Article
Cell Biology
Ann-Kathrin Reuschl, Dejan Mesner, Maitreyi Shivkumar, Matthew V. X. Whelan, Laura J. Pallett, Jose Afonso Guerra-Assuncao, Rajhmun Madansein, Kaylesh J. Dullabh, Alex Sigal, John P. Thornhill, Carolina Herrera, Sarah Fidler, Mahdad Noursadeghi, Mala K. Maini, Clare Jolly
Summary: HIV-1 can infect resting memory T cells through cell-to-cell spread, and the infection leads to a reprogramming of T cells, acquiring characteristics of tissue-resident memory T cells.
Article
Microbiology
Mathieu Dube, Olivier Tastet, Caroline Dufour, Geremy Sannier, Nathalie Brassard, Gloria-Gabrielle Delgado, Amelie Pagliuzza, Corentin Richard, Manon Nayrac, Jean-Pierre Routy, Alexandre Prat, Jacob D. Estes, Remi Fromentin, Nicolas Chomont, Daniel E. Kaufmann
Summary: During suppressive antiretroviral therapy, spontaneous transcription and translation of HIV can persist, with p24(-)expressing cells evident in 39% of participants. Active reservoirs are enriched in central memory T cells and CCR6(-) and activation marker-expressing cells. The magnitude of the active reservoir positively correlates with HIV-specific CD4(+) and CD8(+) T cell responses and multiple HIV-specific T cell clusters.
CELL HOST & MICROBE
(2023)
Review
Immunology
Constance Renault, Nicolas Veyrenche, Franck Mennechet, Anne-Sophie Bedin, Jean-Pierre Routy, Philippe Van de Perre, Jacques Reynes, Edouard Tuaillon
Summary: Th17 cells play a crucial role in defending against pathogens at mucosal barriers, but they are also vulnerable to HIV-1 infection and depletion from gut mucosal sites. The imbalance caused by the loss of Th17 cells impairs cytokine production and leads to damage in the gut mucosal barrier, promoting HIV-1 disease progression. The expression of specific receptors by Th17 cells contributes to their susceptibility to HIV infection. Moreover, Th17 cells serve as long-lived viral reservoirs in HIV patients receiving antiretroviral therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Sijia He, Jia Guo, Yajing Fu, Mark Spear, Chaolong Qin, Shuai Fu, Zongqiang Cui, Wenwen Jin, Xuehua Xu, Wanjun Chen, Hong Shang, Yuntao Wu
Summary: CD2 is identified as a novel target for blocking HIV-1 infection of blood resting T cells. CD2 binding initiates competitive signaling leading to cofilin activation and localized actin polymerization, spatially inhibiting HIV-1-initiated local actin polymerization required for viral nuclear migration.
Article
Biochemistry & Molecular Biology
Yashwanth Subbannayya, Markus Haug, Sneha M. Pinto, Varshasnata Mohanty, Hany Zakaria Meas, Trude Helen Flo, T. S. Keshava Prasad, Richard K. Kandasamy
Summary: This study conducted label-free high-resolution proteomic profiling of resting and activated CD4+ T cells, identifying significant alterations in the levels of numerous proteins and observed changes in stimulatory/inhibitory immune checkpoint markers between the two states. Network analysis revealed regulatory hubs of CD4+ T cell activation, and comparisons with other cell types indicated interspecies proteomic differences.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Chantal L. Duurland, Saskia J. Santegoets, Ziena Abdulrahman, Nikki M. Loof, Gregor Sturm, Tom H. Wesselink, Ramon Arens, Sanne Boekestijn, Ilina Ehsan, Mariette I. E. van Poelgeest, Francesca Finotello, Hubert Hackl, Zlatko Trajanoski, Peter Ten Dijke, Veronique M. Braud, Marij J. P. Welters, Sjoerd H. van der Burg
Summary: The expression of CD4+CD161+ effector memory T cells is associated with improved survival in HPV16+ oropharyngeal squamous cell carcinoma. Therapeutic vaccination activates and expands CD4+CD161+ effector T cells. CD161 functions dynamically and is regulated by cell intrinsic and extrinsic factors. CD161 expressing CD4+ T cells respond more vigorously to suboptimal antigen stimulation and may amplify TCR signals.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Zhuo Wang, Xiaowan Yin, Meichen Ma, Hongchi Ge, Bin Lang, Hong Sun, Sijia He, Yajing Fu, Yu Sun, Xiaowen Yu, Zining Zhang, Hualu Cui, Xiaoxu Han, Junjie Xu, Haibo Ding, Zhenxing Chu, Hong Shang, Yuntao Wu, Yongjun Jiang
Summary: The study revealed the important role of IP-10 in establishing HIV reservoirs in CD4+ T cells, with elevated plasma IP-10 levels being positively correlated with HIV viral load and reservoir size. Through enhancing cofilin activity and actin dynamics, IP-10 facilitated latent HIV infection of resting CD4+ T cells, while therapeutic targeting of IP-10 could potentially be a strategy to inhibit HIV latent infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Alex J. Warr, Christine Anterasian, Javeed A. Shah, Stephen C. De Rosa, Felicia K. Nguyen, Elizabeth Maleche-Obimbo, Lisa M. Cranmer, Daniel Matemo, Jerphason Mecha, John Kinuthia, Sylvia M. LaCourse, Grace C. John-Stewart, Thomas R. Hawn
Summary: This study investigates the relationship between immune cell responses after BCG vaccination and Mycobacterium tuberculosis (Mtb) infection in HIV-exposed but uninfected infants, as well as their impact on tuberculin skin test (TST) induration. The results show that a monofunctional TNF+ CD4+ effector memory T-cell response at 6-10 weeks of age is associated with Mtb infection at 14 months, while mycobacterial antigen-specific polyfunctional effector memory Th1 responses at 6-10 weeks correlate positively with TST induration in infants without evidence of Mtb infection, which is attenuated by INH therapy.
