Review
Biochemistry & Molecular Biology
Ayleen Fernandez-Fierro, Samanta C. Funes, Mariana Rios, Camila Covian, Jorge Gonzalez, Alexis M. Kalergis
Summary: The heme oxygenase (HO) system involves three isoforms, with HO-1 being the most studied and overexpression of this enzyme promoting anti-inflammatory products. However, overexpression of HO leading to neonatal jaundice has prompted the development of inhibitors. Various types of inhibitors have been identified, including competitive and non-competitive ones, with potential medical implications in metabolic diseases and immune-mediated diseases such as cancer and Alzheimer's disease. Selective inhibition of HO isoforms may contribute to the treatment of these ailments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Giuseppe Floresta, Antonino N. Fallica, Loredana Salerno, Valeria Sorrenti, Valeria Pittala, Antonio Rescifina
Summary: Up-regulation of HO-1 in human malignancies has been frequently reported and its inhibition is considered a valuable approach for anticancer therapy. A structure-guided fragment-based approach was used to identify novel HO-1 inhibitors, with two lead compounds identified to effectively inhibit HO-1 activity. The successful synthesis and evaluation of these compounds suggest promising potential for further development in anticancer drug discovery.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Giuseppe Floresta, Antonino Nicolo Fallica, Vincenzo Patamia, Valeria Sorrenti, Khaled Greish, Antonio Rescifina, Valeria Pittala
Summary: HO-1 overexpression has been observed in various human malignancies, with poor clinical outcomes reported in most cases. Inhibition of HO-1 is considered an effective approach for anticancer therapy. This study utilized a fragment-based approach to identify novel indole-based compounds as HO-1 inhibitors, with some showing micromolar activity and one molecule (4d) demonstrating strong inhibition of HO-1 with an IC50 of 1.03 μM. The results suggest the success of the approach in generating a novel hit compound for further development.
Article
Multidisciplinary Sciences
Zhen Liang, Zhaoshi Zheng, Qi Guo, Meng Tian, Jing Yang, Xiu Liu, Xiaojuan Zhu, Songyan Liu
Summary: This study investigates the role of hypoxia-inducible factor (HIF)-1 alpha/heme oxygenase (HO)-1 in hippocampal neuron ferroptosis during epilepsy. The results suggest that there are metabolic differences between epilepsy patients and healthy individuals, with increased oxidative stress, heightened bilirubin, and augmented iron metabolism in epileptic blood. The active HIF-1 pathway in epileptic pathogenesis and perturbations in HIF-1 alpha signaling are reinforced by the analysis. The study implicates that HIF-1 alpha/HO-1 potentially regulates hippocampal neuronal ferroptosis, iron metabolism, and oxidative stress, thereby promoting the propagation of epilepsy.
Review
Biochemistry & Molecular Biology
Maria G. Detsika, Elias A. Lianos
Summary: Heme oxygenase-1 has a new cytoprotective role by regulating the complement control protein, which helps prevent kidney injury. Targeting HO-1 induction in specific cells could be a novel approach to attenuate complement-dependent kidney diseases.
Article
Pharmacology & Pharmacy
Hye-Eun Choi, Eun Jeong Jeon, Dong Young Kim, Mi Jin Choi, Hana Yu, Jea Il Kim, Hyae Gyeong Cheon
Summary: This study investigated the effects of sodium salicylate on adipocyte browning and found that it can induce browning by up-regulating HO-1 and promoting M2 polarization.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang Ho, Tzen-Wen Chen, Tung-Po Huang, Ying-Hwa Chen, Der-Cherng Tarng
Summary: This study found that serum bilirubin levels and HO-1 and UGT1A1 gene polymorphisms were associated with cardiovascular disease among patients receiving chronic hemodialysis.
