Article
Genetics & Heredity
Sara Biagiotti, Ambra Barone, Mattia Paolo Aliano, Giulia Federici, Marco Malatesta, Caterina Caputi, Silvia Soddu, Vincenzo Leuzzi, Luciana Chessa, Mauro Magnani
Summary: Most ATM variants associated with Ataxia Telangiectasia are classified as variants with uncertain significance. This study focused on a specific ATM variant found in Lebanese brothers, revealing it to be pathogenic even though it causes an atypical phenotype. Dexamethasone showed therapeutic potential on this and possibly other missense ATM variants.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Goutham Narayanan Subramanian, Abrey Jie Yeo, Magtouf Hnaidi Gatei, David John Coman, Martin Francis Lavin
Summary: The ATM protein kinase has diverse functions in the cell, including protecting DNA, maintaining cellular homeostasis, and safeguarding against external and internal damage.
Article
Biochemistry & Molecular Biology
Meredith Juncker, Catherine Kim, Ryan Reed, Arthur Haas, Joshua Schwartzenburg, Shyamal Desai
Summary: The study reveals defective mitophagy in neurodegenerative diseases such as Ataxia Telangiectasia and Amyotrophic Lateral Sclerosis, which is associated with constitutively elevated ISG15 pathway. Inhibition of the ISG15 pathway restores mitophagy, reduces oxidative stress, and unhealthy mitochondria levels, suggesting a potential therapeutic avenue for neurodegenerative disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Review
Health Care Sciences & Services
Sharon A. McGrath-Morrow, Cynthia C. Rothblum-Oviatt, Jennifer Wright, Haley Schlechter, Maureen A. Lefton-Greif, Valerie A. Natale, Thomas O. Crawford, Howard M. Lederman
Summary: Ataxia telangiectasia (A-T) is a rare autosomal recessive disease characterized by progressive ataxia, oculocutaneous telangiectasias, and immune system impairment. Patients with A-T have an increased risk of malignancy, leading to premature death.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2021)
Article
Biology
Harvey Perez, May F. Abdallah, Jose Chavira, Angelina S. Norris, Martin T. Egeland, Karen L. Vo, Callan L. Buechsenschuetz, Valentina Sanghez, Jeannie L. Kim, Molly Pind, Kotoka Nakamura, Geoffrey G. Hicks, Richard A. Gatti, Joaquin Madrenas, Michelina Iacovino, Peter J. McKinnon, Paul J. Mathews
Summary: By introducing null mutations in both the Atm and Aptx genes in mice, researchers have created a novel mouse model that exhibits progressively severe ataxic phenotype and cerebellar molecular layer atrophy. The perturbations significantly alter the biophysical properties of cerebellar Purkinje neurons and their neural activity, correlating with cerebellar atrophy and ataxia over the animal's first year of life. Additionally, the double mutant mice also show a predisposition to cancer and immune abnormalities, resembling symptoms of A-T.
Article
Genetics & Heredity
Boxun Zhao, Minh A. Nguyen, Sijae Woo, Jinkuk Kim, Timothy W. Yu, Eunjung Alice Lee
Summary: This study conducted retroelement profiling on whole-genome sequencing data from 237 individuals with ataxia telangiectasia (A-T), and found retroelement insertions in the ATM gene in 15 individuals. Most of the insertions were located in noncoding regions, and 12 intronic insertions led to ATM loss of function. The study also presented proof-of-concept antisense oligonucleotides that can suppress cryptic exonization caused by deep intronic retroelement insertion.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Genetics & Heredity
B. Dalmasso, L. Pastorino, V Nathan, N. N. Shah, J. M. Palmer, M. Howlie, P. A. Johansson, N. D. Freedman, B. D. Carter, L. Beane-Freeman, B. Hicks, A. Molven, H. Helgadottir, A. Sankar, H. Tsao, A. J. Stratigos, P. Helsing, R. Van Doorn, N. A. Gruis, M. Visser, K. A. W. Wadt, G. Mann, E. A. Holland, E. Nagore, M. Potrony, S. Puig, C. Menin, K. Peris, M. C. Fargnoli, D. Calista, N. Soufir, M. Harland, T. Bishop, P. A. Kanetsky, D. E. Elder, V Andreotti, I Vanni, W. Bruno, V Hoiom, M. A. Tucker, X. R. Yang, P. A. Andresen, D. J. Adams, M. T. Landi, N. K. Hayward, A. M. Goldstein, P. Ghiorzo
Summary: This study supports the role of ATM as a melanoma predisposition gene, with LOF variants suggesting a moderate-risk.
