Article
Oncology
Chaohui Bao, Na An, Hong Xie, Ling Xu, Boping Zhou, Jun Luo, Wanqiu Huang, Jian Huang
Summary: By conducting whole-exome sequencing and systematic bioinformatics analysis, we identified C>T transitions in both CINs and CCs, with significantly higher somatic mutations in CCs compared to CINs. Additionally, potential driver genes were identified and new neoantigens were found, providing a solid foundation for further research on the pathogenesis of CC and the development of novel immunotherapeutic approaches.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Shengqin Yue, Qian Wang, Jiajun Zhang, Qinyong Hu, Chao Liu
Summary: This review provides an overview of the recent advances made in understanding the heterogeneity of the cervical cancer ecosystem through single-cell sequencing studies. It highlights the potential of high-resolution single-cell dissection in driving targeted therapies and personalized medicine.
Review
Oncology
Xiaojing Yang, Hanru Ren, Jie Fu
Summary: Immunotherapy, combined with radiotherapy, has shown significant improvement in the effective cure rate for cancer patients, challenging the traditional belief that radiotherapy kills immune cells and has immunosuppressive effects. This article reviews and summarizes the molecular mechanism, clinical treatment, and safety of the combination of radiotherapy and immunotherapy. It also highlights the unanswered questions and future research needs, providing reference for clinicians in guiding subsequent clinical medicine.
Editorial Material
Oncology
Sarah E. Podwika, Linda R. Duska
Summary: Cervical cancer remains a significant issue for women worldwide, despite the availability of preventive measures such as vaccines and screening programs. While surgery, radiation, and chemotherapy have been the traditional treatments for cervical cancer, new therapies such as immunotherapy and antibody-drug conjugates offer promising options for women with advanced or recurrent disease. However, there are still disparities in access to care, clinical trials, and survival rates among different populations. It is crucial to address these inequities and prioritize prevention through vaccination and screening.
Review
Biotechnology & Applied Microbiology
Jeaneen Venkatas, Moganavelli Singh
Summary: Cervical cancer presents immense complexity at the molecular level, limiting traditional treatment methods. Immunotherapy and nanotechnology offer new hope for cancer treatment, but their efficacy varies depending on the patient population, requiring further research and improvement.
Review
Medicine, General & Internal
Dean E. Watkins, Daniel J. Craig, Shahnaz D. Vellani, Ahmad Hegazi, Kaylee J. Fredrickson, Adam Walter, Laura Stanbery, John Nemunaitis
Summary: Cervical cancer is a global public health crisis, but it can be prevented and treated effectively through vaccination and immunotherapeutic agents.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Microbiology
Zi-Wei Zhou, Hui-Zhi Long, Yan Cheng, Hong-Yu Luo, Dan-Dan Wen, Li-Chen Gao
Summary: The symbiotic relationship between microbes and hosts plays a key role in the development of cervical cancer, with inflammation contributing to disease progression. Studying cervical microbes can provide new insights for the treatment of cervical cancer. Probiotic therapy and immunotherapy offer potential treatment options.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Oncology
Dennis Mauricio, Burak Zeybek, Joan Tymon-Rosario, Justin Harold, Alessandro D. Santin
Summary: Various immunotherapy and targeted therapies are showing promise in the treatment of cervical cancer, including immune checkpoint inhibitors, PARP inhibitors, angiogenesis inhibitors, antibody-drug conjugates, therapeutic vaccines, and adoptive immunotherapy. Participation in these investigative treatments can benefit and improve outcomes for patients with cervical cancer.
CURRENT ONCOLOGY REPORTS
(2021)
Article
Immunology
Wenyi Zhang, Pei Xiao, Jiayi Tang, Rui Wang, Xiangdong Wang, Fengxu Wang, Junpu Ruan, Shali Yu, Juan Tang, Rongrong Huang, Xinyuan Zhao
Summary: This study demonstrates the important roles of m6A modification patterns in cervical cancer. Analysis of m6A modification patterns can enhance our understanding of the tumor microenvironment in cervical cancer and facilitate the development of better immunotherapy strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Shuping Yin, Han Cui, Shuang Qin, Shengnan Yu
Summary: Cervical cancer is a serious global threat to women's health, and identifying key molecules associated with its progression is crucial for drug development, disease monitoring, and precision therapy. TGF-beta has recently emerged as a promising target for cervical cancer treatment, particularly in the field of immunotherapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Oncology
Qian Sun, Liangliang Wang, Cong Zhang, Zhenya Hong, Zhiqiang Han
Summary: Cervical cancer heterogeneity is crucial for effective prevention and treatment, involving aspects such as immune clearance of viruses, tumorigenesis, metastasis, and drug resistance. The combination of cervical cancer therapeutic vaccine and immune checkpoint inhibitors is an effective strategy to address treatment heterogeneity. Understanding global vaccination rates, screening rates, incidence, and mortality, as well as genomic factors, is important for cervical cancer prevention and control.
