Innate immunity in the central nervous system

Cutting Edge: Instructive Role of Peripheral Tissue Cells in the Imprinting of T Cell Homing Receptor Patterns

(2014) F. Edele et al.   JOURNAL OF IMMUNOLOGY

Myelin Repair Is Accelerated by Inactivating CXCR2 on Nonhematopoietic Cells

(2013) L. Liu et al.   JOURNAL OF NEUROSCIENCE

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Physiologic and anatomic characterization of the brain surface glia barrier of Drosophila

(2011) Michael K. Desalvo et al.   GLIA

Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens

(2011) Anne Dudeck et al.   IMMUNITY

Epicutaneous challenge of orally immunized mice redirects antigen-specific gut-homing T cells to the skin

(2011) Michiko K. Oyoshi et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Mast Cells Regulate Disease Severity in a Relapsing-Remitting Model of Multiple Sclerosis

(2011) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

Kit (W-sh) Mice Develop Earlier and More Severe Experimental Autoimmune Encephalomyelitis Due to Absence of Immune Suppression

(2011) H. Li et al.   JOURNAL OF IMMUNOLOGY

Functional Duality of Astrocytes in Myelination

(2011) B. Nash et al.   JOURNAL OF NEUROSCIENCE

Exacerbated experimental autoimmune encephalomyelitis in mast-cell-deficient KitW-sh/W-sh mice

(2011) Silvia Piconese et al.   LABORATORY INVESTIGATION

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

NLR functions beyond pathogen recognition

(2011) Thomas A Kufer et al.   NATURE IMMUNOLOGY

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

(2011) Marco Prinz et al.   NATURE NEUROSCIENCE

Interleukin-33 biology with potential insights into human diseases

(2011) Gaby Palmer et al.   Nature Reviews Rheumatology

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

Disease-associated amyloid and misfolded protein aggregates activate the inflammasome

(2011) Seth L. Masters et al.   TRENDS IN MOLECULAR MEDICINE

Astrocyte–neuron metabolic relationships: for better and for worse

(2011) Igor Allaman et al.   TRENDS IN NEUROSCIENCES

Research progress on interleukin-33 and its roles in the central nervous system

(2011) Ping Han et al.   Neuroscience Bulletin

CD11c-expressing cells reside in the juxtavascular parenchyma and extend processes into the glia limitans of the mouse nervous system

(2010) Carolin Prodinger et al.   ACTA NEUROPATHOLOGICA

CX3CR1 Deficiency Alters Microglial Activation and Reduces Beta-Amyloid Deposition in Two Alzheimer's Disease Mouse Models

(2010) Sungho Lee et al.   AMERICAN JOURNAL OF PATHOLOGY

Astrocytes modulate the chemokine network in a pathogen-specific manner

(2010) Clive S. McKimmie et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The blood–brain barrier, chemokines and multiple sclerosis

(2010) David W. Holman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS?

(2010) Catherine E Downes et al.   BRITISH JOURNAL OF PHARMACOLOGY

New understandings on the pathophysiology of bacterial meningitis

(2010) Uwe Koedel et al.   CURRENT OPINION IN INFECTIOUS DISEASES

EAE mediated by a non-IFN-γ/non-IL-17 pathway

(2010) Mark A. Kroenke et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mast cells in allergy and infection: Versatile effector and regulatory cells in innate and adaptive immunity

(2010) Stephen J. Galli et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Antigen presentation in EAE: role of microglia, macrophages and dendritic cells

(2010) Beatriz Almolda   Frontiers in Bioscience-Landmark

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Mast Cells as Early Responders in the Regulation of Acute Blood–Brain Barrier Changes after Cerebral Ischemia and Hemorrhage

(2010) Perttu Johannes Lindsberg et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Meningeal Mast Cells Affect Early T Cell Central Nervous System Infiltration and Blood-Brain Barrier Integrity through TNF: A Role for Neutrophil Recruitment?

