Review
Cell Biology
You Mie Lee
Summary: The RUNX family of transcription factors, involved in cellular processes like differentiation and proliferation, plays a strategic role in tumorigenesis by interacting with the hypoxic tumor microenvironment and regulating tumor angiogenesis and signaling pathways.
Article
Biochemistry & Molecular Biology
Magdalena Szymanska, Ketan Shrestha, Eliezer Girsh, Avi Harlev, Iris Eisenberg, Tal Imbar, Rina Meidan
Summary: Granulosa-lutein cells (GLCs) from PCOS women exhibit reduced levels of HIF-1 alpha and EDN2, with microRNA-210 playing a key role in regulating this process. The disrupted hypoxic response in the GLCs of periovulatory follicles in PCOS may contribute to ovulation failure and reduced fertility in this syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
H. S. Jeffrey Man, Noeline Subramaniam, Tiana Downs, Aravin N. Sukumar, Aninda D. Saha, Ranju Nair, Lucy Chen, Daniel Teitelbaum, Paul J. Turgeon, Kyung Ha Ku, Eileen Tran, Marc de Perrot, Philip A. Marsden
Summary: A novel EC-enriched lncRNA, GATA2-AS1, was discovered to be involved in the physiologic adaptation and angiogenesis of vascular endothelial cells. It regulates HIF1-alpha induction and mitochondrial biogenesis in acute hypoxia. Additionally, GATA2-AS1 plays a role in angiogenesis and is perturbed in atherosclerotic disease.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Immunology
Hongkai Zhuang, Shujie Wang, Bo Chen, Zedan Zhang, Zuyi Ma, Zhenchong Li, Chunsheng Liu, Zixuan Zhou, Yuanfeng Gong, Shanzhou Huang, Baohua Hou, Yajin Chen, Chuanzhao Zhang
Summary: The study established a specific HIF-1 score system to discriminate PDAC with various hypoxia statuses and immune microenvironments. For highly hypoxic and immunosuppressive tumors, a combination treatment strategy should be considered in the future.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Alejandro Berna-Erro, Maria Purificacion Granados, Juan Antonio Rosado, Pedro Cosme Redondo
Summary: Hypoxia is a stressful physiological condition that may occur during labor and pregnancy. Newborns adapt to temporary hypoxic conditions through changes in organ functions and intracellular molecular pathways. This review analyzes the main platelet modifications at the protein level during hypoxia and provides updates on research related to platelet markers and regulation of platelet function in response to hypoxia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zhilong Ren, Duilio Michele Potenza, Yiqiong Ma, Guillaume Ajalbert, David Hoogewijs, Xiu-Fen Ming, Zhihong Yang
Summary: Hypoxia causes injury to podocytes, and the presence of Arg-II in podocytes contributes to this injury. However, the elimination of Arg-II does not significantly affect hypoxia-induced albuminuria, but it does reduce albuminuria in aging.
Article
Pharmacology & Pharmacy
Wanfu Lin, Shu Li, Yongbin Meng, Guokai Huang, Shufang Liang, Juan Du, Qun Liu, Binbin Cheng
Summary: This study found that ursodeoxycholic acid (UDCA) can inhibit hypoxic hepatocellular carcinoma (HCC) cell-induced angiogenesis by suppressing HIF-1 alpha/VEGF/IL-8-mediated intercellular signaling.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Alexander Pietras
Summary: A newfound deubiquitinase has been identified to differentially stabilize HIF-2alpha in stem-like glioblastoma cells, shedding light on the regulation of hypoxic response in various tissues and cancers.
Review
Oncology
Daniela Magliulo, Rosa Bernardi
Summary: Hypoxia-inducible transcription factors (HIFs) play important roles in the regulation of leukemia, but their specific functions remain to be fully defined. HIFs are mainly driven by oxygen-labile alpha subunits HIF1α and HIF2α, and their activation may lead to opposite consequences in different types of leukemia.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Sonia Mazumder, Paul J. Higgins, Rohan Samarakoon
Summary: Mutations in the VHL gene contribute to the development of renal cell carcinoma, particularly the clear cell variant. HIF-2 alpha plays a crucial role in promoting tumor progression and metastasis in these cases. Inhibiting HIF-2 alpha and its associated molecular pathways can be an effective strategy to suppress the aggressiveness of ccRCC.
