Modeling Parkinson’s Disease Using Patient-specific Induced Pluripotent Stem Cells

An in vivo model of functional and vascularized human brain organoids

(2018) Abed AlFatah Mansour et al.   NATURE BIOTECHNOLOGY

Parkin absence accelerates microtubule aging in dopaminergic neurons

(2018) Daniele Cartelli et al.   NEUROBIOLOGY OF AGING

Parkinson's Disease Is Not Simply a Prion Disorder

(2017) D. James Surmeier et al.   JOURNAL OF NEUROSCIENCE

Prying into the Prion Hypothesis for Parkinson's Disease

(2017) Patrik Brundin et al.   JOURNAL OF NEUROSCIENCE

A simplified protocol for differentiation of electrophysiologically mature neuronal networks from human induced pluripotent stem cells

(2017) N Gunhanlar et al.   MOLECULAR PSYCHIATRY

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Animal models of α-synucleinopathy for Parkinson disease drug development

(2017) James B. Koprich et al.   NATURE REVIEWS NEUROSCIENCE

iPSC-Derived Human Microglia-like Cells to Study Neurological Diseases

(2017) Edsel M. Abud et al.   NEURON

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Transactivator protein: An alternative for delivery of recombinant proteins for safer reprogramming of induced Pluripotent Stem Cell

(2017) Fazlina Nordin et al.   VIRUS RESEARCH

Dopamine Induces Oscillatory Activities in Human Midbrain Neurons with Parkin Mutations

(2017) Ping Zhong et al.   Cell Reports

An updated review of Parkinson's disease genetics and clinicopathological correlations

(2016) M. Ferreira et al.   ACTA NEUROLOGICA SCANDINAVICA

Functional Impairment in Miro Degradation and Mitophagy Is a Shared Feature in Familial and Sporadic Parkinson’s Disease

(2016) Chung-Han Hsieh et al.   Cell Stem Cell

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

(2016) Dena G. Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

LRRK2 Expression Is Deregulated in Fibroblasts and Neurons from Parkinson Patients with Mutations in PINK1

(2016) Garikoitz Azkona et al.   MOLECULAR NEUROBIOLOGY

LRRK2 at the interface of autophagosomes, endosomes and lysosomes

(2016) Dorien A. Roosen et al.   Molecular Neurodegeneration

Parkinson-associated risk variant in distal enhancer of α-synuclein modulates target gene expression

(2016) Frank Soldner et al.   NATURE

Efficient derivation of microglia-like cells from human pluripotent stem cells

(2016) Julien Muffat et al.   NATURE MEDICINE

The Evolution of Genetics: Alzheimer’s and Parkinson’s Diseases

(2016) Andrew Singleton et al.   NEURON

Robust production of human neural cells by establishing neuroepithelial-like stem cells from peripheral blood mononuclear cell-derived feeder-free iPSCs under xeno-free conditions

(2016) Miho Isoda et al.   NEUROSCIENCE RESEARCH

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking

(2016) A. Raquel Esteves et al.   NEUROSCIENTIST

Astrocyte Differentiation of Human Pluripotent Stem Cells: New Tools for Neurological Disorder Research

(2016) Abinaya Chandrasekaran et al.   Frontiers in Cellular Neuroscience

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

(2016) Christian Dölle et al.   Nature Communications

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

(2016) Sun Young Chung et al.   Stem Cell Reports

Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients withMAPTmutations

(2015) Mariangela Iovino et al.   BRAIN

Feeder-free and xeno-free culture of human pluripotent stem cells using UCBS matrix

(2015) Yan Ding et al.   CELL BIOLOGY INTERNATIONAL

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Distinct clinical and neuropathological features of G51D SNCA mutation cases compared with SNCA duplication and H50Q mutation

(2015) Aoife P. Kiely et al.   Molecular Neurodegeneration

A comparison of genetically matched cell lines reveals the equivalence of human iPSCs and ESCs

(2015) Jiho Choi et al.   NATURE BIOTECHNOLOGY

Age-specific penetrance ofLRRK2G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium

(2015) Karen Marder et al.   NEUROLOGY

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Correction: Behavioral Phenotyping of Parkin-Deficient Mice: Looking for Early Preclinical Features of Parkinson's Disease

