Article
Biochemistry & Molecular Biology
Danica Matusovits, Zsolt Murlasits, Krisztina Kupai, Zoltan Barath, Hsu Lin Kang, Peter Osvath, Miklos Szucs, Daniel Priksz, Bela Juhasz, Zsolt Radak, Tamas Varkonyi, Imre Pavo, Aniko Posa
Summary: In cardiovascular applications, paclitaxel inhibits smooth muscle cell proliferation and migration, reducing restenosis and target lesion revascularization. However, its cellular effects on the myocardium are not well understood.
Article
Plant Sciences
Yan Lu, Meiling Yang, Meizhong Peng, Lingling Xie, Aling Shen, Shan Lin, Bin Huang, Jianfeng Chu, Jun Peng
Summary: The study showed that Kuanxiong aerosol (KXA) has a protective effect on isoproterenol-induced myocardial injury (MI) in rats by inhibiting apoptosis through the MAPK signaling pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Irfan Cinar, Muhammed Yayla, Taha Tavaci, Erdem Toktay, Rustem Anil Ugan, Pinar Bayram, Hamza Halici
Summary: The study demonstrated that gossypin has cardioprotective effects by regulating apoptosis and oxidative stress pathways, both in vitro and in vivo. Gossypin decreased the damage caused by isoproterenol in cells and restored related markers in the experiment.
CARDIOVASCULAR TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Muthana M. Jghef, Khadija Boukholda, Yassine Chtourou, Bernd L. Fiebich, Mohammed Kebieche, Rachid Soulimani, Fatiha Chigr, Hamadi Fetoui
Summary: This study evaluated the protective effects of punicalagin (PU), a compound found in pomegranates, against isoproterenol (ISO)-induced acute myocardial damage and investigated its underlying vascular mechanisms using a rat model. The results showed that PU can protect the myocardium from oxidative injury, inflammatory response, and cell death induced by ISO by upregulating Nrf2/HO-1 signaling and antioxidants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
R. S. Soumya, K. Binu Raj, Annie Abraham
Summary: PE juice demonstrated cardioprotective effects in the rat model of myocardial infarction, mitigating cardiac injury induced by ISO.
PLANT FOODS FOR HUMAN NUTRITION
(2021)
Article
Pharmacology & Pharmacy
Meire S. S. Goncalves, Eric Aian P. Silva, Danillo M. Santos, Izabel R. Santana, Diego S. Souza, Andreza M. Araujo, Luana Heimfarth, Carla M. L. Vasconcelos, Vinicius C. O. Santos, Marcio R. Santos, Rosana de S. S. Barreto, Lucindo J. Quintans Junior, Andre S. Barreto
Summary: Nerolidol was found to effectively attenuate isoproterenol-induced myocardial infarction by reducing infarction size and suppressing oxidative stress.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2022)
Article
Cell Biology
Ke Peng, Hong Liu, Bin Yan, Xiao-Wen Meng, Shao-Yong Song, Fu-Hai Ji, Zhengyuan Xia
Summary: This study identified and validated key candidate genes related to inflammation and apoptosis pathways underlying myocardial I/R injury. Inhibition of Cathepsin S was shown to alleviate myocardial I/R-induced injury by suppressing inflammation and apoptosis, potentially offering clinical applications in cardioprotection.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mohamed M. M. Elseweidy, Sousou I. I. Ali, Mohamed A. A. Shaheen, Asmaa M. M. Abdelghafour, Sally K. K. Hammad
Summary: Myocardial infarction (MI) is a serious health issue with high morbidity and mortality rates. Recent studies have shown that vanillin has potential angiogenic effects and when combined with pentoxifylline, it can ameliorate cardiac injury in rats. This therapy modulates oxidative stress, inflammation, and apoptosis to promote cardiac angiogenesis.
