Citrullinated Autoantigens: From Diagnostic Markers to Pathogenetic Mechanisms

Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase–AIF pathway

(2014) Kin Pong U et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

PAD2 Overexpression in Transgenic Mice Promotes Spontaneous Skin Neoplasia

(2014) J. L. McElwee et al.   CANCER RESEARCH

Deimination of linker histones links neutrophil extracellular trap release with autoantibodies in systemic autoimmunity

(2014) Nishant Dwivedi et al.   FASEB JOURNAL

Histone Deimination As a Response to Inflammatory Stimuli in Neutrophils

(2014) I. Neeli et al.   JOURNAL OF IMMUNOLOGY

Localisation of citrullinated proteins in normal appearing white matter and lesions in the central nervous system in multiple sclerosis

(2014) Claire M. Bradford et al.   JOURNAL OF NEUROIMMUNOLOGY

Citrullination regulates pluripotency and histone H1 binding to chromatin

(2014) Maria A. Christophorou et al.   NATURE

Identification of New Citrulline-Specific Autoantibodies, Which Bind to Human Arthritic Cartilage, by Mass Spectrometric Analysis of Citrullinated Type II Collagen

(2014) Sabrina Haag et al.   Arthritis & Rheumatology

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

(2013) Federico Pratesi et al.   ANNALS OF THE RHEUMATIC DISEASES

The fibrin-derived citrullinated peptide β60–74Cit60,72,74bears the major ACPA epitope recognised by the rheumatoid arthritis-specific anticitrullinated fibrinogen autoantibodies and anti-CCP2 antibodies

(2013) M Cornillet et al.   ANNALS OF THE RHEUMATIC DISEASES

Low-avidity anticitrullinated protein antibodies (ACPA) are associated with a higher rate of joint destruction in rheumatoid arthritis

(2013) Parawee Suwannalai et al.   ANNALS OF THE RHEUMATIC DISEASES

Citrullination of autoantigens implicates NETosis in the induction of autoimmunity

(2013) Nishant Dwivedi et al.   ANNALS OF THE RHEUMATIC DISEASES

Elevated Levels of Circulating DNA and Chromatin Are Independently Associated With Severe Coronary Atherosclerosis and a Prothrombotic State

(2013) Julian I. Borissoff et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autoantibodies to Posttranslationally Modified Type II Collagen as Potential Biomarkers for Rheumatoid Arthritis

(2013) Rocky Strollo et al.   ARTHRITIS AND RHEUMATISM

Identification of Citrullinated Hsp90 Isoforms as Novel Autoantigens in Rheumatoid Arthritis-Associated Interstitial Lung Disease

(2013) Lisa Harlow et al.   ARTHRITIS AND RHEUMATISM

Multiplex Analyses of Antibodies Against Citrullinated Peptides in Individuals Prior to Development of Rheumatoid Arthritis

(2013) Mikael Brink et al.   ARTHRITIS AND RHEUMATISM

Citrullinated Peptides in the Diagnosis of Rheumatoid Arthritis

(2013) Maria J. Gomara et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus

(2013) Jason S. Knight et al.   JOURNAL OF CLINICAL INVESTIGATION

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

(2013) Khaled Amara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Novel Inhibitors of Protein Arginine Deiminase with Potential Activity in Multiple Sclerosis Animal Model

(2013) Lianhu Wei et al.   JOURNAL OF MEDICINAL CHEMISTRY

H1 histones: current perspectives and challenges

(2013) S. W. Harshman et al.   NUCLEIC ACIDS RESEARCH

Dysregulation of PAD4-mediated citrullination of nuclear GSK3  activates TGF-  signaling and induces epithelial-to-mesenchymal transition in breast cancer cells

(2013) S. C. Stadler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice

(2013) K. Martinod et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

Citrullinated calreticulin potentiates rheumatoid arthritis shared epitope signaling

(2012) Song Ling et al.   ARTHRITIS AND RHEUMATISM

Potential role for PADI-mediated histone citrullination in preimplantation development

(2012) Rui Kan et al.   BMC DEVELOPMENTAL BIOLOGY

Citrullination of TNF-α by peptidylarginine deiminases reduces its capacity to stimulate the production of inflammatory chemokines

(2012) Eva A.V. Moelants et al.   CYTOKINE

Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity

(2012) Yuji Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil extracellular traps: Is immunity the second function of chromatin?

