Article
Pharmacology & Pharmacy
Noelia Ruzafa, Xandra Pereiro, Alex Fonollosa, Javier Araiz, Arantxa Acera, Elena Vecino
Summary: PRGF compromises the survival of RGCs but promotes the survival of Muller cells, potentially contributing to retina healing, with further studies needed to evaluate its effect on neurons and its inflammatory role.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
A. Denise R. Garcia
Summary: The Sonic hedgehog (Shh) molecular signaling pathway is a key regulator of neurodevelopment, with diverse functions in various cell types and developmental stages. In addition to its roles in development, Shh signaling continues into adulthood and is now recognized as an important regulator of astrocyte function. Astrocytes play essential roles in nervous system functions, including synapse formation, coordination of CNS inflammatory responses, and Shh signaling mediates communication between neurons and astrocytes, influencing astrocyte identity, synaptic organization, and inflammation regulation.
Review
Cell Biology
Lauren H. Fairley, Amandine Grimm, Anne Eckert
Summary: Intercellular mitochondria transfer is a novel form of cell signalling that plays an important role in brain disorders and is considered a potential therapeutic strategy.
Article
Biochemistry & Molecular Biology
Mengmeng Jin, Hui Zhang, Baijie Xu, Yanan Li, Huiwen Qin, Shuguang Yu, Jie He
Summary: This study reveals the interaction between neurons and glial cells mediated by Jag2b and Notch3/Notch1b in the developing zebrafish retina, which is crucial for the generation and differentiation of Muller glia (MG) and the irreversible differentiation of MG.
Review
Biochemistry & Molecular Biology
Shuanglong Yi, Linfang Wang, Honglei Wang, Margaret S. Ho, Shiping Zhang
Summary: Parkinson's disease is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons and the accumulation of alpha-synuclein. Glial activation and neuroinflammation have been identified as new features of PD, and understanding the interaction between neurons and glia can provide insight into PD pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Behavioral Sciences
Catarina Carvalhas-Almeida, Joana Serra, Joaquim Moita, Claudia Cavadas, Ana Rita Alvaro
Summary: According to the World Health Organization, insomnia symptoms affect about one-third of the population, with chronic insomnia affecting around 10-15% of individuals. Chronic sleep deprivation and insomnia can lead to disruption in the internal synchronisation of biological clocks, resulting in negative health impacts. Glial cells, particularly microglia and astrocytes, play a role in circadian rhythm regulation and sleep/circadian regulation and overall healthy brain function. Understanding the interplay between glial cells and neurons is crucial in addressing sleep disorders and maintaining brain health.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Noelia Ruzafa, Xandra Pereiro, Alex Fonollosa, Javier Araiz, Arantxa Acera, Elena Vecino
Summary: PRGF can stimulate microglial migration in organotypic cultures, potentially due to the presence of pro-inflammatory cytokines. The migratory effect can be reduced by heat inactivation, dexamethasone, or anti-cytokine factors. However, PRGF does not seem to affect gliosis, proliferation, or RGC survival in adult porcine retinas. Further research is needed to assess the potential positive effects of microglial cells on retinal function when using PRGF.