Article
Pharmacology & Pharmacy
Yen-Chang Chen, Jia-Hong Chen, Cheng-Fang Tsai, Chen-Teng Wu, Miao-Hsiang Wu, Pei-Chun Chang, Wei-Lan Yeh
Summary: The study found that nicardipine can inhibit the migration and colony formation of breast cancer cells, and increase the expression of Nrf2 and HO-1. The reduction of matrix metalloproteinase-9 by nicardipine is regulated by Nrf2/HO-1 axis and its catalytic end products.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cristina Fernandez-Mendivil, Enrique Luengo, Paula Trigo-Alonso, Nuria Garcia-Magro, Pilar Negredo, Manuela G. Lopez
Summary: The study revealed that overexpression of HO-1 in microglial cells in aged mice leads to neurotoxic iron accumulation, oxidative stress, and cognitive decline. Inhibiting HO-1 or using an iron chelator can prevent these issues, providing new insights for treating age-related neurodegenerative diseases.
Review
Cell Biology
Mohammad Sadeghi, Mehrdad Fathi, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Mehdi Yousefi, Mohammad Hojjat-Farsangi, Afshin Namdar, Ali Akbar Movasaghpour Akbari, Farhad Jadidi-Niaragh
Summary: Heme oxygenase-1 (HO-1) is overexpressed in hematological malignancies and associated with disease severity. It induces tumor progression and prevents apoptosis through various pathways, making it a potential therapeutic target. However, the exact role of HO-1 in Chronic Lymphocytic Leukemia (CLL) remains unclear.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Xiangyun Li, Jianbo Yu, Lirong Gong, Yuan Zhang, Shuan Dong, Jia Shi, Cui Li, Yuting Li, Yanfang Zhang, Haibo Li
Summary: Sepsis-induced acute lung injury leads to oxidative stress, inflammation, apoptosis, and changes in Golgi morphology. Activating the HO-1 pathway can alleviate Golgi stress and oxidative stress, providing a therapeutic target for treating acute lung injury.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Gelare Ghajar-Rahimi, Amie M. Traylor, Bini Mathew, James R. Bostwick, N. Miranda Nebane, Anna A. Zmijewska, Stephanie K. Esman, Saakshi Thukral, Ling Zhai, Vijaya Sambandam, Rita M. Cowell, Mark J. Suto, James F. George, Corinne E. Augelli-Szafran, Anupam Agarwal
Summary: Acute kidney injury is a major health concern with no current effective treatments. This study identifies small-molecule inducers of HO-1 as potential therapeutic candidates for AKI.
Article
Biochemistry & Molecular Biology
Maria G. Detsika, Ioanna Nikitopoulou, Dimitris Veroutis, Alice G. Vassiliou, Edison Jahaj, Stamatis Tsipilis, Nikolaos Athanassiou, Hariklia Gakiopoulou, Vassilis G. Gorgoulis, Ioanna Dimopoulou, Stylianos E. Orfanos, Anastasia Kotanidou
Summary: The increase in HO-1 expression observed in critically ill COVID-19 patients is associated with disease progression and poor outcome. The upregulation of HO-1 in blood and tissues of severe patients may serve as a protective mechanism against coagulation and thrombosis.
