In vitro and in silico assessment of the developability of a designed monoclonal antibody library
出版年份 2018 全文链接
标题
In vitro and in silico assessment of the developability of a designed monoclonal antibody library
作者
关键词
-
出版物
mAbs
Volume -, Issue -, Pages 1-13
出版商
Informa UK Limited
发表日期
2018-12-07
DOI
10.1080/19420862.2018.1556082
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Principles of Protein Stability and Their Application in Computational Design
- (2018) Adi Goldenzweig et al. Annual Review of Biochemistry
- Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics
- (2018) Lindsay B. Avery et al. mAbs
- RosettaAntibodyDesign (RAbD): A general framework for computational antibody design
- (2018) Jared Adolf-Bryfogle et al. PLoS Computational Biology
- SODA: prediction of protein solubility from disorder and aggregation propensity
- (2017) Lisanna Paladin et al. NUCLEIC ACIDS RESEARCH
- Biophysical properties of the clinical-stage antibody landscape
- (2017) Tushar Jain et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Rapid and accurate in silico solubility screening of a monoclonal antibody library
- (2017) Pietro Sormanni et al. Scientific Reports
- PON-Sol: prediction of effects of amino acid substitutions on protein solubility
- (2016) Yang Yang et al. BIOINFORMATICS
- Antibodies to watch in 2017
- (2016) Janice M. Reichert mAbs
- Mitigation of reversible self-association and viscosity in a human IgG1 monoclonal antibody by rational, structure-guided Fv engineering
- (2016) James C. Geoghegan et al. mAbs
- Measurements of Monoclonal Antibody Self-Association Are Correlated with Complex Biophysical Properties
- (2016) Steven B. Geng et al. MOLECULAR PHARMACEUTICS
- Solubis: a webserver to reduce protein aggregation through mutation
- (2016) Joost Van Durme et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability
- (2016) Carlo Camilloni et al. Scientific Reports
- The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility
- (2015) Pietro Sormanni et al. JOURNAL OF MOLECULAR BIOLOGY
- Developability Assessment During the Selection of Novel Therapeutic Antibodies
- (2015) Alexander Jarasch et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- An alternative assay to hydrophobic interaction chromatography for high-throughput characterization of monoclonal antibodies
- (2015) Patricia Estep et al. mAbs
- A novel screening method to assess developability of antibody-like molecules
- (2015) Neeraj Kohli et al. mAbs
- High throughput cross-interaction measures for human IgG1 antibodies correlate with clearance rates in mice
- (2015) Ryan L Kelly et al. mAbs
- Discovery of highly soluble antibodies prior to purification using affinity-capture self-interaction nanoparticle spectroscopy
- (2015) Jiemin Wu et al. PROTEIN ENGINEERING DESIGN & SELECTION
- The therapeutic monoclonal antibody market
- (2014) Dawn M Ecker et al. mAbs
- Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties
- (2014) Li Li et al. PHARMACEUTICAL RESEARCH
- In silico selection of therapeutic antibodies for development: Viscosity, clearance, and chemical stability
- (2014) Vikas K. Sharma et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Therapeutic protein aggregation: mechanisms, design, and control
- (2014) Christopher J. Roberts TRENDS IN BIOTECHNOLOGY
- Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass – Prediction of viscosity through protein–protein interaction measurements
- (2013) Martin S. Neergaard et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Application of a Kosmotrope-Based Solubility Assay to Multiple Protein Therapeutic Classes Indicates Broad Use as a High-Throughput Screen for Protein Therapeutic Aggregation Propensity
- (2013) Aaron P. Yamniuk et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Stability of Monoclonal Antibodies at High-Concentration: Head-to-Head Comparison of the IgG1 and IgG4 Subclass
- (2013) Martin S. Neergaard et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- High-throughput screening for developability during early-stage antibody discovery using self-interaction nanoparticle spectroscopy
- (2013) Yuqi Liu et al. mAbs
- Somatic hypermutation maintains antibody thermodynamic stability during affinity maturation
- (2013) Feng Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A strategy for risk mitigation of antibodies with fast clearance
- (2012) Isidro Hötzel et al. mAbs
- Solubility evaluation of murine hybridoma antibodies
- (2012) Stacey Spencer et al. mAbs
- Mechanisms of self-association of a human monoclonal antibody CNTO607
- (2012) Deidra Bethea et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Computer-aided antibody design
- (2012) D. Kuroda et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions
- (2012) J. M. Perchiacca et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Engineering Aggregation-Resistant Antibodies
- (2012) Joseph M. Perchiacca et al. Annual Review of Chemical and Biomolecular Engineering
- Prediction of the aggregation propensity of proteins from the primary sequence: Aggregation properties of proteomes
- (2011) Virginia Castillo et al. Biotechnology Journal
- Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions
- (2011) Neeraj J. Agrawal et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity
- (2011) Timothy M. Lauer et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Diffusion and Sedimentation Interaction Parameters for Measuring the Second Virial Coefficient and Their Utility as Predictors of Protein Aggregation
- (2010) Atul Saluja et al. BIOPHYSICAL JOURNAL
- SOLpro: accurate sequence-based prediction of protein solubility
- (2009) Christophe N. Magnan et al. BIOINFORMATICS
- Cross-Interaction Chromatography: A Rapid Method to Identify Highly Soluble Monoclonal Antibody Candidates
- (2009) Steven A. Jacobs et al. PHARMACEUTICAL RESEARCH
- Design of therapeutic proteins with enhanced stability
- (2009) N. Chennamsetty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Developability assessment in pharmaceutical industry: An integrated group approach for selecting developable candidates
- (2008) Vishal Saxena et al. JOURNAL OF PHARMACEUTICAL SCIENCES
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started