IL-21 and probiotic therapy improve Th17 frequencies, microbial translocation and microbiome in ARV-treated, SIV-infected macaques

Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

(2014) Yoshiyuki Goto et al.   IMMUNITY

Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication

(2014) Jan Kristoff et al.   JOURNAL OF CLINICAL INVESTIGATION

The Kynurenine Pathway of Tryptophan Catabolism, CD4+ T-Cell Recovery, and Mortality Among HIV-Infected Ugandans Initiating Antiretroviral Therapy

(2014) H. Byakwaga et al.   JOURNAL OF INFECTIOUS DISEASES

Focused specificity of intestinal TH17 cells towards commensal bacterial antigens

(2014) Yi Yang et al.   NATURE

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

IL-21 induces IL-22 production in CD4+ T cells

(2014) Ada Yeste et al.   Nature Communications

Microbial Translocation in the Pathogenesis of HIV Infection and AIDS

(2013) Giulia Marchetti et al.   CLINICAL MICROBIOLOGY REVIEWS

Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment

(2013) N. Iida et al.   SCIENCE

The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide

(2013) S. Viaud et al.   SCIENCE

Dysbiosis of the Gut Microbiota Is Associated with HIV Disease Progression and Tryptophan Catabolism

(2013) Ivan Vujkovic-Cvijin et al.   Science Translational Medicine

Maintenance of Intestinal Th17 Cells and Reduced Microbial Translocation in SIV-infected Rhesus Macaques Treated with Interleukin (IL)-21

(2013) Suresh Pallikkuth et al.   PLoS Pathogens

Paucity of IL-21-producing CD4+ T cells is associated with Th17 cell depletion in SIV infection of rhesus macaques

(2012) L. Micci et al.   BLOOD

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

(2012) J. M. Brenchley et al.   BLOOD

Loss of mucosal CD103+ DCs and IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection

(2012) N R Klatt et al.   Mucosal Immunology

Role of the Commensal Microbiota in Normal and Pathogenic Host Immune Responses

(2011) Dan R. Littman et al.   Cell Host & Microbe

Interleukin-21 administration to rhesus macaques chronically infected with simian immunodeficiency virus increases cytotoxic effector molecules in T cells and NK cells and enhances B cell function without increasing immune activation or viral replication

(2011) Suresh Pallikkuth et al.   VACCINE

Antiretroviral therapy and management of HIV infection

(2010) Paul A Volberding et al.   LANCET

Compromised gastrointestinal integrity in pigtail macaques is associated with increased microbial translocation, immune activation and IL-17 production in the absence of SIV infection

(2010) N R Klatt et al.   Mucosal Immunology

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

(2010) D. Favre et al.   Science Translational Medicine

Th17 and regulatory T cells: implications for AIDS pathogenesis

(2010) Bittoo Kanwar et al.   Current Opinion in HIV and AIDS

Damaged Intestinal Epithelial Integrity Linked to Microbial Translocation in Pathogenic Simian Immunodeficiency Virus Infections

(2010) Jacob D. Estes et al.   PLoS Pathogens

Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria

(2009) Ivaylo I. Ivanov et al.   CELL

Precarious Balance: Th17 Cells in Host Defense

(2009) A. Peck et al.   INFECTION AND IMMUNITY

Thrombocytopenia Is Strongly Associated With Simian AIDS in Pigtail Macaques

(2009) Sheilajen Alcantara et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Critical Loss of the Balance between Th17 and T Regulatory Cell Populations in Pathogenic SIV Infection

(2009) David Favre et al.   PLoS Pathogens

Differential Th17 CD4 T-cell depletion in pathogenic and nonpathogenic lentiviral infections

(2008) J. M. Brenchley et al.   BLOOD

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

(2008) Ivaylo I. Ivanov et al.   Cell Host & Microbe

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

(2008) Liang Zhou et al.   NATURE

Simian immunodeficiency virus–induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut

(2008) Manuela Raffatellu et al.   NATURE MEDICINE