Review
Pharmacology & Pharmacy
Yumin Wang, Luyan Gao, Jichao Chen, Qiang Li, Liang Huo, Yanchao Wang, Hongquan Wang, Jichen Du
Summary: Parkinson's disease is a complex neurodegenerative disorder characterized by the loss of dopaminergic neurons in the brain. Oxidative stress has been implicated in its pathogenesis, with the transcription factor Nrf2 playing a key role in activating protective genes against oxidative stress. Recent studies have shown that bioactive compounds can activate Nrf2 and ameliorate neurotoxins associated with PD, suggesting a potential therapeutic target for the treatment of the disease.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Physical
Kalieswaran Vidhya, Kumar Praveen Kumar, Shanmughavel Piramanayagam, Mani Arulkumar, Janani Balraj, Karunyadevi Jairaman, Gopalan Subashini, Jayaraman Angayarkanni
Summary: Novel L-Histidine-based Schiff base derivatives were synthesized and characterized as inhibitors of microbial-HO, showing good antimicrobial activity against various microbes. Different compounds exhibited varied antimicrobial activity against different microbes.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Review
Biochemistry & Molecular Biology
Mohamed Haider, Amr Elsherbeny, Valeria Pittala, Valeria Consoli, Maha Ali Alghamdi, Zahid Hussain, Ghalia Khoder, Khaled Greish
Summary: Lung cancer is a major cause of cancer occurrence and mortality worldwide. Drug resistance is a complex process in lung cancer, and nanomedicine provides promising tools for reversing resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Valeria Consoli, Valeria Sorrenti, Valeria Pittala, Khaled Greish, Agata Grazia D'Amico, Giuseppe Romeo, Sebastiano Intagliata, Loredana Salerno, Luca Vanella
Summary: Ferroptosis is suggested as a potential new strategy for treating breast cancer, particularly triple negative breast cancer. The study reveals the importance of HO in ferroptosis, with HO-1 induction potentially accelerating the process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Valeria Ciaffaglione, Valeria Consoli, Sebastiano Intagliata, Agostino Marrazzo, Giuseppe Romeo, Valeria Pittala, Khaled Greish, Luca Vanella, Giuseppe Floresta, Antonio Rescifina, Loredana Salerno, Valeria Sorrenti
Summary: This paper presents a novel series of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia, showing high inhibition against the BCR-ABL protein. Molecular docking studies revealed insights into the binding mode with different targets, providing a structural explanation for the varying activities of the compounds.
Article
Public, Environmental & Occupational Health
Mohamed Daoudi, Mattia Calzolari, Samia Boussaa, Paolo Bonilauri, Deborah Torri, Giuseppe Romeo, Davide Lelli, Antonio Lavazza, Mohamed Hafidi, Michele Dottori, Ali Boumezzough
Summary: This study analyzed the specific composition of sand fly populations in endemic and non-endemic areas of leishmaniasis in Morocco and detected the presence of Toscana virus for the first time in central Morocco. The findings have important epidemiological implications for monitoring the circulation of Toscana virus and implementing surveillance plans for sand fly-borne phleboviruses in Morocco.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Astronomy & Astrophysics
S. Vercellone, C. Bigongiari, A. Burtovoi, M. Cardillo, O. Catalano, A. Franceschini, S. Lombardi, L. Nava, F. Pintore, A. Stamerra, F. Tavecchio, L. Zampieri, R. Alves Batista, E. Amato, L. A. Antonelli, C. Arcaro, J. Becerra Gonzalez, G. Bonnoli, M. Boettcher, G. Brunetti, A. A. Compagnino, S. Crestan, A. D'Ai, M. Fiori, G. Galanti, A. Giuliani, E. M. de Gouveia Dal Pino, J. G. Green, A. Lamastra, M. Landoni, F. Lucarelli, G. Morlino, B. Olmi, E. Peretti, G. Piano, G. Ponti, E. Poretti, P. Romano, F. G. Saturni, S. Scuderi, A. Tutone, G. Umana, J. A. Acosta-Pulido, P. Barai, A. Bonanno, G. Bonanno, P. Bruno, A. Bulgarelli, V. Conforti, A. Costa, G. Cusumano, M. Del Santo, M. V. del Valle, R. Della Ceca, D. A. Falceta-Goncalves, V. Fioretti, S. Germani, R. J. Garcia-Lopez, A. Ghedina, F. Gianotti, V. Giordano, M. Kreter, F. Incardona, S. Iovenitti, A. La Barbera, N. La Palombara, V. La Parola, G. Leto, F. Longo, A. Lopez-Oramas, M. C. Maccarone, S. Mereghetti, R. Millul, G. Naletto, A. Pagliaro, N. Parmiggiani, C. Righi, J. C. Rodriguez-Ramirez, G. Romeo, P. Sangiorgi, R. Santos de Lima, G. Tagliaferri, V. Testa, G. Tosti, M. Vazquez Acosta, N. Zywucka, P. A. Caraveo, G. Pareschi
Summary: The ASTRI Project led by INAF is developing the ASTRI Mini-Array, a small telescope array consisting of nine telescopes similar to ASTRI-Horn. The Mini-Array will surpass the current Cherenkov telescope array's sensitivity and extend the energy band well above hundreds of TeV.