GENETICS IN MEDICINE
(2021)
Article
Immunology
Geraldine Blanchard-Rohner, Anna Peirolo, Ludivine Coulon, Christian Korff, Judit Horvath, Pierre R. Burkhard, Fabienne Gumy-Pause, Emmanuelle Ranza, Peter Jandus, Harpreet Dibra, Alexander Malcolm R. Taylor, Joel Fluss
Summary: Ataxia-telangiectasia (A-T) is a neurodegenerative and primary immunodeficiency disorder characterized by various symptoms. This study presents a case series highlighting the phenotypic variability of A-T and emphasizes the importance of early diagnosis of variant A-T and classical A-T.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jakub Czarny, Marta Andrzejewska, Olga Zajac-Spychala, Elzbieta Latos-Grazynska, Agata Pastorczak, Kamila Wypyszczak, Aleksandra Szczawinska-Poplonyk, Izabela Niewiadomska-Wojnalowicz, Agnieszka Wziatek, Patrycja Marciniak-Stepak, Michal Dopierala, Jadwiga Maldyk, Katarzyna Jonczyk-Potoczna, Katarzyna Derwich
Summary: Ataxia-telangiectasia (AT) is a rare genetic disorder characterized by DNA repair defect, chromosomal instability, and hypersensitivity to radiation. Successful clinical management of patients with AT is challenging due to poor treatment response, high toxicity, and the need to avoid radiation exposure. This case report describes a 7-year-old female patient with AT and LBCL with IRF4 rearrangement who achieved a favorable outcome through treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Rebecca Presterud, Wei Hai Deng, Anna Berit Wennerstrom, Trudy Burgers, Bharat Gajera, Kirsten Mattsson, Agnes Solberg, Evandro F. Fang, Anni I. Nieminen, Asbjorg Stray-Pedersen, Hilde Nilsen
Summary: Long-term supplementation of nicotinamide riboside (NR) appears to be safe and well tolerated in patients with ataxia telangiectasia (A-T), and it improves motor coordination and eye movements.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Marius Theis, Helena Donath, Sandra Woelke, Shahrzad Bakhtiar, Emilia Salzmann-Manrique, Stefan Zielen, Matthias Kieslich
Summary: This study aimed to evaluate peripheral neurodegeneration and age-dependent neuropathy development in A-T patients through neurophysiological measurements. The findings revealed that neuropathic changes can be observed as early as the first year of life in A-T patients, although subjective symptoms are rarely reported. Motor neuropathy in the upper extremities was predominantly of a demyelinating type, while sensory neuropathy was predominantly of a mixed type. In the lower extremities, both motor and sensory neuropathy were predominantly of a mixed type. Age was found to have a significant correlation with the development of motor and sensory polyneuropathy in A-T patients compared to healthy controls.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Rudel A. Saunders, Thomas F. Michniacki, Courtney Hames, Hilary A. Moale, Carol Wilke, Molly E. Kuo, Johnathan Nguyen, Andrea J. Hartlerode, Bethany B. Moore, JoAnn M. Sekiguchi
Summary: Ataxia-telangiectasia (A-T) is a multisystem disorder with lung complications as a major cause of mortality. This study demonstrates the significant role of ATM-deficient immune cells in causing lung pathologies in A-T, and suggests that targeted inhibition of aberrant inflammatory responses could be a viable therapeutic strategy for A-T lung disease.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Maria Likhatcheva, Roben G. Gieling, James A. L. Brown, Constantinos Demonacos, Kaye J. Williams
Summary: Genotoxic stress can activate the ATM kinase, with potential involvement of Suv39H1 and Tip60 in ATM activation under hypoxic conditions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Barila
Summary: There is a strong interplay between autophagy and genomic stability, with recent evidence linking DNA Damage Response (DDR) and autophagy in influencing cell fate. ATM kinase plays a crucial role in balancing senescence and apoptosis in response to stimuli, and its aberrant deregulation is linked to the development of pathologies like cancer and neurodegeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Majd Haj, Amit Levon, Yann Frey, Noa Hourvitz, Judith Campisi, Yehuda Tzfati, Ran Elkon, Yael Ziv, Yosef Shiloh
Summary: The genetic disorder A-T is caused by loss of the homeostatic protein kinase ATM and leads to genome instability, tissue degeneration, cancer predisposition, and premature aging. Lowering the oxygen concentration to a physiological level range significantly extends the proliferative lifespan of A-T fibroblasts, but they still undergo premature senescence and exhibit high genome instability. Senescing A-T fibroblasts show distinct transcriptional dynamics, including activation of interferon-stimulated genes and altered expression of genes associated with extracellular matrix remodeling.
