Article
Biochemistry & Molecular Biology
Jiuchun Qiu, Daiqi Liu, Pengsha Li, Lingling Zhou, Lu Zhou, Xing Liu, Yue Zhang, Meng Yuan, Gary Tse, Guangping Li, Tong Liu
Summary: Oxidative stress and mitochondrial dysfunction play important roles in the development of diabetic cardiomyopathy in type 2 diabetes mellitus. This study established a type 2 diabetes model and found that inhibiting NADPH oxidase can improve ventricular remodeling and reduce the incidence of DCM.
Article
Cell Biology
Biljana Musicki, Serkan Karakus, Justin D. La Favor, Haolin Chen, Fabio H. Silva, Mikael Sturny, Barry R. Zirkin, Arthur L. Burnett
Summary: The study suggests that stimulating the production of endogenous testosterone can help reduce priapism in patients with SCD without affecting fertility. This treatment approach may work by activating TSPO, restoring phosphodiesterase 5 activity, and reducing oxidative stress levels.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Medicine, Research & Experimental
Ankit P. Laddha, Yogesh A. Kulkarni
Summary: The study focused on the effect of daidzein in an experimental model of diabetic cardiomyopathy in rats. Daidzein treatment improved cardiac function, restored ECG and hemodynamic parameters, prevented the loss of cardiac marker enzymes, and reduced cardiac tissue necrosis and fibrosis in diabetic rats, suggesting its potential in mitigating the progression of diabetic cardiomyopathy.
Article
Biochemistry & Molecular Biology
Simona-Adriana Manea, Mihaela-Loredana Vlad, Alexandra-Gela Lazar, Horia Muresian, Maya Simionescu, Adrian Manea
Summary: Dysregulated epigenetic mechanisms, specifically LSD1/KDM1A, play a crucial role in atherosclerosis by promoting oxidative stress and inflammation. Inhibition of LSD1 effectively reduces the extent of atherosclerotic lesions and decreases markers of immune cell infiltration and vascular inflammation, making it a potential therapeutic target.
Article
Pharmacology & Pharmacy
Mariana Garces, Timoteo Marchini, Lourdes Caceres, Valeria Calabro, Andrea M. Mebert, Maria Victoria Tuttolomondo, Tamara Vico, Virginia Vanasco, Fiorella Tesan, Jimena Salgueiro, Marcela Zubillaga, Martin F. Desimone, Giuseppe Valacchi, Silvia Alvarez, Natalia D. Magnani, Pablo A. Evelson
Summary: This study aimed to investigate the toxicological mechanisms in cardiorespiratory oxidative metabolism induced by acute exposure to Ni-doped-NP. Results showed that Ni-NP mainly accumulated in the lungs, leading to increased oxidative reactions and damage to the antioxidant system, resulting in various pathological responses.
Article
Biochemistry & Molecular Biology
Silvia S. Barbieri, Leonardo Sandrini, Laura Musazzi, Maurizio Popoli, Alessandro Ieraci
Summary: Anxiety disorders are common mental health diseases, with stress being a major risk factor. The study found that apocynin can prevent the development of anxiety-like phenotype, reduce histone acetylation decrease, and block the upregulation of specific biochemical molecules.
Review
Biochemistry & Molecular Biology
Leticia Guadalupe Fragoso-Morales, Jose Correa-Basurto, Martha Cecilia Rosales-Hernandez
Summary: Alzheimer's disease is a major human dementia characterized by memory loss associated with oxidative stress in brain cells. Overexpression of NADPH oxidase in AD leads to the production of large amounts of reactive oxygen species, damaging brain cells and vasculature, making it a potential therapeutic target for AD.
