标题
Combination therapies: The next logical Step for the treatment of synucleinopathies?
作者
关键词
-
出版物
MOVEMENT DISORDERS
Volume 31, Issue 2, Pages 225-234
出版商
Wiley
发表日期
2015-09-21
DOI
10.1002/mds.26428
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- The combination of lithium and l-Dopa/Carbidopa reduces MPTP-induced abnormal involuntary movements (AIMs) via calpain-1 inhibition in a mouse model: Relevance for Parkinson׳s disease therapy
- (2015) Carol A. Lazzara et al. BRAIN RESEARCH
- The Effect of Creatine and Coenzyme Q10 Combination Therapy on Mild Cognitive Impairment in Parkinson's Disease
- (2015) Zhenguang Li et al. EUROPEAN NEUROLOGY
- The optimal combination therapy for the treatment of early rheumatoid arthritis
- (2015) Diederik De Cock et al. EXPERT OPINION ON PHARMACOTHERAPY
- Interactive effects of GPI stimulation and levodopa on postural control in Parkinson's disease
- (2015) Liam Johnson et al. GAIT & POSTURE
- Phenolic compounds prevent the oligomerization of α-synuclein and reduce synaptic toxicity
- (2015) Ryoichi Takahashi et al. JOURNAL OF NEUROCHEMISTRY
- Lenalidomide reduces microglial activation and behavioral deficits in a transgenic model of Parkinson’s disease
- (2015) Elvira Valera et al. Journal of Neuroinflammation
- Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases
- (2015) Yu Tang et al. MOLECULAR NEUROBIOLOGY
- Active immunization against alpha-synuclein ameliorates the degenerative pathology and prevents demyelination in a model of multiple system atrophy
- (2015) Markus Mandler et al. Molecular Neurodegeneration
- Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial
- (2015) Fabian J. David et al. MOVEMENT DISORDERS
- Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled, confirmatory phase III trial
- (2015) Manabu Ikeda et al. Alzheimers Research & Therapy
- Combined Rasagiline and Antidepressant Use in Parkinson Disease in the ADAGIO Study
- (2015) Kara M. Smith et al. JAMA Neurology
- Normalization of Overexpressed α-Synuclein Causing Parkinson's Disease By a Moderate Gene Silencing With RNA Interference
- (2015) Masaki Takahashi et al. Molecular Therapy-Nucleic Acids
- Curcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic Mice
- (2015) Kateri J. Spinelli et al. PLoS One
- Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials
- (2014) Markus Mandler et al. ACTA NEUROPATHOLOGICA
- Safety and Efficacy of Rasagiline in Addition to Levodopa for the Treatment of Idiopathic Parkinson's Disease: A Meta-Analysis of Randomised Controlled Trials
- (2014) Jiang-Ping Cai et al. EUROPEAN NEUROLOGY
- Alpha-synuclein mRNA expression in oligodendrocytes in MSA
- (2014) Yasmine T. Asi et al. GLIA
- Quercetin Glycosides Induced Neuroprotection by Changes in the Gene Expression in a Cellular Model of Parkinson’s Disease
- (2014) Kasthuri Bai Magalingam et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Acute Neuroinflammation Impairs Context Discrimination Memory and Disrupts Pattern Separation Processes in Hippocampus
- (2014) J. Czerniawski et al. JOURNAL OF NEUROSCIENCE
- Reducing C-Terminal-Truncated Alpha-Synuclein by Immunotherapy Attenuates Neurodegeneration and Propagation in Parkinson's Disease-Like Models
- (2014) D. Games et al. JOURNAL OF NEUROSCIENCE
- α-Synuclein Misfolding Versus Aggregation Relevance to Parkinson’s Disease: Critical Assessment and Modeling
- (2014) Ruben Berrocal et al. MOLECULAR NEUROBIOLOGY
- Combining cell transplants or gene therapy with deep brain stimulation for Parkinson's disease
- (2014) Nathan C. Rowland et al. MOVEMENT DISORDERS
- Potential neuroprotective effect of ibuprofen, insights from the mice model of Parkinson's disease
- (2014) Maciej Świątkiewicz et al. Pharmacological Reports
- Potential Therapeutic Competition in Community-Living Older Adults in the U.S.: Use of Medications That May Adversely Affect a Coexisting Condition
- (2014) Songprod Jonathan Lorgunpai et al. PLoS One
- Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation
- (2014) Luis Fonseca-Ornelas et al. Nature Communications
- Immunotherapy for Alzheimer’s disease: past, present and future
- (2014) Brian Spencer et al. Frontiers in Aging Neuroscience
- Systematic Comparison of the Effects of Alpha-synuclein Mutations on Its Oligomerization and Aggregation
- (2014) Diana F. Lázaro et al. PLoS Genetics
- A Randomized Clinical Trial of High-Dosage Coenzyme Q10 in Early Parkinson Disease
- (2014) et al. JAMA Neurology
- Products of the Parkinson's disease-related glyoxalase DJ-1, D-lactate and glycolate, support mitochondrial membrane potential and neuronal survival
- (2014) Y. Toyoda et al. Biology Open
- Cerebrospinal fluid inflammatory markers in Parkinson’s disease – Associations with depression, fatigue, and cognitive impairment
- (2013) Daniel Lindqvist et al. BRAIN BEHAVIOR AND IMMUNITY
- Managing Therapeutic Competition in Patients with Heart Failure, Lower Urinary Tract Symptoms and Incontinence
- (2013) Cara Tannenbaum et al. DRUGS & AGING
- Can parkin be a target for future treatment of Parkinson's disease?