Article
Cell Biology
Eri Sugawara, Masaru Kato, Yuki Kudo, Wenshi Lee, Ryo Hisada, Yuichiro Fujieda, Kenji Oku, Toshiyuki Bohgaki, Olga Amengual, Shinsuke Yasuda, Tomohiro Onodera, Shigetsugu Hatakeyama, Tatsuya Atsumi
Article
Multidisciplinary Sciences
Hidehisa Takahashi, Amol Ranjan, Shiyuan Chen, Hidefumi Suzuki, Mio Shibata, Tomonori Hirose, Hiroko Hirose, Kazunori Sasaki, Ryota Abe, Kai Chen, Yanfeng He, Ying Zhang, Ichigaku Takigawa, Tadasuke Tsukiyama, Masashi Watanabe, Satoshi Fujii, Midori Iida, Junichi Yamamoto, Yuki Yamaguchi, Yutaka Suzuki, Masaki Matsumoto, Keiichi Nakayama, Michael P. Washburn, Anita Saraf, Laurence Florens, Shigeo Sato, Chieri Tomomori-Sato, Ronald C. Conaway, Joan W. Conaway, Shigetsugu Hatakeyama
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Tadasuke Tsukiyama, Juqi Zou, Jihoon Kim, Shohei Ogamino, Yuki Shino, Takamasa Masuda, Alessandra Merenda, Masaki Matsumoto, Yoichiro Fujioka, Tomonori Hirose, Sayuri Terai, Hidehisa Takahashi, Tohru Ishitani, Keiichi I. Nakayama, Yusuke Ohba, Bon-Kyoung Koo, Shigetsugu Hatakeyama
NATURE COMMUNICATIONS
(2020)
Article
Biology
Masashi Watanabe, Yasushi Saeki, Hidehisa Takahashi, Fumiaki Ohtake, Yukiko Yoshida, Yusuke Kasuga, Takeshi Kondo, Hiroaki Yaguchi, Masanobu Suzuki, Hiroki Ishida, Keiji Tanaka, Shigetsugu Hatakeyama
COMMUNICATIONS BIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Tadasuke Tsukiyama, Bon-Kyoung Koo, Shigetsugu Hatakeyama
Summary: Wnt signaling pathway plays crucial roles in various stages of life, regulating morphogenesis in embryo development and tissue homeostasis in adults. Regulation of Wnt signaling occurs at multiple levels, including on receptors, beta-catenin protein, and through transcriptional regulation. Recent studies have focused on Wnt receptor regulation mechanisms, particularly targeting RNF43 and ZNRF3, mutated genes associated with cancer, with ongoing discoveries and unanswered questions.
