NMR spectroscopy as a tool to close the gap on metabolite characterization under MIST

Metabolites in Safety Testing: “MIST” for the Clinical Pharmacologist

(2010) C B Frederick et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Hyperpolarized13C spectroscopy and an NMR-compatible bioreactor system for the investigation of real-time cellular metabolism

(2010) Kayvan R. Keshari et al.   MAGNETIC RESONANCE IN MEDICINE

Integrated strategies for assessment of metabolite exposure in humans during drug development: analytical challenges and clinical development considerations

(2009) Mingshe Zhu et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Metabolites in safety testing: metabolite identification strategies in discovery and development

(2009) Angus N. R. Nedderman   BIOPHARMACEUTICS & DRUG DISPOSITION

Structure Elucidation of Major Metabolites from Medroxyprogesterone Acetate by P450

(2009) Jianjun Chen et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Introduction: Human Metabolites in Safety Testing (MIST) Issue

(2009) F. Peter Guengerich   CHEMICAL RESEARCH IN TOXICOLOGY

Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development

(2009) Laurent Leclercq et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Approaches to the Assessment of Stable and Chemically Reactive Drug Metabolites in Early Clinical Trials

(2009) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY

Metabolite Identification and Profiling in Drug Design: Current Practice and Future Directions

(2009) Zhoupeng Zhang et al.   CURRENT PHARMACEUTICAL DESIGN

Metabolism and Excretion of an Oral Taxane Analog, [14C]3'-tert-Butyl-3'-N-tert-butyloxycarbonyl-4-deacetyl-3'-dephenyl-3'-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs

(2009) V. T. Ly et al.   DRUG METABOLISM AND DISPOSITION

Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries

(2009) A. Srivastava et al.   DRUG METABOLISM AND DISPOSITION

The Absolute Configuration of the (+)- and (−)-cis- and (+)- and (−)-trans-1-Benzyl-4-hydroxypiperidine-3-methanols: An Unusual Application of the1H-NMR-MosherMethod

(2009) Christian Clerc et al.   HELVETICA CHIMICA ACTA

Mass defect filter technique and its applications to drug metabolite identification by high-resolution mass spectrometry

(2009) Haiying Zhang et al.   JOURNAL OF MASS SPECTROMETRY

Application of diffusion-edited NMR spectroscopy for the structural characterization of drug metabolites in mixtures

(2009) Smriti Khera et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Multiple Ultrafast, Broadband 2D NMR Spectra of Hyperpolarized Natural Products

(2009) Patrick Giraudeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification and quantification of water-soluble metabolites by cryoprobe-assisted nuclear magnetic resonance spectroscopy applied to microbial fermentation

(2009) Damian Carrieri et al.   MAGNETIC RESONANCE IN CHEMISTRY

Quantitative19F imaging of nmol-level F-nucleotides/-sides from 5-FU withT2mapping in mice at 9.4T

(2009) Yoshihiro Doi et al.   MAGNETIC RESONANCE IN MEDICINE

Obtaining Exposures of Metabolites in Preclinical Species through Plasma Pooling and Quantitative NMR: Addressing Metabolites in Safety Testing (MIST) Guidance without Using Radiolabeled Compounds and Chemically Synthesized Metabolite Standards

(2008) Karthick Vishwanathan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Nuclear Magnetic Resonance Spectroscopy as a Quantitative Tool To Determine the Concentrations of Biologically Produced Metabolites: Implications in Metabolites in Safety Testing

(2008) Robert Espina et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Clearing the MIST (metabolites in safety testing) of time: The impact of duration of administration on drug metabolite toxicity

(2008) Dennis A. Smith et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Comparison of LC-NMR and conventional NMR for structure elucidation in drug metabolism studies

(2008) Gregory S Walker et al.   Expert Opinion on Drug Metabolism & Toxicology

Evaluation of preparative high performance liquid chromatography and cryoprobe-nuclear magnetic resonance spectroscopy for the early quantitative estimation of drug metabolites in human plasma

(2008) G.J. Dear et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Hyperdimensional NMR Spectroscopy with Nonlinear Sampling

(2008) Victor A. Jaravine et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Metabolism and Toxicity of Drugs. Two Decades of Progress in Industrial Drug Metabolism

(2007) Thomas A. Baillie   CHEMICAL RESEARCH IN TOXICOLOGY