Article
Biochemistry & Molecular Biology
Zhiyuan Dou, Chunping Qiu, Xun Zhang, Shu Yao, Chen Zhao, Zixiang Wang, Ran Chu, Jingying Chen, Zhongshao Chen, Rongrong Li, Kun Wang, Penglin Liu, Chang Liu, Kun Song, Beihua Kong
Summary: This study found that HJURP is overexpressed in ovarian cancer and is associated with unfavorable prognosis. Knockdown of HJURP inhibits proliferation, metastasis, and induces cell stagnation in ovarian cancer cells. Mechanistically, HJURP regulates WEE1 through the MYC pathway, affecting chemosensitivity and DNA repair in ovarian cancer cells. Moreover, silencing HJURP enhances sensitivity to cisplatin and improves the synergistic effect of combined therapy with cisplatin and AZD1775 in ovarian cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Yadan Fan, Yinglian Pan, Liping Jia, Shuzhen Gu, Binxin Liu, Ziman Mei, Chunyan Lv, Haohao Huang, Genhai Zhu, Qingchun Deng
Summary: In this study, we observed an upregulation of BIRC5 in cisplatin-resistant cell lines, which was associated with enhanced chemoresistance. Intriguingly, BIRC5 exhibited a high number of m(6)A binding sites. Modification of m(6)A was found to enhance BIRC5 expression. IGF2BP1 stabilized BIRC5 mRNA and synergized with METTL3 to intensify chemoresistance. Our in vivo experiments showed that tumors were significantly smaller in size and volume when BIRC5 was silenced. These results underscore the importance of BIRC5 in chemoresistance.
Review
Oncology
Hussein Chehade, Roslyn Tedja, Harry Ramos, Tejeshwar Singh Bawa, Nicholas Adzibolosu, Radhika Gogoi, Gil Mor, Ayesha B. Alvero
Summary: Adipocytes play a crucial role in the ovarian tumor microenvironment, as their secreted factors and direct interaction with ovarian cancer cells can support tumor progression. Elucidating the molecular pathways involved is vital in identifying relevant targets.
Article
Cell Biology
Neng Tang, Shanshan Xu, Taiyu Song, Yudong Qiu, Jian He, Xiao Fu
Summary: ZFP91 is overexpressed in pancreatic cancer and correlates negatively with overall survival. Knock-down of ZFP91 attenuates proliferation, migration, and invasion of pancreatic cancer cells. Beta-catenin is a downstream gene of ZFP91, and its agonist can reverse the phenotype.
CELL PROLIFERATION
(2021)
Article
Genetics & Heredity
Zhen Zheng, Xiao Li, Bikang Yang, QinYang Xu, Xiaolu Zhu, Lipeng Hu, Yincheng Teng
Summary: Ovarian cancer (OC) has a poor prognosis and resistance to cisplatin (CDDP) treatment due to high expression of ATP-binding cassette (ABC) transporters. This study investigated the role of sortilin-related receptor 1 (SORL1) in OC response to CDDP. SORL1 was found to be closely related to CDDP resistance and predicts a poor prognosis in OC. Knockdown of SORL1 enhanced the effect of CDDP on resistant OC cells by inhibiting the EEA1 pathway and sensitizing cells to CDDP.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Multidisciplinary Sciences
Wei Zhu, Meiyuan Huang, Abhimanyu Thakur, Yuanliang Yan, Xiaoying Wu
Summary: This study found that FGF19 promotes cisplatin resistance in ovarian cancer cells by inducing autophagy. NGS analysis of 62 cases of high grade serous ovarian cancer identified a significantly amplified gene, FGF19. Furthermore, the expression level of FGF19 in ovarian cancer samples was higher than that in normal samples.
