New ex vivo approaches distinguish effective and ineffective single agents for reversing HIV-1 latency in vivo

BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism

(2013) Daniela Boehm et al.   CELL CYCLE

Histone Deacetylase Inhibitors (HDACis) That Release the Positive Transcription Elongation Factor b (P-TEFb) from Its Inhibitory Complex Also Activate HIV Transcription

(2013) Koen Bartholomeeusen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel PCR Assay for Quantification of HIV-1 RNA

(2013) L. Shan et al.   JOURNAL OF VIROLOGY

Reactivation of latent HIV by histone deacetylase inhibitors

(2013) Kotaro Shirakawa et al.   TRENDS IN MICROBIOLOGY

Eliminating the latent HIV reservoir by reactivation strategies: Advancing to clinical trials

(2013) Thomas Rasmussen et al.   Human Vaccines & Immunotherapeutics

Rapid Quantification of the Latent Reservoir for HIV-1 Using a Viral Outgrowth Assay

(2013) Gregory M. Laird et al.   PLoS Pathogens

Disulfiram reactivates latent HIV-1 expression through depletion of the phosphatase and tensin homolog

(2012) Geneviève Doyon et al.   AIDS

Effect of Histone Deacetylase Inhibitors on HIV Production in Latently Infected, Resting CD4+ T Cells From Infected Individuals Receiving Effective Antiretroviral Therapy

(2012) J. Blazkova et al.   JOURNAL OF INFECTIOUS DISEASES

BET bromodomain inhibition as a novel strategy for reactivation of HIV-1

(2012) Camellia Banerjee et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

(2012) N. M. Archin et al.   NATURE

Designed, synthetically accessible bryostatin analogues potently induce activation of latent HIV reservoirs in vitro

(2012) Brian A. DeChristopher et al.   Nature Chemistry

The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation

(2012) Zichong Li et al.   NUCLEIC ACIDS RESEARCH

Reactivation of Latent HIV-1 by Inhibition of BRD4

(2012) Jian Zhu et al.   Cell Reports

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency

(2011) Shailesh K. Choudhary et al.   Annual Review of Pharmacology and Toxicology

Disulfiram Reactivates Latent HIV-1 in a Bcl-2-Transduced Primary CD4+ T Cell Model without Inducing Global T Cell Activation

(2011) S. Xing et al.   JOURNAL OF VIROLOGY

Bryostatin Modulates Latent HIV-1 Infection via PKC and AMPK Signaling but Inhibits Acute Infection in a Receptor Independent Manner

(2010) Rajeev Mehla et al.   PLoS One

The molecular biology of HIV latency: breaking and restoring the Tat-dependent transcriptional circuit

(2010) Jonathan Karn   Current Opinion in HIV and AIDS

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid

(2009) Nancie M. Archin et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells

(2009) Xavier Contreras et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Challenge of Finding a Cure for HIV Infection

(2009) D. D. Richman et al.   SCIENCE