Role of Sirt1 During the Ageing Process: Relevance to Protection of Synapses in the Brain

The role of polyphenols in the modulation of sirtuins and other pathways involved in Alzheimer's disease

(2013) T. Jayasena et al.   AGEING RESEARCH REVIEWS

Sirtuin deacetylases in neurodegenerative diseases of aging

(2013) Adrianna Z Herskovits et al.   CELL RESEARCH

Peroxisome Proliferator-Activated Receptor (PPAR) γ and PPARα Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders?

(2013) Juan M. Zolezzi et al.   PLoS One

Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators

(2013) B. P. Hubbard et al.   SCIENCE

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Sirtuins in cognitive ageing and Alzheimerʼs disease

(2012) Nady Braidy et al.   CURRENT OPINION IN PSYCHIATRY

Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons

(2012) Malgorzata Urbanska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR: at the crossroads of aging, chaperones, and Alzheimer's disease

(2012) Gunnar K. Gouras   JOURNAL OF NEUROCHEMISTRY

Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

(2012) I. Ahmed et al.   JOURNAL OF NEUROSCIENCE

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

(2012) Hassina Massudi et al.   PLoS One

SIRT1 Regulates Dendritic Development in Hippocampal Neurons

(2012) Juan F. Codocedo et al.   PLoS One

NAD+metabolism and oxidative stress: the golden nucleotide on a crown of thorns

(2012) Hassina Massudi et al.   REDOX REPORT

Mitochondrial dynamics in neurodegeneration

(2012) Kie Itoh et al.   TRENDS IN CELL BIOLOGY

Characterizing cognitive aging of recognition memory and related processes in animal models and in humans

(2012) Sara N. Burke et al.   Frontiers in Aging Neuroscience

Postsynaptic Receptors for Amyloid-β Oligomers as Mediators of Neuronal Damage in Alzheimer’s Disease

(2012) Margarita C. Dinamarca et al.   Frontiers in Physiology

Regulation of PGC-1α, a nodal regulator of mitochondrial biogenesis

(2011) Pablo J Fernandez-Marcos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Sirtuins in Neurodegenerative Diseases: A Biological-Chemical Perspective

(2011) Aparna Raghavan et al.   Neurodegenerative Diseases

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

(2011) Nady Braidy et al.   PLoS One

Aging of the cerebral cortex differs between humans and chimpanzees

(2011) Chet C. Sherwood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective effects and mechanisms of sirtuins in the nervous system

(2011) Feng Zhang et al.   PROGRESS IN NEUROBIOLOGY

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

(2010) S. Michan et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

(2010) Tao Ma et al.   PLoS One

Integration of Clearance Mechanisms: The Proteasome and Autophagy

(2010) E. Wong et al.   Cold Spring Harbor Perspectives in Biology

Recent progress in the biology and physiology of sirtuins

(2009) Toren Finkel et al.   NATURE

Candida albicans, a distinctive fungal model for cellular aging study

(2008) Xiao-Hong Fu et al.   AGING CELL

The human SIRT3 protein deacetylase is exclusively mitochondrial

(2008) Helen M. Cooper et al.   BIOCHEMICAL JOURNAL

Lysosomes and oxidative stress in aging and apoptosis

(2008) Tino Kurz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration

(2008) Danica Chen et al.   EXPERIMENTAL GERONTOLOGY

Substrates and Regulation Mechanisms for the Human Mitochondrial Sirtuins Sirt3 and Sirt5

(2008) Christine Schlicker et al.   JOURNAL OF MOLECULAR BIOLOGY

Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

(2008) M. A. King et al.   MOLECULAR PHARMACOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

The coming acceleration of global population ageing

(2008) Wolfgang Lutz et al.   NATURE

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

(2008) Sofia Papadia et al.   NATURE NEUROSCIENCE

Modulation of SIRT1 expression in different neurodegenerative models and human pathologies

(2008) M. Pallàs et al.   NEUROSCIENCE

A Low Dose of Dietary Resveratrol Partially Mimics Caloric Restriction and Retards Aging Parameters in Mice

(2008) Jamie L. Barger et al.   PLoS One

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Resveratrol and quercetin, two natural polyphenols, reduce apoptotic neuronal cell death induced by neuroinflammation

(2007) Genevieve Bureau et al.   JOURNAL OF NEUROSCIENCE RESEARCH