Review
Biochemistry & Molecular Biology
Sana Kouba, Frederic Hague, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Summary: In the fight against cancer, the appearance of resistant cancer stem cells (CSCs) is a major obstacle for therapeutic strategies using cisplatin. Altered Ca2+ signaling, which is essential for various cellular processes, including proliferation and survival, has been linked to CSC functions and therapy resistance. Understanding the molecular mechanisms linking Ca2+ to cisplatin-induced resistance and CSC behaviors could lead to alternative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Han Wu, Xibo Zhao, Jing Wang, Xinyan Jiang, Yan Cheng, Yanan He, Liyuan Sun, Guangmei Zhang
Summary: This study elucidates the role of CDR1as in cisplatin-resistant ovarian cancer and provides new insights for the clinical applications of cisplatin-resistant ovarian cancer.
FRONTIERS IN GENETICS
(2022)
Review
Cell Biology
Tamsin Wesley, Stuart Berzins, George Kannourakis, Nuzhat Ahmed
Summary: The plakin family of cytoskeletal proteins, particularly plectin, periplakin, and envoplakin, play crucial roles in disease-states and cancers, with a focus on ovarian cancer. They are involved in regulating cancer cell growth, survival, migration, invasion, and drug resistance, potentially impacting progression, chemoresistance, and recurrence. Abnormal expression of plakins may lead to the transition of benign ovarian tumors to carcinomas and contribute to the sustenance and progression of the disease.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Medicine, Research & Experimental
Wenjing Zhang, Carolina Torres-Rojas, Junming Yue, Bing-Mei Zhu
Summary: Ovarian cancer, the deadliest gynecological malignancy, is influenced by the interactions between adipose-derived stem cells and cancer cells in the tumor microenvironment, leading to tumor progression and chemoresistance.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Review
Immunology
Aiping Zheng, Yuhao Wei, Yunuo Zhao, Tao Zhang, Xuelei Ma
Summary: Ovarian cancer is a common malignant tumor in females with limited treatment options. Cancer-associated mesothelial cells in the tumor microenvironment play a significant role in the progression and prognosis of ovarian cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Michal Kielbik, Izabela Szulc-Kielbik, Magdalena Klink
Summary: SNAIL1, rather than SNAIL2, is implicated in cisplatin resistance of ovarian cancer cells. STAT3 serves as a universal regulator for the expression of SNAIL1/2 in ovarian cancer cells, regardless of their chemoresistance or invasive capabilities. The expression of SNAIL1 and N-cadherin is associated with cisplatin resistance, while SNAIL2 and E-cadherin levels are related to sensitivity to cisplatin in ovarian cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Luomeng Qian, Xiaoshan Yang, Shaohui Li, Hang Zhao, Yunge Gao, Shuhui Zhao, Xiaohui Lv, Xiyuan Zhang, Lingxia Li, Lianghao Zhai, Fuxing Zhou, Biliang Chen
Summary: In ovarian cancer, decreased O-GlcNAcylation promotes exosome secretion, leading to increased efflux of the chemotherapeutic drug cisplatin from cancer cells and resulting in chemoresistance. Mechanistically, downregulation of O-GlcNAcylation transferase (OGT) reduces O-GlcNAcylation of SNAP-23, which is crucial for regulating exosome release in ovarian cancer cells.
CELL DEATH DISCOVERY
(2021)
Article
Medicine, Research & Experimental
Yiping Wen, Yaya Hou, Xiaoqing Yi, Si Sun, Jing Guo, Xiaoqi He, Tao Li, Jing Cai, Zehua Wang
Summary: The study revealed that EZH2 plays a critical role in ovarian cancer stemness and chemo-resistance, with CHK1 being a target involved in CSC stemness regulated by EZH2. Clinical samples showed that high levels of EZH2 and CHK1 were associated with poorer prognosis and increased resistance to platinum drugs in ovarian cancer patients.
Article
Oncology
Feikai Lin, Xiaoduan Li, Xinjing Wang, Huizhen Sun, Ziliang Wang, Xipeng Wang
Summary: This study found that STC1 is significantly enhanced in ovarian cancer tissues, especially in peritoneal metastasis tissues. STC1 promotes metastasis, lipid metabolism, and cisplatin chemoresistance in ovarian cancer through the FOXC2/ITGB6 signaling pathway. Therefore, STC1 may serve as a prognostic indicator for metastatic ovarian cancer and a potential therapeutic target for patients with cisplatin resistance.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)