Article
Immunology
Pierre Gantner, Supranee Buranapraditkun, Amelie Pagliuzza, Caroline Dufour, Marion Pardons, Julie L. Mitchell, Eugene Kroon, Carlo Sacdalan, Nicha Tulmethakaan, Suteeraporn Pinyakorn, Merlin L. Robb, Nittaya Phanuphak, Jintanat Ananworanich, Denise Hsu, Sandhya Vasan, Lydie Trautmann, Remi Fromentin, Nicolas Chomont
Summary: During early stages of HIV infection, the virus initially targets a small population of proliferating memory CD4+ T cells with high surface expression of CCR5. Productively infected cells exhibit different phenotypes and TCR sequences depending on the stage of infection and location within the body. The TCR repertoire of infected cells is biased towards previously expanded and disseminated clones, suggesting independent infection events. Latent genetically intact proviruses are present early in infection, indicating simultaneous generation of latent infected cells.
Article
Multidisciplinary Sciences
Caroline Dufour, Corentin Richard, Marion Pardons, Marta Massanella, Antoine Ackaoui, Ben Murrell, Bertrand Routy, Rejean Thomas, Jean-Pierre Routy, Remi Fromentin, Nicolas Chomont
Summary: The phenotypic diversity of HIV-infected cells persisting during antiretroviral therapies (ART) was investigated. CD4+ T cells expressing integrin VLA-4 were found to be enriched in replication-competent HIV. Clonally expanded cells with identical proviruses displayed diverse phenotypes, indicating the role of cellular proliferation in the phenotypic diversification of the HIV reservoir. Genetically intact and inducible viral genomes were associated with higher levels of VLA-4 expression in CD4+ T cells. Replication-competent HIV was highly enriched in memory CD4+ T cells expressing high levels of VLA-4.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Hugues Allard-Chamard, Faisal Alsufyani, Naoki Kaneko, Kelly Xing, Cory Perugino, Vinay S. Mahajan, Joseph L. Wheat, George S. Deepe, James Loyd, Shiv Pillai
Summary: This study found that fibrotic diseases such as fibrosing mediastinitis may be induced and activated by fungal antigens, indicating that T cells, specifically CD4(+)CTLs, play a significant role in inflammatory fibrosis. The research provides important insights into the pathogenesis of idiopathic fibrotic diseases.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Jeffrey M. Jacobson, Julie K. Jadlowsky, Simon F. Lacey, Joseph A. Fraietta, Gabriela Plesa, Hideto Chono, Dong H. Lee, Irina Kulikovskaya, Chelsie Bartoszek, Fang Chen, Lifeng Tian, Alexander Dimitri, Bruce L. Levine, Elizabeth A. Veloso, Wei-Ting Hwang, Carl H. June
Summary: The study of a single infusion of MazF-modified CD4 T lymphocytes in HIV-infected individuals demonstrated potential therapeutic effects, including increased CD4 and CD8 cell counts, sustained MazF expression and activity, and detection of modified cells in blood and lymph tissue. Further research on the impact on viremia and latent proviral reservoir is needed.
