Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?
出版年份 2018 全文链接
标题
Can Stemness and Chemoresistance Be Therapeutically Targeted via Signaling Pathways in Ovarian Cancer?
作者
关键词
-
出版物
Cancers
Volume 10, Issue 8, Pages 241
出版商
MDPI AG
发表日期
2018-07-24
DOI
10.3390/cancers10080241
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- STAT3/PIAS3Levels Serve as “Early Signature” Genes in the Development of High-Grade Serous Carcinoma from the Fallopian Tube
- (2018) Uksha Saini et al. CANCER RESEARCH
- PTEN loss in the fallopian tube induces hyperplasia and ovarian tumor formation
- (2018) Angela Russo et al. ONCOGENE
- Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance
- (2018) Aleksandra Klemba et al. Wspolczesna Onkologia-Contemporary Oncology
- Activation of hedgehog signaling and its association with cisplatin resistance in ovarian epithelial tumors
- (2018) Xueling Song et al. Oncology Letters
- JAK2/STAT3 pathway as a therapeutic target in ovarian cancers
- (2018) Tomoyuki Yoshikawa et al. Oncology Letters
- Treatment of ovarian cancer by targeting the tumor stem cell-associated carbohydrate antigen, Sialyl-Thomsen-nouveau
- (2018) Kristen Starbuck et al. Oncotarget
- Exploring the clonal evolution of CD133/aldehyde-dehydrogenase-1 (ALDH1)-positive cancer stem-like cells from primary to recurrent high-grade serous ovarian cancer (HGSOC). A study of the Ovarian Cancer Therapy–Innovative Models Prolong Survival (OCTIPS) Consortium
- (2017) Ilary Ruscito et al. EUROPEAN JOURNAL OF CANCER
- Drug Resistance Driven by Cancer Stem Cells and Their Niche
- (2017) Marta Prieto-Vila et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Ovarian cancer stem cells more questions than answers
- (2017) Petronella Beatrix Ottevanger SEMINARS IN CANCER BIOLOGY
- Molecular analysis of high-grade serous ovarian carcinoma with and without associated serous tubal intra-epithelial carcinoma
- (2017) Jennifer Ducie et al. Nature Communications
- LGR5 and LGR6 in stem cell biology and ovarian cancer
- (2017) Adam J. Schindler et al. Oncotarget
- Let-7d increases ovarian cancer cell sensitivity to a genistein analog by targeting c-Myc
- (2017) Ying-Xia Ning et al. Oncotarget
- hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells
- (2017) Saswati Karmakar et al. Oncotarget
- The Crosstalk between Ovarian Cancer Stem Cell Niche and the Tumor Microenvironment
- (2017) Manuel Varas-Godoy et al. Stem Cells International
- The Dualistic Model of Ovarian Carcinogenesis
- (2016) Robert J. Kurman et al. AMERICAN JOURNAL OF PATHOLOGY
- The prognostic value and clinicopathological significance of CD44 expression in ovarian cancer: a meta-analysis
- (2016) Luyang Zhao et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- NANOG regulates epithelial–mesenchymal transition and chemoresistance in ovarian cancer
- (2016) Shan Qin et al. BIOSCIENCE REPORTS
- Ovarian carcinoma diagnosis: the clinical impact of 15 years of change
- (2016) Stefan Kommoss et al. BRITISH JOURNAL OF CANCER
- Association of Vasculogenic Mimicry Formation and CD133 Expression with Poor Prognosis in Ovarian Cancer
- (2016) Jun Liang et al. GYNECOLOGIC AND OBSTETRIC INVESTIGATION
- Low-grade serous ovarian cancer: A review
- (2016) Anis Kaldawy et al. GYNECOLOGIC ONCOLOGY
- Molecular Characterization of Epithelial Ovarian Cancer: Implications for Diagnosis and Treatment
- (2016) Veronica Rojas et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Clinical relevance of CD44 surface expression in advanced stage serous epithelial ovarian cancer: a prospective study
- (2016) Alaa A. Elzarkaa et al. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
- Autotaxin Regulates Maintenance of Ovarian Cancer Stem Cells through Lysophosphatidic Acid-Mediated Autocrine Mechanism
- (2016) Eun Jin Seo et al. STEM CELLS
- Wnt5a Signaling in Cancer
- (2016) Marwa Asem et al. Cancers
- The NF-κB Pathway and Cancer Stem Cells
- (2016) Amanda Rinkenbaugh et al. Cells
- The Ovary Is an Alternative Site of Origin for High-Grade Serous Ovarian Cancer in Mice
- (2015) Jaeyeon Kim et al. ENDOCRINOLOGY
- Predictive markers of chemoresistance in advanced stages epithelial ovarian carcinoma
- (2015) Claire Bonneau et al. GYNECOLOGIC ONCOLOGY
- Should All Cases of High-Grade Serous Ovarian, Tubal, and Primary Peritoneal Carcinomas Be Reclassified as Tubo-Ovarian Serous Carcinoma?
