Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Biochemistry & Molecular Biology
Beatriz Castejon-Vega, Mario D. D. Cordero, Alberto Sanz
Summary: In the past, mtROS were seen as byproducts of cellular metabolism and drivers of ageing and age-related diseases. Now, we know that mtROS serve as important cellular messengers, playing a role in maintaining cellular homeostasis and influencing cellular differentiation, proliferation, and survival. However, dysregulated mtROS signaling can contribute to degenerative diseases. This review focuses on the signaling pathways involving mtROS and their role in ageing.
Article
Multidisciplinary Sciences
Tal Yardeni, Ana G. Cristancho, Almedia J. McCoy, Patrick M. Schaefer, Meagan J. McManus, Eric D. Marsh, Douglas C. Wallace
Summary: Autism spectrum disorders (ASDs) may be caused by systemic mitochondrial deficiency, as recent studies have identified mtDNA variants in ASD. Experimental evidence shows that mild systemic mitochondrial defects can lead to ASD, and systemic mitochondrial mutations can cause tissue-specific brain defects with regional neurophysiological alterations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Siwen Li, Yang Cao, Qiangwen Pan, Yewei Xiao, Yanling Wang, Xiali Wang, Xinlian Li, Qiuyue Li, Xiaoqing Tang, Bing Ran
Summary: The study suggests that neonicotinoids may induce liver damage through Ca2+ overload and S-phase arrest, with NAC alleviating the damage caused by DIN. Additionally, DIN treatment may lead to mitochondrial dysfunction, which can be reversed by specific activators.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Christophe Glorieux, Pedro Buc Calderon
Summary: The significance of vitamin C in cancer treatment has a debated history, but recent studies have shown its potential in selectively targeting mutant cancer cells. The benefits of antioxidants remain inconclusive, yet the low toxicity of vitamin C presents a safe option in cancer treatment. Further research into the interactions between vitamin C and reactive species could lead to optimal combinations with standard treatments.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Chemistry, Physical
Xin Hu, Pengxuan Zhao, Yongping Lu, Yani Liu
Summary: Atherosclerosis is the leading cause of death in western developed countries, and early prevention and effective treatment are crucial. Nanoparticles with unique characteristics offer new options for AS treatment, especially through ROS-based NPs for targeted therapy, prolonged effects, and reduced side effects.
Article
Biochemistry & Molecular Biology
Ana Vujic, Amy N. M. Koo, Hiran A. Prag, Thomas Krieg
Summary: Mitochondria play a crucial role in cellular processes and heart function, with communication between mitochondria and the nucleus maintaining cardiomyocyte homeostasis. Excessive generation of ROS can lead to irreversible cell damage, contributing to various pathologies. Additionally, myocardial impairments are associated with specific metabolic changes and dysregulated inflammatory responses.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Alessandra Mozzi, Monica Oldani, Matilde E. Forcella, Chiara Vantaggiato, Gioia Cappelletti, Chiara Pontremoli, Francesca Valenti, Diego Forni, Marina Saresella, Mara Biasin, Manuela Sironi, Paola Fusi, Rachele Cagliani
Summary: Coronaviruses encode a variety of accessory proteins involved in host-virus interaction, immune response suppression, and immune evasion. The role of the ORF3c accessory protein in SARS-CoV-2 has been unclear, but this study shows that it alters mitochondrial metabolism, enhances oxidative phosphorylation, and affects autophagy. Additionally, there are differences in the effects of ORF3c proteins between SARS-CoV-2 and batCoV RaTG13, with the 36R and 40K sites playing crucial roles.
Article
Biochemistry & Molecular Biology
Firoz Akhter, Doris Chen, Asma Akhter, Shi Fang Yan, Shirley ShiDu Yan
Summary: The accumulation of metabolites associated with aging can lead to oxidative stress and mitochondrial dysfunction in the brain, but scavenging mitochondrial ROS can help reduce AGEs and dicarbonyls accumulation, improving mitochondrial function.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Nutrition & Dietetics
Hengfang Tang, Zhiming Zheng, Han Wang, Li Wang, Genhai Zhao, Peng Wang
Summary: Vitamin K2 can alleviate neuronal cell death mediated by mitochondrial damage by regulating the mitochondrial quality-control loop and repairing mitochondrial dysfunction.
Article
Biochemistry & Molecular Biology
Jorge Reyes-Garcia, Abril Carbajal-Garcia, Annarita Di Mise, Yun-Min Zheng, Xiangdong Wang, Yong-Xiao Wang
Summary: Mitochondria play important roles in the development of pulmonary hypertension, including ROS production, regulation of Ca2+ signaling, fatty acid oxidation, and ketone synthesis. Dysfunction of mitochondrial ROS and Ca2+ signaling can lead to inflammatory responses and oxidative stress mediated by ketones, contributing to the progression of pulmonary hypertension and associated diseases.
Article
Oncology
Tania Capeloa, Justine A. Van de Velde, Donatienne D'Hose, Sara G. Lipari, Francoise Derouane, Loic Hamelin, Marie Bedin, Thibaut Vazeille, Francois P. Duhoux, Michael P. Murphy, Paolo E. Porporato, Bernard Gallez, Pierre Sonveaux
Summary: This study suggests that inhibiting mitochondrial redox signaling could be a potential therapeutic option to prevent metastatic progression of pancreatic cancer. The mitochondria-targeted antioxidant, MitoQ, selectively represses the respiration of mesenchymal pancreatic cancer cells and reduces the production of harmful substances. Additionally, MitoQ inhibits cancer cell migration, invasion, and the expression of stem cell markers. Combination treatments with chemotherapy are also feasible.