JOURNAL OF HIGH ENERGY ASTROPHYSICS
(2022)
Article
Astronomy & Astrophysics
S. Scuderi, A. Giuliani, G. Pareschi, G. Tosti, O. Catalano, E. Amato, L. A. Antonelli, J. Becerra Gonzales, G. Bellassai, C. Bigongiari, B. Biondo, M. Bottcher, G. Bonanno, G. Bonnoli, P. Bruno, A. Bulgarelli, R. Canestrari, M. Capalbi, P. Caraveo, M. Cardillo, V. Conforti, G. Contino, M. Corpora, A. Costa, G. Cusumano, A. D'Ai, E. de Gouveia Dal Pino, R. Della Ceca, E. Escribano Rodriguez, D. Falceta-Goncalves, C. Fermino, M. Fiori, V. Fioretti, M. Fiorini, S. Gallozzi, C. Gargano, S. Garozzo, S. Germani, A. Ghedina, F. Gianotti, S. Giarrusso, R. Gimenes, V. Giordano, A. Grillo, C. Grivel Gelly, D. Impiombato, F. Incardona, S. Incorvaia, S. Iovenitti, A. La Barbera, N. La Palombara, V. La Parola, A. Lamastra, L. Lessio, G. Leto, F. Lo Gerfo, M. Lodi, S. Lombardi, F. Longo, F. Lucarelli, M. C. Maccarone, D. Marano, E. Martinetti, S. Mereghetti, A. Micciche, R. Millul, T. Mineo, D. Mollica, G. Morlino, A. Morselli, G. Naletto, G. Nicotra, A. Pagliaro, N. Parmiggiani, G. Piano, F. Pintore, E. Poretti, B. Olmi, G. Rodeghiero, G. Rodriguez Fernandez, P. Romano, G. Romeo, F. Russo, P. Sangiorgi, F. G. Saturni, J. H. Schwarz, E. Sciacca, G. Sironi, G. Sottile, A. Stamerra, G. Tagliaferri, V. Testa, G. Umana, M. Uslenghi, S. Vercellone, L. Zampieri, R. Zanmar Sanchez
Summary: The ASTRI Mini-Array (MA) is an INAF project that aims to study high-energy astronomical sources in the TeV spectral band. Consisting of a group of innovative Imaging Atmospheric Cherenkov telescopes, the ASTRI MA will be installed at the Teide Astronomical Observatory in Tenerife. With better overall performance than current Cherenkov telescope arrays, the ASTRI MA will be an important instrument for deep observations at energies ranging from approximately 5 TeV to 100 TeV and beyond.
JOURNAL OF HIGH ENERGY ASTROPHYSICS
(2022)
Review
Health Care Sciences & Services
Maha Ali Alghamdi, Antonino N. Fallica, Nicola Virzi, Prashant Kesharwani, Valeria Pittala, Khaled Greish
Summary: Personalized medicine and nanomedicine are both new concepts in medical practice. Personalized medicine aims to customize therapeutic management based on a patient's personal attributes, while nanomedicine applies nanotechnology advances in medicine for diagnosis and treatment. The integration of these two fields can provide more effective treatment options tailored to individual patients.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Astronomy & Astrophysics
Simon Wing, Drew L. Turner, Aleksandr Y. Ukhorskiy, Jay R. Johnson, Thomas Sotirelis, Romina Nikoukar, Giuseppe Romeo
Summary: An empirical model of radiation belt relativistic electrons is developed, with inputs of solar wind and magnetospheric parameters and outputs of radiation belt electron phase space density. The model is constructed using neural networks assisted by information theory and can be used to forecast the phase space density of radiation belt electrons 30-60 minutes in advance.