- (2015) Esther Louise Moss et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- Primary chemotherapy versus primary surgery for newly diagnosed advanced ovarian cancer (CHORUS): an open-label, randomised, controlled, non-inferiority trial
- (2015) Sean Kehoe et al. LANCET
- CD24+ Ovarian Cancer Cells Are Enriched for Cancer-Initiating Cells and Dependent on JAK2 Signaling for Growth and Metastasis
- (2015) D. Burgos-Ojeda et al. MOLECULAR CANCER THERAPEUTICS
- The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids
- (2015) Mirjana Kessler et al. Nature Communications
- Pathobiology of ovarian carcinomas
- (2015) Mojgan Devouassoux-Shisheboran et al. Chinese Journal of Cancer
- Specific TP53 Mutants Overrepresented in Ovarian Cancer Impact CNV, TP53 Activity, Responses to Nutlin-3a, and Cell Survival
- (2015) Lisa K. Mullany et al. NEOPLASIA
- ARID3B increases ovarian tumor burden and is associated with a cancer stem cell gene signature
- (2015) Lynn Roy et al. Oncotarget
- The Epidermal Growth Factor Receptor Responsive miR-125a Represses Mesenchymal Morphology in Ovarian Cancer Cells
- (2015) Karen D. Cowden Dahl et al. NEOPLASIA
- PI3K/AKT/mTOR signaling pathway as a therapeutic target for ovarian cancer
- (2014) HaiXia Li et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Inhibition of the JAK2/STAT3 pathway in ovarian cancer results in the loss of cancer stem cell-like characteristics and a reduced tumor burden
- (2014) Khalid Abubaker et al. BMC CANCER
- Akt confers cisplatin chemoresistance in human gynecological carcinoma cells by modulating PPM1D stability
- (2014) Ahmed Y. Ali et al. MOLECULAR CARCINOGENESIS
- Lgr5 marks stem/progenitor cells in ovary and tubal epithelia
- (2014) Annie Ng et al. NATURE CELL BIOLOGY
- The Role of the PTEN/PI3K/Akt Pathway on Prognosis in Epithelial Ovarian Cancer: A Meta-Analysis
- (2014) J. Cai et al. ONCOLOGIST
- Ovarian cancer stem cells express ROR1, which can be targeted for anti–cancer-stem-cell therapy
- (2014) Suping Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ROR1 expression correlated with poor clinical outcome in human ovarian cancer
- (2014) Huilin Zhang et al. Scientific Reports
- Recent Concepts of Ovarian Carcinogenesis: Type I and Type II
- (2014) Masafumi Koshiyama et al. Biomed Research International
- Enrichment for Chemoresistant Ovarian Cancer Stem Cells from Human Cell Lines
- (2014) Jennifer M. Cole et al. Jove-Journal of Visualized Experiments
- Transformation of the Fallopian Tube Secretory Epithelium Leads to High-Grade Serous Ovarian Cancer in Brca;Tp53;Pten Models
- (2013) Ruth Perets et al. CANCER CELL
- Ovarian tumor initiating cell populations persist following paclitaxel and carboplatin chemotherapy treatment in vivo
- (2013) Kashmira Kulkarni-Datar et al. CANCER LETTERS
- Enrichment of ovarian cancer stem-like cells is associated with epithelial to mesenchymal transition through an miRNA-activated AKT pathway
- (2013) X. Luo et al. CELL PROLIFERATION
- The Molecular Fingerprint of High Grade Serous Ovarian Cancer Reflects Its Fallopian Tube Origin
- (2013) Mirjana Kessler et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Loss of ARID1A expression and its relationship with PI3K-Akt pathway alterations and ZNF217 amplification in ovarian clear cell carcinoma
- (2013) Hsien-Neng Huang et al. MODERN PATHOLOGY
- Ovarian cancer stem cells: Molecular concepts and relevance as therapeutic targets
- (2013) Nuzhat Ahmed et al. MOLECULAR ASPECTS OF MEDICINE
- Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche
- (2013) Andrea Flesken-Nikitin et al. NATURE
- The stem cell markers Oct4A, Nanog and c-Myc are expressed in ascites cells and tumor tissue of ovarian cancer patients
- (2013) Jiabo Di et al. CELLULAR ONCOLOGY
- ALDH1-Bright Epithelial Ovarian Cancer Cells Are Associated with CD44 Expression, Drug Resistance, and Poor Clinical Outcome
