Review
Pharmacology & Pharmacy
Zohreh Yaghobi, Aliakbar Movassaghpour, Mehdi Talebi, Mahdi Abdoli Shadbad, Khalil Hajiasgharzadeh, Shiva Pourvahdani, Behzad Baradaran
Summary: CD44, overexpressed on cancer stem cells, interacts with hyaluronan to influence tumor development and chemoresistance, inhibiting the cytotoxic effect of chemotherapy medications. Therefore, high expression of CD44 is associated with poor prognosis in cancer patients.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, Research & Experimental
P. Torres-Barrera, H. Mayani, A. Chavez-Gonzalez
Summary: CML is a myeloproliferative disease caused by the transformation of primitive hematopoietic cells induced by the BCR-ABL gene, with effective therapy involving tyrosine kinase inhibitors. While there is significant knowledge about the intrinsic biology of CML cells, further research is needed to understand the alterations in their bone marrow microenvironment.
CURRENT RESEARCH IN TRANSLATIONAL MEDICINE
(2021)
Review
Biotechnology & Applied Microbiology
Marianela Zanolla, Raquel Carmona, Leonardo Mata, Julio De la Rosa, Alison Sherwood, Carlos Navarro Barranco, Antonio Roman Munoz, Maria Altamirano
Summary: Asparagopsis species are widely distributed invasive seaweeds with remarkable genetic diversity. They decrease biodiversity and abundance in native algal communities. The chemical composition and potential application in inhibiting methane release from ruminant animals of Asparagopsis have attracted significant attention.
JOURNAL OF APPLIED PHYCOLOGY
(2022)
Review
Cell Biology
Soudeh Ghafouri-Fard, Vahid Niazi, Mohammad Taheri, Abbas Basiri
Summary: Hematopoietic stem cells play a crucial role in both preserving the blood system and potentially differentiating into non-hematopoietic cells for the treatment of human disorders.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Bernard J. Smilde, Esmee Botman, Teun J. de Vries, Ralph de Vries, Dimitra Micha, Ton Schoenmaker, Jeroen J. W. M. Janssen, Elisabeth M. W. Eekhoff
Summary: Fibroblasts play a crucial role in maintaining the extracellular matrix of connective tissues. Recent studies have found donor-derived fibroblasts in bone marrow transplant recipients, though some findings were not replicated. This systematic review provides an overview of hematopoietic stem cells differentiating into fibroblasts in various tissues, revealing evidence of fibroblasts derived from hematopoietic stem cells in almost all organs.
Review
Biotechnology & Applied Microbiology
Hasaan Hayat, Hanaan Hayat, Bennett Francis Dwan, Mithil Gudi, Jack Owen Bishop, Ping Wang
Summary: This review highlights the important role of CSCs in altering the cellular microenvironment to favor cancer progression, as well as the development of novel interventions targeting CSCs for cancer therapy.
ONCOTARGETS AND THERAPY
(2021)
Review
Cell Biology
Daniel Levin, Mohammed S. Osman, Caylib Durand, Hyein Kim, Iman Hemmati, Kareem Jamani, Jonathan G. Howlett, Kerri A. Johannson, Jason Weatherald, Matthew Woo, Jason Lee, Jan Storek
Summary: Systemic sclerosis is a complex connective tissue disease with limited efficacy from conventional therapies. Autologous hematopoietic stem cell transplantation shows promise but comes with associated risks. Patient selection, efficacy, and toxicity are vital considerations for treatment.
Review
Biotechnology & Applied Microbiology
Mohammad Soleimani, Kasra Cheraqpour, Raghuram Koganti, Seyed Mahbod Baharnoori, Ali R. Djalilian
Summary: The corneal epithelium consists of nonkeratinized stratified squamous cells, which undergo a significant turnover rate. The limbal epithelial stem cells (LESCs) located in the basal epithelial layer of the limbus play a crucial role in maintaining corneal homeostasis. The limbal stem cell niche (LSCN), composed of various cells, extracellular matrix, and signaling molecules, provides the microenvironment necessary for the proper functioning of LESCs. Damage to the LSCN can lead to limbal stem cell deficiency (LSCD) and conjunctivalization of the cornea. This review summarizes the basics of LSCN and discusses current and emerging bioengineering strategies for LSCN restoration to combat LSCD.