SPACE WEATHER-THE INTERNATIONAL JOURNAL OF RESEARCH AND APPLICATIONS
(2022)
Article
Astronomy & Astrophysics
A. D'Ai, E. Amato, A. Burtovoi, A. A. Compagnino, M. Fiori, A. Giuliani, N. La Palombara, A. Paizis, G. Piano, F. G. Saturni, A. Tutone, A. Belfiore, M. Cardillo, S. Crestan, G. Cusumano, M. Della Valle, M. Del Santo, A. La Barbera, V. La Parola, S. Lombardi, S. Mereghetti, G. Morlino, F. Pintore, P. Romano, S. Vercellone, A. Antonelli, C. Arcaro, C. Bigongiari, M. Boettcher, P. Bruno, A. Bulgarelli, V. Conforti, A. Costa, E. de Gouveia Dal Pino, V. Fioretti, S. Germani, A. Ghedina, F. Gianotti, V. Giordano, F. Incardona, G. Leto, F. Longo, A. Lopez Oramas, F. Lucarelli, B. Olmi, A. Pagliaro, N. Parmiggiani, G. Romeo, A. Stamerra, V. Testa, G. Tosti, G. Umana, L. Zampieri, P. Caraveo, G. Pareschi
Summary: The ASTRI Mini-Array is a set of nine imaging atmospheric Cherenkov telescopes used for astrophysical observations. It offers high angular and energy resolutions and can be applied to different astrophysical environments. The core-science program focuses on key targets, while additional observations extend to a wider sky.
JOURNAL OF HIGH ENERGY ASTROPHYSICS
(2022)
Article
Biochemistry & Molecular Biology
Shereen Morsi, Valeria Pittala, Mohammad Alqudah, Mohamed Haider, Khaled Greish
Summary: The study revealed that AgNPs have inhibitory effects on pain response and show dose-dependent behavior in animal models. The findings indicate that AgNPs can significantly increase the paw withdrawal threshold in animals with CCI.
Article
Biochemistry & Molecular Biology
Lucia Longhitano, Giuseppe Broggi, Sebastiano Giallongo, Maria Failla, Lidia Puzzo, Teresio Avitabile, Daniele Tibullo, Alfio Distefano, Valeria Pittala, Michele Reibaldi, Guido Nicola Zanghi, Antonio Longo, Andrea Russo, Rosario Caltabiano, Giovanni Li Volti, Nicolo Musso
Summary: The study revealed the important role of HO-1 in regulating uveal melanoma progression, with an increase of HO-1 promoting cellular proliferation and wound healing ability of tumor cells, suggesting HO-1 protein expression may serve as a potential prognostic and therapeutic factor in UM patients.
Article
Virology
Mohamed Daoudi, Giuseppe Romeo, Katia Marzani, Angelica Petrella, Paolo Bonilauri, Davide Lelli, Ali Boumezzough, Samia Boussaa, Michele Dottori, Mattia Calzolari
Summary: The number of newly described sandfly-borne phleboviruses has been increasing in recent years. This study investigated the circulation of these viruses in the Emilia-Romagna region and identified a strain of a Ponticelli III virus. Future research is needed to understand the ecological processes driving the occurrence of these novel phleboviruses and their potential impact on public health.
Article
Chemistry, Medicinal
Loredana Salerno, Valeria Sorrenti, Valeria Pittala, Valeria Consoli, Maria N. Modica, Giuseppe Romeo, Agostino Marrazzo, Michela Giuliano, Pawel Zajdel, Luca Vanella, Sebastiano Intagliata
Summary: In this work, novel mutual prodrugs, SI 1/20 and SI 1/22, were designed and synthesized as 5-fluorouracil/heme oxygenase 1 (5-FU/HO-1) inhibitor hybrids. These hybrids showed good drug-likeness and pharmacokinetic properties according to experimental hydrolysis rate and in silico ADMET predictions. They exhibited enhanced anticancer activity against prostate DU145 cancer cells compared to the parent compounds, with lower toxicity against non-tumorigenic human benign prostatic hyperplasia (BPH-1) cell line. Furthermore, the mutual prodrugs inhibited HO-1 activity, downregulated HO-1 expression, and increased reactive oxygen species (ROS) levels.
