Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties
出版年份 2014 全文链接
标题
Concentration Dependent Viscosity of Monoclonal Antibody Solutions: Explaining Experimental Behavior in Terms of Molecular Properties
作者
关键词
concentration, electrostatics, formulation, molecular modeling, monoclonal antibodies, subcutaneous delivery, viscosity
出版物
PHARMACEUTICAL RESEARCH
Volume 31, Issue 11, Pages 3161-3178
出版商
Springer Nature
发表日期
2014-06-11
DOI
10.1007/s11095-014-1409-0
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass – Prediction of viscosity through protein–protein interaction measurements
- (2013) Martin S. Neergaard et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Structural Determinants of Unique Properties of Human IgG4-Fc
- (2013) Anna M. Davies et al. JOURNAL OF MOLECULAR BIOLOGY
- Polar Solvents Decrease the Viscosity of High Concentration IgG1 Solutions Through Hydrophobic Solvation and Interaction: Formulation and Biocompatibility Considerations
- (2013) Tim J. Kamerzell et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- The Role of Amino Acid Sequence in the Self-Association of Therapeutic Monoclonal Antibodies: Insights from Coarse-Grained Modeling
- (2013) Anuj Chaudhri et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Monoclonal Antibody Self-Association, Cluster Formation, and Rheology at High Concentrations
- (2013) Wayne G. Lilyestrom et al. JOURNAL OF PHYSICAL CHEMISTRY B
- An engineered Fc variant of an IgG eliminates all immune effector functions via structural perturbations
- (2013) Omid Vafa et al. METHODS
- IgG2 Fc structure and the dynamic features of the IgG CH2–CH3 interface
- (2013) Alexey Teplyakov et al. MOLECULAR IMMUNOLOGY
- Characterization and Suitability of Therapeutic Antibody Dense Phases for Subcutaneous Delivery
- (2013) Harvey R. Johnson et al. MOLECULAR PHARMACEUTICS
- Non-Aqueous Suspensions of Antibodies are Much Less Viscous Than Equally Concentrated Aqueous Solutions
- (2013) Charudharshini Srinivasan et al. PHARMACEUTICAL RESEARCH
- Impact of deglycosylation and thermal stress on conformational stability of a full length murine igG2a monoclonal antibody: Observations from molecular dynamics simulations
- (2013) Xiaoling Wang et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- On the Role of Aggregation Prone Regions in Protein Evolution, Stability, and Enzymatic Catalysis: Insights from Diverse Analyses
- (2013) Patrick M. Buck et al. PLoS Computational Biology
- Weak Interactions Govern the Viscosity of Concentrated Antibody Solutions: High-Throughput Analysis Using the Diffusion Interaction Parameter
- (2012) Brian D. Connolly et al. BIOPHYSICAL JOURNAL
- Current strategies in antibody engineering: Fc engineering and pH-dependent antigen binding, bispecific antibodies and antibody drug conjugates
- (2012) Karen J. Vincent et al. Biotechnology Journal
- Proximity energies: a framework for understanding concentrated solutions
- (2012) Tom Laue JOURNAL OF MOLECULAR RECOGNITION
- Coarse-Grained Modeling of the Self-Association of Therapeutic Monoclonal Antibodies
- (2012) Anuj Chaudhri et al. JOURNAL OF PHYSICAL CHEMISTRY B
- The Influence of Charge Distribution on Self-Association and Viscosity Behavior of Monoclonal Antibody Solutions
- (2012) Sandeep Yadav et al. MOLECULAR PHARMACEUTICS
- Structure-Activity Relationship for Hydrophobic Salts as Viscosity-Lowering Excipients for Concentrated Solutions of Monoclonal Antibodies
- (2012) Zheng Guo et al. PHARMACEUTICAL RESEARCH
- Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics
- (2012) P. M. Buck et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Viscosity of concentrated therapeutic protein compositions
- (2011) Jan Jezek et al. ADVANCED DRUG DELIVERY REVIEWS
- Development of high concentration protein biopharmaceuticals: The use of platform approaches in formulation development
- (2011) Nicholas W. Warne EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- Selective and specific ion binding on proteins at physiologically-relevant concentrations
- (2011) Linlin Miao et al. FEBS LETTERS
- Aggregation in Protein-Based Biotherapeutics: Computational Studies and Tools to Identify Aggregation-Prone Regions
- (2011) Neeraj J. Agrawal et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Assessment of Net Charge and Protein–Protein Interactions of Different Monoclonal Antibodies
- (2011) Christian Lehermayr et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Viscosity Behavior of High-Concentration Protein Mixtures
- (2011) William J. Galush et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Viscosity Behavior of High-Concentration Monoclonal Antibody Solutions: Correlation with Interaction Parameter and Electroviscous Effects
- (2011) Sandeep Yadav et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies
- (2011) Sandeep Yadav et al. PHARMACEUTICAL RESEARCH
- Behavior of Monoclonal Antibodies: Relation Between the Second Virial Coefficient (B 2) at Low Concentrations and Aggregation Propensity and Viscosity at High Concentrations
- (2011) Shuntaro Saito et al. PHARMACEUTICAL RESEARCH
- Effective charge measurements reveal selective and preferential accumulation of anions, but not cations, at the protein surface in dilute salt solutions
- (2011) Yatin R. Gokarn et al. PROTEIN SCIENCE
- Graphical analysis of pH-dependent properties of proteins predicted using PROPKA
- (2011) Michał Rostkowski et al. BMC STRUCTURAL BIOLOGY
- Effect of protein and solution properties on the donnan effect during the ultrafiltration of proteins
- (2010) Glen R. Bolton et al. BIOTECHNOLOGY PROGRESS
- Factors Affecting the Viscosity in High Concentration Solutions of Different Monoclonal Antibodies
- (2010) Sandeep Yadav et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Potential aggregation prone regions in biotherapeutics
- (2010) Xiaoling Wang et al. mAbs
- Exploring the sequence determinants of amyloid structure using position-specific scoring matrices
- (2010) Sebastian Maurer-Stroh et al. NATURE METHODS
- Potential Aggregation-Prone Regions in Complementarity-Determining Regions of Antibodies and Their Contribution Towards Antigen Recognition: A Computational Analysis
- (2010) Xiaoling Wang et al. PHARMACEUTICAL RESEARCH
- High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions
- (2009) Feng He et al. ANALYTICAL BIOCHEMISTRY
- Intrinsic amino acid side-chain hydrophilicity/hydrophobicity coefficients determined by reversed-phase high-performance liquid chromatography of model peptides: Comparison with other hydrophilicity/hydrophobicity scales
- (2009) Colin T. Mant et al. BIOPOLYMERS
- High throughput thermostability screening of monoclonal antibody formulations
- (2009) Feng He et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Specific interactions in high concentration antibody solutions resulting in high viscosity
- (2009) Sandeep Yadav et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Increasing IgG Concentration Modulates the Conformational Heterogeneity and Bonding Network that Influence Solution Properties
- (2009) Tim J. Kamerzell et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Design of therapeutic proteins with enhanced stability
- (2009) N. Chennamsetty et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Very fast prediction and rationalization of pKa values for protein-ligand complexes
- (2008) Delphine C. Bas et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now