Article
Immunology
Zabrina L. Brumme, Francis Mwimanzi, Hope R. Lapointe, Peter Cheung, Yurou Sang, Maggie C. Duncan, Fatima Yaseen, Olga Agafitei, Siobhan Ennis, Kurtis Ng, Simran Basra, Li Yi Lim, Rebecca Kalikawe, Sarah Speckmaier, Nadia Moran-Garcia, Landon Young, Hesham Ali, Bruce Ganase, Gisele Umviligihozo, F. Harrison Omondi, Kieran Atkinson, Hanwei Sudderuddin, Junine Toy, Paul Sereda, Laura Burns, Cecilia T. Costiniuk, Curtis Cooper, Aslam H. Anis, Victor Leung, Daniel Holmes, Mari L. DeMarco, Janet Simons, Malcolm Hedgcock, Marc G. Romney, Rolando Barrios, Silvia Guillemi, Chanson J. Brumme, Ralph Pantophlet, Julio S. G. Montaner, Masahiro Niikura, Marianne Harris, Mark Hull, Mark A. Brockman
Summary: This study suggests that people living with HIV who have well-controlled viral loads and CD4+ T-cell counts in a healthy range generally have strong humoral responses to dual COVID-19 vaccination. Factors such as age, comorbidities, vaccine brand, response durability, and the emergence of new SARS-CoV-2 variants will impact when individuals with HIV will benefit from additional vaccine doses.
Article
Immunology
Stefanie Kroeze, Theresa M. Rossouw, Helen C. Steel, Ferdinand W. Wit, Cissy M. Kityo, Margaret Siwale, Sulaimon Akanmu, Kishor Mandaliya, Marleen De Jager, Pascale Ondoa, Peter Reiss, Tobias F. Rinke De Wit, Neeltje A. Kootstra, Raph L. Hamers
Summary: Persistent systemic inflammation, as indicated by plasma biomarkers, during suppressive antiretroviral therapy in HIV-1-infected individuals, may impact CD4(+) T-cell recovery and viral rebound during long-term treatment. Changes in biomarker concentrations could affect viral replication and immune recovery in patients. Further research is needed to understand these potential mechanisms in order to improve clinical outcomes.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Jing Ma, Yan Jin, Kedi Jiao, Yao Wang, Lijie Gao, Xinrui Li, Wei Ma
Summary: Treatment interruption is relatively prevalent among HIV-positive adults in Jinan, China, and assessing socioeconomic status at treatment initiation is important. While almost half of the interrupters returned to care within 16 weeks, further measures are needed to reduce long-term interruptions and maximize the resumption of care as soon as possible to avoid adverse clinical events.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Medicine, General & Internal
Hendrik Streeck, Alvino Maestri, Daniel Habermann, Trevor A. Crowell, Allahna L. Esber, Gowoon Son, Leigh Anne Eller, Michael A. Eller, Ajay P. Parikh, Peter A. Horn, Lucas Maganga, Emmanuel Bahemana, Yakubu Adamu, Francis Kiweewa, Jonah Maswai, John Owuoth, Merlin L. Robb, Nelson L. Michael, Christina S. Polyak, Daniel Hoffmann, Julie A. Ake
Summary: Chronic immune activation in HIV-1 infection is influenced by factors such as HIV viral load, sex, age, region, and ART use. Predictors and associations among biomarkers and co-infections affect biomarkers associated with noncommunicable diseases.
Article
Public, Environmental & Occupational Health
Jing Ma, Kedi Jiao, Meizhen Liao, Chunmei Wang, Dianmin Kang, Yuxi Lin, Yu Yan, Yijun Li, Chunxiao Cheng, Wenwen Jia, Jing Meng, Lina Wang, Xuan Yang, Yanwen Cao, Zhonghui Zhao, Xinting Wang, Wei Ma
Summary: This study examines the current situation and associated factors of HIV disclosure among HIV-positive Chinese men who have sex with men. The findings suggest that younger, married/cohabiting individuals who identify as homosexual/bisexual are more likely to disclose their HIV status, while those with higher education levels or personal monthly incomes are less likely to disclose.
Review
Urology & Nephrology
Zunaid Barday, Kathryn Manning, Robert Freercks, Laurie Bertels, Nicola Wearne, Elmi Muller
Summary: Managing the interaction between ART and CNI immunosuppression in HIV-positive kidney transplant recipients is challenging. This study retrospectively analyzed ART regimen switches in 53 patients and found that PI-based regimen may be associated with increased rejection rates.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Multidisciplinary Sciences
Emmanuel Sendaula, Michael Buwembo, Denis Opio
Summary: The holistic care model supports individuals living with HIV in various aspects of their lives, resulting in improved treatment outcomes. Age and adherence are significantly associated with viral load suppression in HIV-infected adults receiving a holistic approach of care.
Article
Immunology
Alinda G. Vos, Caitlin N. Dodd, Eveline M. Delemarre, Stefan Nierkens, Celicia Serenata, Diederick E. Grobbee, Kerstin Klipstein-Grobusch, W. D. Francois Venter
Summary: Insight into inflammation patterns is crucial for understanding the pathophysiology of HIV and related CVD. This study found that HIV-positive individuals and HIV-negative controls had similar immune activation patterns, with PDL1 being a significant marker associated with CIMT in HIV-negative individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Sarah Nabukeera, Joseph Kagaayi, Fredrick Edward Makumbi, Henry Mugerwa, Joseph K. B. Matovu
Summary: Despite an increase in the proportion of HIV-positive children on antiretroviral therapy (ART) in recent years, up to 60% of children on ART do not achieve virological suppression. Factors such as being at WHO clinical stage 4 at ART initiation and experiencing ART-induced side effects were significantly associated with virological non-suppression, while older age at ART initiation was protective. This suggests a need for age-specific interventions to improve virological suppression among HIV-positive children receiving ART.
Article
Medicine, Research & Experimental
Ruxandra-Cristina Marin, Simona Gabriela Bungau, Delia Mirela Tit, Paul Andrei Negru, Andrei-Flavius Radu, Radu Dumitru Moleriu
Summary: Approximately two-thirds of Romanian HIV patients were parenterally infected with the F subtype of HIV in early childhood. They are now facing immunological aging, with immunosuppression posing an additional challenge in developing effective and well-tolerated regimens. A retrospective study compared the immune recovery of 462 HIV-infected patients who received different treatment regimens, showing normal immune response but a significant difference between groups. The study also assessed the relationship between immune and virological responses to therapy, finding an association at the final visit.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Public, Environmental & Occupational Health
Christopher T. Andersen, Christopher P. Duggan, Karim Manji, George R. Seage, Donna Spiegelman, Nandita Perumal, Nzovu Ulenga, Wafaie W. Fawzi
Summary: This study found that iron supplementation in HIV-infected children may increase the risk of mortality and disease progression, while reducing the risk of anemia.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Medicine, General & Internal
Antonella Cingolani, Alessandro Tavelli, Franco Maggiolo, Annalisa Perziano, Annalisa Saracino, Francesca Vichi, Massimo Cernuschi, Giovanni Guaraldi, Eugenia Quiros-Roldan, Antonella Castagna, Andrea Antinori, Antonella d'Arminio Monforte
Summary: Treatment burden is a multidimensional concept that has been poorly explored in people living with HIV (PLHIV). A recent survey found that one out of five PLHIV experienced a high level of treatment and disease burden. Factors associated with high burden included younger age, lower satisfaction with antiretroviral therapy (ART), the need for better communication with the treating physician, and self-perceived lower overall health status.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Microbiology
Harrison Omondi, Hanwei Sudderuddin, Aniqa Shahid, Natalie N. Kinloch, Bradley R. Jones, Rachel L. Miller, Olivia Tsai, Daniel MacMillan, Alicja Trocha, Mark A. Brockman, Chanson J. Brumme, Jeffrey B. Joy, Richard Liang, Bruce D. Walker, Zabrina L. Brumme
Summary: Curing HIV requires eliminating the reservoir of integrated, replication-competent proviruses that persist despite ART. Understanding the genetic diversity and longevity of persisting proviruses in different individuals is crucial to this goal. Studying viremic controllers, who naturally suppress HIV to low levels, can provide valuable insights into the dynamics of proviral turnover.
