Article
Medicine, Research & Experimental
Jiahui Si, Yuanyuan Ma, Chao Lv, Yang Hong, Hongyu Tan, Yue Yang
Summary: The overexpression of long non-coding RNA HIF1A-AS2 in lung adenocarcinoma (LUAD) patients is associated with tumor progression and resistance to osimertinib. Through targeting the miR-146b5p/IL-6/STAT3 axis, HIF1A-AS2 functions as an oncogenic factor in LUAD cells and may serve as a potential prognostic indicator for patient outcomes.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Biochemistry & Molecular Biology
Sun-Ae Park, Young Ju Seo, Lee Kyung Kim, Hee Jung Kim, Kee Dong Yoon, Tae-Hwe Heo
Summary: The study found that Butea monosperma, a traditional Indian medicine, has potent anti-IL-6 activity and can be used for the treatment of ovarian cancer. It inhibits IL-6 signaling pathway, suppresses cell proliferation, migration, and invasion, induces cell cycle arrest and apoptosis, and significantly inhibits the growth of ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Danfei Liu, Xiangyuan Luo, Meng Xie, Tongyue Zhang, Xiaoping Chen, Bixiang Zhang, Mengyu Sun, Yijun Wang, Yangyang Feng, Xiaoyu Ji, Yiwei Li, Bifeng Liu, Wenjie Huang, Limin Xia
Summary: The study reveals the clinical value, functional role, and molecular mechanism of heterogeneous nuclear ribonucleoprotein C (HNRNPC) in hepatocellular carcinoma (HCC), highlighting its potential as a biomarker for diagnosis, prognosis, and therapeutic targets.
Review
Oncology
Junnv Xu, Haifeng Lin, Gang Wu, Mingyue Zhu, Mengsen Li
Summary: IL-6 plays a crucial role in the occurrence and development of hepatocellular carcinoma (HCC), and targeting the IL-6/STAT3 signaling pathway is essential for therapy. Several inhibitors of IL-6/STAT3 have been developed for cancer treatment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Isak W. Tengesdal, Alberto Dinarello, Nicholas E. Powers, Matthew A. Burchill, Leo A. B. Joosten, Carlo Marchetti, Charles A. Dinarello
Summary: This study reveals that in melanoma, IL-1 beta-induced inflammation is linked to the expansion of immunosuppressive cells, and inhibition of NLRP3 can reduce STAT3 signaling, preventing the expression of immunosuppressive genes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Di Han, Haiying Gong, Yun Wei, Yong Xu, Xianmei Zhou, Zhichao Wang, Fanchao Feng
Summary: Hesperidin can inhibit lung fibroblast senescence and alleviate pulmonary fibrosis, indicating its potential as a treatment for idiopathic pulmonary fibrosis (IPF).
Article
Integrative & Complementary Medicine
Hyo In Kim, Sol Ji Lee, Yu-Jeong Choi, Min Jeong Kim, Tai Young Kim, Seong-Gyu Ko
Summary: This study found that quercetin can induce apoptosis in GBM cells by inhibiting the Axl/IL-6/STAT3 signaling pathway, suggesting its potential as an anticancer agent.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2021)
Article
Integrative & Complementary Medicine
Chun-lei Zheng, Ke-zuo Hou, An-qi Wang, Wan-xia Fang, Shi-tong Yu, Jin-e Liang, Hai-yan Qi, Xiu-juan Qu, Yun-peng Liu, Xiao-fang Che
Summary: The study found that KAI exerts anti-proliferative effects in gastric cancer cells by inhibiting the IL-6/STAT3 signaling pathway and inducing G1 phase arrest.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2022)
Article
Multidisciplinary Sciences
Edouard Charlebois, Kostas Pantopoulos
Summary: Hepatocellular iron overload suppresses hepcidin production by inhibiting the SMAD and STAT3 signaling pathways downstream of their respective ligands.
Article
Medicine, Research & Experimental
Minmin Xu, Li Ren, Jinhua Fan, Lu Huang, Liming Zhou, Xuegang Li, Xiaoli Ye
Summary: Berberine was found to inhibit proliferation, induce apoptosis and cell cycle arrest of gastric cancer cells, as well as suppress migration and invasion. In addition, it was shown to modulate signaling pathways related to IL-6/JAK2/STAT3, providing a theoretical basis for its use in gastric cancer prevention.
