p53 Acetylation: Regulation and Consequences

Lysine-specific modifications of p53: a matter of life and death?

(2015) Diana Marouco et al.   Oncotarget

PDCD5 Interacts with Tip60 and Functions as a Cooperator in Acetyltransferase Activity and DNA Damage-Induced Apoptosis

(2015) Lanjun Xu et al.   NEOPLASIA

Chromatin dynamics: Interplay between remodeling enzymes and histone modifications

(2014) Sarah G. Swygert et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Nuclear interactor of ARF and Mdm2 regulates multiple pathways to activate p53

(2014) Sara M Reed et al.   CELL CYCLE

Illuminating p53 function in cancer with genetically engineered mouse models

(2014) Patty B. Garcia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Differences in Specificity and Selectivity Between CBP and p300 Acetylation of Histone H3 and H3/H4

(2013) Ryan A. Henry et al.   BIOCHEMISTRY

ING5 Is a Tip60 Cofactor That Acetylates p53 in Response to DNA Damage

(2013) N. Liu et al.   CANCER RESEARCH

Engaging the p53 metabolic brake drives senescence

(2013) Dadi Jiang et al.   CELL RESEARCH

HDAC6 promotes hepatocellular carcinoma progression by inhibiting P53 transcriptional activity

(2013) Gang Ding et al.   FEBS LETTERS

Negative Regulation of the Acetyltransferase TIP60-p53 Interplay by UHRF1 (Ubiquitin-like with PHD and RING Finger Domains 1)

(2013) Chao Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S100A6 Competes with the TAZ2 Domain of p300 for Binding to p53 and Attenuates p53 Acetylation

(2013) Agnieszka Graczyk et al.   JOURNAL OF MOLECULAR BIOLOGY

Specific Acetylation of p53 by HDAC Inhibition Prevents DNA Damage-Induced Apoptosis in Neurons

(2013) C. Brochier et al.   JOURNAL OF NEUROSCIENCE

Deubiquitination of Tip60 by USP7 Determines the Activity of the p53-Dependent Apoptotic Pathway

(2013) Ashraf Dar et al.   MOLECULAR AND CELLULAR BIOLOGY

Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence

(2013) Peng Jiang et al.   NATURE

RGS6 suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 degradation and promoting apoptosis

(2013) J Huang et al.   ONCOGENE

The ribosomal protein S26 regulates p53 activity in response to DNA damage

(2013) D Cui et al.   ONCOGENE

MOZ increases p53 acetylation and premature senescence through its complex formation with PML

(2013) S. Rokudai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin E3 ligases controlling p53 stability

(2012) Seong Won Lee et al.   Animal Cells and Systems

SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation

(2012) Inna Grishina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence

(2012) Tongyuan Li et al.   CELL

Tumor Suppression by p53: Fall of the Triumvirate?

(2012) Andreas K. Hock et al.   CELL

Conservation of all three p53 family members and Mdm2 and Mdm4 in the cartilaginous fish

(2012) David P. Lane et al.   CELL CYCLE

Induction of ASAP (MAP9) contributes to p53 stabilization in response to DNA damage

(2012) Jihane Basbous et al.   CELL CYCLE

The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3

(2012) Ian M. Love et al.   CELL CYCLE

PIASy-mediated Tip60 sumoylation regulates p53-induced autophagy

(2012) Samisubbu R. Naidu et al.   CELL CYCLE

Role of Tip60 in Human Melanoma Cell Migration, Metastasis, and Patient Survival

(2012) Guangdi Chen et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The WTX Tumor Suppressor Enhances p53 Acetylation by CBP/p300

(2012) Woo Jae Kim et al.   MOLECULAR CELL

TRIM29 negatively regulates p53 via inhibition of Tip60

(2011) Takuya Sho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Regulator of G Protein Signaling 6 Mediates Doxorubicin-Induced ATM and p53 Activation by a Reactive Oxygen Species-Dependent Mechanism

(2011) J. Huang et al.   CANCER RESEARCH

Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression

(2011) Colleen A. Brady et al.   CELL

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Acetylation is indispensable for p53 antiviral activity

(2011) Cesar Muñoz-Fontela et al.   CELL CYCLE

Double null cells reveal that CBP and p300 are dispensable for p53 targetsp21andMdm2but variably required for target genes of other signaling pathways

(2011) Lawryn H. Kasper et al.   CELL CYCLE

The Histone Acetyltransferase TIP60 Interacts with c-Myb and Inactivates Its Transcriptional Activity in Human Leukemia

(2011) Huiwu Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of Tip60 by GSK-3 Determines the Induction of PUMA and Apoptosis by p53

(2011) Céline Charvet et al.   MOLECULAR CELL

p53-Dependent Transcription and Tumor Suppression Are Not Affected in Set7/9-Deficient Mice

(2011) Bernhard Lehnertz et al.   MOLECULAR CELL

The Methyltransferase Set7/9 (Setd7) Is Dispensable for the p53-Mediated DNA Damage Response In Vivo

(2011) Stefano Campaner et al.   MOLECULAR CELL

Inhibition of p53 acetylation by INHAT subunit SET/TAF-Iβ represses p53 activity

(2011) Ji-Young Kim et al.   NUCLEIC ACIDS RESEARCH

Differential effects on p53-mediated cell cycle arrest vs. apoptosis by p90

(2011) C. Dai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages

(2011) D. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration

(2011) E. Arbely et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The impact of acetylation and deacetylation on the p53 pathway

