The Mitochondrion-lysosome Axis in Adaptive and Innate Immunity: Effect of Lupus Regulator Peptide P140 on Mitochondria Autophagy and NETosis

Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide

(2018) Baihui Li et al.   JOURNAL OF AUTOIMMUNITY

Lupus Regulator Peptide P140 Represses B Cell Differentiation by Reducing HLA Class II Molecule Overexpression

(2018) Maud Wilhelm et al.   Arthritis & Rheumatology

Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils

(2018) Leonardo Iula et al.   Frontiers in Immunology

Aging-related Atg5 defect impairs neutrophil extracellular traps formation

(2017) Fengying Xu et al.   IMMUNOLOGY

Neither eosinophils nor neutrophils require ATG5-dependent autophagy for extracellular DNA trap formation

(2017) Nina Germic et al.   IMMUNOLOGY

The interrelationship between phagocytosis, autophagy and formation of neutrophil extracellular traps following infection of human neutrophils by Streptococcus pneumoniae

(2017) Ihsan Ullah et al.   Innate Immunity

Regulated in development and DNA damage responses 1 (REDD1) links stress with IL-1β–mediated familial Mediterranean fever attack through autophagy-driven neutrophil extracellular traps

(2017) Panagiotis Skendros et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The pharmacological regulation of cellular mitophagy

(2017) Nikolaos D Georgakopoulos et al.   Nature Chemical Biology

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Diverse stimuli engage different neutrophil extracellular trap pathways

(2017) Elaine F Kenny et al.   eLife

Capability of Neutrophils to Form NETs Is Not Directly Influenced by a CMA-Targeting Peptide

(2017) Christian Maueröder et al.   Frontiers in Immunology

B Cell Tolerance to Deiminated Histones in BALB/c, C57BL/6, and Autoimmune-Prone Mouse Strains

(2017) Nishant Dwivedi et al.   Frontiers in Immunology

Assessing Autophagy in Mouse Models and Patients with Systemic Autoimmune Diseases

(2017) Fengjuan Wang et al.   Cells

Autophagy is induced by anti-neutrophil cytoplasmic Abs and promotes neutrophil extracellular traps formation

(2016) Li-Li Sha et al.   Innate Immunity

Autoimmunity, neuroinflammation, pathogen load: A decisive crosstalk in neuropsychiatric SLE

(2016) Hélène Jeltsch-David et al.   JOURNAL OF AUTOIMMUNITY

Loss of Mitochondrial Function Impairs Lysosomes

(2016) Julie Demers-Lamarche et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease

(2016) Christian Lood et al.   NATURE MEDICINE

Citrullination and autoimmunity

(2015) Guido Valesini et al.   AUTOIMMUNITY REVIEWS

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide

(2015) Christophe Macri et al.   Autophagy

Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses

(2015) J Arnold et al.   CELL DEATH AND DIFFERENTIATION

A central role for HSC70 in regulating antigen trafficking and MHC class II presentation

(2015) Sarah N. Deffit et al.   MOLECULAR IMMUNOLOGY

Autophagy and autophagy-related proteins in the immune system

(2015) Shusaku T Shibutani et al.   NATURE IMMUNOLOGY

A novel quantitative assay of mitophagy: Combining high content fluorescence microscopy and mitochondrial DNA load to quantify mitophagy and identify novel pharmacological tools against pathogenic heteroplasmic mtDNA

(2015) Alan Diot et al.   PHARMACOLOGICAL RESEARCH

Beclin orthologs: integrative hubs of cell signaling, membrane trafficking, and physiology

(2015) Beth Levine et al.   TRENDS IN CELL BIOLOGY

Manipulating Autophagic Processes in Autoimmune Diseases: A Special Focus on Modulating Chaperone-Mediated Autophagy, an Emerging Therapeutic Target

(2015) Fengjuan Wang et al.   Frontiers in Immunology

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

Pharmacological regulators of autophagy and their link with modulators of lupus disease