- (2013) Shin-ichiro Kubo et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Antidepressants reduce neuroinflammatory responses and astroglial alpha-synuclein accumulation in a transgenic mouse model of multiple system atrophy
- (2013) Elvira Valera et al. GLIA
- Modulation of 5-Lipoxygenase in Proteotoxicity and Alzheimer's Disease
- (2013) E. Valera et al. JOURNAL OF NEUROSCIENCE
- Calculated treatment
- (2013) Natalia L. Komarova et al. NATURE
- Mutations in COQ2 in Familial and Sporadic Multiple-System Atrophy
- (2013) NEW ENGLAND JOURNAL OF MEDICINE
- Unfolded protein response in Gaucher disease: from human to Drosophila
- (2013) Gali Maor et al. Orphanet Journal of Rare Diseases
- Update on novel familial forms of Parkinson's disease and multiple system atrophy
- (2013) Shinsuke Fujioka et al. PARKINSONISM & RELATED DISORDERS
- Immunotherapy for neurodegenerative diseases: Focus on α-synucleinopathies
- (2013) Elvira Valera et al. PHARMACOLOGY & THERAPEUTICS
- GDNF, NGF and BDNF as therapeutic options for neurodegeneration
- (2013) Shelley J. Allen et al. PHARMACOLOGY & THERAPEUTICS
- Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies
- (2013) S. Pablo Sardi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural and functional characterization of two alpha-synuclein strains
- (2013) Luc Bousset et al. Nature Communications
- -Synuclein in Parkinson's Disease
- (2013) L. Stefanis Cold Spring Harbor Perspectives in Medicine
- The Role of Autophagy in Parkinson's Disease
- (2013) M. A. Lynch-Day et al. Cold Spring Harbor Perspectives in Medicine
- Incidence of Dementia With Lewy Bodies and Parkinson Disease Dementia
- (2013) Rodolfo Savica et al. JAMA Neurology
- Neuroinflammation and Non-motor Symptoms: The Dark Passenger of Parkinson’s Disease?
- (2012) Christopher J. Barnum et al. Current Neurology and Neuroscience Reports
- Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model
- (2012) Zacharias Kohl et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Fluoxetine ameliorates behavioral and neuropathological deficits in a transgenic model mouse of α-synucleinopathy
- (2012) Kiren Ubhi et al. EXPERIMENTAL NEUROLOGY
- Antibody-Aided Clearance of Extracellular -Synuclein Prevents Cell-to-Cell Aggregate Transmission
- (2012) E.-J. Bae et al. JOURNAL OF NEUROSCIENCE
- Lentivirus Mediated Delivery of Neurosin Promotes Clearance of Wild-type α-Synuclein and Reduces the Pathology in an α-Synuclein Model of LBD
- (2012) Brian Spencer et al. MOLECULAR THERAPY
- Donepezil in Parkinson's disease dementia: A randomized, double-blind efficacy and safety study
- (2012) Bruno Dubois et al. MOVEMENT DISORDERS
- 100 years of Lewy pathology
- (2012) Michel Goedert et al. Nature Reviews Neurology
- GBA mutations increase risk for Lewy body disease with and without Alzheimer disease pathology
- (2012) D. Tsuang et al. NEUROLOGY
- Peripheral inflammation increases the deleterious effect of CNS inflammation on the nigrostriatal dopaminergic system
- (2012) Mª Carmen Hernández-Romero et al. NEUROTOXICOLOGY
- Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease
- (2012) Byoung Dae Lee et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
- (2011) Marie-Christine Chartier-Harlin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- α-Synuclein misfolding and Parkinson's disease
- (2011) Leonid Breydo et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- C-reactive protein is related to memory and medial temporal brain volume in older adults
- (2011) Brianne Magouirk Bettcher et al. BRAIN BEHAVIOR AND IMMUNITY
- Inhibition and disaggregation of α-synuclein oligomers by natural polyphenolic compounds
- (2011) Mario Caruana et al. FEBS LETTERS
- Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
- (2011) Zhaohui Liu et al. HUMAN MOLECULAR GENETICS
- Enhanced Phosphatase Activity Attenuates -Synucleinopathy in a Mouse Model
- (2011) K.-W. Lee et al. JOURNAL OF NEUROSCIENCE
- Antidepressants and Neuroinflammation: Can Antidepressants Calm Glial Rage Down?