Article
Immunology
Aude Christelle Ka'e, Aubin Joseph Nanfack, Georgia Ambada, Maria Mercedes Santoro, Desire Takou, Ezechiel Ngoufack Jagni Semengue, Alex Durand Nka, Marie Laure Mpouel Bala, Orphelie Ndoh Endougou, Elise Elong, Grace Beloumou, Sandrine Djupsa, Davy Hyacinthe Gouissi, Nadine Fainguem, Michel Carlos Tommo Tchouaket, Samuel Martin Sosso, Daniel Kesseng, Francis Ateba Ndongo, Nelson Sonela, Arnaud Cedric Lacmago Kamta, Hyppolite K. Tchidjou, Therese Ndomgue, Suzie Tetang Moyo Ndiang, Anne Esther Njom Nlend, Celine Nguefeu Nkenfou, Carla Montesano, Gregory Edie Halle-Ekane, Giulia Cappelli, Caroline T. Tiemessen, Vittorio Colizzi, Francesca Ceccherini-Silberstein, Carlo-Federico Perno, Joseph Fokam
Summary: Antiretroviral therapy (ART) has improved the lifespan of people living with HIV, but their immune system remains in a state of sustained activation/inflammation. This study investigated the inflammatory profile of adolescents living with perinatal HIV-1 infection (ALPHI) receiving ART in an African context.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Infectious Diseases
Radha Rajasingham, Nelesh P. Govender, Alexander Jordan, Angela Loyse, Amir Shroufi, David W. Denning, David B. Meya, Tom M. Chiller, David R. Boulware
Summary: This study provides estimates of the global burden of HIV-associated cryptococcal infection (antigenaemia), cryptococcal meningitis, and cryptococcal-related deaths in 2020. Despite a reduction in the estimated absolute burden of HIV-associated cryptococcal meningitis compared with 2014, it still accounts for 19% of AIDS-related deaths.
LANCET INFECTIOUS DISEASES
(2022)
Article
Immunology
Nadine Jaschinski, Lauren Greenberg, Bastian Neesgaard, Jose M. Miro, Katharina Grabmeier-Pfistershammer, Gilles Wandeler, Colette Smith, Stephane De Wit, Ferdinand Wit, Annegret Pelchen-Matthews, Cristina Mussini, Antonella Castagna, Christian Pradier, Antonella D'Arminio Monforte, Jorg Vehreschild, Anders Sonnerborg, Alain Anne, Andrew Carr, Loveleen Bansi-Matharu, Jens Lundgren, Harmony Garges, Felipe Rogatto, Robert Zangerle, Huldrych F. Gunthard, Line D. Rasmussen, Coca Nescoi, Marc Van der Valk, Marianna Menozzi, Camilla Muccini, Amanda Mocroft, Lars Peters, Lene Ryom
Summary: This study assessed the association between ABC and CVD in people with HIV. The results showed that recent ABC use was associated with a higher incidence of CVD. This association was not explained by the presence of pre-existing CVD or CKD risk.
Article
Immunology
Eveline Hofmann, Bernard Surial, Noemie Boillat-Blanco, Huldrych F. Guenthard, Marcel Stoeckle, Enos Bernasconi, Patrick Schmid, Alexandra Calmy, Franziska Suter-Riniker, Andri Rauch, Gilles Wandeler, Charles Beguelin
Summary: In the Swiss HIV Cohort Study, researchers found that 27% of HIV-suppressed individuals with chronic hepatitis B virus (HBV) infection had HBV replication after two years on tenofovir. However, 77% of them were able to achieve suppression thereafter. Self-reported adherence to therapy and HBV viral load at tenofovir initiation were identified as predictors of persistent replication.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Emma F. Avery, Julia N. Kleynhans, Bruno Ledergerber, Isabella C. Schoepf, Christian W. Thorball, Neeltje A. Kootstra, Peter Reiss, Lene Ryom, Dominique L. Braun, Maria C. Thurnheer, Catia Marzolini, Marco Seneghini, Enos Bernasconi, Matthias Cavassini, Helene Buvelot, Roger D. Kouyos, Jacques Fellay, Huldrych F. Guenthard, Philip E. Tarr
Summary: In Switzerland, leukocyte count is independently associated with coronary artery disease (CAD) events in people with HIV (PWH), even after adjusting for traditional and HIV-related risk factors.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Medicine, General & Internal