Article
Immunology
Akira Nakazono, Yuji Nakamaru, Mahnaz Ramezanpour, Takeshi Kondo, Masashi Watanabe, Shigetsugu Hatakeyama, Shogo Kimura, Aya Honma, P. J. Wormald, Sarah Vreugde, Masanobu Suzuki, Akihiro Homma
Summary: SARS-CoV-2 cell entry in the nasal mucosa is promoted by the activation of innate immune signals via TLR3, but this expression is suppressed in the presence of the corticosteroid fluticasone propionate (FP). Further studies are needed to determine whether FP can suppress SARS-CoV-2 viral cell entry.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Review
Allergy
Masanobu Suzuki, Takayoshi Suzuki, Masashi Watanabe, Shigetsugu Hatakeyama, Shogo Kimura, Akira Nakazono, Aya Honma, Yuji Nakamaru, Sarah Vreugde, Akihiro Homma
Summary: Zinc plays a crucial role in maintaining immune system function, and decreased zinc levels may lead to various inflammatory diseases. There is a potential vicious cycle between zinc deficiency and inflammatory conditions, highlighting the importance of maintaining adequate zinc levels for overall health and immunity.
ALLERGOLOGY INTERNATIONAL
(2021)
Article
Dermatology
Keiko Tokuchi, Shinya Kitamura, Takuya Maeda, Masashi Watanabe, Shigetsugu Hatakeyama, Satoshi Kano, Shinya Tanaka, Hideyuki Ujiie, Teruki Yanagi
Summary: The study revealed that the expression of FAM83H is lower in cutaneous squamous cell carcinoma compared to normal epidermis, and is associated with differentiation grade. FAM83H plays a critical role in regulating keratin distribution and cell migration/invasion in SCC.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Dermatology
Hideyuki Kosumi, Mika Watanabe, Satoru Shinkuma, Takuma Nohara, Yu Fujimura, Tadasuke Tsukiyama, Giacomo Donati, Hiroaki Iwata, Hideki Nakamura, Hideyuki Ujiie, Ken Natsuga
Summary: Inhibition of Wnt signaling disrupts the organization of Hemidesmosomes in keratinocytes. Wnt inhibition leads to the depletion of Hemidesmosomes components and structures, but does not affect keratinocyte differentiation. The atypical protein kinase C pathway is involved in the disruption of Hemidesmosomes induced by Wnt inhibition.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ayano Inoue, Masashi Watanabe, Takeshi Kondo, Satoshi Hirano, Shigetsugu Hatakeyama
Summary: There has been a remarkable breakthrough in cancer treatment, particularly in the field of checkpoint blockade immunotherapy. Recent studies have shown that TRIM22 negatively regulates MHC-II expression and inhibiting TRIM22 can increase MHC-II expression in cancer cells, which may provide a therapeutic target to enhance immunotherapy effectiveness.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Multidisciplinary Sciences
Yusuke Kasuga, Ryota Ouda, Masashi Watanabe, Xin Sun, Miki Kimura, Shigetsugu Hatakeyama, Koichi S. Kobayashi
Summary: Major histocompatibility complex (MHC) class I and II molecules are critical for adaptive immunity. The protein FBXO11 has been identified as an E3 ligase that regulates CIITA protein level through ubiquitination-mediated degradation, thus determining the level of MHC-II.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Otorhinolaryngology
Shogo Kimura, Masanobu Suzuki, Yuji Nakamaru, Satoshi Kano, Masashi Watanabe, Aya Honma, Akira Nakazono, Nayuta Tsushima, Shigetsugu Hatakeyama, Akihiro Homma
Summary: This study found that high expression of TRIM27 in sinonasal mucosal melanoma (SNMM) is associated with advanced disease, poor prognosis, and distant metastasis, suggesting that TRIM27 may serve as a novel biomarker for prognosis in SNMM.