BIOMARKER RESEARCH
(2022)
Review
Oncology
C. Gennigens, G. Jerusalem, L. Lapaille, M. De Cuypere, S. Streel, F. Kridelka, I Ray-Coquard
Summary: Despite existing screening programs and human papillomavirus vaccines, there is still a significant number of women with primary metastatic cervical cancer and recurrent cases with poor prognosis. Previous standard treatments include cisplatin-based therapies, but the addition of bevacizumab to chemotherapy has shown promise. Recent interest has focused on using immunotherapeutic drugs, such as immune checkpoint inhibitors and antibody-drug conjugates, to achieve durable responses and improve overall survival. However, the identification of potent biomarkers and targeted therapies is crucial for personalized treatment strategies.
Article
Immunology
Yang Xing, Feroza Yasinjan, Yajie Du, Huayue Geng, Ying Zhang, Minghua He, Rui Guo, Lei Yang, Jiayue Cui, Dongmei Mu, Ziling Liu, Hong Wang
Summary: Cervical cancer is a major global health issue, with limited treatment options for advanced cases. Immunotherapy has emerged as a promising approach for these patients and has shown significant progress in recent years.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Adriana Gutierrez-Hoya, Isabel Soto-Cruz
Summary: NK cells play a significant role in the treatment of cervical cancer through various strategies, but current research is limited. Cellular immunotherapy has the potential to become an effective strategy in fighting against tumors.
Review
Pharmacology & Pharmacy
Xuyan Zhou, Haiying Lian, Hongpeng Li, Meiling Fan, Wei Xu, Ye Jin
Summary: Immunotherapy is a promising method for treating cervical cancer, but its clinical application is limited by adverse effects. Nanotechnology offers potential advantages in cervical cancer treatment by enhancing drug delivery, reducing adverse effects, and improving the immune microenvironment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Mathematics, Applied
Mingquan Wei
Summary: This paper introduces and studies the mixed central bounded mean oscillation space C(M), showing its relationship with the mixed Herz-Hardy space HA. The characterization of C(M) is given based on the boundedness of certain commutators involving ndimensional Hardy operator and its dual operator.
APPLICABLE ANALYSIS
(2022)
Article
Mathematics, Applied
Mingquan Wei
Summary: In this paper, we establish the boundedness of Calderon-Zygmund operators and their commutators, as well as the Rubio de Francia inequalities on generalized mixed Morrey spaces by refining the extrapolation theory. By extending the extrapolation theorem to generalized mixed Hardy-Morrey spaces, we also obtain the boundedness of the maximal Bochner-Riesz means, the parametric Marcinkiewicz integrals, and the Fourier multiplier on generalized mixed Hardy-Morrey spaces.
BANACH JOURNAL OF MATHEMATICAL ANALYSIS
(2022)
Article
Mathematics, Applied
Mingquan Wei, Lanyin Sun
Summary: In this paper, we establish the boundedness of the modified fractional integral operator from mixed Morrey spaces to the bounded mean oscillation space and Lipschitz spaces, respectively.
JOURNAL OF FUNCTION SPACES
(2022)
Article
Mathematics, Applied
Mingquan Wei, Qianjun He, Xiang Li, Zequn Wang
Summary: In this paper, we establish the sharp constant for the q-analogus of Hausdorff operators on central q-Morrey spaces. Several sharp constants for related operators are deduced.
JOURNAL OF FUNCTION SPACES
(2022)
Article
Mathematics, Applied
Ming Quan Wei, Dun Yan Yan
Summary: In this paper, we introduce the weak Lipschitz spaces WLip(q,alpha), which are analogous to the weak Lebesgue spaces L-q(infinity) in the context of Lipschitz space. We establish the equivalence between the norms parallel to center dot parallel to Lip(alpha) and parallel to center dot parallel to WLip(q,alpha). Moreover, we explore the boundedness of commutators to characterize the weak central bounded mean oscillation space WCBMO(q,alpha).
ACTA MATHEMATICA SINICA-ENGLISH SERIES
(2022)
Article
Mathematics
Mingquan Wei
Summary: This paper establishes the extrapolation theory on weighted product Morrey spaces and introduces the weighted product block spaces to prove the main results. The results include the John-Nirenberg inequality, a new characterization of little bmo, and the mapping properties of certain operators on weighted product Morrey spaces. The results are novel even in the unweighted setting.