(2015)   PLoS One

Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells

(2015) L M A Oliveira et al.   Cell Death & Disease

Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines

(2015) Atossa Shaltouki et al.   Stem Cell Reports

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Human ESC-Derived Dopamine Neurons Show Similar Preclinical Efficacy and Potency to Fetal Neurons when Grafted in a Rat Model of Parkinson’s Disease

(2014) Shane Grealish et al.   Cell Stem Cell

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

(2014) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies

(2014) G. Skibinski et al.   JOURNAL OF NEUROSCIENCE

Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia

(2014) K Brennand et al.   MOLECULAR PSYCHIATRY

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Phenotypic characterization of recessive gene knockout rat models of Parkinson's disease

(2014) Kuldip D. Dave et al.   NEUROBIOLOGY OF DISEASE

Higher Vulnerability and Stress Sensitivity of Neuronal Precursor Cells Carrying an Alpha-Synuclein Gene Triplication

(2014) Adrian Flierl et al.   PLoS One

PINK1 Loss-of-Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling

(2014) V. A. Morais et al.   SCIENCE

Production of Human Pluripotent Stem Cell Therapeutics under Defined Xeno-free Conditions: Progress and Challenges

(2014) Yongjia Fan et al.   Stem Cell Reviews and Reports

Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-Derived Human Neurons

(2014) Yong Ren et al.   STEM CELLS

Parkin and PINK1: much more than mitophagy

(2014) Leslie A. Scarffe et al.   TRENDS IN NEUROSCIENCES

iPSC-derived neurons from GBA1-associated Parkinson’s disease patients show autophagic defects and impaired calcium homeostasis

(2014) David C. Schöndorf et al.   Nature Communications

iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease

(2014) Chris M. Woodard et al.   Cell Reports

α-Synucleinopathy associated with G51D SNCA mutation: a link between Parkinson’s disease and multiple system atrophy?

(2013) Aoife P. Kiely et al.   ACTA NEUROPATHOLOGICA

The Winding Road to Pluripotency (Nobel Lecture)

(2013) Shinya Yamanaka   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Accumulation of mitochondrial DNA deletions within dopaminergic neurons triggers neuroprotective mechanisms

(2013) Celine Perier et al.   BRAIN

Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

(2013) Scott D. Ryan et al.   CELL

Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging

(2013) Justine D. Miller et al.   Cell Stem Cell

Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

(2013) Peter Reinhardt et al.   Cell Stem Cell

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

(2013) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

Oscillations and the basal ganglia: Motor control and beyond

(2013) John-Stuart Brittain et al.   NEUROIMAGE

Identification and Rescue of  -Synuclein Toxicity in Parkinson Patient-Derived Neurons

(2013) C. Y. Chung et al.   SCIENCE

The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease

(2013) Eleftheria K. Pissadaki et al.   Frontiers in Computational Neuroscience

Genetic Correction of Tauopathy Phenotypes in Neurons Derived from Human Induced Pluripotent Stem Cells

(2013) Helen Fong et al.   Stem Cell Reports

Parkin- and PINK1-Dependent Mitophagy in Neurons: Will the Real Pathway Please Stand Up?

(2013) Karl Grenier et al.   Frontiers in Neurology

An ECM-based culture system for the generation and maintenance of xeno-free human iPS cells

(2012) Hyeong-Taek Kim et al.   BIOMATERIALS

Redefining Parkinson’s Disease Research Using Induced Pluripotent Stem Cells

(2012) Jiali Pu et al.   Current Neurology and Neuroscience Reports

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Mitochondrial processing peptidase regulates PINK1 processing, import and Parkin recruitment

(2012) Andrew W Greene et al.   EMBO REPORTS

Phosphatase and Tensin Homolog (PTEN)-induced Putative Kinase 1 (PINK1)-dependent Ubiquitination of Endogenous Parkin Attenuates Mitophagy

(2012) Aleksandar Rakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial division ensures the survival of postmitotic neurons by suppressing oxidative damage

(2012) Yusuke Kageyama et al.   JOURNAL OF CELL BIOLOGY

The link between the GBA gene and parkinsonism

(2012) Ellen Sidransky et al.   LANCET NEUROLOGY

Neuronal vulnerability, pathogenesis, and Parkinson's disease

(2012) David Sulzer et al.   MOVEMENT DISORDERS

Living on the edge with too many mouths to feed: Why dopamine neurons die

(2012) J. Paul Bolam et al.   MOVEMENT DISORDERS

Passaging and colony expansion of human pluripotent stem cells by enzyme-free dissociation in chemically defined culture conditions