Review
Biochemistry & Molecular Biology
Mariam Rusidze, Marine Adlanmerini, Elodie Chantalat, I. Raymond-Letron, Surya Cayre, Jean-Francois Arnal, Marie-Ange Deugnier, Francoise Lenfant
Summary: This review discusses the role of ER alpha in mammary gland development and breast cancer progression, highlighting both the classical nuclear genomic and membrane non-genomic actions of ER alpha in regulating mammary development at different stages. It also provides an overview of the characteristics of luminal cell lineage expressing ER alpha and the impact of ER alpha signaling in transgenic mouse models, emphasizing its pivotal role in mammary gland morphogenesis and function as well as its implication in tumorigenesis. Additionally, the review covers the main features of ER alpha-positive luminal breast cancers and their modeling in mice.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Immunology
Yi Ye, Qiying Xu, Tana Wuren
Summary: Hypoxic pulmonary hypertension (HPH) is a complex vascular disorder characterized by elevated blood pressure in the lungs. It is driven by the reprogramming of gene expression patterns, leading to cellular metabolism, inflammation, and proliferation. Hypoxia plays a key role in HPH by promoting immune/inflammatory processes that control vascular remodeling. However, many animal models used to study HPH may not accurately represent the human disease state and are not suitable for testing new therapies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaning Li, Xinyue Liang, Gang Che, Yutong Chen, Lisi Luo, Kecheng Liu, Rongzhi Xie, Linjuan Zeng
Summary: This study explored the lipid metabolism under hypoxic microenvironment in PDAC. Based on metabolic signatures, we identified prognosis subtypes linking lipid metabolism to hypoxia. These classifications may facilitate the development of personalized treatment programs targeting metabolic profiles.
Article
Biochemistry & Molecular Biology
Ekaterina Ivanova, Shrey Dharamvir Sharma, Anna Brichkina, Petra Pfefferle, Ursula Keber, Axel Pagenstecher, Matthias Lauth
Summary: In neuroblastoma, the overexpression of DYRK3 kinase is associated with decreased survival rate in patients. DYRK3 functions as a negative regulator of HIF-driven transcriptional responses in NB cells and negatively impacts cell differentiation, suggesting an oncogenic role in the etiology of NB.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Cell Biology
Taku Kaitsuka, Masayuki Matsushita, Nobuko Matsushita
Summary: Members of the sirtuin family play crucial roles in aging, metabolism, stress responses, and aging-related diseases, with SIRT2 being a unique sirtuin expressed in the cytosol and abundant in neuronal cells. Recent studies have focused on the regulation of stress responses by SIRT2, posttranscriptional regulation of SIRT2 by microRNAs, and the implications of the SIRT2-miRNA axis in aging-related diseases.
Article
Chemistry, Organic
M. A. Lumba, L. M. Willis, S. Santra, R. Rana, L. Schito, S. Rey, B. G. Wouters, M. Nitz
ORGANIC & BIOMOLECULAR CHEMISTRY
(2017)
Review
Cell Biology
Luana Schito, Sergio Rey
TRENDS IN CELL BIOLOGY
(2018)
Article
Hematology
Sergio Rey, Weibo Luo, Larissa A. Shimoda, Gregg L. Semenza
Review
Cardiac & Cardiovascular Systems
Sergio Rey, Gregg L. Semenza
CARDIOVASCULAR RESEARCH
(2010)
Article
Cardiac & Cardiovascular Systems
Kakali Sarkar, Sergio Rey, Xianjie Zhang, Raul Sebastian, Guy P. Marti, Karen Fox-Talbot, Amanda V. Cardona, Junkai Du, Yee Sun Tan, Lixin Liu, Frank Lay, Frank J. Gonzalez, John W. Harmon, Gregg L. Semenza
CARDIOVASCULAR RESEARCH
(2012)
Article
Genetics & Heredity
Xianjie Zhang, Kakali Sarkar, Sergio Rey, Raul Sebastian, Efstathia Andrikopoulou, Guy P. Marti, Karen Fox-Talbot, Gregg L. Semenza, John W. Harmon
JOURNAL OF MOLECULAR MEDICINE-JMM
(2011)
Article
Plant Sciences
Pilar M. Gil, Luis Gurovich, Bruce Schaffer, Julio Alcayaga, Sergio Rey, Rodrigo Iturriaga
JOURNAL OF PLANT PHYSIOLOGY
(2008)
Article
Multidisciplinary Sciences
KangAe Lee, David Z. Qian, Sergio Rey, Hong Wei, Jun O. Liu, Gregg L. Semenza
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
Sergio Rey, KangAe Lee, C. Joanne Wang, Kshitiz Gupta, Shaoping Chen, Alexandra McMillan, Nupura Bhise, Andre Levchenko, Gregg L. Semenza
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Multidisciplinary Sciences
KangAe Lee, Huafeng Zhang, David Z. Qian, Sergio Rey, Jun O. Liu, Gregg L. Semenza
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Biochemistry & Molecular Biology
Kshitiz, Maimon E. Hubbi, Eun Hyun Ahn, John Downey, Junaid Afzal, Deok-Ho Kim, Sergio Rey, Connie Chang, Arnab Kundu, Gregg L. Semenza, Roselle M. Abraham, Andre Levchenko
Review
Oncology
Sergio Rey, Luana Schito, Bradly G. Wouters, Scott Eliasof, Robert S. Kerbel
Review
Biochemistry & Molecular Biology
Luana Schito, Sergio Rey
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2017)
Review
Pharmacology & Pharmacy
Sergio Rey, Luana Schito, Marianne Koritzinsky, Bradly G. Wouters
ADVANCED DRUG DELIVERY REVIEWS
(2017)