Article
Oncology
Wenjin Xiao, Yuxia Shen, Youjia Xu
Summary: The study showed that LOXG473A significantly enhances the formation, ring formation, and bone resorptive activity of osteoclasts, promoting their proliferation through the IL-6/JAK2/STAT3 signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Plant Sciences
Yiran Chen, Xiao Miao, Yanwei Xiang, Le Kuai, Xiaojie Ding, Tian Ma, Bin Li, Bin Fan
Summary: This study aimed to investigate the molecular mechanisms of Qinzhu Liangxue (QZLX) in treating psoriasis. The results showed that QZLX alleviated IL-6-induced hyperproliferation and inflammation in psoriasis by regulating the METTL14/SOCS3/STAT3 axis, indicating a potential anti-psoriasis effect.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Fisheries
Huifeng Dang, Zeinab Hassan, Zhao Jia, Yaxin Wu, Hehe Xiao, Wenji Huang, Xu Guo, Xin Zhao, Yaoguo Li, Jun Zou, Junya Wang
Summary: In this study, the R1 type receptor (CiIL-20R1/CRFB8) and the R2 type receptor (CiIL-20R2/ CRFB16) were identified in grass carp. The expression analysis showed that IL-20R2 was highly expressed in the gills and skin of healthy fish. Infection with Flavobacterium columnare resulted in the downregulation of both receptors in the gill, while infection with grass carp reovirus induced their expression in the head kidney and spleen.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Integrative & Complementary Medicine
Chen Yao-Dong, Cai Fang-Yu, Mao Yu-Ze, Yang Yong-Sheng, Xu Kun, Liu Xiao-Fang, Fan Wen-Wen, Chen Wu, Jiang Feng-Qi, Zhang Hui
Summary: Aloperine effectively inhibits the proliferation, migration, and invasion of HeLa cells by inducing cell cycle arrest, promoting apoptosis, and suppressing epithelial-to-mesenchymal transition. These anticancer properties are associated with the suppression of the IL-6-JAK1-STAT3 feedback loop.
CHINESE JOURNAL OF NATURAL MEDICINES
(2021)
Article
Geriatrics & Gerontology
Pengying Gu, Daidi Tao, Yuanyuan Xu, Qian Yang, Tingting Bai, Shilian Hu, Xingyuan Yang
Summary: This study investigated the effects and mechanisms of osteocalcin on autophagy in myoblasts and its potential therapeutic effects in aging muscles. The results showed that osteocalcin promoted autophagy, increased intracellular reactive oxygen species (ROS) levels, and activated STAT3 signaling. The findings suggest that osteocalcin may be a promising candidate for treating aging-related muscle pathologies.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qianqian Li, Zhaoqing Shi, Fan Zhang, Weiwei Zeng, Dunwan Zhu, Lin Mei
Summary: The immune system plays a critical role in cancer initiation and progression. Recent advancements in nanomaterials have expanded their applications in cancer immunotherapies, including drug carriers, inducers of immunogenic cell death, and immunomodulators. Nanomaterials can act as an integrated platform targeting multiple steps of the cancer-immunity cycle simultaneously, enhancing the effectiveness of anticancer immune response.
ACTA PHARMACEUTICA SINICA B
(2022)
Review
Pharmacology & Pharmacy
Li Yang, Yao Yang, Hongzhong Chen, Lin Mei, Xiaowei Zeng
Summary: Parenteral sustained release drug formulations have been widely used in clinical practice as preferable platforms for long-term exposure therapy. However, the requirement for hypodermic injection hinders their further applications due to issues such as needle-phobia, needle-stick injuries, and inappropriate needle reuse. Microneedles offer an alternative system that is minimally invasive and allows for self-administration.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Biomedical
Ting Chen, Weiwei Zeng, Changjun Tie, Mian Yu, Huisong Hao, Yang Deng, Qianqian Li, Hairong Zheng, Meiying Wu, Lin Mei
Summary: "Translation: The article introduces a new nanoplatform for sonodynamic therapy that uses ultrasound to induce the production of reactive oxygen species. The nanoplatform, Au/BP@MS, shows an increase in the efficiency of reactive oxygen species generation in tumor tissues, leading to significant inhibition of tumor growth. Furthermore, the nanoplatform exhibits responsiveness and degradability in the tumor microenvironment, enhancing its potential for clinical theranostics."
BIOACTIVE MATERIALS
(2022)
Article
Pharmacology & Pharmacy
Zhaoqing Shi, Jing Tang, Chuchu Lin, Ting Chen, Fan Zhang, Yuxing Huang, Ping Luan, Zhuo Xin, Qianqian Li, Lin Mei
Summary: This study developed an iron-mineralized black phosphorene nanosheet as a promising strategy for selective inhibition of tumor cells. The nanosheet showed enhanced cytotoxicity and excellent anti-tumor effects in combination with photothermal therapy.
Review
Chemistry, Multidisciplinary
Chao Pan, Zhuo Mao, Xue Yuan, Hanjie Zhang, Lin Mei, Xiaoyuan Ji
Summary: This review summarizes the recent progress and applications of heterojunction nanomedicine, discusses the catalytic mechanisms and properties in relation to biomedical applications, and presents some challenges and future directions in research.
Article
Engineering, Biomedical
Zimu Li, Zhidong Chen, Hongzhong Chen, Kebing Chen, Wei Tao, Xiao-kun Ouyang, Lin Mei, Xiaowei Zeng
Summary: Polyphenol-based hydrogels, as nature-derived bioactive materials, possess unique properties and have been widely used in biomedical fields. This review elaborates the evolution process of these hydrogels from crosslinking structures to biomedical applications and proposes efficient design considerations.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Yan Zhang, Yuanchao Sun, Xia Dong, Qiang-Song Wang, Dunwan Zhu, Lin Mei, Husheng Yan, Feng Lv
Summary: In this study, a biomimetic platelet intelligent vehicle with navigation system was developed for controllable and visible drug delivery. The intelligent vehicle achieved efficient drug loading and controlled release by encapsulating photothermal-/pH-sensitive chemotherapeutic nanoparticles. It showed good tumor targeting and therapeutic efficacy in mouse models.
