Article
Oncology
Maria Sol Recouvreux, Jiangyong Miao, Maricel C. Gozo, Jingni Wu, Ann E. Walts, Beth Y. Karlan, Sandra Orsulic
Summary: Tumors require a continuous supply of oxygen and nutrients for growth, and vasculogenic mimicry is a coping mechanism where cancer cells form vascular-like structures. FOXC2 gene expression is associated with vasculogenic mimicry and aggressive cancer behavior.
Article
Immunology
Haitao Hu, Ting Ma, Nanqi Liu, Hong Hong, Lujiao Yu, Dantong Lyu, Xin Meng, Biao Wang, Xuefeng Jiang
Summary: Vasculogenic mimicry (VM) is a vessel-like structure independent of endothelial cells, commonly found in solid tumors. It is closely associated with tumor proliferation, invasion, metastasis, and poor patient prognosis. Various factors, including immune cells, cytokines, and signaling molecules, have been reported to be involved in ovarian cancer progression and VM formation. This review discusses the mechanisms regulating VM formation in ovarian cancer, the impact of cells, cytokines, and signaling molecules in the tumor microenvironment on VM formation, and the current clinical application of drugs targeting VM formation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Estefania Contreras-Sanzon, Carlos Palma-Flores, Ali Flores-Perez, Yarely M. Salinas-Vera, Macrina B. Silva-Cazares, Laurence A. Marchat, Rodolfo G. Avila-Bonilla, Olga N. Hernandez de la Cruz, Maria E. Alvarez-Sanchez, Carlos Perez-Plasencia, Alma D. Campos-Parra, Cesar Lopez-Camarillo
Summary: The study suggests that CREB5 may serve as a potential biomarker for disease progression in basal subtype of breast cancer, and the dysregulation of the miR-204/CREB5 axis plays an important role in VM development in breast cancer cells.
Article
Oncology
Shiva Sabazade, Viktor Gill, Christina Herrspiegel, Gustav Stalhammar
Summary: Tumors from uveal melanoma patients that report a visual field shadow are likely to display vasculogenic mimicry (VM) and greater periodic acid-Schiff positive histological patterns density, explaining the association with poor prognosis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Respiratory System
Fan Shi, Jiatao Wu, Qianhao Jia, Kairui Li, Wenjuan Li, Yuqi Shi, Yufei Wang, Shiwu Wu
Summary: The expression of ARHGAP25 and RhoA is associated with VM in NSCLC, and may have potential value in predicting tumor metastasis, prognosis, and targeted therapy. ARHGAP25 expression affects the proliferation and migration abilities of NSCLC cells, and reducing ARHGAP25 expression increases NSCLC cell proliferation and migration. ARHGAP25, RhoA, and VM have an impact on the prognosis of patients with NSCLC.
BMC PULMONARY MEDICINE
(2022)
Review
Cell Biology
Gabriela Morales-Guadarrama, Rocio Garcia-Becerra, Edgar Armando Mendez-Perez, Janice Garcia-Quiroz, Euclides Avila, Lorenza Diaz
Summary: In solid tumors, vasculogenic mimicry (VM) involves the formation of vascular structures by cancer cells, contributing to tumor neovascularization, promoting metastasis, and driving resistance to antiangiogenic therapy. Various factors, including hypoxia and specific genes, play a role in this process.
Article
Genetics & Heredity
Weichang Yang, Zhouhua Li, Wenjun Wang, Juan Wu, Jinbo Li, Xiaotian Huang, Xinyi Zhang, Xiaoqun Ye
Summary: This study found that VM-related genes are associated with the prognosis and immune landscape of lung adenocarcinoma (LUAD) patients. A VM score was developed and a predictive model was constructed to evaluate the prognosis and immune landscape of LUAD patients.
