Manipulating Autophagic Processes in Autoimmune Diseases: A Special Focus on Modulating Chaperone-Mediated Autophagy, an Emerging Therapeutic Target

Hydroxychloroquine as an anti-thrombotic in antiphospholipid syndrome

(2015) Cristina Belizna   AUTOIMMUNITY REVIEWS

Modulation of deregulated chaperone-mediated autophagy by a phosphopeptide

(2015) Christophe Macri et al.   Autophagy

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease

(2015) Raquel Alvarado et al.   IMMUNOBIOLOGY

Mannose 6 phosphorylation of lysosomal enzymes controls B cell functions

(2015) Takanobu Otomo et al.   JOURNAL OF CELL BIOLOGY

Antigen Presentation by MHC-Dressed Cells

(2015) Masafumi Nakayama   Frontiers in Immunology

Safety of synthetic and biological DMARDs: a systematic literature review informing the 2013 update of the EULAR recommendations for management of rheumatoid arthritis

(2014) Sofia Ramiro et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy is activated in systemic lupus erythematosus and required for plasmablast development

(2014) Alexander J Clarke et al.   ANNALS OF THE RHEUMATIC DISEASES

Pharmacological regulators of autophagy and their link with modulators of lupus disease

(2014) Frédéric Gros et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endo-lysosomal proteases in antigen presentation

(2014) Sander I van Kasteren et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Autophagy and the immune function in aging

(2014) Ana Maria Cuervo et al.   CURRENT OPINION IN IMMUNOLOGY

Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: Evidence for a role in retinal degenerations

(2014) Sonia Guha et al.   EXPERIMENTAL EYE RESEARCH

Autophagy in T-cell development, activation and differentiation

(2014) Alisha W Bronietzki et al.   IMMUNOLOGY AND CELL BIOLOGY

Emerging View of Autophagy in Systemic Lupus Erythematosus

(2014) Xu-jie Zhou et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The Roles of Lysosomes in Inflammation and Autoimmune Diseases

(2014) Wei Ge et al.   INTERNATIONAL REVIEWS OF IMMUNOLOGY

Effects of Hydroxychloroquine on Symptomatic Improvement in Primary Sjögren Syndrome

(2014) Jacques-Eric Gottenberg et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases

(2014) Haijian Wu et al.   MOLECULAR NEUROBIOLOGY

A Crohn’s disease variant in Atg16l1 enhances its degradation by caspase 3

(2014) Aditya Murthy et al.   NATURE

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

(2014) Baptiste Ronan et al.   Nature Chemical Biology

Chaperone-mediated autophagy regulates T cell responses through targeted degradation of negative regulators of T cell activation

(2014) Rut Valdor et al.   NATURE IMMUNOLOGY

Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation

(2014) Xuelai Fan et al.   NATURE NEUROSCIENCE

Mitochondrial dynamics and inheritance during cell division, development and disease

(2014) Prashant Mishra et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cathepsin B Regulates the Appearance and Severity of Mercury-Induced Inflammation and Autoimmunity

(2014) Christopher B. Toomey et al.   TOXICOLOGICAL SCIENCES

Targeting autophagy in neurodegenerative diseases

(2014) René L. Vidal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tear Cathepsin S as a Candidate Biomarker for Sjögren's Syndrome

(2014) Sarah F. Hamm-Alvarez et al.   Arthritis & Rheumatology

Autophagy-lysosome pathway associated neuropathology and axonal degeneration in the brains of alpha-galactosidase A-deficient mice

(2014) Michael P Nelson et al.   Acta Neuropathologica Communications

Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

(2013) Khader Valli Rupanagudi et al.   ANNALS OF THE RHEUMATIC DISEASES

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Recent insights on the putative role of autophagy in autoimmune diseases

(2013) Elena Gianchecchi et al.   AUTOIMMUNITY REVIEWS

ATG5 regulates plasma cell differentiation

(2013) Kara L. Conway et al.   Autophagy

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Chaperone-mediated autophagy: roles in disease and aging

(2013) Ana Maria Cuervo et al.   CELL RESEARCH

Up-to-date membrane biogenesis in the autophagosome formation

(2013) Maho Hamasaki et al.   CURRENT OPINION IN CELL BIOLOGY

Ca2+–Sensor Proteins in the Autophagic and Endocytic Traffic

(2013) Ghita Ghislat et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification

(2013) Devin M. Wolfe et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Autophagy as a pathogenic mechanism and drug target in lymphoproliferative disorders

(2013) Marina Pierdominici et al.   FASEB JOURNAL

Dendritic cells treated with chloroquine modulate experimental autoimmune encephalomyelitis

(2013) Rodolfo Thomé et al.   IMMUNOLOGY AND CELL BIOLOGY

Autophagy and inflammatory diseases

(2013) Sarah A Jones et al.   IMMUNOLOGY AND CELL BIOLOGY

Chloroquine: Modes of action of an undervalued drug

(2013) Rodolfo Thomé et al.   IMMUNOLOGY LETTERS

How do cells optimize luminal environments of endosomes/lysosomes for efficient inflammatory responses?

