Oxidative Stress in β-Thalassemia

Mitochondrial membrane potential

(2018) Ljubava D. Zorova et al.   ANALYTICAL BIOCHEMISTRY

Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis

(2018) Alessandro Matte et al.   ANTIOXIDANTS & REDOX SIGNALING

Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia

(2018) Alexis A. Thompson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anemia of Inflammation

(2017) Paula G. Fraenkel   MEDICAL CLINICS OF NORTH AMERICA

The transferrin receptor: the cellular iron gate

(2017) Elena Gammella et al.   Metallomics

Iron overload in hematological disorders

(2017) Eitan Fibach et al.   PRESSE MEDICALE

2017 Clinical trials update in new treatments of β-thalassemia

(2016) Alexandros Makis et al.   AMERICAN JOURNAL OF HEMATOLOGY

Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers

(2016) L. Breda et al.   BLOOD

How we manage patients with hereditary haemochromatosis

(2016) Eva Rombout-Sestrienkova et al.   BRITISH JOURNAL OF HAEMATOLOGY

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

(2016) Sachith Mettananda et al.   HAEMATOLOGICA

Hemoglobin genetics: recent contributions of GWAS and gene editing

(2016) Elenoe C. Smith et al.   HUMAN MOLECULAR GENETICS

The mutual control of iron and erythropoiesis

(2016) C. Camaschella et al.   International Journal of Laboratory Hematology

Safety profile of a liquid formulation of deferiprone in young children with transfusion-induced iron overload: a 1-year experience

(2016) Ampaiwan Chuansumrit et al.   Paediatrics and International Child Health

Selective silencing of α-globin by the histone demethylase inhibitor IOX1: a potentially new pathway for treatment of β-thalassemia

(2016) Sachith Mettananda et al.   HAEMATOLOGICA

A Focus on Heme Oxygenase-1 (HO-1) Inhibitors

(2016) V. Pittalà et al.   CURRENT MEDICINAL CHEMISTRY

Thalassemia 2016: Modern medicine battles an ancient disease

(2015) Deborah Rund   AMERICAN JOURNAL OF HEMATOLOGY

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Knockdown of transcription factor forkhead box O3 (FOXO3) suppresses erythroid differentiation in human cells and zebrafish

(2015) Hai Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Erythroferrone contributes to hepcidin suppression and iron overload in a mouse model of  -thalassemia

(2015) L. Kautz et al.   BLOOD

Synergistic intracellular iron chelation combinations: mechanisms and conditions for optimizing iron mobilization

(2015) Evangelia Vlachodimitropoulou Koumoutsea et al.   BRITISH JOURNAL OF HAEMATOLOGY

Efficacy of Rapamycin as Inducer of Hb F in Primary Erythroid Cultures from Sickle Cell Disease andβ-Thalassemia Patients

(2015) Alice Pecoraro et al.   HEMOGLOBIN

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction

(2015) Swaroopa Guda et al.   MOLECULAR THERAPY

Cardioprotective Effects of Tannic Acid on Isoproterenol-Induced Myocardial Injury in Rats: Further Insight into ‘French Paradox’

(2015) Xitian Hu et al.   PHYTOTHERAPY RESEARCH

The Effect of Fermented Papaya Preparation on Radioactive Exposure

(2015) Eitan Fibach et al.   RADIATION RESEARCH

Coupling of Ribostasis and Proteostasis: Hsp70 Proteins in mRNA Metabolism

(2015) Robert W. Walters et al.   TRENDS IN BIOCHEMICAL SCIENCES

Oxidative stress in β-thalassaemia and sickle cell disease

(2015) S. Voskou et al.   Redox Biology

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis

(2015) Joe Dan Dunn et al.   Redox Biology

FOXO3-mTOR metabolic cooperation in the regulation of erythroid cell maturation and homeostasis

(2014) Xin Zhang et al.   AMERICAN JOURNAL OF HEMATOLOGY

Induction of fetal hemoglobin through enhanced translation efficiency of  -globin mRNA

(2014) C. K. Hahn et al.   BLOOD

Reactivation of Developmentally Silenced Globin Genes by Forced Chromatin Looping

(2014) Wulan Deng et al.   CELL

Hepcidin and the Global Burden of Iron Deficiency

(2014) T. Ganz   CLINICAL CHEMISTRY

Translational control by heme-regulated eIF2α kinase during erythropoiesis

(2014) Jane-Jane Chen   CURRENT OPINION IN HEMATOLOGY

Are we altering the natural history of primary myelofibrosis?