(2012) Volker Brinkmann et al.   JOURNAL OF CELL BIOLOGY

Neutrophil Extracellular Traps: Double-Edged Swords of Innate Immunity

(2012) M. J. Kaplan et al.   JOURNAL OF IMMUNOLOGY

NADPH Oxidase Inhibits the Pathogenesis of Systemic Lupus Erythematosus

(2012) A. M. Campbell et al.   Science Translational Medicine

Citrullination of fibronectin modulates synovial fibroblast behavior

(2012) Miriam A Shelef et al.   ARTHRITIS RESEARCH & THERAPY

Regulation of histone modification and chromatin structure by the p53–PADI4 pathway

(2012) Chizu Tanikawa et al.   Nature Communications

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

(2011) Alexander A. Chumanevich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

(2011) Nishant Dwivedi et al.   ARTHRITIS AND RHEUMATISM

The antigen specificity of the rheumatoid arthritis-associated ACPA directed to citrullinated fibrin is very closely restricted

(2011) Cristina Iobagiu et al.   JOURNAL OF AUTOIMMUNITY

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

Netting Neutrophils Induce Endothelial Damage, Infiltrate Tissues, and Expose Immunostimulatory Molecules in Systemic Lupus Erythematosus

(2011) E. Villanueva et al.   JOURNAL OF IMMUNOLOGY

Anti-CCP antibodies: the past, the present and the future

(2011) Walther J. van Venrooij et al.   Nature Reviews Rheumatology

Detection and Quantification of Citrullinated Chemokines

(2011) Eva A. V. Moelants et al.   PLoS One

Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus

(2011) R. Lande et al.   Science Translational Medicine

Identification of citrullinated histone H3 as a potential serum protein biomarker in a lethal model of lipopolysaccharide-induced shock

(2011) Yongqing Li et al.   SURGERY

Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and pro-inflammatory role of citrullinated BiP in collagen-induced arthritis

(2011) Hirofumi Shoda et al.   ARTHRITIS RESEARCH & THERAPY

Genome-Wide Analysis Reveals PADI4 Cooperates with Elk-1 to Activate c-Fos Expression in Breast Cancer Cells

(2011) Xuesen Zhang et al.   PLoS Genetics

Autocitrullination of human peptidyl arginine deiminase type 4 regulates protein citrullination during cell activation

(2010) Felipe Andrade et al.   ARTHRITIS AND RHEUMATISM

Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and α-enolase: Implications for autoimmunity in rheumatoid arthritis

(2010) Natalia Wegner et al.   ARTHRITIS AND RHEUMATISM

2010 Rheumatoid arthritis classification criteria: An American College of Rheumatology/European League Against Rheumatism collaborative initiative

(2010) Daniel Aletaha et al.   ARTHRITIS AND RHEUMATISM

Regulation of human neutrophil Fcγ receptor IIa by C5a receptor promotes inflammatory arthritis in mice

(2010) Naotake Tsuboi et al.   ARTHRITIS AND RHEUMATISM

Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo

(2010) M. W. Munks et al.   BLOOD

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins

(2010) Katleen Van Steendam et al.   ARTHRITIS RESEARCH & THERAPY

Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation

(2009) Yanming Wang et al.   JOURNAL OF CELL BIOLOGY

Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation

(2008) T. Loos et al.   BLOOD

Histone H1 and its isoforms: Contribution to chromatin structure and function

(2008) Nicole Happel et al.   GENE

Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation

(2008) Paul Proost et al.   JOURNAL OF EXPERIMENTAL MEDICINE