Article
Chemistry, Multidisciplinary
Meitong Ou, Chuchu Lin, Ying Wang, Yuting Lu, Wenyan Wang, Zimu Li, Weiwei Zeng, Xiaowei Zeng, Xiaoyuan Ji, Lin Mei
Summary: This study explores a new approach of utilizing active photosynthetic Chlorella functionalized with black phosphorus nanosheets for enhanced photodynamic therapy. The functionalized Chlorella improves tumor hypoxia and enhances immune cell activity and proliferation through photosynthesis. Additionally, the black phosphorus nanosheets improve the conversion efficiency of light and mediate chemodynamic therapy. The synergistic therapy shows high biocompatibility and potential biodegradability, suggesting promising clinical applications.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Chuchu Lin, Chenyi Huang, Zhaoqing Shi, Meitong Ou, Shengjie Sun, Mian Yu, Ting Chen, Yunfei Yi, Xiaoyuan Ji, Feng Lv, Meiying Wu, Lin Mei
Summary: Hydrogen sulfide (H2S) acts as a gasotransmitter molecule, activating intracellular signaling pathways and exerting concentration-dependent antitumor effects. By encapsulating calcium sulfide (CaS) and indocyanine green (ICG) into a biodegradable nanomodulator, researchers have achieved pH-responsive H2S release, enabling the suppression of catalase activity, abnormal Ca2?? retention, mitochondrial destruction, and oxidative stress amplification. This leads to blocked ATP synthesis and downregulated heat shock protein expression, effectively inhibiting tumor growth.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemical Research Methods
Yunfei Yi, Chan Feng, Mian Yu, Lin Mei, Meiying Wu, Wei Tao
Summary: Efficient gene delivery in an integrated drug delivery system is crucial for multimodal antitumor therapy. This study presents a protocol for constructing a peptide-based siRNA delivery system that achieves tumor vascular normalization and gene silencing in 4T1 cells. The system highlights four major steps and has the potential to silence gene expression and perform other treatments based on different peptide segments.
Review
Chemistry, Inorganic & Nuclear
Jun Li, Wang Liao, Dongqing Huang, Meitong Ou, Tongkai Chen, Xinlu Wang, Ruiyue Zhao, Lingyan Zhang, Lin Mei, Jun Liu, Ping Luan
Summary: Alzheimer's disease is a common central neurodegenerative disorder characterized by behavioral disturbance and progressive cognitive impairment. Accumulation of soluble oligomers and amyloid plaques outside nerve cells are crucial in its development. Advanced strategies for detecting and modulating amyloid beta (A beta) in diagnosis and treatment include the use of large-scale apparatus and novel devices, as well as therapeutic agents and nanomaterials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Guozheng Xing, Xuya Yu, Yan Zhang, Shupei Sheng, Limin Jin, Dunwan Zhu, Lin Mei, Xia Dong, Feng Lv
Summary: Pyroptosis-based immunotherapy using macrophage-based biohybrid microrobots shows promise in breast cancer treatment, as it can evade drug resistance, inhibit metastasis, and trigger an immune response. This novel strategy combines photothermal conversion, targeted drug delivery, and controlled drug release to achieve tumor-specific pyroptosis and enhance immunotherapy.
Article
Materials Science, Multidisciplinary
Hongzhong Chen, Tao Sun, Weiwei Zeng, Xiaowei Zeng, Lin Mei, Chen Jiang, Yanli Zhao
Summary: A hypoxia-activated prodrug has been developed in this study for combination therapy with photodynamic therapy (PDT), making the best use of the hypoxic tumor microenvironment. The combination of a hypoxia-responsive camptothecin (CPT)-based prodrug and a near-infrared (NIR) BODIPY photosensitizer allows for effectively combined PDT and chemotherapy, providing a promising approach for cancer treatment.
ACS MATERIALS LETTERS
(2022)
Review
Nanoscience & Nanotechnology
Yao Yang, Weiwei Zeng, Ping Huang, Xiaowei Zeng, Lin Mei
Summary: Smart materials play a crucial role in drug delivery, with endogenous/exogenous responsive materials possessing properties such as controlled drug release and enhanced diagnostic accuracy. Significant research advancements have been made in the development of smart materials responsive to various triggers.
Article
Chemistry, Multidisciplinary
Yong Kang, Lei Lei, Chunfeng Zhu, Hanjie Zhang, Lin Mei, Xiaoyuan Ji
Summary: The piezo-photocatalytic therapy utilizing thermally treated natural sphalerite nanosheet heterojunction efficiently induced intracellular ROS burst and apoptosis of cancer cells by minimizing charge recombination and leading to high-performance radical generation and GSH depletion.
MATERIALS HORIZONS
(2021)