(2013) T. Kobayashi et al.   JOURNAL OF BIOCHEMISTRY

Diminished Autophagy Limits Cardiac Injury in Mouse Models of Type 1 Diabetes

(2013) Xianmin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misregulation of autophagy and protein degradation systems in myopathies and muscular dystrophies

(2013) M. Sandri et al.   JOURNAL OF CELL SCIENCE

Macroautophagy substrates are loaded onto MHC class II of medullary thymic epithelial cells for central tolerance

(2013) Martin Aichinger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Mechanism and Physiological Function of Macroautophagy

(2013) Daniel J. Klionsky et al.   Journal of Innate Immunity

Identification of Potent and Selective Cathepsin S Inhibitors Containing Different Central Cyclic Scaffolds

(2013) Hans Hilpert et al.   JOURNAL OF MEDICINAL CHEMISTRY

Decreased apopto-phagocytic gene expression in the macrophages of systemic lupus erythematosus patients

(2013) G Majai et al.   LUPUS

Chemical modulation of chaperone-mediated autophagy by retinoic acid derivatives

(2013) Jaime Anguiano et al.   Nature Chemical Biology

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Association between Variants of the Autophagy Related Gene – IRGM and Susceptibility to Crohn’s Disease and Ulcerative Colitis: A Meta-Analysis

(2013) Xiao Cheng Lu et al.   PLoS One

Checking the garbage bin for problems in the house, or how autophagy assists in antigen presentation to the immune system

(2013) Susana Romao et al.   SEMINARS IN CANCER BIOLOGY

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy

(2013) Kosuke Yamahara et al.   Journal of Diabetes Research

Dual Role of Autophagy in Stress-Induced Cell Death in Rheumatoid Arthritis Synovial Fibroblasts

(2013) Masaru Kato et al.   Arthritis & Rheumatology

Proteases: Essential Actors in Processing Antigens and Intracellular Toll-Like Receptors

(2013) Bénédicte Manoury   Frontiers in Immunology

Meta-analysis Followed by Replication Identifies Loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as Associated with Systemic Lupus Erythematosus in Asians

(2012) Wanling Yang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hydroxychloroquine in systemic lupus erythematosus: results of a French multicentre controlled trial (PLUS Study)

(2012) Nathalie Costedoat-Chalumeau et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy regulates TNFα-mediated joint destruction in experimental arthritis

(2012) Neng-Yu Lin et al.   ANNALS OF THE RHEUMATIC DISEASES

Lupuzor/P140 peptide in patients with systemic lupus erythematosus: a randomised, double-blind, placebo-controlled phase IIb clinical trial

(2012) Robert Zimmer et al.   ANNALS OF THE RHEUMATIC DISEASES

Autophagy in immunity

(2012) Xu-Jie Zhou et al.   Autophagy

Autophagy in lysosomal storage disorders

(2012) Andrew P. Lieberman et al.   Autophagy

Macroautophagy is deregulated in murine and human lupus T lymphocytes

(2012) Frédéric Gros et al.   Autophagy

Autophagic dysfunction in a lysosomal storage disorder due to impaired proteolysis

(2012) Matthew J. Elrick et al.   Autophagy

Autophagy-regulating small molecules and their therapeutic applications

(2012) Kyung-Hwa Baek et al.   CHEMICAL SOCIETY REVIEWS

Metabolic regulation of organelle homeostasis in lupus T cells

(2012) Tiffany N. Caza et al.   CLINICAL IMMUNOLOGY

Role of autophagy in immunity and autoimmunity, with a special focus on systemic lupus erythematosus

(2012) Marina Pierdominici et al.   FASEB JOURNAL

T lymphocytes from patients with systemic lupus erythematosus are resistant to induction of autophagy

(2012) Cristiano Alessandri et al.   FASEB JOURNAL

Peptide-based approaches to treat lupus and other autoimmune diseases

(2012) Nicolas Schall et al.   JOURNAL OF AUTOIMMUNITY

Proteolytic Processing Regulates Toll-like Receptor 3 Stability and Endosomal Localization

(2012) Rongsu Qi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleaved/Associated TLR3 Represents the Primary Form of the Signaling Receptor