Article
Cell Biology
Junqiang Yan, Jiarui Huang, Anran Liu, Jiannan Wu, Hua Fan, Mengmeng Shen, Xiaoyi Lai, Hongxia Ma, Wenjie Sun, Jianxue Yang, Yunqi Xu
Summary: Parkinson's disease is a neurodegenerative disease caused by the loss of dopaminergic neurons. Atorvastatin was found to improve muscle capacity, anxiety, and depression by inhibiting NOX2, potentially through NOX2-mediated oxidative stress and autophagy. Atorvastatin may be a promising drug for improving behavioral disorders in PD, with NOX2 as a potential gene target for new drug development.
Article
Biochemistry & Molecular Biology
Sttefany Viana Gomes, Bruna Vidal Dias, Pedro Alves Machado Junior, Renata Rebeca Pereira, Debora Maria Soares de Souza, Gustavo Silveira Breguez, Wanderson Geraldo de Lima, Cintia Lopes de Brito Magalhaes, Silvia Dantas Cangussu, Andre Talvani, Karina Barbosa Queiroz, Allan Jefferson Cruz Calsavara, Daniela Caldeira Costa
Summary: High-fat diet intake can worsen metabolic adaptation and protection against pathogens in sepsis by causing immunometabolic changes in the liver and white adipose tissue. A study on female mice found that chronic high-fat diet decreased survival rate, increased serum cytokine storm, exacerbated white adipose tissue inflammation, and caused hepatocellular injury in septic mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Aishwarya R. Vaidya, Nina Wolska, Dina Vara, Reiner K. Mailer, Katrin Schroder, Giordano Pula
Summary: Diabetes mellitus is the fifth most common cause of death globally, with type 2 diabetes being the most prevalent form. Diabetes patients have a higher risk of developing cardiovascular disease, largely due to platelet hyperactivity.
Article
Cardiac & Cardiovascular Systems
Haicheng Li, Ting Li, Heting Wang, Xuemin He, Ying Li, Siying Wen, Rongdong Peng, Yuanpeng Nie, Yan Lu, He Yang, Yinong Ye, Guojun Shi, Yanming Chen
Summary: This study identified CCN1 as an important regulator in the pathogenesis of DR. Increased expression of CCN1 stimulates oxidative stress and disrupts tight junction integrity in endothelial cells. Targeting the CCN1/NOX4 axis provides a therapeutic strategy for treating DR by alleviating endothelial cell injury.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Je Won Ko, Sookyoung Jeon, Young Hye Kwon
Summary: This study found that VB6 restriction aggravates neurodegeneration and worsens the effects of high-fat diet-induced neuronal damage in mice. The research highlights the essential role of VB6 in maintaining brain health.
Article
Neurosciences
Yuri Zilberter, Dennis R. Tabuena, Misha Zilberter
Summary: Neurodegenerative diseases (NDDs) causing cognitive impairment and dementia are difficult to treat due to a lack of understanding of their primary initiating factors. Recent research suggests that early oxidative stress caused by NADPH oxidase (NOX) activation may be a shared initiating mechanism among major sporadic NDDs. This study focuses on Alzheimer's disease (AD), Parkinson's disease (PD), and acquired epilepsy, and explores the commonalities in neuroinflammation and NOX involvement to identify therapeutic targets and gain a deeper understanding of the underlying causes of NDDs.
PROGRESS IN NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jorge G. Garcia, Eduardo Ansorena, Fermin I. Milagro, Guillermo Zalba, Carlos de Miguel
Summary: This study suggests that endothelial NOX5 expression may regulate glucose sensitivity and lipid homeostasis in adipose tissue under conditions of high-calorie diet.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Keum-Jin Yang, Won Jung Choi, Yoon-Kyung Chang, Cheol Whee Park, Suk Young Kim, Yu Ah Hong
Summary: Xanthine oxidase (XO) inhibition showed renoprotective effects in diabetic kidney disease (DKD) by inhibiting vascular endothelial growth factor (VEGF) and NADPH oxidase (NOX) and reducing oxidative stress. This study provides important insights into the therapeutic potential of XO inhibition in DKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)