LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking

LRRK2 Promotes Tau Accumulation, Aggregation and Release

(2015) Patrícia Silva Guerreiro et al.   MOLECULAR NEUROBIOLOGY

Mutations in LRRK2 potentiate age-related impairment of autophagic flux

(2015) Shamol Saha et al.   Molecular Neurodegeneration

LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis

(2014) A. Raquel Esteves et al.   EXPERIMENTAL NEUROLOGY

Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

(2014) J. Schapansky et al.   HUMAN MOLECULAR GENETICS

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

(2014) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

The Upshot of LRRK2 Inhibition to Parkinson’s Disease Paradigm

(2014) A. R. Esteves et al.   MOLECULAR NEUROBIOLOGY

LRRK2 Transport Is Regulated by Its Novel Interacting Partner Rab32

(2014) Dieter Waschbüsch et al.   PLoS One

G2019S LRRK2 mutant fibroblasts from Parkinson’s disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy

(2014) Sokhna M.S. Yakhine-Diop et al.   TOXICOLOGY

Mitochondrial dysfunction driven by the LRRK2-mediated pathway is associated with loss of Purkinje cells and motor coordination deficits in diabetic rat model

(2014) S Yang et al.   Cell Death & Disease

The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling

(2014) S Saez-Atienzar et al.   Cell Death & Disease

Increasing microtubule acetylation rescues axonal transport and locomotor deficits caused by LRRK2 Roc-COR domain mutations

(2014) Vinay K. Godena et al.   Nature Communications

LRRK2 phosphorylates novel tau epitopes and promotes tauopathy

(2013) Rachel M. Bailey et al.   ACTA NEUROPATHOLOGICA

Pathogenic Parkinson’s disease mutations across the functional domains of LRRK2 alter the autophagic/lysosomal response to starvation

(2013) Claudia Manzoni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

(2013) A.R. Esteves et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Inhibition of LRRK2 kinase activity stimulates macroautophagy

(2013) Claudia Manzoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

LRRK2p.G2019S Mutation Is Not Common among Alzheimer’s Disease Patients in Brazil

(2013) Cíntia Barros Santos-Rebouças et al.   DISEASE MARKERS

Leucine-rich repeat kinase 2 regulates tau phosphorylation through direct activation of glycogen synthase kinase-3β

(2013) Fumitaka Kawakami et al.   FEBS Journal

Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation

(2013) Yu-Chin Su et al.   HUMAN MOLECULAR GENETICS

Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily

(2013) Klodjan Stafa et al.   HUMAN MOLECULAR GENETICS

A Direct Interaction between Leucine-rich Repeat Kinase 2 and Specific β-Tubulin Isoforms Regulates Tubulin Acetylation

(2013) Bernard M. H. Law et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration

(2013) Mareike Caesar et al.   NEUROBIOLOGY OF DISEASE

LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction

(2013) Laurie H. Sanders et al.   NEUROBIOLOGY OF DISEASE

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

(2012) Salvatore J. Cherra et al.   AMERICAN JOURNAL OF PATHOLOGY

Maturation of autophagosomes and endosomes: A key role for Rab7

(2012) Juha M.T. Hyttinen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?

(2012) Iakov N Rudenko et al.   BMC Medicine

The LRRK2 G2019S mutant exacerbates basal autophagy through activation of the MEK/ERK pathway

(2012) José M. Bravo-San Pedro et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease

(2012) Adriana Sánchez-Danés et al.   EMBO Molecular Medicine

Mitochondrial metabolism in Parkinson's disease impairs quality control autophagy by hampering microtubule-dependent traffic

(2012) Daniela M. Arduíno et al.   HUMAN MOLECULAR GENETICS

G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization

(2012) Tatiana D. Papkovskaia et al.   HUMAN MOLECULAR GENETICS

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein

(2012) Jingwen Niu et al.   JOURNAL OF NEUROCHEMISTRY

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

(2012) Youren Tong et al.   Molecular Neurodegeneration

LRRK2 Phosphorylates Tubulin-Associated Tau but Not the Free Molecule: LRRK2-Mediated Regulation of the Tau-Tubulin Association and Neurite Outgrowth

(2012) Fumitaka Kawakami et al.   PLoS One

Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease

(2012) O. Cooper et al.   Science Translational Medicine

The Mitochondrial Cascade Hypothesis for Parkinsons Disease

(2011) Sandra M. Cardoso   CURRENT PHARMACEUTICAL DESIGN

LRRK2 Parkinson disease mutations enhance its microtubule association

(2011) Lauren R. Kett et al.   HUMAN MOLECULAR GENETICS

Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning

(2011) M. W. Dodson et al.   HUMAN MOLECULAR GENETICS

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

(2011) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

Mutations inLRRK2increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

(2011) Dario C. Angeles et al.   HUMAN MUTATION

Regulation of Physiologic Actions of LRRK2: Focus on Autophagy

(2011) Andrew Ferree et al.   Neurodegenerative Diseases

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Coordinate Regulation of Neurite Outgrowth by LRRK2 and Its Interactor, Rab5

(2011) Hye Young Heo et al.   Experimental Neurobiology

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2

(2010) H. Mortiboys et al.   NEUROLOGY

Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of  -synuclein, and apoptotic cell death in aged mice

(2010) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

(2010) Yulan Xiong et al.   PLoS Genetics

Leucine-Rich Repeat Kinase 2 Mutations and Parkinson's Disease: Three Questions

(2009) Elisa Greggio et al.   ASN Neuro

The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites

(2009) Elisa Greggio et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model

(2009) Javier Alegre-Abarrategui et al.   HUMAN MOLECULAR GENETICS

Leucine-rich repeat kinase 2 phosphorylates brain tubulin-beta isoforms and modulates microtubule stability - a point of convergence in Parkinsonian neurodegeneration?

(2009) Frank Gillardon   JOURNAL OF NEUROCHEMISTRY

Abnormal Localization of Leucine-Rich Repeat Kinase 2 to the Endosomal-Lysosomal Compartment in Lewy Body Disease

(2009) Shinji Higashi et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phosphorylation of Ezrin/Radixin/Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis

(2009) L. Parisiadou et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

(2009) S. Saha et al.   JOURNAL OF NEUROSCIENCE

The biology and pathobiology of LRRK2: Implications for Parkinson's disease

(2008) Darren J. Moore   PARKINSONISM & RELATED DISORDERS

Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease

(2007) E.K. Tan et al.   NEUROBIOLOGY OF AGING