FRONTIERS IN GENETICS
(2023)
Article
Immunology
Jie Wang, Wei Xia, Yujie Huang, Haoran Li, Yuchen Tang, Ye Li, Bin Yi, Zixiang Zhang, Jian Yang, Zhifei Cao, Jian Zhou
Summary: In this study, a novel risk score model and nomogram were constructed for gastric cancer (GC), showing satisfactory predictive performance. The study also confirmed the association between vascular mimicry (VM) and immune infiltration, and identified SERPINF1 and TFPI2 as immunologic and prognostic biomarkers related to VM in GC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ilaria Giusti, Giuseppina Poppa, Sandra D'Ascenzo, Letizia Esposito, Anna Rita Vitale, Giuseppe Calvisi, Vincenza Dolo
Summary: Extracellular vesicles play a crucial role in cell-to-cell communication during cancer progression. Recent studies suggest that 3D culture models present a more accurate representation. Ovarian cancer cells were cultured using the hanging drop method to form tumor spheroids, allowing for the observation and isolation of extracellular vesicles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Deok-Soo Han, Eun-Ok Lee
Summary: This study investigated the crucial role of Sp1 in the process of vasculogenic mimicry (VM) in human prostate cancer cells. The results demonstrated that Sp1 mediates VM formation through interacting with the twist/VE-cadherin/AKT pathway in human PCa cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Khuloud Bajbouj, Abeer Al-Ali, Jasmin Shafarin, Lina Sahnoon, Ahmad Sawan, Ahmed Shehada, Walaaeldin Elkhalifa, Maha Saber-Ayad, Jibran Sualeh Muhammad, Adel B. Elmoselhi, Salman Y. Guraya, Mawieh Hamad
Summary: This study demonstrates that vitamin D exerts its anti-tumor effects in BC cells by inhibiting and curtailing their potential for VM formation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui Yu, Rongrong Zhao, Xiaopeng Sun, Zongpu Zhang, Shaobo Wang, Xiao Gao, Zhongzheng Sun, Hao Xue, Gang Li
Summary: This study revealed that miR-588, under hypoxic conditions, regulates the invasive and proliferative abilities of glioblastoma cells by targeting ROBO1. The findings suggest that miR-588 may serve as a prognostic marker for glioblastoma and have potential implications in gene therapy.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Oncology
Lei Yan, Ruoqi Li, Dijun Li, Yuanyuan Zhu, Zhi Lv, Bin Wang
Summary: This study established a three-gene signature that can predict the prognosis of osteosarcoma patients. This signature can serve as prognostic markers and prediction factors for different clinicopathological features of osteosarcoma, and guide the use of different chemotherapeutic drugs.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Ana K. Herrera-Vargas, Eduardo Garcia-Rodriguez, Monserrat Olea-Flores, Miguel A. Mendoza-Catalan, Eugenia Flores-Alfaro, Napoleon Navarro-Tito
Summary: The ability of leptin to induce angiogenesis and vasculogenic mimicry in different types of cancer has been studied, with significant relationships observed in breast cancer. Leptin activates multiple pathways to promote the expression of angiogenic factors and vasculogenic mimicry, suggesting its potential role as a therapeutic target for tumor survival and metastasis.
CYTOKINE & GROWTH FACTOR REVIEWS
(2021)
Article
Cell Biology
Fan Li, Huizhi Sun, Yihui Yu, Na Che, Jiyuan Han, Runfen Cheng, Nan Zhao, Yuhong Guo, Chongbiao Huang, Danfang Zhang
Summary: In this study, it was found that RIPK1-dependent necroptosis promoted vasculogenic mimicry (VM) formation in triple-negative breast cancer (TNBC). The activation of RIPK1/p-AKT/eIF4E signaling pathway played a role in this process. Furthermore, eIF4E promoted epithelial-mesenchymal transition (EMT) and MMP2 expression and activity, contributing to VM formation. The findings suggest potential therapeutic targets for TNBC through necroptosis-mediated VM.
CELL DEATH & DISEASE
(2023)