- (2011) S. Hashioka MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Efficient Gene Therapy for Parkinson's Disease Using Astrocytes as Hosts for Localized Neurotrophic Factor Delivery
- (2011) Anja Drinkut et al. MOLECULAR THERAPY
- Role of Mendelian genes in “sporadic” Parkinson's disease
- (2011) Suzanne Lesage et al. PARKINSONISM & RELATED DISORDERS
- Passive Immunization Reduces Behavioral and Neuropathological Deficits in an Alpha-Synuclein Transgenic Model of Lewy Body Disease
- (2011) Eliezer Masliah et al. PLoS One
- In vivo demonstration that -synuclein oligomers are toxic
- (2011) B. Winner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cognitive and Neuropsychiatric Profile of the Synucleinopathies
- (2010) Aimee W. Kao et al. ALZHEIMER DISEASE & ASSOCIATED DISORDERS
- Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease
- (2010) Todd L. Edwards et al. ANNALS OF HUMAN GENETICS
- Mechanisms Underlying Inflammation in Neurodegeneration
- (2010) Christopher K. Glass et al. CELL
- Heat-shock protein 70 modulates toxic extracellular α-synuclein oligomers and rescues trans-synaptic toxicity
- (2010) Karin M. Danzer et al. FASEB JOURNAL
- Post-transcriptional Regulation of α-Synuclein Expression by mir-7 and mir-153
- (2010) Epaminondas Doxakis JOURNAL OF BIOLOGICAL CHEMISTRY
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- Treatment of the nonmotor symptoms of Parkinson disease
- (2010) Werner Poewe Nature Reviews Neurology
- Extracellular neurosin degrades α-synuclein in cultured cells
- (2010) Harutsugu Tatebe et al. NEUROSCIENCE RESEARCH
- Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection
- (2010) He-Jin Lee et al. Oxidative Medicine and Cellular Longevity
- Selective Molecular Alterations in the Autophagy Pathway in Patients with Lewy Body Disease and in Models of α-Synucleinopathy
- (2010) Leslie Crews et al. PLoS One
- Long-term Effect of Initiating Pramipexole vs Levodopa in Early Parkinson Disease
- (2009) ARCHIVES OF NEUROLOGY
- Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells
- (2009) Simona Bancos et al. CELLULAR IMMUNOLOGY
- Striatal transplantation for multiple system atrophy — Are grafts affected by α-synucleinopathy?
- (2009) Nadia Stefanova et al. EXPERIMENTAL NEUROLOGY
- Do polymorphisms in the familial Parkinsonism genes contribute to risk for sporadic Parkinson's disease?
- (2009) Greg T. Sutherland et al. MOVEMENT DISORDERS
- Minocycline 1-year therapy in multiple-system-atrophy: Effect on clinical symptoms and [11C](R)-PK11195 PET (MEMSA-trial)
- (2009) Richard Dodel et al. MOVEMENT DISORDERS
- Repression of -synuclein expression and toxicity by microRNA-7
- (2009) E. Junn et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Identification of compounds that inhibit the kinase activity of leucine-rich repeat kinase 2
- (2008) Jason P. Covy et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†
- (2008) Daniel Sevlever et al. BIOCHEMISTRY
- A critical evaluation of current staging of α-synuclein pathology in Lewy body disorders
- (2008) Kurt A. Jellinger BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Increased α-synuclein aggregation following limited cleavage by certain matrix metalloproteinases
- (2008) Johannes Levin et al. EXPERIMENTAL NEUROLOGY
- PYM50028, a novel, orally active, nonpeptide neurotrophic factor inducer, prevents and reverses neuronal damage induced by MPP+ in mesencephalic neurons and by MPTP in a mouse model of Parkinson’s disease
- (2008) Naomi P. Visanji et al. FASEB JOURNAL
- Lewy bodies in grafted neurons in subjects with Parkinson's disease suggest host-to-graft disease propagation
- (2008) Jia-Yi Li et al. NATURE MEDICINE
- Second consensus statement on the diagnosis of multiple system atrophy
- (2008) S. Gilman et al. NEUROLOGY
- Non-steroidal anti-inflammatory drugs have potent anti-fibrillogenic and fibril-destabilizing effects for α-synuclein fibrils in vitro
- (2007) Mie Hirohata et al. NEUROPHARMACOLOGY
Become a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get StartedAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started