BIOENGINEERING-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Nattaya Damkham, Surapol Issaragrisil, Chanchao Lorthongpanich
Summary: This review provides an update on the regulation of YAP and TAZ, transcriptional coactivators in the Hippo signaling pathway, in stem cell behaviors and differentiation. It highlights their roles in mechanosensing and mechanotransduction, as well as the importance of understanding how cells perceive and respond to their microenvironment for improving the efficiency and efficacy of stem cell products.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Mattia Algeri, Pietro Merli, Franco Locatelli, Daria Pagliara
Summary: Allogeneic hematopoietic stem cell transplantation (HSCT) provides a potentially curative treatment for high-risk or relapsed acute leukemia in children by combining intense preparative radio/chemotherapy with the graft-versus-leukemia (GvL) effect. Advances in donor typing, conditioning regimens, GvHD prophylaxis, and MRD-directed interventions have continuously improved transplant outcomes, expanding the potential application of allotransplantation to most patients. Simultaneously, refinements in chemotherapy protocols and targeted therapies may redefine the indications for HSCT in the future.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Michelle Janssen, Anke Bruns, Juergen Kuball, Reinier Raijmakers, Debbie van Baarle
Summary: This review highlights the importance of vaccination post-stem cell transplantation for patients at risk of infection, emphasizing the significance of timing in order to obtain proper immune response. Individualized approaches may be necessary to optimize vaccine responses, as consensus on optimal timing is currently lacking.
Review
Cell Biology
Geovanny Genaro Reivan Ortiz, Yasaman Mohammadi, Ahmad Nazari, Mehrnaz Ataeinaeini, Parisa Kazemi, Saman Yasamineh, Bashar Zuhair Talib Al-Naqeeb, Haider Kamil Zaidan, Omid Gholizadeh
Summary: Aging is a biological process that leads to a decrease in the organism's standard of living due to time-related cellular and functional impairments. Recent advances in aging investigation have revealed that the rate of senescence can be regulated through genetic pathways and biological processes. Hematopoietic stem cells (HSCs) maintain blood generation throughout an organism's lifetime but are also affected by the senescence process, resulting in a decline in their capabilities. MicroRNAs (miRNAs) play a crucial role in controlling HSCs and can modulate senescence and age-associated diseases.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Cell Biology
Stefania Crippa, Ludovica Santi, Margherita Berti, Giada De Ponti, Maria Ester Bernardo
Summary: The human organism requires the production of approximately 1 trillion new blood cells per day through hematopoiesis in the bone marrow, regulated by the BM microenvironment and HSPCs. The BM niche, defined by interactions between HSPCs and non-hematopoietic cells, controls HSPC maintenance and orchestrates hematopoiesis according to the body's needs. Mesenchymal stromal cells (MSCs) play a key role in the BM niche by regulating HSPC homeostasis and impacting the outcome of hematopoietic stem cell transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ifeanyi D. Nwachukwu, Roghayeh Amini Sarteshnizi, Chibuike C. Udenigwe, Rotimi E. Aluko
Summary: Research is focusing on developing natural alternatives to synthetic antioxidants, relying on chemical or cell culture assays to screen antioxidant properties.
Review
Hematology
Jodi Chiu, Alejandro Lazo-Langner
Summary: Venous thromboembolism (VTE) is a common complication after hematopoietic stem cell transplantation (HSCT), and treatment decisions become challenging due to the complex risk balance between thrombosis and bleeding. Currently, there is a lack of validated risk assessment models and guidelines for thromboprophylaxis and VTE treatment in HSCT patients. This review summarizes the various risk factors for VTE in HSCT patients and discusses current strategies for thromboprophylaxis and VTE management, as well as the development of risk assessment models for targeted intervention in high-risk subgroups.
THROMBOSIS RESEARCH
(2023)
Article
Hematology
D. Loncaric, V. Labat, C. Debeissat, P. Brunet de la Grange, L. Rodriguez, M. Vlaski-Lafarge, Z. Ivanovic
TRANSFUSION CLINIQUE ET BIOLOGIQUE
(2019)
Article
Cell & Tissue Engineering
Sandie Gerby, Mathias Simplicien, Pascale Duchez, Jean Chevaleyre, Zoran Ivanovic, Marija Vlaski-Lafarge
Article
Oncology
Marija Vlaski-Lafarge, Veronique Labat, Alexandra Brandy, Alice Refeyton, Pascale Duchez, Laura Rodriguez, Nyere Gibson, Philippe Brunet de la Grange, Zoran Ivanoyic
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Margaux Mombled, Laura Rodriguez, Maryse Avalon, Pascale Duchez, Marija Vlaski-Lafarge, Christelle Debeissat, Baptiste Perard, Katherine M. Sawai, Jean Max Pasquet, Fontanet Bijou, Florian Thevenot, Txomin Cabantous, Zoran Ivanovic, Philippe Brunet de la Grange
Article
Hematology
Marija Vlaski-Lafarge, Jean Chevaleyre, Julie Cohen, Zoran Ivanovic, Xavier Lafarge
Article
Immunology
Adeline Crinier, Pierre-Yves Dumas, Bertrand Escaliere, Christelle Piperoglou, Laurine Gil, Arnaud Villacreces, Frederic Vely, Zoran Ivanovic, Pierre Milpied, Emilie Narni-Mancinelli, Eric Vivier
Summary: NK cells in human bone marrow can be classified into three subpopulations, with NK0 cells believed to be precursors of circulating CD56(dim) NK1-like NK cells and CD56(bright) NK2-like NK cells under physiological conditions. Transcriptomic analysis showed stress-induced repression of NK cell effector functions in bone marrow NK cells from patients with acute myeloid leukemia (AML), with reduced levels of CD160, but higher survival rates in the CD160(high) group.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Laura Rodriguez, Pascale Duchez, Nicolas Touya, Christelle Debeissat, Amelie V. Guitart, Jean-Max Pasquet, Marija Vlaski-Lafarge, Philippe Brunet de la Grange, Zoran Ivanovic
Summary: Alpha tocopherol acetate affects the metabolic energy profile and functional properties of hematopoietic stem cells by attenuating oxidative phosphorylation and inhibiting the expression of Hypoxia-Inducible Factor-2 alpha. Experiments in ex vivo show that alpha TOA helps maintain stem cell activity, but its role in vivo remains unclear.