(2012) F. Toscano et al.   JOURNAL OF IMMUNOLOGY

Therapeutic targets in cancer cell metabolism and autophagy

(2012) Heesun Cheong et al.   NATURE BIOTECHNOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Chaperone-mediated autophagy: a unique way to enter the lysosome world

(2012) Susmita Kaushik et al.   TRENDS IN CELL BIOLOGY

Intersection of autophagy with pathways of antigen presentation

(2012) Natalie L. Patterson et al.   Protein & Cell

Antigen Processing for MHC Class II Presentation via Autophagy

(2012) Christian Münz   Frontiers in Immunology

The Role of Autophagy in Crohn’s Disease

(2012) Paul Henderson et al.   Cells

Lysosomal Acidification Mechanisms

(2011) Joseph A. Mindell   Annual Review of Physiology

Calcium signaling in systemic lupus erythematosus T cells: A treatment target

(2011) Vasileios C. Kyttaris et al.   ARTHRITIS AND RHEUMATISM

Microautophagy of Cytosolic Proteins by Late Endosomes

(2011) Ranjit Sahu et al.   DEVELOPMENTAL CELL

Cathepsin S inhibitors: 2004 – 2010

(2011) Alice Lee-Dutra et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Autophagy, Microbial Sensing, Endoplasmic Reticulum Stress, and Epithelial Function in Inflammatory Bowel Disease

(2011) Arthur Kaser et al.   GASTROENTEROLOGY

Murine Models of Systemic Lupus Erythematosus

(2011) Daniel Perry et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Azithromycin blocks autophagy and may predispose cystic fibrosis patients to mycobacterial infection

(2011) Maurizio Renna et al.   JOURNAL OF CLINICAL INVESTIGATION

Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase

(2011) Sarah E. Ewald et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells

(2011) Jamie M. Ireland et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy in immunity and inflammation

(2011) Beth Levine et al.   NATURE

Study of the common genetic background for rheumatoid arthritis and systemic lupus erythematosus

(2010) G. Orozco et al.   ANNALS OF THE RHEUMATIC DISEASES

HSC70 blockade by the therapeutic peptide P140 affects autophagic processes and endogenous MHCII presentation in murine lupus

(2010) N. Page et al.   ANNALS OF THE RHEUMATIC DISEASES

Acetylated microtubules are required for fusion of autophagosomes with lysosomes

(2010) Rui Xie et al.   BMC CELL BIOLOGY

Chaperone-mediated autophagy: machinery, regulation and biological consequences

(2010) Wenming Li et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells

(2010) Heung Kyu Lee et al.   IMMUNITY

Mucopolysaccharidosis IIIB, a lysosomal storage disease, triggers a pathogenic CNS autoimmune response

(2010) Smruti Killedar et al.   Journal of Neuroinflammation

Chemical modulators of autophagy as biological probes and potential therapeutics

(2010) Angeleen Fleming et al.   Nature Chemical Biology

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Elevated ATG5 expression in autoimmune demyelination and multiple sclerosis

(2009) Mehrdad Alirezaei et al.   Autophagy

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

(2009) Fernando E. Sepulveda et al.   IMMUNITY

Odanacatib, a Cathepsin-K Inhibitor for Osteoporosis: A Two-Year Study in Postmenopausal Women With Low Bone Density

(2009) Henry G Bone et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Cathepsin S Regulates Class II MHC Processing in Human CD4+ HLA-DR+ T Cells

(2009) C. M. Costantino et al.   JOURNAL OF IMMUNOLOGY

Autophagy and Its Role in MHC-Mediated Antigen Presentation

(2009) V. L. Crotzer et al.   JOURNAL OF IMMUNOLOGY

The Spliceosomal Phosphopeptide P140 Controls the Lupus Disease by Interacting with the HSC70 Protein and via a Mechanism Mediated by γδ T Cells

(2009) Nicolas Page et al.   PLoS One

Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review

(2008) G Ruiz-Irastorza et al.   ANNALS OF THE RHEUMATIC DISEASES

Spliceosomal peptide P140 for immunotherapy of systemic lupus erythematosus: Results of an early phase II clinical trial

(2008) Sylviane Muller et al.   ARTHRITIS AND RHEUMATISM

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

Constitutive Activation of Chaperone-mediated Autophagy in Cells with Impaired Macroautophagy

(2008) Susmita Kaushik et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in thymic epithelium shapes the T-cell repertoire and is essential for tolerance

(2008) Jelena Nedjic et al.   NATURE

Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci

(2008) John B Harley et al.   NATURE GENETICS