Article
Astronomy & Astrophysics
F. Acero, A. Acharyya, R. Adam, A. Aguasca-Cabot, I. Agudo, A. Aguirre-Santaella, J. Alfaro, R. Aloisio, N. Alvarez Crespo, R. Alves Batista, L. Amati, E. Amato, G. Ambrosi, E. O. Anguner, C. Aramo, C. Arcaro, T. Armstrong, K. Asano, Y. Ascasibar, J. Aschersleben, M. Backes, A. Baktash, C. Balazs, M. Balbo, J. Ballet, A. Baquero Larriva, V. Barbosa Martins, U. Barres de Almeida, J. A. Barrio, D. Bastieri, J. R. Baxter, J. Becker Tjus, W. Benbow, M. I. Bernardos-Martin, J. Bernete, A. Berti, B. Bertucci, V. Beshley, P. Bhattacharjee, S. Bhattacharyya, A. Biland, E. Bissaldi, J. Biteau, O. Blanch, P. Bordas, E. Bottacini, J. Bregeon, R. Brose, N. Bucciantini, A. Bulgarelli, M. Capasso, R. A. Capuzzo Dolcetta, P. Caraveo, M. Cardillo, R. Carosi, S. Casanova, E. Cascone, F. Cassol, F. Catalani, M. Cerruti, P. Chadwick, S. Chaty, A. Chen, M. Chernyakova, A. Chiavassa, J. Chudoba, C. Coimbra-Araujo, V. Conforti, J. L. Contreras, A. Costa, H. Costantini, P. Cristofari, R. Crocker, G. D'Amico, F. D'Ammando, A. De Angelis, V. De Caprio, E. M. de Gouveia Dal Pino, E. de Ona Wilhelmi, V. de Souza, C. Delgado, D. della Volp, D. Depaoli, T. Di Girolamo, F. Di Pierro, R. Di Tria, L. Di Venere, S. Diebold, J. I. Djuvsland, A. Donini, M. Doro, R. d. C. Dos Anjos, V. V. Dwarkadas, S. Einecke, D. Elsaesser, G. Emery, C. Evoli, D. Falceta-Goncalves, E. Fedorova, S. Fegan, G. Ferrand, E. Fiandrini, M. Filipovic, V. Fioretti, M. Fiori, L. Foffano, G. Fontaine, S. Fukami, G. Galanti, G. Galaz, V. Gammaldi, C. Gasbarra, A. Ghalumyan, G. Ghirlanda, M. Giarrusso, G. Giavitto, N. Giglietto, F. Giordano, M. Giroletti, A. Giuliani, L. Giunti, N. Godinovic, J. Goulart Coelho, L. Greaux, D. Green, M. -H. Grondin, O. Gueta, S. Gunji, T. Hassan, M. Heller, S. Hernandez-Cadena, J. Hinton, B. Hnatyk, R. Hnatyk, D. Hoffmann, W. Hofmann, J. Holder, D. Horan, P. Horvath, M. Hrabovsky, D. Hrupec, T. Inada, F. Incardona, S. Inoue, K. Ishio, M. Jamrozy, P. Janecek, I. Jimenez Martinez, W. Jin, I. Jung-Richardt, J. Jurysek, P. Kaaret, V. Karas, U. Katz, D. Kerszberg, B. Khelifi, D. B. Kieda, R. Kissmann, T. Kleiner, G. Kluge, W. Kluzniak, J. Knodlseder, Y. Kobayashi, K. Kohri, N. Komin, P. Kornecki, H. Kubo, N. La