IL-10 derived from M2 macrophage promotes cancer stemness via JAK1/STAT1/NF-κB/Notch1 pathway in non-small cell lung cancer

Anti-IL-10–mediated Enhancement of Antitumor Efficacy of a Dendritic Cell–targeting MIP3α-gp100 Vaccine in the B16F10 Mouse Melanoma Model Is Dependent on Type I Interferons

(2018) James T. Gordy et al.   JOURNAL OF IMMUNOTHERAPY

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

Baricitinib, Methotrexate, or Combination in Patients With Rheumatoid Arthritis and No or Limited Prior Disease-Modifying Antirheumatic Drug Treatment

(2017) Roy Fleischmann et al.   Arthritis & Rheumatology

RAD51 Mediates Resistance of Cancer Stem Cells to PARP Inhibition in Triple-Negative Breast Cancer

(2016) Yajing Liu et al.   CLINICAL CANCER RESEARCH

Role of the Microenvironment in Liver Metastasis: From Pre- to Prometastatic Niches

(2016) P. Brodt   CLINICAL CANCER RESEARCH

Impaired T cell function in malignant pleural effusion is caused by TGF-β derived predominantly from macrophages

(2016) Lifeng Li et al.   INTERNATIONAL JOURNAL OF CANCER

Correlation of EGFR Del 19 with Fn14/JAK/STAT signaling molecules in non-small cell lung cancer

(2016) Ying Sun et al.   ONCOLOGY REPORTS

Role of KEAP1 / NRF2 and TP53 Mutations in Lung Squamous Cell Carcinoma Development and Radiation Resistance

(2016) Youngtae Jeong et al.   Cancer Discovery

Rationally Repurposing Ruxolitinib (Jakafi®) as a Solid Tumor Therapeutic

(2016) Mehrad Tavallai et al.   Frontiers in Oncology

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

CD163+CD14+ macrophages, a potential immune biomarker for malignant pleural effusion

(2015) Fei Wang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Metastasis Suppressors Regulate the Tumor Microenvironment by Blocking Recruitment of Prometastatic Tumor-Associated Macrophages

(2015) C. Frankenberger et al.   CANCER RESEARCH

Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression

(2015) Yu Shi et al.   Cell Stem Cell

A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors

(2015) E. G. Chiorean et al.   CLINICAL CANCER RESEARCH

Temporary elimination of IL-10 enhanced the effectiveness of cyclophosphamide and BMDC-based therapy by decrease of the suppressor activity of MDSCs and activation of antitumour immune response

(2015) Joanna Rossowska et al.   IMMUNOBIOLOGY

1-O-acetylbritannilactone combined with gemcitabine elicits growth inhibition and apoptosis in A549 human non-small cell lung cancer cells

(2015) FENG WANG et al.   Molecular Medicine Reports

Cancer stem cells and tumor-associated macrophages: a roadmap for multitargeting strategies

(2015) C Raggi et al.   ONCOGENE

Homoharringtonine induces apoptosis and inhibits STAT3 via IL-6/JAK1/STAT3 signal pathway in Gefitinib-resistant lung cancer cells

(2015) Wei Cao et al.   Scientific Reports

Targeting Tumor-Associated Macrophages with Anti-CSF-1R Antibody Reveals a Strategy for Cancer Therapy

(2014) Carola H. Ries et al.   CANCER CELL

IL-10 signalling blockade at the time of immunization inhibits Human papillomavirus 16 E7 transformed TC-1 tumour cells growth in mice

(2014) Shu Chen et al.   CELLULAR IMMUNOLOGY

Tumor-Associated Macrophages Produce Interleukin 6 and Signal via STAT3 to Promote Expansion of Human Hepatocellular Carcinoma Stem Cells

(2014) Shanshan Wan et al.   GASTROENTEROLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

(2014) Manesh Chittezhath et al.   IMMUNITY

Cancer Stem Cells: Impact, Heterogeneity, and Uncertainty

(2012) Jeffrey A. Magee et al.   CANCER CELL

Targeting Tumor-Infiltrating Macrophages Decreases Tumor-Initiating Cells, Relieves Immunosuppression, and Improves Chemotherapeutic Responses

(2012) J. B. Mitchem et al.   CANCER RESEARCH

Activation of IL-6R/JAK1/STAT3 Signaling Induces De Novo Resistance to Irreversible EGFR Inhibitors in Non-Small Cell Lung Cancer with T790M Resistance Mutation

(2012) S. M. Kim et al.   MOLECULAR CANCER THERAPEUTICS

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Tumor-Associated Macrophages Regulate Murine Breast Cancer Stem Cells Through a Novel Paracrine EGFR/Stat3/Sox-2 Signaling Pathway

(2012) Jian Yang et al.   STEM CELLS

Differential macrophage programming in the tumor microenvironment

(2012) Brian Ruffell et al.   TRENDS IN IMMUNOLOGY

Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells through Cytokine Networks

(2011) Suling Liu et al.   CANCER RESEARCH

Nodal/Activin Signaling Drives Self-Renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy

(2011) Enza Lonardo et al.   Cell Stem Cell

Down-regulation of JAK1 by RNA interference inhibits growth of the lung cancer cell line A549 and interferes with the PI3K/mTOR pathway

(2011) Dan Liu et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Tumor-associated macrophages regulate tumorigenicity and anticancer drug responses of cancer stem/initiating cells

(2011) M. Jinushi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Trends in Stage Distribution for Patients with Non-small Cell Lung Cancer: A National Cancer Database Survey

(2010) Daniel Morgensztern et al.   Journal of Thoracic Oncology

Preclinical Profile of a Potent  -Secretase Inhibitor Targeting Notch Signaling with In vivo Efficacy and Pharmacodynamic Properties

(2009) L. Luistro et al.   CANCER RESEARCH

Tumor Microenvironment of Metastasis in Human Breast Carcinoma: A Potential Prognostic Marker Linked to Hematogenous Dissemination

(2009) B. D. Robinson et al.   CLINICAL CANCER RESEARCH