-Catalyzed C–H Bond Activation and Functionalization

(2012) Percia Beatrice Arockiam et al.   CHEMICAL REVIEWS

Synthesis of Heterocycles via Palladium-Catalyzed Carbonylations

(2012) Xiao-Feng Wu et al.   CHEMICAL REVIEWS

Connecting Binuclear Pd(III) and Mononuclear Pd(IV) Chemistry by Pd–Pd Bond Cleavage

(2012) David C. Powers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Iridium-catalyzed C–H borylation of quinolines and unsymmetrical 1,2-disubstituted benzenes: insights into steric and electronic effects on selectivity

(2012) Hazmi Tajuddin et al.   Chemical Science

Innate and Guided C–H Functionalization Logic

(2011) Tobias Brückl et al.   ACCOUNTS OF CHEMICAL RESEARCH

Borylation and Silylation of C–H Bonds: A Platform for Diverse C–H Bond Functionalizations

(2011) John F. Hartwig   ACCOUNTS OF CHEMICAL RESEARCH

Removable Directing Groups in Organic Synthesis and Catalysis

(2011) Géraldine Rousseau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds

(2011) Olivier Baudoin   CHEMICAL SOCIETY REVIEWS

Regioselectivity of the borylation of alkanes and arenes

(2011) John F. Hartwig   CHEMICAL SOCIETY REVIEWS

Ruthenium-catalyzed C–H Silylation of Methylboronic Acid Using a Removable α-Directing Modifier on the Boron Atom

(2011) Hideki Ihara et al.   CHEMISTRY LETTERS

Anthranilamide: A Simple, Removableortho-Directing Modifier for Arylboronic Acids Serving also as a Protecting Group in Cross-Coupling Reactions

(2011) Hideki Ihara et al.   ORGANIC LETTERS

Emergence of Palladium(IV) Chemistry in Synthesis and Catalysis

(2010) Petr Sehnal et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Ligand-Directed C−H Functionalization Reactions

(2010) Thomas W. Lyons et al.   CHEMICAL REVIEWS

C—H Bond Activation in Transition Metal Species from a Computational Perspective

(2010) David Balcells et al.   CHEMICAL REVIEWS

Ligand-Accelerated C−H Activation Reactions: Evidence for a Switch of Mechanism

(2010) Keary M. Engle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bimetallic Reductive Elimination from Dinuclear Pd(III) Complexes

(2010) David C. Powers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-Catalyzed C−C Bond Formation via Heteroatom-Directed C−H Bond Activation

(2009) Denise A. Colby et al.   CHEMICAL REVIEWS

C−H Activation for the Construction of C−B Bonds

(2009) Ibraheem A. I. Mkhalid et al.   CHEMICAL REVIEWS

Directed Ortho Borylation of Functionalized Arenes Catalyzed by a Silica-Supported Compact Phosphine−Iridium System

(2009) Soichiro Kawamorita et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Easily Attachable and Detachableortho-Directing Agent for Arylboronic Acids in Ruthenium-Catalyzed Aromatic C−H Silylation

(2009) Hideki Ihara et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bimetallic Palladium Catalysis: Direct Observation of Pd(III)−Pd(III) Intermediates

(2009) David C. Powers et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Erratum: Bimetallic Pd(III) complexes in palladium-catalysed carbon–heteroatom bond formation

(2009) David C. Powers et al.   Nature Chemistry

Analysis of the Concerted Metalation-Deprotonation Mechanism in Palladium-Catalyzed Direct Arylation Across a Broad Range of Aromatic Substrates

(2008) Serge I. Gorelsky et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY