Epigenetic control of HIV-1 post integration latency: implications for therapy

Progress and challenges in the use of latent HIV-1 reactivating agents

(2015) Hong-tao Shang et al.   ACTA PHARMACOLOGICA SINICA

A new model for post-integration latency in macroglial cells to study HIV-1 reservoirs of the brain

(2015) Martha Schneider et al.   AIDS

Histone Deacetylase Inhibitor Romidepsin InhibitsDe NovoHIV-1 Infections

(2015) Kasper L. Jønsson et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

MicroRNA-155 Reinforces HIV Latency

(2015) Debbie S. Ruelas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Remarkable Stability of the Latent Reservoir for HIV-1 in Resting Memory CD4+T Cells

(2015) Janet M. Siliciano et al.   JOURNAL OF INFECTIOUS DISEASES

Regulation of HIV-1 Latency by Chromatin Structure and Nuclear Architecture

(2015) Marina Lusic et al.   JOURNAL OF MOLECULAR BIOLOGY

H3K27 Demethylation at the Proviral Promoter Sensitizes Latent HIV to the Effects of Vorinostat inEx VivoCultures of Resting CD4+T Cells

(2015) Manoj K. Tripathy et al.   JOURNAL OF VIROLOGY

Innate Immune Activity Correlates with CD4 T Cell-Associated HIV-1 DNA Decline during Latency-Reversing Treatment with Panobinostat

(2015) Rikke Olesen et al.   JOURNAL OF VIROLOGY

Enigma of HIV-1 latent infection in astrocytes: an in-vitro study using protein kinase C agonist as a latency reversing agent

(2015) Ashok Chauhan   MICROBES AND INFECTION

Nuclear architecture dictates HIV-1 integration site selection

(2015) Bruna Marini et al.   NATURE

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

(2015) Meghan K. Rothenberger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 IN/Pol recruits LEDGF/p75 into viral particles

(2015) Belete Desimmie et al.   Retrovirology

MicroRNA regulation of viral immunity, latency, and carcinogenesis of selected tumor viruses and HIV

(2015) Ling Wang et al.   REVIEWS IN MEDICAL VIROLOGY

Eradication of HIV-1 from the Macrophage Reservoir: An Uncertain Goal?

(2015) Wasim Abbas et al.   Viruses-Basel

Chromatin organization at the nuclear pore favours HIV replication

(2015) Mickaël Lelek et al.   Nature Communications

An In-Depth Comparison of Latency-Reversing Agent Combinations in Various In Vitro and Ex Vivo HIV-1 Latency Models Identified Bryostatin-1+JQ1 and Ingenol-B+JQ1 to Potently Reactivate Viral Gene Expression

(2015) Gilles Darcis et al.   PLoS Pathogens

Human Immunodeficiency Virus (HIV)-1 Integration Sites in Viral Latency

(2015) Simin D. Rezaei et al.   Current HIV/AIDS Reports

Epigenetic Modulations in Activated Cells Early after HIV-1 Infection and Their Possible Functional Consequences

(2015) Juliana T. Maricato et al.   PLoS One

Adherence to antiretroviral therapy in adolescents living with HIV

(2014) Sung-Hee Kim et al.   AIDS

Reactivation of HIV latency by a newly modified Ingenol derivative via protein kinase Cδ–NF-κB signaling

(2014) Guochun Jiang et al.   AIDS

Translational challenges in targeting latent HIV infection and the CNS reservoir problem

(2014) Carolina Garrido et al.   JOURNAL OF NEUROVIROLOGY

New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

(2014) C Korin Bullen et al.   NATURE MEDICINE

Eradicating HIV-1 infection: seeking to clear a persistent pathogen

(2014) Nancie M. Archin et al.   NATURE REVIEWS MICROBIOLOGY

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

(2014) Prithviraj Bose et al.   PHARMACOLOGY & THERAPEUTICS

Selective HDAC Inhibition for the Disruption of Latent HIV-1 Infection

(2014) Kirston M. Barton et al.   PLoS One

Ex Vivo Response to Histone Deacetylase (HDAC) Inhibitors of the HIV Long Terminal Repeat (LTR) Derived from HIV-Infected Patients on Antiretroviral Therapy

(2014) Hao K. Lu et al.   PLoS One

The microRNA miR-29a is associated with human immunodeficiency virus latency

(2014) Paresh Patel et al.   Retrovirology

A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat

(2014) Nina Verstraete et al.   Retrovirology

HIV-1 Latency in Monocytes/Macrophages

(2014) Amit Kumar et al.   Viruses-Basel

DNA Methylation in Mammals

(2014) E. Li et al.   Cold Spring Harbor Perspectives in Biology

Epigenetic regulation of human cytomegalovirus latency: an update

(2014) Amit Kumar et al.   Epigenomics

Is the central nervous system a reservoir of HIV-1?

(2014) Lachlan R. Gray et al.   Current Opinion in HIV and AIDS

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy

(2014) Julian H. Elliott et al.   PLoS Pathogens

Histone Deacetylase Inhibitor Romidepsin Induces HIV Expression in CD4 T Cells from Patients on Suppressive Antiretroviral Therapy at Concentrations Achieved by Clinical Dosing

(2014) Datsen George Wei et al.   PLoS Pathogens

Panobinostat, a histone deacetylase inhibitor, for latent-virus reactivation in HIV-infected patients on suppressive antiretroviral therapy: a phase 1/2, single group, clinical trial

(2014) Thomas A Rasmussen et al.   Lancet HIV

Entinostat is a histone deacetylase inhibitor selective for class 1 histone deacetylases and activates HIV production from latently infected primary T cells

(2013) Fiona Wightman et al.   AIDS

Interleukin-7 promotes HIV persistence during antiretroviral therapy

(2013) C. Vandergeeten et al.   BLOOD

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

A Pilot Study Assessing the Safety and Latency-Reversing Activity of Disulfiram in HIV-1-Infected Adults on Antiretroviral Therapy

(2013) A. M. Spivak et al.   CLINICAL INFECTIOUS DISEASES

Emerging strategies to deplete the HIV reservoir

(2013) Nancie M. Archin et al.   CURRENT OPINION IN INFECTIOUS DISEASES

The Distribution of HIV DNA and RNA in Cell Subsets Differs in Gut and Blood of HIV-Positive Patients on ART: Implications for Viral Persistence

(2013) Steven A. Yukl et al.   JOURNAL OF INFECTIOUS DISEASES

MicroRNAs and HIV-1 Infection: Antiviral Activities and Beyond

(2013) Gokul Swaminathan et al.   JOURNAL OF MOLECULAR BIOLOGY

HIV-1 transcription and latency: an update

(2013) Carine Van Lint et al.   Retrovirology

Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy

(2013) Sarah Palmer   Current Opinion in HIV and AIDS

HIV Latency

(2013) R. F. Siliciano et al.   Cold Spring Harbor Perspectives in Medicine

Comparison of HDAC inhibitors in clinical development

(2013) Thomas Aagaard Rasmussen et al.   Human Vaccines & Immunotherapeutics

Comparative Analysis of Measures of Viral Reservoirs in HIV-1 Eradication Studies

(2013) Susanne Eriksson et al.   PLoS Pathogens

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

(2012) Sophie Bouchat et al.   AIDS

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

(2012) Geneviève Doyon et al.   AIDS

Control of HIV Latency by Epigenetic and Non-Epigenetic Mechanisms

(2012) Jonathan Karn et al.   CURRENT HIV RESEARCH

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

Translation of Pur-α is targeted by cellular miRNAs to modulate the differentiation-dependent susceptibility of monocytes to HIV-1 infection

(2012) Chan-Juan Shen et al.   FASEB JOURNAL

Valproic acid in association with highly active antiretroviral therapy for reducing systemic HIV-1 reservoirs: results from a multicentre randomized clinical study

(2012) JP Routy et al.   HIV MEDICINE

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A dynamic multi-compartmental model of DNA methylation with demonstrable predictive value in hematological malignancies

(2012) Andrew P. McGovern et al.   JOURNAL OF THEORETICAL BIOLOGY

Paucity of HIV DNA Methylation in Latently Infected, Resting CD4+ T Cells from Infected Individuals Receiving Antiretroviral Therapy

(2012) J. Blazkova et al.   JOURNAL OF VIROLOGY

Trials with ‘epigenetic’ drugs: An update

(2012) Angela Nebbioso et al.   Molecular Oncology

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Shock and kill

(2012) Steven G. Deeks   NATURE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

PKC phosphorylates HEXIM1 and regulates P-TEFb activity

(2012) Koh Fujinaga et al.   NUCLEIC ACIDS RESEARCH

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

(2012) Zichong Li et al.   NUCLEIC ACIDS RESEARCH

Selective Histonedeacetylase Inhibitor M344 Intervenes in HIV-1 Latency through Increasing Histone Acetylation and Activation of NF-kappaB

(2012) Hao Ying et al.   PLoS One

Amino acid starvation induces reactivation of silenced transgenes and latent HIV-1 provirus via down-regulation of histone deacetylase 4 (HDAC4)

(2012) I. Palmisano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase C-delta regulates HIV-1 replication at an early post-entry step in macrophages

(2012) Xavier Contreras et al.   Retrovirology

The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV-1 without producing a T cell response

(2011) Wendy Bernhard et al.   FEBS LETTERS

HIV-1 Tat Protein Promotes Neuronal Dysfunction through Disruption of MicroRNAs

(2011) J. Robert Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibitors of Histone Deacetylases

(2011) Kelly Huber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Influence of Host Gene Transcription Level and Orientation on HIV-1 Latency in a Primary-Cell Model

(2011) L. Shan et al.   JOURNAL OF VIROLOGY

Epigenetic Silencing of HIV-1 by the Histone H3 Lysine 27 Methyltransferase Enhancer of Zeste 2

(2011) J. Friedman et al.   JOURNAL OF VIROLOGY

Chromatin Reassembly Factors Are Involved in Transcriptional Interference Promoting HIV Latency

(2011) E. Gallastegui et al.   JOURNAL OF VIROLOGY

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation

(2011) S. Xing et al.   JOURNAL OF VIROLOGY

Regulation of Cyclin T1 and HIV-1 Replication by MicroRNAs in Resting CD4+ T Lymphocytes

(2011) K. Chiang et al.   JOURNAL OF VIROLOGY

Deep sequencing of virus-infected cells reveals HIV-encoded small RNAs

(2011) N. C. T. Schopman et al.   NUCLEIC ACIDS RESEARCH

Activation of Latent HIV Using Drug-Loaded Nanoparticles

(2011) Michael Kovochich et al.   PLoS One

Epigenetic regulation of HIV-1 transcription

(2011) Manoj Kumar Tripathy et al.   Epigenomics

HIV Integration Targeting: A Pathway Involving Transportin-3 and the Nuclear Pore Protein RanBP2

(2011) Karen E. Ocwieja et al.   PLoS Pathogens

Stromal Down-Regulation of Macrophage CD4/CCR5 Expression and NF-κB Activation Mediates HIV-1 Non-Permissiveness in Intestinal Macrophages

(2011) Ruizhong Shen et al.   PLoS Pathogens

Novel histone deacetylase inhibitors CG05 and CG06 effectively reactivate latently infected HIV-1