(2014) Michael R. Savona   LEUKEMIA RESEARCH

An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia

(2014) Michael Dussiot et al.   NATURE MEDICINE

Oxidative Stress, Prooxidants, and Antioxidants: The Interplay

(2014) Anu Rahal et al.   Biomed Research International

The eIF2α kinases: their structures and functions

(2013) Neysan Donnelly et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

(2013) S. S. Franco et al.   HAEMATOLOGICA

MicroRNA-486-3p Regulates γ-Globin Expression in Human Erythroid Cells by Directly Modulating BCL11A

(2013) Valentina Lulli et al.   PLoS One

Peroxiredoxin II is essential for preventing hemolytic anemia from oxidative stress through maintaining hemoglobin stability

(2012) Ying-Hao Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Heme-regulated eIF2  kinase activated Atf4 signaling pathway in oxidative stress and erythropoiesis

(2012) R. N. V. S. Suragani et al.   BLOOD

Deletion of TMPRSS6 attenuates the phenotype in a mouse model of  -thalassemia

(2012) A. Nai et al.   BLOOD

Heterogeneity of F cells in β-thalassemia

(2012) Eugenia Prus et al.   TRANSFUSION

Mi2β Is Required for γ-Globin Gene Silencing: Temporal Assembly of a GATA-1-FOG-1-Mi2 Repressor Complex in β-YAC Transgenic Mice

(2012) Flávia C. Costa et al.   PLoS Genetics

Regulation of cellular iron metabolism

(2011) Jian Wang et al.   BIOCHEMICAL JOURNAL

Oxidative stress modulates heme synthesis and induces peroxiredoxin-2 as a novel cytoprotective response in  -thalassemic erythropoiesis

(2011) L. De Franceschi et al.   HAEMATOLOGICA

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Quantifying Oxidant-Scavenging Ability of Blood

(2011) Isaac Ginsburg et al.   NEW ENGLAND JOURNAL OF MEDICINE

Oxidative stress contributes to hemolysis in patients with hereditary spherocytosis and can be ameliorated by fermented papaya preparation

(2010) Hussam Ghoti et al.   ANNALS OF HEMATOLOGY

Therapeutic levels of fetal hemoglobin in erythroid progeny of  -thalassemic CD34+ cells after lentiviral vector-mediated gene transfer

(2010) A. Wilber et al.   BLOOD

Polyphenols enhance total oxidant-scavenging capacities of human blood by binding to red blood cells

(2010) Erez Koren et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Transferrin therapy ameliorates disease in β-thalassemic mice

(2010) Huihui Li et al.   NATURE MEDICINE

Amelioration of oxidative stress in red blood cells from patients with β-thalassemia major and intermedia and E-β-thalassemia following administration of a fermented papaya preparation

(2010) Eitan Fibach et al.   PHYTOTHERAPY RESEARCH

Effect of Iron Chelators on Labile Iron and Oxidative Status of Thalassaemic Erythroid Cells

(2009) Eugenia Prus et al.   ACTA HAEMATOLOGICA

A flow cytometry approach for quantitative analysis of cellular phosphatidylserine distribution and shedding

(2009) Inna Freikman et al.   ANALYTICAL BIOCHEMISTRY

Involvement of oxygen-sensing pathways in physiologic and pathologic erythropoiesis

(2009) G. L. Semenza   BLOOD

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in  -thalassemia

(2008) I. V. Libani et al.   BLOOD

The labile iron pool in human erythroid cells

(2008) Eugenia Prus et al.   BRITISH JOURNAL OF HAEMATOLOGY

Global epidemiology of haemoglobin disorders and derived service indicators

(2008) Bernadette Modell   BULLETIN OF THE WORLD HEALTH ORGANIZATION

The Role of Oxidative Stress in Hemolytic Anemia

(2008) Eitan Fibach et al.   CURRENT MOLECULAR MEDICINE

Fermented papaya preparation as redox regulator in blood cells ofβ-thalassemic mice and patients

(2008) Johnny Amer et al.   PHYTOTHERAPY RESEARCH

Flow cytometry measurement of the labile iron pool in human hematopoietic cells

(2007) Eugenia Prus et al.   CYTOMETRY PART A