Article
Integrative & Complementary Medicine
Yulei Ma, Penghe Wang, Zimei Wu, Mengru Li, Yuting Gu, Hong Wu, Hongrui Liu
Summary: This study investigated the protective effects of curdione and its underlying mechanisms in an ISO-induced myocardial injury model. The results showed that curdione exerted a protective effect against ISO-induced myocardial damage by inhibiting apoptosis and oxidative stress.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Medicine, Research & Experimental
Emanuel Tenorio Paulino, Amanda Karine Barros Ferreira Rodrigues, Maria Luiza Dal Pont Machado, Kelly Rayane Vital de Oliveira, Alessando Cesar Bernardino, Lucindo Jose Quintans-Junior, Aldeidia Pereira Oliveira, Eurica Adelia Nogueira Ribeiro
Summary: This study investigates the cardioprotective action of alpha-terpineol (TPN) against isoproterenol-induced cardiotoxicity. The results demonstrate that TPN significantly reduces cardiac damage induced by isoproterenol, suggesting its potential therapeutic effects for myocardial infarction.
Review
Cardiac & Cardiovascular Systems
Yuqing Li, Yi Gao, Guangping Li
Summary: Despite promising treatments for ischemic reperfusion injury, translating these methods to clinically beneficial therapies for patients with acute myocardial infarction remains challenging due to lack of understanding of the complex pathophysiological mechanisms, presence of comorbidities in clinical patients, and discrepancies between preclinical animal models and real-life situations.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Heba M. Obeidat, Osama Y. Althunibat, Manal A. Alfwuaires, Saleem H. Aladaileh, Abdulmohsen Algefare, Afaf F. Almuqati, Fawaz Alasmari, Hammad Khalifeh Aldal'in, Abdulkareem A. Alanezi, Bader Alsuwayt, Mohammad H. Abukhalil
Summary: This study demonstrates that (+)-taxifolin (TAX) has a significant protective effect against isoproterenol (ISO)-induced acute myocardial injury, reducing oxidative tissue damage and inflammation response by activating the Nrf2/HO-1 signaling pathway and attenuating apoptosis.
Article
Cell & Tissue Engineering
Charlotte Sarre, Rafael Contreras-Lopez, Nitirut Nernpermpisooth, Christian Barrere, Sarah Bahraoui, Claudia Terraza, Gautier Tejedor, Anne Vincent, Patricia Luz-Crawford, Kantapich Kongpol, Sarawut Kumphune, Christophe Piot, Joel Nargeot, Christian Jorgensen, Farida Djouad, Stephanie Barrere-Lemaire
Summary: This study investigated the role of PPAR beta/delta modulation in the therapeutic properties of MSC in myocardial infarction. The results showed that MSC pre-treated with a PPAR beta/delta agonist exhibited increased resistance to oxidative stress and enhanced anti-apoptotic properties on cardiac cells in vitro. When injected during reperfusion, these pre-treated MSC showed similar cardioprotective efficiency as the optimal dose of naive MSC in an ex vivo heart model of myocardial infarction. In contrast, inhibition of PPAR beta/delta in MSC decreased their cardioprotective effects. These findings suggest that PPAR beta/delta-primed MSC could enhance the cardioprotection of injured myocardium in AMI patients and decrease the required injected dose.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Chemistry, Medicinal
Mohamed I. Ahmed, Heba M. A. Abdelrazek, Yasser M. Moustafa, Samar Z. Alshawwa, Maysa A. Mobasher, Basel A. Abdel-Wahab, Fathy Elsayed Abdelgawad, Dina M. Khodeer
Summary: This study investigates the cardioprotective effect of flibanserin against isoproterenol-induced myocardial infarction in rats. The results demonstrate that flibanserin can significantly attenuate isoproterenol-induced myocardial infarction, reducing cardiac markers, oxidative stress markers, serotonin levels, and calcium concentration, as well as upregulating 5-HT2A receptor gene expression. Additionally, flibanserin improves electrocardiogram and histopathological findings associated with myocardial infarction.
Review
Cell Biology
Shuangyu Lv, Xiaotian Li, Shizhen Zhao, Huiyang Liu, Honggang Wang
Summary: Ischemia/reperfusion (I/R) injury refers to the changes in functional and structural changes during blood flow recovery after ischemia. Myocardial I/R injury, aggravated by sudden blood circulation disorder, is still not fully understood despite numerous studies. Hydrogen sulfide (H2S) has shown potential in improving myocardial I/R injury, but the underlying signal pathways remain unclear, warranting further research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)