Article
Engineering, Environmental
Sang-Soo Baek, Younghun Choi, Junho Jeon, JongCheol Pyo, Jongkwan Park, Kyung Hwa Cho
Summary: The study developed data-driven models to estimate micropollutant concentrations without relying on the SIL standard, with ResNet 101 and RF exhibiting the best performance. The trained models showed accurate training and validation results, providing a potential rapid and economic alternative for micropollutant measurement.
Article
Radiology, Nuclear Medicine & Medical Imaging
Eros Montin, Riccardo Lattanzi
Summary: The study compared six SNR estimation methods and found that AC provided accurate and robust SNR estimation, while PMR and GPR were more generally applicable. Additionally, DI and TIC should be used at low acceleration factors, and SIS can serve as an alternative to DI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Chemistry, Analytical
Ching-Yi Hsieh, Cheng-Hsuan Sung, Yi-Liang (eric) Shen, Ying-Chieh Lai, Kuan-Ying Lu, Gigin Lin
Summary: Hyperpolarized carbon-13 MRI allows for the real-time study of glycolytic flow in vivo or in vitro. A new method was developed to estimate accurate metabolite signals using a kinetic model and background noise. The method showed consistent results in simulations and in vitro experiments, accurately measuring metabolite signals and demonstrating changes in glycolytic flow. This technique has implications for studying tumor cell metabolism and can benefit personalized health care and patient stratification.
Article
Oceanography
Yankun Gong, Jieshuo Xie, Jiexin Xu, Zhiwu Chen, Yinghui He, Shuqun Cai
Summary: This study investigates the reflection and dissipation processes of nonlinear internal waves (NLIWs) over a slope. They find that the rate of reflection of NLIWs is lower than that of internal tides, and that incoming internal tides gradually transform into NLIWs during the shoaling process. The study also shows that around Imperieuse Reef, 60% of the offshore-reflecting internal waves dissipate with an e-folding length scale of about 22 km.
JOURNAL OF GEOPHYSICAL RESEARCH-OCEANS
(2022)
Article
Microbiology
Shilei Wang, Qun Wu, Ying Han, Rubing Du, Xiaoyong Wang, Yao Nie, Xiaowei Du, Yan Xu
Summary: The study introduced a gradient internal standard absolute quantification method to address the issue of amplicon sequencing's inability to determine microbiota absolute abundance. Demonstrated through experiments, the method proved reliable and accurate, with potential for rapid application in various ecosystem studies.
Article
Environmental Sciences
Susanna Edith Medellin-Garibay, Luz Eugenia Alcantara-Quintana, Ana Socorro Rodriguez-Baez, Julia Sagahon-Azua, Maribel Rodriguez-Aguilar, Maria de los Angeles Hernandez Cueto, Jose Esteban Munoz Medina, Rosa del Carmen Milan-Segovia, Rogelio Flores-Ramirez
Summary: This study reveals high levels of phthalates, particularly MEHP, in urine samples of women with CC associated with human papillomavirus (HPV) infection. Further studies are needed to evaluate the possible role of phthalates in synergy with HPV in progression to CC.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Nuclear Science & Technology
Changsik Oh, Sangmin Lee, Myung Jo Jhung
Summary: This paper presents a simple method for estimating the cross-section stress profiles of nozzles designed according to ASME Code Section III. The effectiveness of the method is validated through comparison with finite element analysis results.
NUCLEAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Inbo Oh, Mi-Kyoung Hwang, Jin-Hee Bang, Wonho Yang, Soontae Kim, Kiyoung Lee, SungChul Seo, Jiho Lee, Yangho Kim
Summary: This study utilized several hybrid, high-resolution models to simulate the variability of ambient NO2 concentrations in Seoul, South Korea. Results show that observation-fused hybrid models offered improved agreement with mobile measurements, highlighting the potential for enhanced predictive accuracy in air pollutant concentration assessments in complex urban areas.
