标题
Rapid and accurate in silico solubility screening of a monoclonal antibody library
作者
关键词
-
出版物
Scientific Reports
Volume 7, Issue 1, Pages -
出版商
Springer Nature
发表日期
2017-08-09
DOI
10.1038/s41598-017-07800-w
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Prediction and Reduction of the Aggregation of Monoclonal Antibodies
- (2017) Rob van der Kant et al. JOURNAL OF MOLECULAR BIOLOGY
- Superposition-free comparison and clustering of antibody binding sites: implications for the prediction of the nature of their antigen
- (2017) Lorenzo Di Rienzo et al. Scientific Reports
- Antibodies to watch in 2017
- (2016) Janice M. Reichert mAbs
- Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development
- (2016) Dheeraj S. Tomar et al. mAbs
- SAbPred: a structure-based antibody prediction server
- (2016) James Dunbar et al. NUCLEIC ACIDS RESEARCH
- Rational design of mutations that change the aggregation rate of a protein while maintaining its native structure and stability
- (2016) Carlo Camilloni et al. Scientific Reports
- Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo
- (2016) Claire L. Dobson et al. Scientific Reports
- Effects of a reduced disulfide bond on aggregation properties of the human IgG1 CH3 domain
- (2015) Kazumasa Sakurai et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Widespread Proteome Remodeling and Aggregation in Aging C. elegans
- (2015) Dirk M. Walther et al. CELL
- The CamSol Method of Rational Design of Protein Mutants with Enhanced Solubility
- (2015) Pietro Sormanni et al. JOURNAL OF MOLECULAR BIOLOGY
- Developability Assessment During the Selection of Novel Therapeutic Antibodies
- (2015) Alexander Jarasch et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Boosting antibody developability through rational sequence optimization
- (2015) Daniel Seeliger et al. mAbs
- Prediction of Peptide and Protein Propensity for Amyloid Formation
- (2015) Carlos Família et al. PLoS One
- The therapeutic monoclonal antibody market
- (2014) Dawn M Ecker et al. mAbs
- Antibody modeling using the Prediction of ImmunoGlobulin Structure (PIGS) web server
- (2014) Paolo Marcatili et al. Nature Protocols
- Structure-Based Prediction of Asparagine and Aspartate Degradation Sites in Antibody Variable Regions
- (2014) Jasmin F. Sydow et al. PLoS One
- Therapeutic protein aggregation: mechanisms, design, and control
- (2014) Christopher J. Roberts TRENDS IN BIOTECHNOLOGY
- Immunogenicity of therapeutic proteins: Influence of aggregation
- (2013) Kirsty D. Ratanji et al. Journal of Immunotoxicology
- Application of a PEG precipitation method for solubility screening: A tool for developing high protein concentration formulations
- (2013) Li Li et al. PROTEIN SCIENCE
- Toward aggregation-resistant antibodies by design
- (2013) Christine C. Lee et al. TRENDS IN BIOTECHNOLOGY
- Structure-Based Design of Supercharged, Highly Thermoresistant Antibodies
- (2012) Aleksandr E. Miklos et al. CHEMISTRY & BIOLOGY
- Advancements in High Throughput Biophysical Technologies: Applications for Characterization and Screening during Early Formulation Development of Monoclonal Antibodies
- (2012) Hardeep S. Samra et al. MOLECULAR PHARMACEUTICS
- Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions
- (2012) J. M. Perchiacca et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Engineering Aggregation-Resistant Antibodies
- (2012) Joseph M. Perchiacca et al. Annual Review of Chemical and Biomolecular Engineering
- Whole-Molecule Antibody Engineering: Generation of a High-Affinity Anti-IL-6 Antibody with Extended Pharmacokinetics
- (2011) Donna K. Finch et al. JOURNAL OF MOLECULAR BIOLOGY
- Developability Index: A Rapid In Silico Tool for the Screening of Antibody Aggregation Propensity
- (2011) Timothy M. Lauer et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Formulation Development of Therapeutic Monoclonal Antibodies Using High-Throughput Fluorescence and Static Light Scattering Techniques: Role of Conformational and Colloidal Stability
- (2010) Deborah S. Goldberg et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Application of a High-Throughput Screening Procedure with PEG-Induced Precipitation to Compare Relative Protein Solubility During Formulation Development with IgG1 Monoclonal Antibodies
- (2010) Todd J. Gibson et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Development trends for human monoclonal antibody therapeutics
- (2010) Aaron L. Nelson et al. NATURE REVIEWS DRUG DISCOVERY
- Stability of Protein Pharmaceuticals: An Update
- (2010) Mark Cornell Manning et al. PHARMACEUTICAL RESEARCH
- Design of therapeutic proteins with enhanced stability
- (2009) N. Chennamsetty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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