POTENTIAL ANALYSIS
(2023)
Article
Mathematics, Applied
Mingquan Wei
Summary: In this paper, we establish the extrapolation theory for Herz-Morrey spaces and deduce the mapping properties of parametric Marcinkiewicz integrals, geometric maximal operator, minimal operator, and Rubio de Francia inequalities on Herz-Morrey spaces. By extending the extrapolation theory to Herz-Morrey-Hardy spaces, we also obtain the boundedness of singular integral operators and maximal Bochner-Riesz means on Herz-Morrey-Hardy spaces.
JOURNAL OF PSEUDO-DIFFERENTIAL OPERATORS AND APPLICATIONS
(2023)
Article
Mathematics, Applied
Na An, Mingquan Wei, Fayou Zhao
Summary: In this paper, necessary and sufficient conditions for the boundedness of multilinear Hausdorff operators on local Morrey-type spaces are established, and sharp constants are provided. As applications, the results are generalized to concrete operators derived from Hausdorff operators, such as the Hardy operator and its dual operator, the weighted Hardy-Littlewood average, among others.
FORUM MATHEMATICUM
(2023)
Article
Mathematics, Applied
Mingquan Wei, Dunyan Yan
Summary: By using the rotation method, the paper obtains sharp bounds and weak-type estimates for n-dimensional Hardy operators on mixed radial-angular central Morrey spaces. The paper also calculates the sharp constants for n-dimensional m-linear Hardy operators from product mixed radial-angular central Morrey spaces to mixed radial-angular weak central Morrey spaces. The main theorems extend various existing results to a more general setting by considering mixed radial-angular central Morrey spaces.
JOURNAL OF INEQUALITIES AND APPLICATIONS
(2023)
Article
Mathematics, Applied
Mingquan Wei
Summary: In this paper, the boundedness of the fractional integral operator I-a on generalized Morrey spaces associated with ball Banach function spaces is studied. Additionally, the boundedness of the commutator of I-a on these spaces is also established. The main results of this study extend previous findings on specific generalized Morrey spaces associated with ball Banach function spaces.
FRACTIONAL CALCULUS AND APPLIED ANALYSIS
(2023)
Article
Mathematics, Applied
Qianjun He, Mingquan Wei, Dunyan Yan
Summary: In this paper, we compute the sharp bound for the generalized m-linear n-dimensional Hardy-Littlewood-Polya operator on power weighted central and non-central homogeneous Morrey spaces. An application of this is obtaining the sharp bound for the Hardy-Littlewood-Polya operator on power weighted central and non-central homogeneous Morrey spaces. Finally, the sharp bound for the Hausdorff operator on power weighted central and non-central homogeneous Morrey spaces is also found, generalizing previous results.
ANALYSIS IN THEORY AND APPLICATIONS
(2023)
Article
Mathematics, Applied
Mingquan Wei, Xiaoyu Liu
Summary: In this note, the authors introduce the discrete (weak) central Morrey spaces, which are central versions of discrete (weak) Morrey spaces. They prove that the sharp bounds for the discrete Hardy operator from discrete central Morrey spaces to discrete weak central Morrey spaces are equal to 1. As an application, they obtain the weak version of the well-known discrete Hardy inequality.
Article
Mathematics, Applied
Mingquan Wei
Summary: This paper studies the boundedness of a large class of sublinear operators on generalized mixed Morrey spaces, including the T-alpha operators generated by Calderon-Zygmund operators and fractional integral operators, as well as their commutators. Applications to various operators such as Hardy-Littlewood maximal operator and Calderon-Zygmund singular integral operators are also discussed.
JOURNAL OF APPLIED ANALYSIS AND COMPUTATION
(2022)
Article
Mathematics
Mingquan Wei, Fangming Su, Lanyin Sun
Summary: This article establishes a generalization of the well-known Stein-Weiss inequality for the fractional integral operator on functions with different integrability properties in the radial and angular direction in local Morrey spaces. It is found that some conditions can be relaxed for the Stein-Weiss inequality for local mixed radial-angular Morrey spaces.
Article
Mathematics, Applied
Mingquan Wei
Summary: This paper studies the boundedness of the weighted Hardy-Littlewood average and its commutator on mixed central Morrey spaces.
JOURNAL OF MATHEMATICAL INEQUALITIES
(2022)
Article
Cell Biology
Jeffrey Maslanka, Gretel Torres, Jennifer Londregan, Naomi Goldman, Daniel Silberman, John Somerville, James E. Riggs
Summary: This study investigates the immunobiology of the peritoneum in ovarian cancer, revealing reduced B1 cells in the ascites and selective loss of B1 and marginal zone B cell subsets in the spleen. These findings suggest a correlation between the depletion of B cell subsets and the influx of myeloid-derived suppressor cells during ovarian cancer.
CELLULAR IMMUNOLOGY
(2024)
