Induction of Autophagy and Activation of SIRT-1 Deacetylation Mechanisms Mediate Neuroprotection by the Pomegranate Metabolite Urolithin A in BV2 Microglia and Differentiated 3D Human Neural Progenitor Cells

An increased autophagic flux contributes to the anti-inflammatory potential of urolithin A in macrophages

(2018) Yaw Duah Boakye et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Urolithins Attenuate LPS-Induced Neuroinflammation in BV2Microglia via MAPK, Akt, and NF-κB Signaling Pathways

(2018) Jialin Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside

(2018) Ravikanth Velagapudi et al.   MOLECULAR NEUROBIOLOGY

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

(2018) Rituraj Niranjan   NEUROCHEMISTRY INTERNATIONAL

Sirtuin 1 and Alzheimer's disease: An up-to-date review

(2018) Liara Rizzi et al.   NEUROPEPTIDES

Anti-neuroinflammatory effects of Ginkgo biloba extract EGb761 in LPS-activated primary microglial cells

(2018) Brahim Gargouri et al.   PHYTOMEDICINE

Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells

(2018) Ravikanth Velagapudi et al.   PHYTOTHERAPY RESEARCH

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

(2018) Bruno Alexandre Quadros Gomes et al.   Oxidative Medicine and Cellular Longevity

The role of autophagy in pro-inflammatory responses of microglia activation via mitochondrial reactive oxygen species in vitro

(2017) Junli Ye et al.   JOURNAL OF NEUROCHEMISTRY

SIRT1 regulates lipopolysaccharide-induced CD40 expression in renal medullary collecting duct cells by suppressing the TLR4-NF-κB signaling pathway

(2017) Qin-qin Lin et al.   LIFE SCIENCES

AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia

(2017) Ravikanth Velagapudi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Therapeutic role of sirtuins in neurodegenerative disease and their modulation by polyphenols

(2017) Marjan Ajami et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro

(2017) Nicholas A. DaSilva et al.   NUTRITIONAL NEUROSCIENCE

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

(2016) Dongryeol Ryu et al.   NATURE MEDICINE

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders

(2016) Henryk Jęśko et al.   NEUROCHEMICAL RESEARCH

Cilostazol Modulates Autophagic Degradation of β-Amyloid Peptide via SIRT1-Coupled LKB1/AMPKα Signaling in Neuronal Cells

(2016) So Youn Park et al.   PLoS One

Pomegranate’s Neuroprotective Effects against Alzheimer’s Disease Are Mediated by Urolithins, Its Ellagitannin-Gut Microbial Derived Metabolites

(2015) Tao Yuan et al.   ACS Chemical Neuroscience

Neuroprotective action of resveratrol

(2015) Stéphane Bastianetto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Long-term treatment with Ginkgo biloba extract EGb 761 improves symptoms and pathology in a transgenic mouse model of Alzheimer’s disease

(2015) Xu Liu et al.   BRAIN BEHAVIOR AND IMMUNITY

Overexpression of SIRT1 Induced by Resveratrol and Inhibitor of miR-204 Suppresses Activation and Proliferation of Microglia

(2015) Lihong Li et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

SIRT1 Deficiency in Microglia Contributes to Cognitive Decline in Aging and Neurodegeneration via Epigenetic Regulation of IL-1 

(2015) S.-H. Cho et al.   JOURNAL OF NEUROSCIENCE

Urolithins, gut microbiota-derived metabolites of ellagitannins, inhibit LPS-induced inflammation in RAW 264.7 murine macrophages

(2015) Jakub P. Piwowarski et al.   MOLECULAR NUTRITION & FOOD RESEARCH

A 3D human neural cell culture system for modeling Alzheimer's disease

(2015) Young Hye Kim et al.   Nature Protocols

Neuroinflammatory paradigms in lysosomal storage diseases

(2015) Megan E. Bosch et al.   Frontiers in Neuroscience

Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain

(2014) Juan A. Godoy et al.   MOLECULAR NEUROBIOLOGY

A three-dimensional human neural cell culture model of Alzheimer’s disease

(2014) Se Hoon Choi et al.   NATURE

Dysfunctional autophagy in Alzheimer’s disease: pathogenic roles and therapeutic implications

(2014) Jun-Hua Liang et al.   Neuroscience Bulletin

SIRT1 and SIRT2: emerging targets in neurodegeneration

(2013) Gizem Donmez et al.   EMBO Molecular Medicine

Redox regulation of SIRT1 in inflammation and cellular senescence

(2013) Jae-woong Hwang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protective effect of SIRT1 on toxicity of microglial-derived factors induced by LPS to PC12 cells via the p53-caspase-3-dependent apoptotic pathway

(2013) Jieming Ye et al.   NEUROSCIENCE LETTERS

SIRT1 Regulates CD40 Expression Induced by TNF-a via NF-?B Pathway in Endothelial Cells

(2012) Lina Yang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

SIRT1 Activators Suppress Inflammatory Responses through Promotion of p65 Deacetylation and Inhibition of NF-κB Activity

(2012) Hongying Yang et al.   PLoS One

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NF-κB-dependent anti-inflammatory activity of urolithins, gut microbiota ellagic acid-derived metabolites, in human colonic fibroblasts

(2010) Antonio González-Sarrías et al.   BRITISH JOURNAL OF NUTRITION

Resveratrol differentially modulates inflammatory responses of microglia and astrocytes

(2010) Xiaofeng Lu et al.   Journal of Neuroinflammation

Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism☆

(2009) Mar Larrosa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prolonged Classical NF-κB Activation Prevents Autophagy uponE. coliStimulation In Vitro: A Potential Resolving Mechanism of Inflammation

(2008) Silke Schlottmann et al.   MEDIATORS OF INFLAMMATION