(2011) Christopher L. Brooks et al.   Protein & Cell

Current strategies to target p53 in cancer

(2010) Fang Chen et al.   BIOCHEMICAL PHARMACOLOGY

Lessons from interconnected ubiquitylation and acetylation of p53: think metastable networks

(2010) Monsef Benkirane et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Making sense of ubiquitin ligases that regulate p53

(2010) Abhinav K. Jain et al.   CANCER BIOLOGY & THERAPY

The p300/CBP - associated factor is frequently down-regulated in intestinal-type gastric carcinoma and constitutes a biomarker for clinical outcome

(2010) Ming-Zhen Ying et al.   CANCER BIOLOGY & THERAPY

Specific inhibition of Mdm2-mediated neddylation by Tip60

(2010) Christoph Dohmesen et al.   CELL CYCLE

p21Waf1is required for cellular senescence but not for cell cycle arrest induced by the HDAC inhibitor sodium butyrate

(2010) Vasily S. Romanov et al.   CELL CYCLE

Restoration of DNA-binding and growth-suppressive activity of mutant forms of p53 via a PCAF-mediated acetylation pathway

(2010) Ricardo E. Perez et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

(2010) Wei Fan et al.   MOLECULAR CELL

Translating p53 into the clinic

(2010) Chit Fang Cheok et al.   Nature Reviews Clinical Oncology

p85α mediates p53 K370 acetylation by p300 and regulates its promoter-specific transactivity in the cellular UVB response

(2010) L Song et al.   ONCOGENE

Graded enhancement of p53 binding to CREB-binding protein (CBP) by multisite phosphorylation

(2010) C. W. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

p53-based Cancer Therapy

(2010) D. P. Lane et al.   Cold Spring Harbor Perspectives in Biology

Two Distinct Motifs within the p53 Transactivation Domain Bind to the Taz2 Domain of p300 and Are Differentially Affected by Phosphorylation†

(2009) Lisa M. Miller Jenkins et al.   BIOCHEMISTRY

Mapping the Interactions of the p53 Transactivation Domain with the KIX Domain of CBP†

(2009) Chul Won Lee et al.   BIOCHEMISTRY

Blinded by the Light: The Growing Complexity of p53

(2009) Karen H. Vousden et al.   CELL

Modes of p53 Regulation

(2009) Jan-Philipp Kruse et al.   CELL

The multiple levels of regulation by p53 ubiquitination

(2009) J T Lee et al.   CELL DEATH AND DIFFERENTIATION

Homozygous disruption of thetip60gene causes early embryonic lethality

(2009) Yaofei Hu et al.   DEVELOPMENTAL DYNAMICS

Crosstalk between sumoylation and acetylation regulates p53-dependent chromatin transcription and DNA binding

(2009) Shwu-Yuan Wu et al.   EMBO JOURNAL

HIPK2 modulates p53 activity towards pro-apoptotic transcription

(2009) Rosa Puca et al.   Molecular Cancer

Two Mammalian MOF Complexes Regulate Transcription Activation by Distinct Mechanisms

(2009) Xiangzhi Li et al.   MOLECULAR CELL

Cytoplasmic functions of the tumour suppressor p53

(2009) Douglas R. Green et al.   NATURE

Regulation by phosphorylation of the relative affinities of the N-terminal transactivation domains of p53 for p300 domains and Mdm2

(2009) D P Teufel et al.   ONCOGENE

Induction of SOX4 by DNA damage is critical for p53 stabilization and function

(2009) X. Pan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2

(2009) J. C. Ferreon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53

(2009) D. Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Posttranslational Modification of p53: Cooperative Integrators of Function

(2009) D. W. Meek et al.   Cold Spring Harbor Perspectives in Biology

TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use

(2009) M. Olivier et al.   Cold Spring Harbor Perspectives in Biology

The mitochondrial p53 pathway

(2008) Angelina V. Vaseva et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Discovery, In Vivo Activity, and Mechanism of Action of a Small-Molecule p53 Activator

(2008) Sonia Lain et al.   CANCER CELL

Impaired DNA Damage Response, Genome Instability, and Tumorigenesis in SIRT1 Mutant Mice

(2008) Rui-Hong Wang et al.   CANCER CELL

Roles of the histone acetyltransferase monocytic leukemia zinc finger protein in normal and malignant hematopoiesis

(2008) Takuo Katsumoto et al.   CANCER SCIENCE

Acetylation Is Indispensable for p53 Activation

(2008) Yi Tang et al.   CELL

Regulation of WRN Protein Cellular Localization and Enzymatic Activities by SIRT1-mediated Deacetylation

(2008) Kai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monocytic Leukemia Zinc Finger (MOZ) Interacts with p53 to Induce p21 Expression and Cell-cycle Arrest

(2008) Susumu Rokudai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mdm2 and Mdm4 Loss Regulates Distinct p53 Activities

(2008) J. A. Barboza et al.   MOLECULAR CANCER RESEARCH

Skp2 Suppresses p53-Dependent Apoptosis by Inhibiting p300

(2008) Mayumi Kitagawa et al.   MOLECULAR CELL

Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo

(2008) Julia K. Kurash et al.   MOLECULAR CELL

Negative regulation of the deacetylase SIRT1 by DBC1

(2008) Wenhui Zhao et al.   NATURE

DBC1 is a negative regulator of SIRT1

(2008) Ja-Eun Kim et al.   NATURE

Regulation of autophagy by cytoplasmic p53

(2008) Ezgi Tasdemir et al.   NATURE CELL BIOLOGY

Transcriptional control of human p53-regulated genes

(2008) Todd Riley et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY