Autism spectrum disorders: emerging mechanisms and mechanism-based treatment

Metabotropic glutamate receptor 5 as drug target for Fragile X syndrome

(2015) Sebastian H Scharf et al.   CURRENT OPINION IN PHARMACOLOGY

Targeted pharmacological treatment of autism spectrum disorders: fragile X and Rett syndromes

(2015) Hansen Wang et al.   Frontiers in Cellular Neuroscience

The methyl-CpG-binding domain (MBD) is crucial for MeCP2’s dysfunction-induced defects in adult newborn neurons

(2015) Na Zhao et al.   Frontiers in Cellular Neuroscience

Fragile X mental retardation protein: from autism to neurodegenerative disease

(2015) Hansen Wang   Frontiers in Cellular Neuroscience

Functional and structural deficits at accumbens synapses in a mouse model of Fragile X

(2015) Daniela Neuhofer et al.   Frontiers in Cellular Neuroscience

SnapShot: FMRP Interacting Proteins

(2014) Emanuela Pasciuto et al.   CELL

The role of de novo mutations in the genetics of autism spectrum disorders

(2014) Michael Ronemus et al.   NATURE REVIEWS GENETICS

A de novo convergence of autism genetics and molecular neuroscience

(2014) Niklas Krumm et al.   TRENDS IN NEUROSCIENCES

Epigenetic effect of testosterone in the behavior of C. elegans. A clue to explain androgen-dependent autistic traits?

(2014) M. Mar Gámez-Del-Estal et al.   Frontiers in Cellular Neuroscience

Synaptic proteins and receptors defects in autism spectrum disorders

(2014) Jianling Chen et al.   Frontiers in Cellular Neuroscience

Distinctive behavioral and cellular responses to fluoxetine in the mouse model for Fragile X syndrome

(2014) Marko Uutela et al.   Frontiers in Cellular Neuroscience

A selective histone deacetylase-6 inhibitor improves BDNF trafficking in hippocampal neurons from Mecp2 knockout mice: implications for Rett syndrome

(2014) Xin Xu et al.   Frontiers in Cellular Neuroscience

2-Methyl-6-(phenylethynyl) pyridine (MPEP) reverses maze learning and PSD-95 deficits in Fmr1 knock-out mice

(2014) Réno M. Gandhi et al.   Frontiers in Cellular Neuroscience

Emerging role of the KCNT1 Slack channel in intellectual disability

(2014) Grace E. Kim et al.   Frontiers in Cellular Neuroscience

Convergence of circuit dysfunction in ASD: a common bridge between diverse genetic and environmental risk factors and common clinical electrophysiology

(2014) Russell G. Port et al.   Frontiers in Cellular Neuroscience

MeCP2 post-translational modifications: a mechanism to control its involvement in synaptic plasticity and homeostasis?

(2014) Elisa Bellini et al.   Frontiers in Cellular Neuroscience

The contribution of inhibitory interneurons to circuit dysfunction in Fragile X Syndrome

(2014) Christian A. Cea-Del Rio et al.   Frontiers in Cellular Neuroscience

The free radical scavenger Trolox dampens neuronal hyperexcitability, reinstates synaptic plasticity, and improves hypoxia tolerance in a mouse model of Rett syndrome

(2014) Oliwia A. Janc et al.   Frontiers in Cellular Neuroscience

CYFIP family proteins between autism and intellectual disability: links with Fragile X syndrome

(2014) Sabiha Abekhoukh et al.   Frontiers in Cellular Neuroscience

5-HT7 receptors as modulators of neuronal excitability, synaptic transmission and plasticity: physiological role and possible implications in autism spectrum disorders

(2014) Lucia Ciranna et al.   Frontiers in Cellular Neuroscience

Genetic aspects of autism spectrum disorders: insights from animal models

(2014) Swati Banerjee et al.   Frontiers in Cellular Neuroscience

Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models

(2014) Caleb A. Doll et al.   Frontiers in Cellular Neuroscience

Auditory Processing in Fragile X Syndrome

(2014) Sarah E. Rotschafer et al.   Frontiers in Cellular Neuroscience

Late onset deficits in synaptic plasticity in the valproic acid rat model of autism

(2014) Henry G. S. Martin et al.   Frontiers in Cellular Neuroscience

Optimizing neuronal differentiation from induced pluripotent stem cells to model ASD

(2014) Dae-Sung Kim et al.   Frontiers in Cellular Neuroscience

Lipid rafts: a signaling platform linking cholesterol metabolism to synaptic deficits in autism spectrum disorders

(2014) Hansen Wang   Frontiers in Behavioral Neuroscience

An AT-Hook Domain in MeCP2 Determines the Clinical Course of Rett Syndrome and Related Disorders

(2013) Steven Andrew Baker et al.   CELL

Autism

(2013) Meng-Chuan Lai et al.   LANCET

Activity-dependent neuronal signalling and autism spectrum disorder

(2013) Daniel H. Ebert et al.   NATURE

Progress toward treatments for synaptic defects in autism

(2013) Richard Delorme et al.   NATURE MEDICINE

A novel DNA-binding feature of MeCP2 contributes to Rett syndrome

(2013) Xin Xu et al.   Frontiers in Cellular Neuroscience

FMRP: a triple threat to PSD-95

(2013) Cara J. Westmark   Frontiers in Cellular Neuroscience

Reversing autism by targeting downstream mTOR signaling

(2013) Hansen Wang et al.   Frontiers in Cellular Neuroscience

The Pathophysiology of Fragile X (and What It Teaches Us about Synapses)

(2012) Asha L. Bhakar et al.   Annual Review of Neuroscience

Multiple Autism-Linked Genes Mediate Synapse Elimination via Proteasomal Degradation of a Synaptic Scaffold PSD-95

(2012) Nien-Pei Tsai et al.   CELL

Preclinical research in Rett syndrome: setting the foundation for translational success

(2012) D. M. Katz et al.   Disease Models & Mechanisms

Autism-related deficits via dysregulated eIF4E-dependent translational control

(2012) Christos G. Gkogkas et al.   NATURE

Induced pluripotent stem cells: the new patient?

(2012) Milena Bellin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Synaptic Dysfunction in Neurodevelopmental Disorders Associated with Autism and Intellectual Disabilities

(2012) H. Y. Zoghbi et al.   Cold Spring Harbor Perspectives in Biology

Induced Pluripotent Stem Cells to Model and Treat Neurogenetic Disorders

(2012) Hansen Wang et al.   NEURAL PLASTICITY

Group I Metabotropic Glutamate Receptor-Mediated Gene Transcription and Implications for Synaptic Plasticity and Diseases

(2012) Hansen Wang et al.   Frontiers in Pharmacology

Molecular Mechanisms of Fragile X Syndrome: A Twenty-Year Perspective

(2011) Michael R. Santoro et al.   Annual Review of Pathology-Mechanisms of Disease

Toward Fulfilling the Promise of Molecular Medicine in Fragile X Syndrome

(2010) Dilja D. Krueger et al.   Annual Review of Medicine