- (2012) Yu-Chi Wang et al. AMERICAN JOURNAL OF PATHOLOGY
- Ovarian cancer stem cell markers: Prognostic and therapeutic implications
- (2012) Daniela Burgos-Ojeda et al. CANCER LETTERS
- Ovarian cancer stem cells: Working towards the root of stemness
- (2012) Rosemary Foster et al. CANCER LETTERS
- Defining NOTCH3 Target Genes in Ovarian Cancer
- (2012) X. Chen et al. CANCER RESEARCH
- Cancer Stem Cells: Current Status and Evolving Complexities
- (2012) Jane E. Visvader et al. Cell Stem Cell
- Ovarian low-grade serous carcinoma: A comprehensive update
- (2012) Ivan Diaz-Padilla et al. GYNECOLOGIC ONCOLOGY
- Cancer stem cells
- (2012) Zuoren Yu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Cancerous ovarian stem cells: Obscure targets for therapy but relevant to chemoresistance
- (2012) Nuzhat Ahmed et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Embryonic Stem Cell Markers
- (2012) Wenxiu Zhao et al. MOLECULES
- Inhibition of Gli1 results in altered c-Jun activation, inhibition of cisplatin-induced upregulation of ERCC1, XPD and XRCC1 and inhibition of platinum–DNA adduct repair
- (2012) K Kudo et al. ONCOGENE
- c-Kit mediates chemoresistance and tumor-initiating capacity of ovarian cancer cells through activation of Wnt/β-catenin–ATP-binding cassette G2 signaling
- (2012) W K Chau et al. ONCOGENE
- Identification of a Potential Ovarian Cancer Stem Cell Gene Expression Profile from Advanced Stage Papillary Serous Ovarian Cancer
- (2012) Vinod Vathipadiekal et al. PLoS One
- High-grade serous ovarian cancer arises from fallopian tube in a mouse model
- (2012) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- High frequency of allelic loss at the BRCA1 locus in ovarian cancers: clinicopathologic and molecular associations
- (2012) Iwona K. Rzepecka et al. Cancer Genetics
- Diverse mechanisms for activation of Wnt signalling in the ovarian tumour microenvironment
- (2011) Maria V. Barbolina et al. BIOCHEMICAL JOURNAL
- Aldehyde Dehydrogenase in Combination with CD133 Defines Angiogenic Ovarian Cancer Stem Cells That Portend Poor Patient Survival
- (2011) I. A. Silva et al. CANCER RESEARCH
- Cancer Stem Cell Niche: The Place to Be
- (2011) T. Borovski et al. CANCER RESEARCH
- Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance
- (2011) Ayesha B. Alvero et al. CELL CYCLE
- Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer
- (2011) A. D. Steg et al. CLINICAL CANCER RESEARCH
- Stem Cell Pathways Contribute to Clinical Chemoresistance in Ovarian Cancer
- (2011) A. D. Steg et al. CLINICAL CANCER RESEARCH
- Ovarian cancer cells with the CD117 phenotype are highly tumorigenic and are related to chemotherapy outcome
- (2011) Lijing Luo et al. EXPERIMENTAL AND MOLECULAR PATHOLOGY
- Side population is increased in paclitaxel-resistant ovarian cancer cell lines regardless of resistance to cisplatin
- (2011) Yoichi Kobayashi et al. GYNECOLOGIC ONCOLOGY
- The cancer stem cell: premises, promises and challenges
- (2011) Hans Clevers NATURE MEDICINE
- Morphological subtypes of ovarian carcinoma: a review with emphasis on new developments and pathogenesis
- (2011) W. Glenn McCluggage PATHOLOGY
- Histologic, Molecular, and Cytogenetic Features of Ovarian Cancers: Implications for Diagnosis and Treatment
- (2011) Neeraj Lalwani et al. RADIOGRAPHICS
- Cancer stem-like cells can be isolated with drug selection in human ovarian cancer cell line SKOV3
- (2010) Li Ma et al. ACTA BIOCHIMICA ET BIOPHYSICA SINICA
- Notch3 Overexpression Is Related to the Recurrence of Ovarian Cancer and Confers Resistance to Carboplatin
- (2010) Joon Tae Park et al. AMERICAN JOURNAL OF PATHOLOGY
- Regulation of Inflammation by the NF-κB Pathway in Ovarian Cancer Stem Cells
- (2010) Aliza L. Leizer et al. AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
- Are All Pelvic (Nonuterine) Serous Carcinomas of Tubal Origin?