(2012) Jeanette Beers et al.   Nature Protocols

Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity

(2012) F. Gillardon et al.   NEUROSCIENCE

Modeling human cortical development in vitro using induced pluripotent stem cells

(2012) J. Mariani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

Concise Review: The Evolution of human pluripotent stem cell culture: From feeder cells to synthetic coatings

(2012) L.G. Villa-Diaz et al.   STEM CELLS

Parkin controls dopamine utilization in human midbrain dopaminergic neurons derived from induced pluripotent stem cells

(2012) Houbo Jiang et al.   Nature Communications

Astrocytes generated from patient induced pluripotent stem cells recapitulate features of Huntington’s disease patient cells

(2012) Tarja A Juopperi et al.   Molecular Brain

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

(2012) Yoichi Imaizumi et al.   Molecular Brain

Use of a Synthetic Xeno-Free Culture Substrate for Induced Pluripotent Stem Cell Induction and Retinal Differentiation

(2012) Budd A. Tucker et al.   Stem Cells Translational Medicine

Cellular Reprogramming Employing Recombinant Sox2 Protein

(2012) Marc Thier et al.   Stem Cells International

Animal models of Parkinson's disease: a source of novel treatments and clues to the cause of the disease

(2011) Susan Duty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

(2011) Frank Soldner et al.   CELL

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Exploring refined conditions for reprogramming cells by recombinant Oct4 protein

(2011) Marc Thier et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

Milestones in PD genetics

(2011) Thomas Gasser et al.   MOVEMENT DISORDERS

Parkinson's disease and α-synuclein expression

(2011) Michael J. Devine et al.   MOVEMENT DISORDERS

Chemically defined conditions for human iPSC derivation and culture

(2011) Guokai Chen et al.   NATURE METHODS

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Genetic characteristics of leucine-rich repeat kinase 2 (LRRK2) associated Parkinson’s disease

(2011) Soraya Bardien et al.   PARKINSONISM & RELATED DISORDERS

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

Impaired mitochondrial transport and Parkin-independent degeneration of respiratory chain-deficient dopamine neurons in vivo

(2011) F. H. Sterky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus

(2011) Michael J. Devine et al.   Nature Communications

The Role of Cysteine Oxidation in DJ-1 Function and Dysfunction

(2010) Mark A. Wilson   ANTIOXIDANTS & REDOX SIGNALING

Highly Efficient Reprogramming to Pluripotency and Directed Differentiation of Human Cells with Synthetic Modified mRNA

(2010) Luigi Warren et al.   Cell Stem Cell

Parkin degrades estrogen-related receptors to limit the expression of monoamine oxidases

(2010) Y. Ren et al.   HUMAN MOLECULAR GENETICS

A nonviral minicircle vector for deriving human iPS cells

(2010) Fangjun Jia et al.   NATURE METHODS

Genetic Analysis of Pathways to Parkinson Disease

(2010) John Hardy   NEURON

Genetic Animal Models of Parkinson's Disease

(2010) Ted M. Dawson et al.   NEURON

Genomewide association study for onset age in Parkinson disease

(2009) Jeanne C Latourelle et al.   BMC Medical Genetics

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

Robust Pacemaking in Substantia Nigra Dopaminergic Neurons

(2009) J. N. Guzman et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

(2009) L. Parisiadou et al.   JOURNAL OF NEUROSCIENCE

Single Nigrostriatal Dopaminergic Neurons Form Widely Spread and Highly Dense Axonal Arborizations in the Neostriatum

(2009) W. Matsuda et al.   JOURNAL OF NEUROSCIENCE

Interplay between Cytosolic Dopamine, Calcium, and α-Synuclein Causes Selective Death of Substantia Nigra Neurons

(2009) Eugene V. Mosharov et al.   NEURON

Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome

(2009) Noemi FUSAKI et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Adenoviral Gene Delivery Can Reprogram Human Fibroblasts to Induced Pluripotent Stem Cells

(2009) Wenbo Zhou et al.   STEM CELLS

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Glial Cells as Players in Parkinsonism: The “Good,” the “Bad,” and the “Mysterious” Glia

(2008) Maria A. Mena et al.   NEUROSCIENTIST

Synuclein activates microglia in a model of Parkinson's disease

(2007) Xiaomin Su et al.   NEUROBIOLOGY OF AGING