ATMOSPHERIC ENVIRONMENT
(2021)
Article
Environmental Sciences
Xinghua Li, Yan Xie, Chuang Li, Zihao Wang, Philip K. Hopke, Chunyu Xue
Summary: Household coal burning in China is a major contributor to PM2.5, BC, OC, PAHs, and CO emissions. Previous studies lacked accurate measurements and quantification of emissions, while this study proposes a new sampling design and quantification method to address these shortcomings. Statistical analysis shows that the new method provides a more representative measurement of actual emissions.
Article
Metallurgy & Metallurgical Engineering
Aldo Fuentes, Jesus M. Casas
Summary: This study contributes to the thermochemical modeling of nitrate brines by estimating solute concentrations indirectly from ionic conductivity and temperature measurements. The calibration and validation of mathematical models using different electrolytic systems like seawater, pure nitrate electrolytes, seawater plus nitrate, and nitrate brines from the industry were successfully carried out. The inverse application of an ionic conductivity model provided good estimates of concentrations for solutes present in the studied brines with a 95% confidence level.
Article
Optics
Liang-Liang Sun, Sixia Yu
Summary: This paper proposes a universal method for providing measurable bounds for most current coherence quantifiers. The method is motivated by the observation that the distance between the state of interest and its diagonal parts in the reference basis can be estimated by the disturbance effect and uncertainty of the reference measurement.
Article
Automation & Control Systems
Zhaofeng Liu, Ren Zheng, Wenlian Lu, Shouhuai Xu
Summary: This paper introduces the use of event-based method to estimate cybersecurity equilibrium in the preventive and reactive cyber defense dynamics, which has been proven globally convergent. The study shows that the estimated equilibrium converges to the dynamics' equilibrium and is Zeno-free, ensuring the usefulness of the event-based method. Numerical examples demonstrate a 98% reduction in observation cost compared to the periodic method.
IEEE-CAA JOURNAL OF AUTOMATICA SINICA
(2021)
Article
Chemistry, Multidisciplinary
Shannon L. W. Accettone, Cassandra DeFrancesco, Lori Van Belle, Joel Smith, Erin Giroux
Summary: In this laboratory experiment, students quantitatively analyze both liquid and solid samples using the internal standard method and ATR-FTIR spectroscopy. Through problem-based selection of internal standards, students gain a deeper understanding of calibration and standard selection. The experiment provides students an opportunity to explore quantitative analysis within the context of quality control and assurance.
JOURNAL OF CHEMICAL EDUCATION
(2022)
Article
Chemistry, Medicinal
Martin Knudsen, Mats Bue, Louise L. Pontoppidan, Magnus A. Hvistendahl, Kjeld Soballe, Maiken Stilling, Pelle Hanberg
Summary: The study indicates that benzylpenicillin is suitable as an internal standard for piperacillin in microdialysis studies. The mean fT>MIC (16 mg/mL) reached a target of 50% fT>MIC, but not all pigs in all compartments achieved this target. Different strategies must be considered for higher targets to be met.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Environmental Sciences
Caitlin R. Sacha, Irene Souter, Paige L. Williams, Jorge E. Chavarro, Jennifer Ford, Shruthi Mahalingaiah, Patricia K. Donahoe, Russ Hauser, David Pepin, Lidia Minguez-Alarcon
Summary: This study found a negative association between urinary concentrations of certain phthalate metabolites and follicular fluid anti-Mullerian hormone concentrations in women undergoing fertility treatment, which may have implications for antral follicle recruitment and fertility treatment outcomes.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Kevin M. Gardinier, Douglas L. Gernert, Warren J. Porter, Jon K. Reel, Paul L. Ornstein, Patrick Spinazze, F. Craig Stevens, Patric Hahn, Sean P. Hollinshead, Daniel Mayhugh, Jeff Schkeryantz, Albert Khilevich, Oscar De Frutos, Scott D. Gleason, Akihiko S. Kato, Debra Luffer-Atlas, Prashant V. Desai, Steven Swanson, Kevin D. Burris, Chunjin Ding, Beverly A. Heinz, Anne B. Need, Vanessa N. Barth, Gregory A. Stephenson, Benjamin A. Diseroad, Tim A. Woods, Hong Yu, David Bredt, Jeffrey M. Witkin