FRONTIERS IN PHARMACOLOGY
(2021)
Editorial Material
Neurosciences
Kelly L. Jordan-Sciutto
Summary: Despite successful viral suppression with antiretroviral (ARV) drugs, people living with HIV still experience persistent cognitive, behavioral, and motor dysfunction, raising questions about the potential contribution of these drugs themselves. Evidence suggests that ARV drugs may have an impact on the central nervous system, highlighting the importance of minimizing ARV-induced cellular and tissue dysfunction to improve the quality of life for individuals dependent on life-long ART for viral suppression.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Neurosciences
Andrew P. Patton, Nicola J. Smyllie, Johanna E. Chesham, Michael H. Hastings
Summary: The suprachiasmatic nucleus (SCN) is the master circadian clock in mammals and is generated and transmitted by the cell-autonomous transcriptional/post-translational feedback loops (TTFLs) of neurons and astrocytes. Astrocytes play an important role in circadian timekeeping by initiating rhythms and controlling the period, but neurons determine the phase of the SCN.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Multidisciplinary Sciences
Baljit S. Khakh, Steven A. Goldman
Summary: Huntington's disease (HD) is a fatal neurodegenerative disease caused by a mutation in the huntingtin gene. Astrocytes in the striatum, a brain region affected in HD, play a role in the pathology of the disease. Dysfunctions in astrocytes contribute to cellular and metabolic abnormalities in HD, suggesting the potential for therapeutic targeting of these cells to restore normal function.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Neurosciences
Du Chen, Hankui Cheng, Siyan Liu, Umar Al-Sheikh, Yuedan Fan, Duo Duan, Wenjuan Zou, Linhui Zhu, Lijun Kang
Summary: The glial L-Type VGCC EGL-19 plays a crucial role in regulating calcium variations and behavioral outputs in C. elegans, and it also affects the morphologies of sensory neurons and glial cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Medicine, Research & Experimental
Ben Rombaut, Sofie Kessels, Melissa Schepers, Assia Tiane, Dean Paes, Yevgeniya Solomina, Elisabeth Piccart, Daniel van den Hove, Bert Brone, Jos Prickaerts, Tim Vanmierlo
Summary: Synapses are essential for neuronal communication in the brain, and their balance is maintained through a careful coordination between synaptogenesis and synaptic pruning. Cell-signaling pathways play a crucial role in synaptic plasticity across different brain cells, with the involvement of second messengers like cGMP and cAMP. Targeting pathways involving phosphodiesterases (PDEs) presents a potential therapeutic strategy for combating excessive synapse loss in various neuropathologies.
Article
Neurosciences
Aline Timmermann, Dario Tascio, Ronald Jabs, Anne Boehlen, Catia Domingos, Magdalena Skubal, Wenhui Huang, Frank Kirchhoff, Christian Henneberger, Andras Bilkei-Gorzo, Gerald Seifert, Christian Steinhaeuser
Summary: NG2 glia is a unique type of macroglial cells in the CNS that receive synaptic input from neurons. Dysfunction in NG2 glia has been found to improve spatial memory but has no effect on social memory. Loss of the K+ channel Kir4.1 in NG2 glia leads to enhanced synaptic depolarizations and expression of myelin basic protein in the hippocampus. Targeted deletion of the K+ channel in NG2 glia impairs long-term potentiation at CA3-CA1 synapses, which can be rescued by extracellular application of a TrkB receptor agonist. These findings highlight the importance of proper NG2 glia function in brain function and behavior.
Review
Neurosciences
Dana F. DeSantis, Cody J. Smith
Summary: The precise organization and arrangement of neural cells is crucial for nervous system functionality, with cellular tiling ensuring non-redundant coverage of receptive fields. While there is extensive knowledge of the mechanisms mediating neuronal tiling, understanding of how glial cells contribute to the overall spatial arrangement of the nervous system remains limited. Further research is needed to explore potential mechanisms of glial tiling and develop new technologies for better understanding.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Environmental Sciences
Kitti Thiankhaw, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: PM2.5 is recognized worldwide as a cause of public health problems, particularly associated with respiratory and cardiovascular diseases. Exposure to PM2.5 is increasingly linked to neurological disorders, such as dementia and Alzheimer's disease, through mechanisms including neuroinflammation, increased ROS production, and neuronal apoptosis.
ENVIRONMENTAL POLLUTION
(2022)
Article
Virology