Meeting Abstract
Oncology
Tadasuke Tsukiyama, Tohru Ishitani, Shigetsugu Hatakeyama
Article
Oncology
Shanshan Liang, Hidehisa Takahashi, Tetsuro Hirose, Yasuhiro Kuramitsu, Shigetsugu Hatakeyama, Hironori Yoshiyama, Ruoyu Wang, Jun-Ichi Hamada, Hisashi Iizasa
CANCER GENOMICS & PROTEOMICS
(2020)
Article
Biochemistry & Molecular Biology
G. F. Senguel, R. Mishra, E. Candiello, P. Schu
Summary: AP2 forms AP2 CCV with clathrin and other coat proteins, and synapses contain different types of CCV. The stability and composition of CCV are regulated by various factors, including Hsc70 and phosphorylation patterns. The knockout of the AP1/O1B complex disrupts synaptic vesicle recycling and endosomal protein sorting, leading to upregulation of endocytosis. Stable CCV, termed stCCV, have distinct characteristics and specialized functions in synaptic plasticity. The phosphorylation of Hsc70 and the levels of kinases play a crucial role in regulating the stability and disassembly of clathrin in CCV.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Martin Fluck, Colline Sanchez, Vincent Jacquemond, Christine Berthier, Marie-Noelle Giraud, Daniel Jacko, Kathe Bersiner, Sebastian Gehlert, Guus Baan, Richard T. Jaspers
Summary: Enhancing CaMKII signaling improves fatigue resistance and contractile characteristics of skeletal muscle by enhancing calcium release.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Letter
Biochemistry & Molecular Biology
Federica Coppola, Sara Monaci, Alessandro Falsini, Carlo Aldinucci, Irene Filippi, Daniela Rossi, Fabio Carraro, Antonella Naldini
Summary: The adaptor protein p62 plays a crucial role in maintaining the survival of dendritic cells (DCs) under hypoxic conditions by preserving Erk1/2 phosphorylation and reducing AMPK activation, thus extending their lifespan to ensure their functions in hypoxic microenvironments.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Jenifer Pendiuk Goncalves, Jorvani Cruz Villarreal, Sierra A. Walker, Xuan Ning Sharon Tan, Chad Borges, Joy Wolfram
Summary: This study used a mass spectrometry-based approach to assess the differences in glycan features between extracellular vesicles (EVs) and originating cells. The results showed that EVs selectively enriched specific glycan features, particularly those associated with binding to the extracellular matrix. The study also found differences in EV glycan sorting between different metastatic cell lines and mouse models, indicating a potential role of glycan diversity in the metastatic process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
De-ao Gong, Peng Zhou, Wen-yi Chang, Jia-yao Yang, Yan-lai Zhang, Ai-long Huang, Ni Tang, Kai Wang
Summary: Liver cancer, ranked sixth globally, is a major contributor to cancer-related mortality. Metastasis is the main cause of treatment failure and deaths in liver cancer. The SPOP-CREB5-MET axis plays a significant role in liver cancer metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ning Huang, Jun Tang, Xiaoyao Yi, Maoxin Zhang, Bin Li, Yuan Cheng, Jin Chen
Summary: This study reveals that glioma-derived S100A9 can induce microglial M2 polarization, inhibit CD8+ T lymphocytes, and promote immunosuppression. The mechanism is related to the interaction with alpha v133 integrin and subsequent activation of AKT1 in microglia. The expression of S100A9 is positively associated with CD206 expression and negatively correlated with CD8+ T lymphocyte accumulation in the TME, suggesting a potential role of S100A9 in regulating the tumor microenvironment and immune evasion in glioma.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Yomna S. Abd El-Aziz, Matthew J. McKay, Mark P. Molloy, Betty McDowell, Elizabeth Moon, Loretta Sioson, Amy Sheen, Angela Chou, Anthony J. Gill, Patric J. Jansson, Sumit Sahni
Summary: This study identified a novel combination of autophagy inhibitors that can effectively inhibit the proliferation of oral squamous cell carcinoma (OSCC) cells, including both chemosensitive and chemoresistant cells. This research is important for the development of new therapies for advanced OSCC tumors.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Luojia Liu, Xiaoqiang Liu, Ying Chen, Meng Kong, Jinghong Zhang, Min Jiang, Hongling Zhou, Jinrui Yang, Xu Chen, Ze Zhang, Chao Wu, Xupin Jiang, Jiaping Zhang