JOURNAL OF MEDICINAL CHEMISTRY
(2016)
Editorial Material
Biochemistry & Molecular Biology
Debra Luffer-Atlas, Aisar Atrakchi
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2017)
Article
Pharmacology & Pharmacy
Jennifer K. Leohr, Debra Luffer-Atlas, M. Jane Luo, David J. DeBrota, Colin Green, Thomas E. Mabry, Jeffrey G. Suico
JOURNAL OF CLINICAL PHARMACOLOGY
(2018)
Article
Pharmacology & Pharmacy
Thomas B. Estridge, Asim B. Dey, Charles Reidy, Xiaohong Yu, Yuke Zhang, Maryalice Hartley, Paul L. Milligan, Najia Jin, Mark C. Kowala, Jennifer K. Leohr, Adrian J. Fretland, Thomas E. Mabry, Debra Luffer-Atlas, M. Jane Luo
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2017)
Article
Chemistry, Medicinal
Bryan H. Norman, Matthew J. Fisher, Matthew A. Schiffler, Steven L. Kuklish, Norman E. Hughes, Boris A. Czeskis, Kenneth C. Cassidy, Trent L. Abraham, Jeffrey J. Alberts, Debra Luffer-Atlas
JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
William Kielbasa, Eshetu Tesfaye, Debra Luffer-Atlas, Malcolm I. Mitchell, Michael A. Turik
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2013)
Article
Radiology, Nuclear Medicine & Medical Imaging
Paolo Zanotti-Fregonara, Vanessa N. Barth, Jeih-San Liow, Sami S. Zoghbi, David T. Clark, Emily Rhoads, Edward Siuda, Beverly A. Heinz, Eric Nisenbaum, Bruce Dressman, Elizabeth Joshi, Debra Luffer-Atlas, Matthew J. Fisher, John J. Masters, Nancy Goebl, Steven L. Kuklish, Cheryl Morse, Johannes Tauscher, Victor W. Pike, Robert B. Innis
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2013)
Review
Biochemistry & Molecular Biology
Debra Luffer-Atlas
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY
(2012)
Article
Biochemical Research Methods
Shelby Anderson, Mary Pat Knadler, Debra Luffer-Atlas
Article
Developmental Biology
Debra Luffer-Atlas, Vijayapal R. Reddy, Kim G. Hilbish, Curtis E. Grace, William J. Breslin
BIRTH DEFECTS RESEARCH
(2018)
Review
Chemistry, Medicinal
Debra Luffer-Atlas, R. Scott Obach, Dennis A. Smith
Summary: In this review, the origins and developments of the joint initiative by the pharmaceutical industry and regulatory authorities to establish a framework for the identification, quantification, and testing of drug metabolites (MIST) are traced. The current approaches and techniques for metabolite assessment in the industry are described, along with case studies demonstrating the limited usefulness of additional nonclinical safety assessment for disproportionate human metabolites. The impact of MIST guidelines on drug safety and industry productivity for new molecular entities is discussed.
MEDICINAL CHEMISTRY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Debra Luffer-Atlas, Darren Wilbraham, Maria M. Posada, John Landry, Max Tsai, Eric M. Pearlman
Summary: The study aimed to evaluate the safety and tolerability of the interaction between Lasmiditan and the drugs rosuvastatin and dabigatran. The results suggest that Lasmiditan has a weak effect on P-gp substrates and no clinically relevant effect on BCRP substrates.
JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Oncology
Caitlin D. Lowery, Wayne Blosser, Michele Dowless, Shelby Knoche, Jennifer Stephens, Huiling Li, David Surguladze, Nick Loizos, Debra Luffer-Atlas, Gerard J. Oakley, Qianxu Guo, Seema Iyer, Brian P. Rubin, Louis Stancato
CLINICAL CANCER RESEARCH
(2018)
Article
Pharmacology & Pharmacy
Gary Mo, John R. Baldwin, Debra Luffer-Atlas, Robert L. Ilaria, Ilaria Conti, Michael Heathman, Damien M. Cronier
CLINICAL PHARMACOKINETICS
(2018)