(2010) B. A. Sayed et al.   JOURNAL OF IMMUNOLOGY

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

(2010) D. Gris et al.   JOURNAL OF IMMUNOLOGY

CX3CR1 in Microglia Regulates Brain Amyloid Deposition through Selective Protofibrillar Amyloid-  Phagocytosis

(2010) Z. Liu et al.   JOURNAL OF NEUROSCIENCE

Neuroscience: Settling the great glia debate

(2010) Kerri Smith   NATURE

Glia

(2010) Tanguy Chouard et al.   NATURE

Myelination and support of axonal integrity by glia

(2010) Klaus-Armin Nave   NATURE

The myeloid cells of the central nervous system parenchyma

(2010) Richard M. Ransohoff et al.   NATURE

Glial and neuronal control of brain blood flow

(2010) David Attwell et al.   NATURE

Regulation of synaptic connectivity by glia

(2010) Cagla Eroglu et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice

(2010) Martine M. Mirrione et al.   NEUROBIOLOGY OF DISEASE

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

IL-33 is a crucial amplifier of innate rather than acquired immunity

(2010) K. Oboki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages

(2010) F. Ginhoux et al.   SCIENCE

Role of TNFα in Early Chemokine Production and Leukocyte Infiltration into Heart Allografts

(2009) D. Ishii et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Mast Cells

(2009) Kavitha N. Rao et al.   Annals of the New York Academy of Sciences

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Astrocytic dysfunction: Insights on the role in neurodegeneration

(2009) Daniela Rossi et al.   BRAIN RESEARCH BULLETIN

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Preconditioning paradigms and pathways in the brain.

(2009) K. B Shpargel et al.   CLEVELAND CLINIC JOURNAL OF MEDICINE

Inactivation of astroglial NF-κB promotes survival of retinal neurons following ischemic injury

(2009) Galina Dvoriantchikova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The roles of TLRs, RLRs and NLRs in pathogen recognition

(2009) T. Kawai et al.   INTERNATIONAL IMMUNOLOGY

Inflammasomes: too big to miss

(2009) Andrea Stutz et al.   JOURNAL OF CLINICAL INVESTIGATION

Mast cells mediate neutrophil recruitment and vascular leakage through the NLRP3 inflammasome in histamine-independent urticaria

(2009) Yuumi Nakamura et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The nuclear receptor PPARγ selectively inhibits Th17 differentiation in a T cell–intrinsic fashion and suppresses CNS autoimmunity

(2009) Luisa Klotz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone Marrow-Derived Mast Cells Accumulate in the Central Nervous System During Inflammation but Are Dispensable for Experimental Autoimmune Encephalomyelitis Pathogenesis

(2009) J. L. Bennett et al.   JOURNAL OF IMMUNOLOGY

Transgenic Inhibition of Astroglial NF- B Improves Functional Outcome in Experimental Autoimmune Encephalomyelitis by Suppressing Chronic Central Nervous System Inflammation

(2009) R. Brambilla et al.   JOURNAL OF IMMUNOLOGY

Transgenic inhibition of astroglial NF-κB leads to increased axonal sparing and sprouting following spinal cord injury

(2009) Roberta Brambilla et al.   JOURNAL OF NEUROCHEMISTRY

Animal models of multiple sclerosis for the development and validation of novel therapies – potential and limitations

(2009) Eilhard Mix et al.   JOURNAL OF NEUROLOGY

Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions

(2009) Ingo Bartholomäus et al.   NATURE

Anatomy and Imaging of the Normal Meninges

(2009) Neel Patel et al.   SEMINARS IN ULTRASOUND CT AND MRI

Imaging of the Meninges and the Extra-Axial Spaces

(2009) Olga Kirmi et al.   SEMINARS IN ULTRASOUND CT AND MRI

The Puzzling Role of CXCR3 and Its Ligands in Organ Allograft Rejection

(2008) P. F. Halloran et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis

(2008) Pia Kivisäkk et al.   ANNALS OF NEUROLOGY

Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA

(2008) Roser Gorina et al.   GLIA

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

GM-CSF mediates autoimmunity by enhancing IL-6–dependent Th17 cell development and survival

(2008) Ivo Sonderegger et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Th17–ELR+CXC chemokine pathway is essential for the development of central nervous system autoimmune disease

(2008) Thaddeus Carlson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

Systemic inflammation switches the inflammatory cytokine profile in CNS Wallerian degeneration

(2007) Karine Palin et al.   NEUROBIOLOGY OF DISEASE