Palombara, M. Lainez, A. Lamastra, J. Lapington, M. Lemoine-Goumard, J. -P. Lenain, F. Leone, G. Leto, F. Leuschner, E. Lindfors, I. Liodakis, T. Lohse, S. Lombardi, F. Longo, R. Lopez-Coto, M. Lopez-Moya, A. Lopez-Oramas, S. Loporchio, P. L. Luque-Escamilla, O. Macias, J. Mackey, P. Majumdar, D. Mandat, M. Manganaro, G. Manico, M. Marconi, J. Marti, G. Martinez, M. Martinez, O. Martinez, A. J. T. S. Mello, S. Menchiari, D. M. -A. Meyer, S. Micanovic, D. Miceli, M. Miceli, J. Michalowski, T. Miener, J. M. Miranda, A. Mitchell, B. Mode, R. Moderski, L. Mohrmann, E. Molina, T. Montaruli, D. Morcuende, G. Morlino, A. Morselli, M. Mose, E. Moulin, R. Mukherjee, K. Munari, T. Murach, A. Nagai, S. Nagataki, R. Nemmen, J. Niemiec, D. Nieto, M. Nievas Rosillo, M. Nikolajuk, K. Nishijima, K. Noda, B. Novosyadlyj, S. Nozaki, M. Ohishi, S. Ohm, Y. Ohtani, A. Okumura, B. Olmi, R. A. Ong, M. Orienti, R. Orito, M. Orlandini, E. Orlando, S. Orlando, M. Ostrowski, I. Oya, F. R. Pantaleo, J. M. Paredes, B. Patricelli, M. Pecimotika, M. Peresano, J. Perez-Romero, M. Persic, O. Petruk, G. Piano, E. Pietropaolo, G. Pirola, C. Pittori, M. Pohl, G. Ponti, E. Prandini, G. Principe, C. Priyadarshi, E. Pueschel, G. Puehlhofer, M. L. Pumo, A. Quirrenbach, R. Rando, S. Razzaque, P. Reichherzer, A. Reimer, O. Reimer, M. Renaud, T. Reposeur, M. Ribo, T. Richtler, J. Rico, F. Rieger, M. Rigoselli, L. Riitano, V. Rizi, E. Roache, P. Romano, G. Romeo, J. Rosado, G. Rowell, B. Rudak, I. Sadeh, S. Safi-Harb, L. Saha, S. Sailer, M. Sanchez-Conde, S. Sarkar, K. Satalecka, F. G. Saturni, A. Scherer, P. Schovanek, F. Schussler, U. Schwanke, S. Scuderi, M. Seglar-Arroyo, O. Sergijenko, M. Servillat, R. -Y. Shang, P. Sharma, H. Siejkowski, V. Sliusar, A. Slowikowska, H. Sol, A. Specovius, S. T. Spencer, G. Spengler, A. Stamerra, S. Stanic, T. Starecki, R. Starling, T. Stolarczyk, L. A. Stuani Pereira, Y. Suda, T. Suomijarvi, I. Sushch, H. Tajima, P. -H. T. Tam, S. J. Tanaka, F. Tavecchio, V. Testa, W. Tian, L. Tibaldo, D. F. Torres, N. Tothill, B. Vallage, P. Vallania, C. van Eldik, J. van Scherpenberg, J. Vandenbroucke, M. Vazquez Acosta, M. Vecchi, S. Vercellone, G. Verna, A. Viana, J. Vignatti, V. Vitale, V. Vodeb, S. Vorobiov, T. Vuillaume, S. J. Wagner, R. Walter, M. White, A. Wierzcholska, M. Will, D. Williams, L. Yang, T. Yoshida, T. Yoshikoshi, G. Zaharijas, L. Zampieri, D. Zavrtanik, M. Zavrtanik, V. I. Zhdanov, M. Zivec
Summary: This study assesses the potential of using very high energy gamma-ray spectral signatures to identify PeVatrons with the Cherenkov Telescope Array (CTA). The simulations show that after scanning the Galactic plane for 10 hours, CTA is expected to detect a gamma-ray signal from an average of 9 PeVatron SNRs. Deep observations with CTA, lasting O(100) hours per source, also have excellent potential to confirm these sources as PeVatrons.
ASTROPARTICLE PHYSICS
(2023)