Article
Geriatrics & Gerontology
Yang Liu, Huiqun Fu, Yan Wu, Binbin Nie, Fangyan Liu, Tianlong Wang, Wei Xiao, Shuyi Yang, Minhui Kan, Long Fan
Summary: Our study found that inhibiting hippocampal neuroinflammation not only reduces inflammatory responses in the hippocampus but also improves brain functional connectivity in regions related to the hippocampus. Early anti-inflammatory treatment with SS-31 has a long-lasting effect on reducing the impact of LPS-induced neuroinflammation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Biology
Valentina Murtaj, Silvia Penati, Sara Belloli, Maria Foti, Angela Coliva, Angela Papagna, Cecilia Gotti, Elisa Toninelli, Remy Chiaffarelli, Stefano Mantero, Susanna Pucci, Michela Matteoli, Maria Luisa Malosio, Rosa Maria Moresco
Summary: The study found that male mice exposed to a high fat diet are more susceptible to metabolic changes compared to female mice, showing faster and higher weight gain, elevated cholesterol and liver enzyme levels, and more prominent brain inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Article
Geriatrics & Gerontology
Bing Jiang, Ying Zhang, Yan Wang, Zheng Li, Qianwei Chen, Jun Tang, Gang Zhu
Summary: The study shows that GLC can effectively reduce brain edema, improve neurofunction deficits after ICH, increase brain-derived neurotrophic factors, and decrease proinflammatory factors. GLC reduces IKK expression in microglia and NF-κB-P65 levels in perihematomal tissue. GLC alleviates ICH-induced neuroinflammation and improves neurological outcomes in aged rats by regulating the NF-κB signaling pathway through the Sur1-Trpm4 channel.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Jing-Yi He, Dai-Di Li, Qian Wen, Ting-Yang Qin, Hong Long, Shi-Bin Zhang, Feng Zhang
Summary: The etiology of Parkinson's disease (PD) is still unknown, but oxidative stress and neuroinflammation play a crucial role in its pathogenesis. This study found that lipopolysaccharide (LPS)-induced neuroinflammation and rotenone (ROT)-induced oxidative stress synergistically aggravated motor dysfunction, dopamine neuron damage, glial cell activation, release of related mediators, activation of Nrf2 signaling, and disruption of oxidative balance in the rat brain. Furthermore, oxidative stress followed by neuroinflammation caused more dopamine neuronal loss than neuroinflammation followed by oxidative stress.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Medicine, Research & Experimental
Ahmed M. Kabel, Hany H. Arab, Aliaa Atef, Remon S. Estfanous
Summary: The combination of omarigliptin and galangin may be a promising therapeutic approach for mitigating LPS-induced neuroinflammation.
Article
Immunology
Eugene Kim, Ines Carreira Figueiredo, Camilla Simmons, Karen Randall, Loreto Rojo Gonzalez, Tobias Wood, Brigida Ranieri, Paula Sureda-Gibert, Oliver Howes, Carmine Pariante, N. I. M. A. NIMA Consortium, Ofer Pasternak, Flavio Dell'Acqua, Federico Turkheimer, Diana Cash
Summary: It has been found that neuroinflammation is crucial in various neurological and psychiatric disorders. Recent studies have shown that diffusion MRI (dMRI) can detect changes in microglial density and morphology related to neuroinflammation, but these studies were mostly conducted ex vivo or in extreme animal models. In this study, the utility of established dMRI methods to detect neuroinflammation in a clinically relevant animal model of sickness behavior was investigated. The results demonstrated that diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI) indicated widespread increases in diffusivity in the brains of rats with a lipopolysaccharide challenge. These findings confirm the sensitivity of dMRI to neuroinflammatory processes and contribute to the development of a noninvasive indicator of neuroinflammation for early diagnosis and treatment monitoring in neurological and psychiatric diseases.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
Louise M. Ince, Jeffrey S. Darling, Kevin Sanchez, Kiersten S. Bell, Jennifer K. Melbourne, Lourdes K. Davis, Kimberly Nixon, Andrew D. Gaudet, Laura. K. Fonken
Summary: Aging is associated with changes in immune system reactivity. Male rats show cognitive decline and increased neuroinflammatory responses, while females do not. Sex differences play a crucial role in the mechanism of aging.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Elisa Navarro, Diana M. Norden, Paige J. Trojanowski, Jonathan P. Godbout, Manuela G. Lopez
Summary: The stimulation of alpha 7 nAChR signaling reduces microglial activation in an in vivo LPS-based model, but this cholinergic-dependent regulation appears to be dysfunctional in microglia of aged mice.