- (2010) Christopher G. Przybycin et al. AMERICAN JOURNAL OF SURGICAL PATHOLOGY
- Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant
- (2010) L Hu et al. BRITISH JOURNAL OF CANCER
- Targeting Hedgehog -- a Cancer Stem Cell Pathway
- (2010) A. A. Merchant et al. CLINICAL CANCER RESEARCH
- Somatic Mutations in BRCA1 and BRCA2 Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer
- (2010) Bryan T.J. Hennessy et al. JOURNAL OF CLINICAL ONCOLOGY
- Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary
- (2010) Ahmed Ashour Ahmed et al. JOURNAL OF PATHOLOGY
- Targeting Aldehyde Dehydrogenase Cancer Stem Cells in Ovarian Cancer
- (2010) C. N. Landen et al. MOLECULAR CANCER THERAPEUTICS
- Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways
- (2010) Naoko Takebe et al. Nature Reviews Clinical Oncology
- Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer
- (2010) S Peng et al. ONCOGENE
- CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells
- (2010) M-Q Gao et al. ONCOGENE
- Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
- (2010) Siân Jones et al. SCIENCE
- Recurrent low-grade serous ovarian carcinoma is relatively chemoresistant
- (2009) David M. Gershenson et al. GYNECOLOGIC ONCOLOGY
- Ovarian carcinoma pathology and genetics: recent advances
- (2009) C. Blake Gilks et al. HUMAN PATHOLOGY
- Histologic Subtypes of Ovarian Carcinoma
- (2009) Robert A. Soslow INTERNATIONAL JOURNAL OF GYNECOLOGICAL PATHOLOGY
- CD133 Expression Defines a Tumor Initiating Cell Population in Primary Human Ovarian Cancer
- (2009) Michael D. Curley et al. STEM CELLS
- Jagged-1 and Notch3 Juxtacrine Loop Regulates Ovarian Tumor Growth and Adhesion
- (2008) J.-H. Choi et al. CANCER RESEARCH
- Identification and Characterization of Ovarian Cancer-Initiating Cells from Primary Human Tumors
- (2008) S. Zhang et al. CANCER RESEARCH
- Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation
- (2008) Xiaoyun Liao et al. CARCINOGENESIS
- Role of Hedgehog Signaling in Ovarian Cancer
- (2008) R. Bhattacharya et al. CLINICAL CANCER RESEARCH
- Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of -catenin in mice
- (2008) T. Grigoryan et al. GENES & DEVELOPMENT
- Neoadjuvant chemotherapy for low-grade serous carcinoma of the ovary or peritoneum
- (2008) Kathleen M. Schmeler et al. GYNECOLOGIC ONCOLOGY
- Hyaluronan-CD44 Interaction Activates Stem Cell Marker Nanog, Stat-3-mediated MDR1 Gene Expression, and Ankyrin-regulated Multidrug Efflux in Breast and Ovarian Tumor Cells
- (2008) Lilly Y. W. Bourguignon et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells
- (2008) T Baba et al. ONCOGENE
- Ovarian cancer: emerging concept on cancer stem cells
- (2008) Moorthy P Ponnusamy et al. Journal of Ovarian Research
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