Challenges and solutions to metabolites in safety testing: impact of the International Conference on Harmonization M3(R2) guidance

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

(2009) Laurent Leclercq et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

(2009) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

(2009) Deepak Dalvie et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolites in Safety Testing (MIST): Considerations of Mechanisms of Toxicity with Dose, Abundance, and Duration of Treatment

(2009) Dennis A. Smith et al.   CHEMICAL RESEARCH IN TOXICOLOGY

In silicomethods for predicting metabolism and mass fragmentation applied to quetiapine in liquid chromatography/time-of-flight mass spectrometry urine drug screening

(2009) Anna Pelander et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies

(2008) Gregory S Walker et al.   Expert Opinion on Drug Metabolism & Toxicology

Biomedical accelerator mass spectrometry: recent applications in metabolism and pharmacokinetics

(2008) Graham Lappin et al.   Expert Opinion on Drug Metabolism & Toxicology

Fractional mass filtering as a means to assess circulating metabolites in early human clinical studies

(2008) Philip R. Tiller et al.   RAPID COMMUNICATIONS IN MASS SPECTROMETRY

Idiosyncratic Drug Reactions: Past, Present, and Future

(2007) Jack Uetrecht   CHEMICAL RESEARCH IN TOXICOLOGY