Article
Neurosciences
Devlina Ghosh, Gajendra Singh, Prabhaker Mishra, Aditi Singh, Alok Kumar, Neeraj Sinha
Summary: Cerebellar dysfunction, which is related to impaired motor coordination and balance, may be influenced by neuroinflammation and aging. This study showed that chronic neuroinflammation in aged mice led to mitochondrial dynamic alteration in the cerebellum, with changes in fusion and fission-related genes. The findings suggest that the interaction between mitochondrial dynamics and activated microglia under chronic neuroinflammatory conditions is crucial for understanding the molecular mechanism of the cerebellum.
NEUROSCIENCE LETTERS
(2023)
Article
Pharmacology & Pharmacy
Andrew B. Hawkey, Erica Pippen, Bruny Kenou, Zade Holloway, Theodore A. Slotkin, Frederic J. Seidler, Edward D. Levin
Summary: This study demonstrates that developmental exposure to low doses of diazinon has persistent and evolving effects on behavior and neurochemistry in rats, particularly as they enter middle age. The effects of diazinon on locomotor activity diminish with age, but deficits in reference memory and attentional accuracy emerge in middle-aged rats. These long-term behavioral impairments are associated with alterations in dopaminergic function.
Article
Materials Science, Multidisciplinary
Chang Xu, Hui Gao, Jing-Wen Cui, Peng Teng, Hao-Sen Zhao, He Tian, Sen Lin, Chang Liu
Summary: Engineered bone marrow-derived macrophage nanovesicles can target the polarization and metabolism of macrophages/microglia, potentially providing therapeutic benefits for inflammatory diseases and brain injuries.
MATERIALS & DESIGN
(2022)
Article
Biochemistry & Molecular Biology
Deiweson Souza-Monteiro, Marcia Cristina dos Santos Guerra, Leonardo Oliveira Bittencourt, Walessa Alana Braganca Aragao, Aline Dionizio, Felipe Martins Silveira, Marilia Afonso Rebelo Buzalaf, Manoela Domingues Martins, Maria Elena Crespo-Lopez, Rafael Rodrigues Lima
Summary: This study investigated the effects of low-dose aluminum exposure on the oxidative biochemistry, proteomic profile, and morphology of the major salivary glands. The results showed that aluminum caused oxidative imbalance, dysregulation of protein expression, and histological alterations in the salivary glands. Prolonged exposure to low doses of aluminum may pose a risk to oral health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Fang Chen, Xiaofeng Wu, Jiayong Yang, Xuben Yu, Bili Liu, Zhiwen Yan
Summary: This study investigated the effects of Gal-3 inhibition on neuroinflammation and cognitive deficits in aged mice with LPS-induced neurotoxicity. The results showed that Gal-3 knockdown in the hippocampus attenuated neuroinflammation and neuronal apoptosis, leading to improved cognitive function. Furthermore, the study suggested that Gal-3 may exert its effects through inhibiting the TLR4/NF-kB pathway. These findings highlight the potential therapeutic target of Gal-3 against AD-associated neuroinflammation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Babaei, Mohammadreza Mirzababaei, Leila Dargahi, Zahra Shahsavari, Marjan Nassiri-Asl, Saeed Karima
Summary: Recent studies have shown that S. boulardii, a yeast probiotic, can improve memory impairment induced by LPS and reduce neuroinflammation and amyloid-fi deposition.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Clinical Neurology
Pedro Efrain Hernandez-Arrambide, Alan Carrasco-Carballo, Irving Parra, Delfino Chamorro-Arenas, Isabel Martinez, Felix Luna, Fernando Sartillo-Piscil, Yousef Tizabi, Liliana Mendieta
Summary: Researchers synthesized a hydroxylated analog of PX called 3HPX and compared its pharmacokinetic and binding properties with PX. In both in silico and in vivo studies, 3HPX showed stronger binding to the serotonin transporter and better clearance, as well as superior effectiveness in reversing immobility and protecting neurons and microglia.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Keith W. VanDusen, Yi-Ju Li, Victor Cai, Ashley Hall, Sarah Hiles, J. Will Thompson, M. Arthur Moseley, Mary Cooter, Leah Acker, Jerrold H. Levy, Kamrouz Ghadimi, Quintin J. Quinones, Michael J. Devinney, Stacey Chung, Niccolo Terrando, Eugene W. Moretti, Jeffrey N. Browndyke, Joseph P. Mathew, Miles Berger