Article
Multidisciplinary Sciences
Paula C. Soto, Valeri H. Terry, Mary K. Lewinski, Savitha Deshmukh, Nadejda Beliakova-Bethell, Celsa A. Spina
Summary: This study investigates the relationship between T cell activation and proliferation and the establishment of HIV latency. The findings suggest that cells infected during the height of cell proliferation retain the least amount of latent infection, while cells that did not divide or exhibited limited division after virus exposure and stimulation contained greater amounts of latent HIV. Co-culture experiments demonstrate that latent infection can be established directly in non-dividing cells through cell-to-cell transmission.
Article
Virology
Lok Yan Yim, Ka Shing Lam, Tsz-Yat Luk, Yufei Mo, Xiaofan Lu, Jinlin Wang, Ka-Wai Cheung, Grace Chung Yan Lui, Denise Pui Chung Chan, Bonnie Chun Kwan Wong, Thomas Tsz-Kan Lau, Chiu Bong Ngan, Dongyan Zhou, Yik Chun Wong, Zhiwu Tan, Li Liu, Hao Wu, Tong Zhang, Shui Shan Lee, Zhiwei Chen
Summary: The study reveals that plasma transforming growth factor beta (TGF-beta) is elevated during acute HIV-1 infection in men who have sex with men (MSM). TGF-beta signaling plays a crucial role in mediating HIV-1 infection of activated and resting memory CD4(+) T cells by upregulating the HIV-1 coreceptor CCR5. TGF-beta also increases CCR7 and CXCR3 expression on memory CD4(+) T cells, potentially promoting viral infection and latency establishment.
JOURNAL OF VIROLOGY
(2023)
Review
Biochemistry & Molecular Biology
David Escors, Ana Bocanegra, Luisa Chocarro, Ester Blanco, Sergio Pineiro-Hermida, Maider Garnica, Leticia Fernandez-Rubio, Ruth Vera, Hugo Arasanz, Grazyna Kochan
Summary: PD-L1/PD-1 blockade immunotherapy has revolutionized cancer treatment, but its mechanisms and effectiveness are still not fully understood. This article reviews the evidence supporting the role of CD4 T cells in anti-tumor immunity and their potential as predictors of response to PD-L1/PD-1 blockade immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rajesh Ramakrishnan, Hongbing Liu, Andrew P. Rice
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2015)
Review
Microbiology
Andrew P. Rice, Jason T. Kimata
CELL HOST & MICROBE
(2015)
Article
Virology
Sona Budhiraja, Hongbing Liu, Jacob Couturier, Anna Malovannaya, Jun Qin, Dorothy E. Lewis, Andrew P. Rice
JOURNAL OF VIROLOGY
(2015)
Review
Cell Biology
Andrew P. Rice
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2015)
Article
Immunology
Md Saha Jamaluddin, Pei-Wen Hu, Yih Jan, Edward B. Siwak, Andrew P. Rice
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2016)
Review
Immunology
Jason T. Kimata, Andrew P. Rice, Jin Wang
CURRENT OPINION IN IMMUNOLOGY
(2016)
Review
Pharmacology & Pharmacy
Andrew P. Rice
EXPERT OPINION ON THERAPEUTIC TARGETS
(2016)
Article
Biochemical Research Methods
Philipp Kaiser, Sunil K. Joshi, Peggy Kim, Peilin Li, Hongbing Liu, Andrew P. Rice, Joseph K. Wong, Steven A. Yukl
JOURNAL OF VIROLOGICAL METHODS
(2017)
Article
Biochemistry & Molecular Biology
Zheng Zhang, Bryan C. Nikolai, Leah A. Gates, Sung Yun Jung, Edward B. Siwak, Bin He, Andrew P. Rice, Bert W. O'Malley, Qin Feng
NUCLEIC ACIDS RESEARCH
(2017)
Article
Immunology
Jamaluddin Md Saha, Hongbing Liu, Pei-Wen Hu, Bryan C. Nikolai, Hulin Wu, Hongyu Miao, Andrew P. Rice
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2018)
News Item
Cell Biology
Andrew P. Rice
Article
Virology
Sona Budhiraja, Marylinda Famiglietti, Alberto Bosque, Vicente Planelles, Andrew P. Rice
JOURNAL OF VIROLOGY
(2013)
Article
Virology
Berenice Carrillo, Jae-Mun Choi, Zachary A. Bornholdt, Banumathi Sankaran, Andrew P. Rice, B. V. Venkataram Prasad
JOURNAL OF VIROLOGY
(2014)
Article
Biochemical Research Methods
Shupeng Gui, Andrew P. Rice, Rui Chen, Liang Wu, Ji Liu, Hongyu Miao
BMC BIOINFORMATICS
(2017)
Review
Pharmacology & Pharmacy
Andrew P. Rice
CURRENT PHARMACEUTICAL DESIGN
(2017)