Dhiraj Acharya, Penghua Wang, Amber M. Paul, Jianfeng Dai, David Gate, Jordan E. Lowery, Dobrivoje S. Stokic, A. Arturo Leis, Richard A. Flavell, Terrence Town, Erol Fikrig, Fengwei Bai
JOURNAL OF VIROLOGY
(2017)
Article
Immunology
Huafang Lai, Amber M. Paul, Haiyan Sun, Junyun He, Ming Yang, Fengwei Bai, Qiang Chen
Article
Microbiology
Amber M. Paul, Dhiraj Acharya, Biswas Neupane, E. Ashely Thompson, Gabriel Gonzalez-Fernandez, Katherine M. Copeland, Me'Lanae Garrett, Haibei Liu, Mariper E. Lopez, Matthew de Cruz, Alex Flynt, Jun Liao, Yan-Lin Guo, Federico Gonzalez-Femandez, Parminder J. S. Vig, Fengwei Bai
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Virology
Daniel Limonta, Juan Jovel, Anil Kumar, Adriana M. Airo, Shangmei Hou, Leina Saito, William Branton, Gane Ka-Shu Wong, Andrew Mason, Christopher Power, Tom C. Hobman
Article
Biochemistry & Molecular Biology
Eliah G. Overbey, Amber M. Paul, Willian A. da Silveira, Candice G. T. Tahimic, Sigrid S. Reinsch, Nathaniel Szewczyk, Seta Stanbouly, Charles Wang, Jonathan M. Galazka, Xiao Wen Mao
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Physiology
Candice G. T. Tahimic, Amber M. Paul, Ann-Sofie Schreurs, Samantha M. Torres, Linda Rubinstein, Sonette Steczina, Moniece Lowe, Sharmila Bhattacharya, Joshua S. Alwood, April E. Ronca, Ruth K. Globus
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Multidisciplinary Sciences
Yen-Ruh Wuu, Burong Hu, Hazeem Okunola, Amber M. Paul, Elizabeth A. Blaber, Margareth Cheng-Campbell, Afshin Beheshti, Peter Grabham
Article
Multidisciplinary Sciences
Amber M. Paul, Margareth Cheng-Campbell, Elizabeth A. Blaber, Sulekha Anand, Sharmila Bhattacharya, Sara R. Zwart, Brian E. Crucian, Scott M. Smith, Robert Meller, Peter Grabham, Afshin Beheshti
Article
Biology
Charlotte A. Nelson, Ana Uriarte Acuna, Amber M. Paul, Ryan T. Scott, Atul J. Butte, Egle Cekanaviciute, Sergio E. Baranzini, Sylvain V. Costes
Summary: Researchers utilized multi-omics data and an heterogeneous knowledge graph integration to identify critical symptoms and physiological changes incurred during spaceflight.
Article
Cell Biology
Linda Rubinstein, Amber M. Paul, Charles Houseman, Metadel Abegaz, Steffy Tabares Ruiz, Nathan O'Neil, Gilad Kunis, Racheli Ofir, Jacob Cohen, April E. Ronca, Ruth K. Globus, Candice G. T. Tahimic
Summary: The study demonstrates that placenta-derived stromal cells partially mitigated some physiological deficits under simulated weightlessness, but did not have an effect on all affected functions, indicating that multiple countermeasures are required for comprehensive protection from the deleterious effects of prolonged spaceflight.
Article
Behavioral Sciences
Siddhita D. Mhatre, Janani Iyer, Stephanie Puukila, Amber M. Paul, Candice G. T. Tahimic, Linda Rubinstein, Moniece Lowe, Joshua S. Alwood, Marianne B. Sowa, Sharmila Bhattacharya, Ruth K. Globus, April E. Ronca
Summary: As human space exploration advances, it is crucial to understand and address the health challenges of living and working in a spaceflight environment. Exposure to radiation, microgravity, isolation, and other hazards pose significant risks to astronauts. Research on neurobiological and neurobehavioral responses, physiological responses controlled by the Central Nervous System (CNS), and identifying potential mechanisms are important for countermeasure development to ensure the brain and behavioral health of crew members during long duration missions.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Biology
Stephanie Puukila, Olivia Siu, Linda Rubinstein, Candice G. T. Tahimic, Moniece Lowe, Steffy Tabares Ruiz, Ivan Korostenskij, Maya Semel, Janani Iyer, Siddhita D. Mhatre, Yasaman Shirazi-Fard, Joshua S. Alwood, Amber M. Paul, April E. Ronca
Summary: Exposure to space galactic cosmic radiation is a major concern for deep space missions, as it can cause neuronal damage and cognitive deficits. It is important to study the neurological and performance responses of male and female rodents to space radiation, especially with upcoming missions involving female crew members.
Article
Immunology
Amber M. Paul, Siddhita D. Mhatre, Egle Cekanaviciute, Ann-Sofie Schreurs, Candice G. T. Tahimic, Ruth K. Globus, Sulekha Anand, Brian E. Crucian, Sharmila Bhattacharya
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Neurosciences
Parminder J. S. Vig, Deyin Lu, Amber M. Paul, Ram Kuwar, Maria Lopez, Dobrivoje S. Stokic, A. Arturo Leis, Michael R. Garrett, Fengwei Bai
Article
Medicine, Research & Experimental
Joanna Jung, Paul Eggleton, Alison Robinson, Jessica Wang, Nick Gutowski, Janet Holley, Jia Newcombe, Elzbieta Dudek, Amber M. Paul, Douglas Zochodne, Allison Kraus, Christopher Power, Luis B. Agellon, Marek Michalak