Summary: In this study, unbiased mass spectrometry was used to identify potential neuroinflammatory pathways underlying POCD, with results demonstrating changes in complement and coagulation pathways in the CSF of POCD patients.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Yang Liu, Huiqun Fu, Yan Wu, Binbin Nie, Fangyan Liu, Tianlong Wang, Wei Xiao, Shuyi Yang, Minhui Kan, Long Fan
Summary: Our study found that inhibiting hippocampal neuroinflammation not only reduces inflammatory responses in the hippocampus but also improves brain functional connectivity in regions related to the hippocampus. Early anti-inflammatory treatment with SS-31 has a long-lasting effect on reducing the impact of LPS-induced neuroinflammation.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Cell Biology
Zunshu Du, Yizhi Song, Xinyue Chen, Wanning Zhang, Guitao Zhang, Hui Li, Lirong Chang, Yan Wu
Summary: The study reveals that astrocytic GluN2A plays a critical role in exerting protective effects on synapses by regulating NGF against A beta synaptotoxicity, through modulating pNF-kappa B, Furin, and VAMP3 to control NGF synthesis, maturation, and secretion. This discovery may contribute to establishing new targets for Alzheimer's disease prevention and early therapy.
Review
Clinical Neurology
Marcia N. Gordon, Michael T. Heneka, Lydia M. Le Page, Christian Limberger, David Morgan, Andrea J. Tenner, Niccolo Terrando, Auriel A. Willette, Sara A. Willette
Summary: COVID-19 infection may increase the risk of cognitive impairment, so further research is needed to study the symptoms, genetic polymorphisms, and treatment decisions associated with cognitive impairment risk, and to establish research consortia to monitor long-term consequences. Additionally, the lack of model systems to test hypotheses related to infection and cognition is a pending issue.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Yizhi Song, Zunshu Du, Xinyue Chen, Wanning Zhang, Guitao Zhang, Hui Li, Lirong Chang, Yan Wu
Summary: The study demonstrated that activation of astrocytic NMDARs can mitigate A beta-induced loss of synaptic proteins by increasing NGF release, while blockade of astrocytic NMDARs inhibits A beta-induced compensatory protective NGF increase. This highlights the important role of NMDARs in neurodegenerative diseases.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Sara V. Maurer, Cuicui Kong, Niccolo Terrando, Christina L. Williams
Summary: The study shows that a high-choline diet prior to surgery can prevent perioperative neurocognitive disorders, by partially reducing the effects of tibial fracture on neuronal function in the brain.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Patrick Miller-Rhodes, Herman Li, Ravikanth Velagapudi, Wesley Chiang, Niccolo Terrando, Harris A. Gelbard
Summary: Systemic perturbations following surgical trauma can lead to a neuroimmune cascade, affecting the blood-brain barrier, activating microglia, and contributing to cognitive deficits such as delirium. Delirium superimposed on dementia is a severe complication that increases the vulnerability of the brain to neuroinflammation and neurodegeneration, with molecular mechanisms not yet fully understood. In this study, using a mouse model, the researchers found that the brain-penetrant anti-inflammatory neuroprotective drug URMC-099 could prevent inflammatory endothelial activation, breakdown of the blood-brain barrier, synapse loss, and microglial activation in the delirium superimposed on dementia model.
Editorial Material
Anesthesiology
Niccolo Terrando, Katerina Akassoglou
Summary: Systemic perturbations induce neurovascular, inflammatory, and cognitive changes. Dysfunction of the blood-brain barrier is a hallmark of aging and various neurological conditions.
BRITISH JOURNAL OF ANAESTHESIA
(2022)
Article
Clinical Neurology
Wanning Zhang, Xinyue Chen, Zunshu Du, Xin Mao, Ruiqi Gao, Ziyan Chen, Hongqi Wang, Guitao Zhang, Ning Zhang, Hui Li, Yizhi Song, Lirong Chang, Yan Wu
Summary: Sleep disorders are associated with cognitive impairments and increased risk of developing Alzheimer's disease. This study reveals a neuroprotective role for astrocytic GluN2A in sleep deprivation, which may contribute to the development of new therapeutic targets for sleep disorders.
