Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders

Sporadic and hereditary amyotrophic lateral sclerosis (ALS)

(2015) Senda Ajroud-Driss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Correlations between predicted protein disorder and post-translational modifications in plants

(2014) Atsushi Kurotani et al.   BIOINFORMATICS

Intrinsically disordered proteins as crucial constituents of cellular aqueous two phase systems and coacervates

(2014) Vladimir N. Uversky et al.   FEBS LETTERS

The triple power of D³: Protein intrinsic disorder in degenerative diseases

(2014) Vladimir Uversky   Frontiers in Bioscience-Landmark

Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models

(2014) Sami J Barmada et al.   Nature Chemical Biology

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

The structural and functional signatures of proteins that undergo multiple events of post-translational modification

(2014) Vikas Pejaver et al.   PROTEIN SCIENCE

Proteostasis impairment in protein-misfolding and -aggregation diseases

(2014) Mark S. Hipp et al.   TRENDS IN CELL BIOLOGY

Amyotrophic lateral sclerosis: Problems and prospects

(2013) Jemeen Sreedharan et al.   ANNALS OF NEUROLOGY

Genealogy of an ancient protein family: the Sirtuins, a family of disordered members

(2013) Susan Costantini et al.   BMC EVOLUTIONARY BIOLOGY

The contribution of intrinsic disorder prediction to the elucidation of protein function

(2013) Domenico Cozzetto et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Alternative splicing of intrinsically disordered regions and rewiring of protein interactions

(2013) Marija Buljan et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Stress granules in neurodegeneration - lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma

(2013) Eva Bentmann et al.   FEBS Journal

Brain Activation of SIRT1: Role in Neuropathology

(2013) Alanna Fernandes Paraíso et al.   MOLECULAR NEUROBIOLOGY

Modulation of allostery by protein intrinsic disorder

(2013) Allan Chris M. Ferreon et al.   NATURE

Protein misfolding in the late-onset neurodegenerative diseases: Common themes and the unique case of amyotrophic lateral sclerosis

(2013) Vikram Khipple Mulligan et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Genetic analysis of SIRT1 gene promoter in sporadic Parkinson’s disease

(2012) Aimei Zhang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ALS und frontotemporale Demenz – Fallbericht und Literaturübersicht

(2012) R. Nass et al.   FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE

Corruption and Spread of Pathogenic Proteins in Neurodegenerative Diseases

(2012) Lary C. Walker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tissue-Specific Splicing of Disordered Segments that Embed Binding Motifs Rewires Protein Interaction Networks

(2012) Marija Buljan et al.   MOLECULAR CELL

Regulated protein aggregation: stress granules and neurodegeneration

(2012) Benjamin Wolozin   Molecular Neurodegeneration

The BioGRID interaction database: 2013 update

(2012) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

Aberrant Localization of FUS and TDP43 Is Associated with Misfolding of SOD1 in Amyotrophic Lateral Sclerosis

(2012) Edward Pokrishevsky et al.   PLoS One

Molecular pathogenesis of sporadic prion diseases in man

(2012) Jiri G. Safar   Prion

Exploring the binding diversity of intrinsically disordered proteins involved in one-to-many binding

(2012) Wei-Lun Hsu et al.   PROTEIN SCIENCE

Protein misfolding and aggregation in cataract disease and prospects for prevention

(2012) Kate L. Moreau et al.   TRENDS IN MOLECULAR MEDICINE

Zn2+-Induced Rearrangement of the Disordered TPPP/p25 Affects Its Microtubule Assembly and GTPase Activity

(2011) Ágnes Zotter et al.   BIOCHEMISTRY

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

(2011) David J Bonda et al.   LANCET NEUROLOGY

Role of metal ions in aggregation of intrinsically disordered proteins in neurodegenerative diseases

(2011) Leonid Breydo et al.   Metallomics

Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway

(2011) Hyunkyung Jeong et al.   NATURE MEDICINE

Understanding protein non-folding

(2010) Vladimir N. Uversky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Flexible Nets of Malleable Guardians: Intrinsically Disordered Chaperones in Neurodegenerative Diseases

(2010) Vladimir N. Uversky   CHEMICAL REVIEWS

Targeting intrinsically disordered proteins in neurodegenerative and protein dysfunction diseases: another illustration of the D2concept

(2010) Vladimir N Uversky   Expert Review of Proteomics

Role of TPPP/p25 on α-synuclein-mediated oligodendroglial degeneration and the protective effect of SIRT2 inhibition in a cellular model of multiple system atrophy☆

(2010) Takafumi Hasegawa et al.   NEUROCHEMISTRY INTERNATIONAL

Acetylation of Tau Inhibits Its Degradation and Contributes to Tauopathy

(2010) Sang-Won Min et al.   NEURON

Hsp70 molecular chaperones and Parkinson's disease

(2009) Stephan N. Witt   BIOPOLYMERS

Cross-Seeding Fibrillation of Q/N-Rich Proteins Offers New Pathomechanism of Polyglutamine Diseases

(2009) Y. Furukawa et al.   JOURNAL OF NEUROSCIENCE

Flexible nets: disorder and induced fit in the associations of p53 and 14-3-3 with their partners

(2008) Christopher J Oldfield et al.   BMC GENOMICS

Phosphoproteomic Analysis of the Mouse Brain Cytosol Reveals a Predominance of Protein Phosphorylation in Regions of Intrinsic Sequence Disorder

(2008) Mark O. Collins et al.   MOLECULAR & CELLULAR PROTEOMICS

Paths of Convergence: Sirtuins in Aging and Neurodegeneration

(2008) Li Gan et al.   NEURON

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion protein aggresomes are poly(A)+ ribonucleoprotein complexes that induce a PKR-mediated deficient cell stress response

(2007) Kevin Goggin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH