Article
Biology
Calvin Jon A. Leonen, Miho Shimada, Caroline E. Weller, Tomoyoshi Nakadai, Peter L. Hsu, Elizabeth L. Tyson, Arpit Mishra, Patrick M. M. Shelton, Martin Sadilek, R. David Hawkins, Ning Zheng, Robert G. Roeder, Champak Chatterjee
Summary: Post-translational modification of histones by the small ubiquitin-like modifier protein SUMO plays a key role in gene silencing, centromeric localization, and DNA repair in eukaryotes. The study demonstrated that H4K12su inhibits acetylation of H4 tail and methylation of H3K4 associated with transcription activation, as well as transcription mediated by RNA polymerase II. Cell-based assays confirmed the negative crosstalk between histone sumoylation and acetylation/methylation in human cells.
Article
Biochemistry & Molecular Biology
Krishna M. Chauhan, Yingxiao Chen, Yiyi Chen, Andrew T. Liu, Xiao-Xin Sun, Mu-Shui Dai
Summary: The study reveals that SENP1 is a critical p53 deSUMOylating enzyme, and its depletion induces p53 transactivation activity and synergizes with DNA damage-inducing agent etoposide to activate p53 and inhibit cancer cell growth.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ayan Chanda, Yoshiho Ikeuchi, Kunal Karve, Anusi Sarkar, Amrita Singh Chandhoke, Lili Deng, Azad Bonni, Shirin Bonni
Summary: Studies show that SUMO E3 ligases PIAS1 and TIF1γ collaborate to promote the SUMOylation of SnoN, suppressing EMT in breast cell-derived tissue organoids. These E3 ligases act in an interdependent manner in the regulation process.
CELL DEATH AND DIFFERENTIATION
(2021)
Article
Cell Biology
Ying Liu, Kejia Liu, Rick F. Thorne, Ronghua Shi, Qingyuan Zhang, Mian Wu, Lianxin Liu
Summary: This article investigates the role of SUMOylation and deSUMOylation of Succinate dehydrogenase (SDH) in regulating cellular metabolism. The study reveals that SDHA is SUMOylated by PIAS3 and deSUMOylated by SENP2, which affects the assembly and activity of the SDH complex. Additionally, acetylation of SENP2 by CBP negatively regulates its deSUMOylation activity, thereby regulating the TCA cycle and electron transport chain activity. This mechanism avoids excessive ROS production and promotes cancer cell survival.
Review
Biochemistry & Molecular Biology
Mathias Boulanger, Mehuli Chakraborty, Denis Tempe, Marc Piechaczyk, Guillaume Bossis
Summary: SUMO plays a crucial role in transcriptional control by modifying various transcriptional factors, coregulators, chromatin components, and transcriptional machineries. Recent large-scale studies have significantly advanced our understanding of the role of SUMO in gene expression control, shedding light on its impact on transcription and chromatin organization.
Article
Multidisciplinary Sciences
Nathaniel G. Jones, Vincent Geoghegan, Gareth Moore, Juliana B. T. Carnielli, Katherine Newling, Felix Calderon, Raquel Gabarro, Julio Martin, Rab K. Prinjha, Inmaculada Rioja, Anthony J. Wilkinson, Jeremy C. Mottram
Summary: Leishmania require the bromodomain-enriched CRKT complex for interpreting histone acetylation marks and maintaining normal gene expression and cellular viability.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxia Shi, Yixin Du, Shujing Li, Huijian Wu
Summary: SUMOylation, a reversible post-translational modification process, plays crucial roles in cell physiology, including cell cycle regulation, DNA damage repair, and protein trafficking and turnover. Dysregulated SUMO E3 ligases may be associated with the occurrence and development of cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medical Laboratory Technology
Wenhui Liu, Min Zeng, Nian Fu
Summary: The nuclear receptor superfamily, a family of ligand-activated transcription factors, plays a key role in cell metabolism and human diseases. They undergo various post-translational modifications, influencing diverse physiological activities. Nuclear receptors are crucial in lipid metabolism, inflammation, while SUMOylation nuclear receptors regulate function and impact cell metabolism.
CLINICA CHIMICA ACTA
(2021)
Article
Microbiology
Junping Li, Libin Liang, Li Jiang, Qian Wang, Xia Wen, Yuhui Zhao, Pengfei Cui, Yaping Zhang, Guangwen Wang, Qibing Li, Guohua Deng, Jianzhong Shi, Guobin Tian, Xianying Zeng, Yongping Jiang, Liling Liu, Hualan Chen, Chengjun Li
Summary: Our study demonstrates the vital role of PB1 K612 SUMOylation in the pathogenesis and transmission of IAVs, providing a potential target for anti-influenza therapies. The SUMOylation at K612 is crucial for PB1 to efficiently bind viral RNA, facilitating the transcription and replication of the viral genome.
Review
Plant Sciences
Shumei Fang, Xue Hou, Xilong Liang
Summary: SUMOylation is a crucial posttranslational modification in eukaryotes, involved in metabolic regulation under various stresses. SIZ1, a SUMO E3 ligase, plays a vital role in substrate-specific recognition and facilitates the binding of SUMO proteins to target proteins. This review provides insights into the characteristics of SUMOylation and the role of SIZ1 in plant adaptation to abiotic stresses, offering valuable references for crop improvement and future research on plant responses to environmental stress.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Mingchao Mu, Qin Zhang, Jing Li, Chenye Zhao, Xiaopeng Li, Zilu Chen, Xuejun Sun, Junhui Yu
Summary: The current study reveals that USP51 promotes colorectal cancer stemness and chemoresistance, and its high expression is associated with poor survival in colorectal cancer patients. USP51 forms a positive feedback loop with HIF1A, regulating its deubiquitination and stabilization. The interaction between USP51 and ELOC is facilitated by the deSUMOylation of ELOC mediated by SENP1. Importantly, USP51 plays a crucial role in promoting HIF1A and SENP1-dependent proliferation, migration, stemness, and chemoresistance under hypoxia in colorectal cancer.
CELL DEATH AND DIFFERENTIATION
(2023)
Article
Biochemistry & Molecular Biology
Danlu Han, Chen Chen, Simin Xia, Jun Liu, Jie Shu, Vi Nguyen, Jianbin Lai, Yuhai Cui, Chengwei Yang
Summary: The study reveals a genome-wide relationship between chromatin-associated SUMOylation and transcriptional switches in Arabidopsis thaliana under heat stress and recovery, suggesting that SUMOylation on chromatin may regulate gene expression in response to high temperature.
PLANT COMMUNICATIONS
(2021)
Review
Genetics & Heredity
Hong Xiao, Hong Zhou, Gaofeng Zeng, Zhenjiang Mao, Junfa Zeng, Anbo Gao
Summary: Small ubiquitin-like modifier (SUMO) plays a key regulatory role in cardiovascular diseases, particularly in the regulation of mitochondrial dynamics and mitophagy. SUMOylation triggers mitochondrial fusion and modifies specific proteins to promote mitochondrial dysfunction. SUMOylation and deSUMOylation regulate the initiation and activation of mitophagy.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Cell Biology
Yingying Tong, Zheng Zhang, Yurong Cheng, Jing Yang, Cong Fan, Xuyang Zhang, Jiandong Yang, Li Wang, Dong Guo, Dong Yan
Summary: NFATc3 is a transcriptional regulator that is constitutively activated in various cancer types, playing crucial roles in cancer development. In pancreatic ductal adenocarcinoma cells, excessive activation of NFATc3 is associated with advanced disease stages and shorter survival time. The deSUMOylation of NFATc3 by SENP3 under hypoxia serves as an essential modulator in PDAC tumor progression.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Qian Wang, Ci Xu, Qiang Fan, Haihua Yuan, Xin Zhang, Biying Chen, Renjie Cai, Yanjie Zhang, Moubin Lin, Ming Xu
Summary: This study reveals novel insights into p38 alpha-SUMOylation and its association with the intracellular oxidative stress response, which is closely related to the processes of gastric cancer. Furthermore, the PIASx alpha/p38 alpha-SUMOylation/MK2 cis-axis may serve as a desirable therapeutic target in gastric cancer as targeting PIASx alpha, MK2, or a specific peptide region of p38 alpha may reconcile the aberrant oxidative stress response in gastric cancer cells.
CELL DEATH & DISEASE
(2021)