Article
Geriatrics & Gerontology
Yang Liu, Huiru Feng, Huiqun Fu, Yan Wu, Binbin Nie, Tianlong Wang
Summary: Inflammatory stress during anesthesia and surgery can lead to long-term cognitive dysfunction in the vulnerable aged brain. This study focused on the network mechanism of this dysfunction and found that the default mode network (DMN) plays a significant role. Changes in both topology structure and functional connectivity (FC) of DMN were observed in aged rats following inflammatory stress-induced cognitive dysfunction. The alterations in FC were long-lasting, while changes in topology structures only lasted for 3 days.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Clinical Neurology
Sarinnapha M. Vasunilashorn, Nadia Lunardi, John C. Newman, Gregory Crosby, Leah Acker, Ted Abel, Seema Bhatnagar, Colm Cunningham, Rafael de Cabo, Laura Dugan, Joseph A. Hippensteel, Yumiko Ishizawa, Shouri Lahiri, Edward R. Marcantonio, Zhongcong Xie, Sharon K. Inouye, Niccolo Terrando, Roderic G. Eckenhoff
Summary: Delirium is a common, morbid, and costly syndrome closely associated with Alzheimer's disease (AD) and AD-related dementias (ADRD). While human studies have improved our understanding of delirium in terms of incidence, risk factors, outcomes, and management, limited knowledge exists about the neurobiology of delirium. This article discusses the use of preclinical and translational animal models to advance our understanding of delirium neurobiology and develop new prevention and treatment strategies. Recommendations for the development and validation of these models are provided to enhance awareness in this important field.
ALZHEIMERS & DEMENTIA
(2023)
Article
Nanoscience & Nanotechnology
Wesley Chiang, Angela Stout, Francine Yanchik-Slade, Herman Li, Niccolo Terrando, Bradley L. L. Nilsson, Harris A. A. Gelbard, Todd D. D. Krauss
Summary: Despite limited evidence for SARS-CoV-2 infection in the central nervous system, cognitive impairment is a common complication in recovered COVID-19 patients. In this study, nanocrystal quantum dot micelles decorated with spike protein were used to investigate neurological damage caused by SARS-CoV-2. The findings provide evidence of an inflammatory response in brain cells without direct exposure to SARS-CoV-2-like nanoparticles and suggest potential neuroprotective strategies.
ACS APPLIED NANO MATERIALS
(2023)
Article
Geriatrics & Gerontology
Xin Mao, Ding Han, Wensheng Guo, Wanning Zhang, Hongqi Wang, Guitao Zhang, Ning Zhang, Liangyun Jin, Binbin Nie, Hui Li, Yizhi Song, Yan Wu, Lirong Chang
Summary: Sleep disturbance is a recognized risk factor for Alzheimer's disease. This study investigated the underlying mechanisms by establishing a rat model and found that sleep deprivation worsened cognitive decline and disrupted white matter integrity in the brain. These findings contribute to our understanding of the complex relationship between sleep disturbance and Alzheimer's disease.
Article
Immunology
Zhiquan Zhang, Qing Ma, Ravikanth Velagapudi, William E. Barclay, Ramona M. Rodriguiz, William C. Wetsel, Ting Yang, Mari L. Shinohara, Niccolo Terrando
Summary: This study developed an orthopedic mouse model to study the impact of surgery on the vulnerable brain and found that neuroinflammation plays a crucial role in perioperative neurocognitive disorders. They also discovered the neuroprotective effects of a biomimetic peptide derived from Annexin-A1, providing a new target for the treatment of these disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Yang Liu, Hui-Qun Fu, Yan Wu, Zun-Shu Du, Bo-Ran Li, Xin Gao, Guan-Wen Lin, Shu-Yi Yang, Tian-Long Wang
Summary: Resting-state functional magnetic resonance imaging (rs-fMRI) is a promising method for studying brain function, typically performed on anesthetized animals. This study found that different anesthesia methods in aged rats can lead to variations in functional connectivity in different brain regions. Isoflurane anesthesia may be a suitable substitute for Isoflurane + Dexmedetomidine anesthesia in default mode network studies, depending on the regions of interest.
CHINESE MEDICAL JOURNAL
(2021)