Rajesh T. Gandhi, Roger Bedimo, Jennifer F. Hoy, Raphael J. Landovitz, Davey M. Smith, Ellen F. Eaton, Clara Lehmann, Sandra A. Springer, Paul E. Sax, Melanie A. Thompson, Constance A. Benson, Susan P. Buchbinder, Carlos del Rio, Joseph J. Eron, Huldrych F. Guenthard, Jean-Michel Molina, Donna M. Jacobsen, Michael S. Saag
Summary: Based on new data, recommendations are provided to clinicians on the use of antiretroviral drugs for the treatment and prevention of HIV, as well as on laboratory monitoring, care of aging individuals with HIV, substance use disorder, and new challenges such as COVID-19 and monkeypox virus infection. The initiation of antiretroviral therapy as soon as possible after HIV diagnosis is recommended, along with addressing barriers to care and ensuring access to medication and adherence support. Advances in treatment and prevention of HIV have improved outcomes, but challenges and opportunities still exist.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Infectious Diseases
Suraj Balakrishna, Tom Loosli, Maryam Zaheri, Paul Frischknecht, Michael Huber, Katharina Kusejko, Sabine Yerly, Karoline Leuzinger, Matthieu Perreau, Alban Ramette, Chris Wymant, Christophe Fraser, Paul Kellam, Astrid Gall, Hans H. Hirsch, Marcel Stoeckle, Andri Rauch, Matthias Cavassini, Enos Bernasconi, Julia Notter, Alexandra Calmy, Huldrych F. Gunthard, Karin J. Metzner, Roger D. Kouyos
Summary: This study compared the reliability of Sanger sequencing and Next-generation sequencing (NGS) in detecting HIV drug resistance mutations (DRMs). The results showed good agreement between the two methods when detecting mutations at a threshold of 5% or higher. However, at lower thresholds, NGS detected a substantial number of low-frequency mutations, which were likely to be sequencing errors.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Gastroenterology & Hepatology
Bernard Surial, Adria Ramirez Mena, Marie Roumet, Andreas Limacher, Colette Smit, Olivier Leleux, Amanda Mocroft, Marc van der Valk, Fabrice Bonnet, Lars Peters, Juergen K. Rockstroh, Huldrych F. Guenthard, Annalisa Berzigotti, Andri Rauch, Gilles Wandeler
Summary: HBV coinfection is the most important cause of hepatocellular carcinoma (HCC) among people living with HIV (PLWH). While risk prediction tools for HCC have been validated in patients with HBV monoinfection, they have not been evaluated in PLWH. This study performed an external validation of PAGE-B in PLWH with HBV coinfection, and found that PAGE-B is a valid tool to determine the need for HCC screening.
JOURNAL OF HEPATOLOGY
(2023)
Article
Immunology
Kalongo Hamusonde, Dunja Nicca, Huldrych F. Gunthard, Marcel Stoeckle, Katharine E. A. Darling, Alexandra Calmy, Enos Bernasconi, David Haerry, Patrick Schmid, Roger D. Kouyos, Andri Rauch, Luisa Salazar-Vizcaya
Summary: We examined the changes in sexual behavior of HIV-positive individuals over a span of 20 years. Since the Swiss U = U statement, the use of condoms with stable partners has consistently decreased from over 90% to 29%, with similar trends observed among men who have sex with men (MSM) and heterosexuals. Despite the COVID-19 pandemic and social distancing measures, MSM have maintained a higher frequency of occasional partnerships compared to heterosexual individuals.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Charles Beguelin, Andrew Atkinson, Anders Boyd, Karolin Falconer, Nikolai Kirkby, Franziska Suter-Riniker, Huldrych F. Guenthard, Juergen K. Rockstroh, Amanda Mocroft, Andri Rauch, Lars Peters, Gilles Wandeler
Summary: A study found a high prevalence of hepatitis delta virus (HDV) infection among persons living with HIV (PLWH) in Europe, which is the most severe form of viral hepatitis. This study analyzed data from a large HIV cohort collaboration to characterize the epidemiological trends of HDV in Europe and its impact on clinical outcomes.