(2014) Frédéric Gros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms

(2014) Sylviane Muller et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Autophagy and the immune function in aging

(2014) Ana Maria Cuervo et al.   CURRENT OPINION IN IMMUNOLOGY

Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria

(2014) Carina Hönscher et al.   DEVELOPMENTAL CELL

Interplay of Infections, Autoimmunity, and Immunosuppression in Systemic Lupus Erythematosus

(2014) Tiffany Caza et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Astrocytic Regulation of Human Monocytic/Microglial Activation

(2014) A. M. Kostianovsky et al.   JOURNAL OF IMMUNOLOGY

Prolonged Neuroinflammation after Lipopolysaccharide Exposure in Aged Rats

(2014) Hui Qun Fu et al.   PLoS One

Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex

(2014) Nicole C. McKnight et al.   PLoS Genetics

U-251 revisited: genetic drift and phenotypic consequences of long-term cultures of glioblastoma cells

(2014) Anja Torsvik et al.   Cancer Medicine

HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE

(2013) Tiffany N Caza et al.   ANNALS OF THE RHEUMATIC DISEASES

Citrullination of autoantigens implicates NETosis in the induction of autoimmunity

(2013) Nishant Dwivedi et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders

(2013) Marina Pierdominici et al.   FASEB JOURNAL

The m.3243A>G mitochondrial DNA mutation and related phenotypes. A matter of gender?

(2013) Michelangelo Mancuso et al.   JOURNAL OF NEUROLOGY

Identification of a candidate therapeutic autophagy-inducing peptide

(2013) Sanae Shoji-Kawata et al.   NATURE

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

NETs: the missing link between cell death and systemic autoimmune diseases?

(2013) Erika Darrah et al.   Frontiers in Immunology

Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release

(2013) Indira Neeli et al.   Frontiers in Immunology

Macroautophagy is deregulated in murine and human lupus T lymphocytes

(2012) Frédéric Gros et al.   Autophagy

T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy

(2012) Cristiano Alessandri et al.   FASEB JOURNAL

Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression

(2012) Hilde Abrahamsen et al.   FEBS LETTERS

Prediction of Liver Injury Induced by Chemicals in Human With a Multiparametric Assay on Isolated Mouse Liver Mitochondria

(2012) Mathieu Porceddu et al.   TOXICOLOGICAL SCIENCES

Mitochondrial pharmacology

(2012) Robin A.J. Smith et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

A therapeutic peptide in lupus alters autophagic processes and stability of MHCII molecules in MRL/lpr B cells

(2011) Nicolas Page et al.   Autophagy

Mitochondria in innate immunity

(2011) Damien Arnoult et al.   EMBO REPORTS

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

(2011) Jamie M. Ireland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

(2010) N. Page et al.   ANNALS OF THE RHEUMATIC DISEASES

Neutrophil extracellular trap cell death requires both autophagy and superoxide generation

(2010) Quinten Remijsen et al.   CELL RESEARCH

The Beclin 1 interactome

(2010) Congcong He et al.   CURRENT OPINION IN CELL BIOLOGY

Identification of Regulators of Chaperone-Mediated Autophagy

(2010) Urmi Bandyopadhyay et al.   MOLECULAR CELL

Use of Human Cancer Cell Lines Mitochondria to Explore the Mechanisms of BH3 Peptides and ABT-737-Induced Mitochondrial Membrane Permeabilization

(2010) Nelly Buron et al.   PLoS One

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Nucleic acid-associated autoantigens: Pathogenic involvement and therapeutic potential

(2009) Markus H. Hoffmann et al.   JOURNAL OF AUTOIMMUNITY

Apoptosis-linked changes in the phosphorylation status and subcellular localization of the spliceosomal autoantigen U1-70K

(2008) J Dieker et al.   CELL DEATH AND DIFFERENTIATION