Correction
Immunology
Adeline Crinier, Pierre-Yves Dumas, Bertrand Escaliere, Christelle Piperoglou, Laurine Gil, Arnaud Villacreces, Frederic Vely, Zoran Ivanovic, Pierre Milpied, Emilie Narni-Mancinelli, Eric Vivier
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Oncology
Marine Dupont, Mathilde Huart, Claire Lauvinerie, Audrey Bidet, Amelie Valerie Guitart, Arnaud Villacreces, Isabelle Vigon, Vanessa Desplat, Ali El Habhab, Arnaud Pigneux, Zoran Ivanovic, Philippe Brunet De la Grange, Pierre-Yves Dumas, Jean-Max Pasquet
Summary: The mutation of fms-like receptor tyrosine kinase 3 is a common molecular abnormality in acute myeloid leukemia (AML), but targeting this mutation alone has not been able to prevent relapse. However, inhibiting autophagy by blocking PI3-kinase class III Vps34 offers a promising window for treating FLT3-ITD AML and reducing relapse. This study provides evidence that remission with low minimal residual disease in FLT3-ITD AML can be effectively treated with a combination of Vps34 inhibition and mobilization in order to target persistent leukemic stem cells.
Article
Biochemistry & Molecular Biology
Veronique Labat, Eva Nguyen van Thanh Dit Bayard, Alice Refeyton, Mathilde Huart, Maryse Avalon, Christelle Debeissat, Laura Rodriguez, Philippe Brunet de la Grange, Zoran Ivanovic, Marija Vlaski-Lafarge
Summary: Physiological low oxygen concentration promotes erythroid development and intersects with Notch signaling. HIF2 plays a critical role in early erythroid development, including Notch signaling.
Article
Biochemistry & Molecular Biology
Christelle Debeissat, Maryse Avalon, Mathilde Huart, Pascale Duchez, Laura Rodriguez, Marija Vlaski-Lafarge, Zoran Ivanovic, Philippe Brunet de la Grange
Summary: Alpha lipoic acid (ALA) enhances ex vivo expansion of CD34 positive cells in peripheral blood, resulting in increased expansion of primitive cells and decreased expansion of differentiated cells. Moreover, ALA improves the redox status of hematopoietic cells.
Editorial Material
Hematology
Zoran Ivanovic
TRANSFUSION CLINIQUE ET BIOLOGIQUE
(2023)
Letter
Biochemistry & Molecular Biology
Zoran Ivanovic, Marija Vlaski-Lafarge
Article
Cell & Tissue Engineering
Darija Loncaric, Laura Rodriguez, Christelle Debeissat, Nicolas Touya, Veronique Labat, Arnaud Villacreces, Anne-Karine Bouzier-Sore, Jean-Max Pasquet, Philippe Brunet de la Grange, Marija Vlaski-Lafarge, Sonja Pavlovic, Zoran Ivanovic
Summary: The data presented suggest that alpha-TOA positively impacts primitive cells within the mesenchymal stromal cell population by maintaining their proliferative capacity. This effect is likely achieved by decreasing the O-2 consumption rate of MStroC, although it does not lead to a compensatory increase in glycolysis activity. The moderate enhancement of mtROS upon alpha-TOA treatment also appears to be a factor, with potential implications for the inactivity of HIF-1 alpha and the maintenance of stemness.
STEM CELL REVIEWS AND REPORTS
(2021)
Article
Biology
Darija Loncaric, Biljana Stankovic, Amani Ghousein, Misa Vreca, Vesna Spasovski, Arnaud Villacreces, Christelle Debeissat, Christophe F. Grosset, Zoran Ivanovic, Sonja Pavlovic
ARCHIVES OF BIOLOGICAL SCIENCES
(2019)