LIVER INTERNATIONAL
(2023)
Article
Immunology
Emily West, Marius Zeeb, Christina Grube, Herbert Kuster, Katrin Wanner, Thomas Scheier, Kathrin Neumann, Lisa Jorimann, Benjamin Hampel, Karin J. Metzner, Roger D. Kouyos, Dominique L. Braun, Huldrych F. Gunthard
Summary: Initiating cART early during primary HIV infection allows sustained virological suppression after switching to DTG monotherapy. This 4-year study showed noninferiority of DTG monotherapy compared to cART in people with early HIV-1 infection.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Marius Zeeb, Burcu Tepekule, Katharina Kusejko, Claudine Reiber, Marisa Kalin, Lena Bartl, Julia Notter, Hansjakob Furrer, Matthias Hoffmann, Hans H. Hirsch, Alexandra Calmy, Matthias Cavassini, Niklaus D. Labhardt, Enos Bernasconi, Dominique L. Braun, Huldrych F. Gunthard, Roger D. Kouyos, Johannes Nemeth
Summary: The incidence of tuberculosis (TB) in people with human immunodeficiency virus type 1 (HIV-1) is decreasing in Switzerland, primarily due to the control of HIV-1 infection and immune system restoration, in addition to TB-specific prevention measures.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Hortensia Alvarez, Amanda Mocroft, Lene Ryom, Bastian Neesgaard, Simon Edwards, Veronica Svedhem, Huldrych F. Guenthard, Robert Zangerle, Colette Smith, Antonella Castagna, Antonella d'Arminio Monforte, Ferdinand Wit, Melanie Stecher, Clara Lehman, Cristina Mussini, Eric Fontas, Eva Gonzalez, Jan-Christian Wasmuth, Anders Soennerborg, Stephane De Wit, Nikoloz Chkhartishvili, Christoph Stephan, Kathy Petoumenos, Nadine Jaschinski, Vani Vannappagari, Joel Gallant, Lital Young, Alain Volny Anne, Lauren Greenberg, Raquel Martin-Iguacel, Eva Poveda, Josep M. Llibre
Summary: High baseline HIV RNA levels and low baseline CD4 T-cell counts are associated with higher rates of viral blips, low-level viremia, and residual viremia in individuals treated with integrase inhibitors or specifically with dolutegravir-based regimens, suggesting an independent impact of these characteristics.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Johannes M. Schwenke, Christian W. Thorball, Isabella C. Schoepf, Lene Ryom, Barbara Hasse, Olivier Lamy, Alexandra Calmy, Gilles Wandeler, Catia Marzolini, Christian R. Kahlert, Enos Bernasconi, Roger D. Kouyos, Huldrych F. Gunthard, Bruno Ledergerber, Jacques Fellay, Felix Burkhalter, Philip E. Tarr, Swiss HIV Cohort Study
Summary: Individual polygenic risk score is associated with osteoporosis in people living with HIV, even after adjusting for traditional and HIV-related risk factors. This study highlights the importance of a polygenic risk score in predicting low bone mineral density in HIV patients.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Frederique Hovaguimian, Patrick E. Beeler, Beat Muellhaupt, Huldrych F. Guenthard, Bettina Maeschli, Philip Bruggmann, Jan S. Fehr, Roger D. Kouyos
Summary: This study used electronic phenotyping strategies to analyze hospital records of individuals with HCV infection in a tertiary referral hospital in Switzerland from 2009 to 2017, and found that HCV infection is strongly associated with increased mortality.
JOURNAL OF VIRAL HEPATITIS
(2023)
Article
Health Care Sciences & Services
Katharina Kusejko, Daniel Smith, Alexandra Scherrer, Paolo Paioni, Malte Kohns Vasconcelos, Karoline Aebi-Popp, Roger D. Kouyos, Huldrych F. Gunthard, Christian R. Kahlert
Summary: The objective of this study was to provide a user-friendly graphical interface for electronic data entry for the Swiss Mother and Child HIV Cohort Study (MoCHiV), using REDCap software. By combining R and REDCap, a systematic pipeline was built to migrate a multicenter longitudinal cohort study from Oracle SQL to REDCap.
JMIR FORMATIVE RESEARCH
(2023)
Article
Geriatrics & Gerontology
Isabella C. Schoepf, Andres Esteban-Cantos, Christian W. Thorball, Berta Rodes, Peter Reiss, Javier Rodriguez-Centeno, Carlotta Riebensahm, Dominique L. Braun, Catia Marzolini, Marco Seneghini, Enos Bernasconi, Matthias Cavassini, Helene Buvelot, Maria Christine Thurnheer, Roger D. Kouyos, Jacques Fellay, Huldrych F. Gunthard, Jose R. Arribas, Bruno Ledergerber, Philip E. Tarr
Summary: In this long-term study, accelerated epigenetic ageing was observed in untreated HIV infection and partial reversal was achieved with effective antiretroviral therapy. It underscores the significance of limiting the duration of untreated HIV infection.
LANCET HEALTHY LONGEVITY
(2023)