(2010) Byeong-Sun Choi et al.   AIDS

HIV-miR-H1 evolvability during HIV pathogenesis

(2010) Susanna L. Lamers et al.   BIOSYSTEMS

The potential of CD4 T-cell memory

(2010) K. Kai McKinstry et al.   IMMUNOLOGY

The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro

(2010) Shay Matalon et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Involvement of Histone H3 Lysine 9 (H3K9) Methyltransferase G9a in the Maintenance of HIV-1 Latency and Its Reactivation by BIX01294

(2010) Kenichi Imai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differences in HIV Burden and Immune Activation within the Gut of HIV‐Positive Patients Receiving Suppressive Antiretroviral Therapy

(2010) Steven A. Yukl et al.   JOURNAL OF INFECTIOUS DISEASES

Histonedeacetylase inhibitor Oxamflatin increase HIV-1 transcription by inducing histone modification in latently infected cells

(2010) Hao Yin et al.   MOLECULAR BIOLOGY REPORTS

Molecular mechanisms of HIV-1 persistence in the monocyte-macrophage lineage

(2010) Valentin Le Douce et al.   Retrovirology

Molecular mechanisms of neuroinvasion by monocytes-macrophages in HIV-1 infection

(2010) Gabriel Gras et al.   Retrovirology

Cell line-dependent variability in HIV activation employing DNMT inhibitors

(2010) Guerau Fernandez et al.   Virology Journal

Histone deacetylase inhibitors and HIV latency

(2010) David M Margolis   Current Opinion in HIV and AIDS

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Extensive astrocyte infection is prominent in human immunodeficiency virus-associated dementia

(2009) Melissa J. Churchill et al.   ANNALS OF NEUROLOGY

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synergistic Activation of HIV-1 Expression by Deacetylase Inhibitors and Prostratin: Implications for Treatment of Latent Infection

(2009) Sophie Reuse et al.   PLoS One

Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies

(2009) Laurence Colin et al.   Retrovirology

"Shock and kill" effects of class I-selective histone deacetylase inhibitors in combination with the glutathione synthesis inhibitor buthionine sulfoximine in cell line models for HIV-1 quiescence

(2009) Andrea Savarino et al.   Retrovirology

miR-198 Inhibits HIV-1 Gene Expression and Replication in Monocytes and Its Mechanism of Action Appears To Involve Repression of Cyclin T1

(2009) Tzu-Ling Sung et al.   PLoS Pathogens

CpG Methylation Controls Reactivation of HIV from Latency

(2009) Jana Blazkova et al.   PLoS Pathogens

Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation

(2009) Steven E. Kauder et al.   PLoS Pathogens

Cellular microRNA expression correlates with susceptibility of monocytes/macrophages to HIV-1 infection

(2008) X. Wang et al.   BLOOD

Orientation-Dependent Regulation of Integrated HIV-1 Expression by Host Gene Transcriptional Readthrough

(2008) Yefei Han et al.   Cell Host & Microbe

Human Immunodeficiency Virus Type 1 Tat Protein Inhibits the SIRT1 Deacetylase and Induces T Cell Hyperactivation

(2008) Hye-Sook Kwon et al.   Cell Host & Microbe

Transcriptional Interference Antagonizes Proviral Gene Expression to Promote HIV Latency

(2008) Tina Lenasi et al.   Cell Host & Microbe

Persistence of HIV in Gut‐Associated Lymphoid Tissue despite Long‐Term Antiretroviral Therapy

(2008) Tae‐Wook Chun et al.   JOURNAL OF INFECTIOUS DISEASES

Histone Deacetylase Inhibitors: From Bench to Clinic

(2008) Marielle Paris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Epigenetic Silencing of Human Immunodeficiency Virus (HIV) Transcription by Formation of Restrictive Chromatin Structures at the Viral Long Terminal Repeat Drives the Progressive Entry of HIV into Latency

(2008) R. Pearson et al.   JOURNAL OF VIROLOGY

Identification of functional microRNAs released through asymmetrical processing of HIV-1 TAR element

(2008) D. L. Ouellet et al.   NUCLEIC ACIDS RESEARCH