Summary: Our study revealed that the Paxillin/HDAC6 signaling pathway regulates microtubule acetylation in electric field-guided keratinocyte migration.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Julia Weikum, Jeroen F. van Dyck, Saranya Subramani, David P. Klebl, Merete Storflor, Stephen P. Muench, Soren Abel, Frank Sobott, J. Preben Morth
Summary: The study reveals the complex interaction between bacterial magnesium transporter A (MgtA) and cardiolipin 18:1 and cardiolipin 16:0, highlighting the importance of lipid environment in protein activity and stability. Further understanding of Mg2+ homeostasis in bacteria will provide insights into bacterial infections.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Sumit Kinger, Yuvraj Anandrao Jagtap, Ankur Rakesh Dubey, Prashant Kumar, Akash Choudhary, Rohan Dhiman, Vijay Kumar Prajapati, Deepak Chitkara, Krishna Mohan Poluri, Amit Mishra
Summary: Efficient protein synthesis and quality control mechanisms are crucial for maintaining proteostasis and preventing neurodegeneration. This study demonstrates that treating cells with Lanosterol can enhance the proteolytic activity of Proteasome and promote the removal of misfolded proteins, suggesting a potential therapeutic approach for abnormal protein accumulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Karolina Stepien, Adrianna Skoneczna, Monika Kula-Maximenko, Lukasz Jurczyk, Mateusz Molon
Summary: The replication of DNA requires a complex machinery called the replisome, which is highly conserved across species. One crucial component of the replisome is the CMG helicase complex, which unwinds DNA and coordinates the assembly and function of other replisome components. In this study, the impact of the absence of one copy of the CMG complex genes on the physiology and aging of yeast cells was investigated. The findings showed disruptions in the cell cycle, extended doubling times, and alterations in the biochemical profile of these cells. Importantly, it was found that heterozygous cells for CMG helicase genes exhibited increased reproductive potential and delayed aging. The study also highlighted potential therapeutic targets for cancer treatment using yeast.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Nishadh Rathod, Guadalupe Guerrero-Serna, Howard S. Young, L. Michel Espinoza-Fonseca
Summary: This study reveals that replacing Lys27 with Asn enhances the inhibitory potency of MLN without affecting SERCA's affinity for Ca2+. The findings suggest that the SERCA site modulating Ca2+ affinity also functions as a catalytic activity switch.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Can Jiang, Chunyang Zhang, Min Dai, Fuyan Wang, Sa Xu, Dan Han, Yanyan Wang, Yajie Cao, Yanyan Liang, Ziyu Zhang, Lina Yan, Yujun Shen, Kewu He, Yuxian Shen, Jun Liu
Summary: The phosphorylation of p65 and the expression of SUMO1 are increased in cancer tissues of HCC patients, and there is a positive correlation between SUMO1 and phosphorylated p65. SUMOylation of p65 by SUMO1 promotes p65 nuclear import and enhances NF-xB activity. Both SUMOylation and phosphorylation of p65 increase the viability and invasion of hepatoma cells, and decrease cell apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Ming-Fo Hsu, Yoshihiro Ito, Jai Prakash Singh, Shu-Fang Hsu, Alan Wells, Kuang-Yu Jen, Tzu-Ching Meng, Fawaz G. Haj
Summary: This study identified alpha-actinin4 as a novel substrate of PTP1B in podocytes and demonstrated their interaction in regulating podocyte function. Targeting PTP1B and alpha-actinin4 could be a potential therapeutic approach for podocyte injury.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
Article
Biochemistry & Molecular Biology
Paulo F. V. Bizerra, Eduardo H. Gilglioni, Hang Lam Li, Simei Go, Ronald P. J. Oude Elferink, Arthur J. Verhoeven, Jung -Chin Chang
Summary: This study investigates the role of cyclic AMP (cAMP) in glycogen metabolism and reveals that cAMP regulates glycogenolysis in opposite directions depending on its site of synthesis within cells and downstream effectors. The canonical tmAC-cAMP-PKA signaling promotes glycogenolysis, while the non-canonical sAC-cAMP-Epac1 signaling suppresses glycogenolysis. This highlights the importance of cAMP microdomain organization for distinct metabolic regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2024)