Article
Multidisciplinary Sciences
Wahid Shah, Qiyue Zhao, Sen Wang, Miaomiao Zhang, Hongyu Ma, Yue Guan, Yi Zhang, Yan Liu, Chunhua Zhu, Sheng Wang, Xiangjian Zhang, Jinghui Dong, Huijie Ma
Summary: Polydatin can restore vasodilation impaired by high glucose conditions by improving endothelial cell function and reducing inflammation and mitochondrial damage. This has important implications for the treatment of cardiovascular diseases such as diabetes.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Volodymyr Lushchak, Michael Duszenko, Dmytro Gospodaryov, Olga Garaschuk
Summary: Neural tissue in mammals is a major consumer of oxygen, generating reactive oxygen (ROS) and nitrogen (RNS) species in the brain. These substances play important signaling roles but can also cause damage, particularly during midlife. Understanding the pathways, defense systems, and changes in energy/ROS balance in midlife is crucial for managing neuroinflammation and oxidative stress.
Article
Chemistry, Organic
Yalan Wu, Wenyi Huang, Danfeng Peng, Xin-An Huang, Jiangyong Gu, Shengjun Wu, Tao Deng, Fang Liu
Summary: A mild synthetic method has been presented for preparing dihydroquinolines which have shown great potential for fluorescence detection of biorelevant hydroxyl radicals (center dot OH). One of the synthetic dihydroquinolines has been demonstrated to enable sensitive and selective detection of center dot OH and intracellular organelle-targeted fluorescence imaging. Dihydroquinoline also exhibits promising potential for constructing advanced fluorescence probes for center dot OH with tunable photophysical properties.
Article
Biochemistry & Molecular Biology
Kerstin C. Wagener, Benedikt Kolbrink, Katharina Dietrich, Kathrin M. Kizina, Lukas S. Terwitte, Belinda Kempkes, Guobin Bao, Michael Mueller
ANTIOXIDANTS & REDOX SIGNALING
(2016)
Article
Biochemistry & Molecular Biology
Liane Wuestefeld, Daniela Winkler, Oliwia A. Janc, Imam Hassouna, Anja Ronnenberg, Katrin Ostmeier, Michael Mueller, Nils Brose, Hannelore Ehrenreich, Sonja M. Wojcik
JOURNAL OF NEUROCHEMISTRY
(2016)
Article
Cell Biology
Doerthe F. Bebensee, Karolina Can, Michael Mueller
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2017)
Article
Multidisciplinary Sciences
Peter Huppke, Susann Weissbach, Joseph A. Church, Rhonda Schnur, Martina Krusen, Steffi Dreha-Kulaczewski, W. Nikolaus Kuehn-Velten, Annika Wolf, Brenda Huppke, Francisca Millan, Amber Begtrup, Fatima Almusafri, Holger Thiele, Janine Altmueller, Peter Nuernberg, Michael Mueller, Jutta Gaertner
NATURE COMMUNICATIONS
(2017)
Editorial Material
Biochemistry & Molecular Biology
Katharina Dietrich, Yvonne Bouter, Michael Mueller, Thomas A. Bayer
Article
Behavioral Sciences
Michael Mueller
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Article
Physiology
Karolina Can, Christiana Menzfeld, Lena Rinne, Peter Rehling, Sebastian Kuegler, Gocha Golubiani, Jan Dudek, Michael Mueller
FRONTIERS IN PHYSIOLOGY
(2019)
Editorial Material
Behavioral Sciences
Dajie Zhang, Francesco Bedogni, Sofie Boterberg, Carol Camfield, Peter Camfield, Tony Charman, Leopold Curfs, Christa Einspieler, Gianluca Esposito, Bianca De Filippis, Robin P. Goin-Kochel, Guenter U. Hoeglinger, Daniel Holzinger, Ana-Maria Iosif, Giulio E. Lancioni, Nicoletta Landsberger, Giovanni Laviola, Eva M. Marco, Michael Mueller, Jeffrey L. Neul, Karin Nielsen-Saines, Anders Nordahl-Hansen, Mark F. O'Reilly, Sally Ozonoff, Luise Poustka, Herbert Roeyers, Marija Rankovic, Jeff Sigafoos, Kristiina Tammimies, Gillian S. Townend, Lonnie Zwaigenbaum, Markus Zweckstetter, Sven Bolte, Peter B. Marschik
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2019)
Article
Biochemistry & Molecular Biology
Olusegun L. Adebayo, Ina Dewenter, Lena Rinne, Gocha Golubiani, Revaz Solomonia, Michael Mueller
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2020)
Article
Cell Biology
Karina Festerling, Karolina Can, Sebastian Kuegler, Michael Mueller
Article
Cell Biology
Gocha Golubiani, Vincenzo Lagani, Revaz Solomonia, Michael Mueller
Summary: Using unsupervised metabolomics, this study identified 101 significantly deregulated metabolites in the cortex of Mecp2-deficient adult male mice with Rett syndrome. Pathway analysis revealed 31 mostly upregulated metabolic pathways, providing further insights into the complex pathogenesis of RTT.
Article
Critical Care Medicine
R. David Andrew, Eszter Farkas, Jed A. Hartings, K. C. Brennan, Oscar Herreras, Michael Mueller, Sergei. A. Kirov, Cenk Ayata, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, Ken D. Dawson-Scully, Ghanim Ullah, Jens P. Dreier
Summary: The spreading depolarizations (SD) theory provides a better explanation for acute neuronal injury caused by brain ischemia than the theory of excessive glutamate release. The challenges in developing therapeutic strategies based on more informed basic science are highlighted, calling for a shift in focus towards understanding the molecular biology of SD initiation and propagation.
NEUROCRITICAL CARE
(2022)
Article
Critical Care Medicine
R. David Andrew, Jed A. Hartings, Cenk Ayata, K. C. Brennan, Ken D. Dawson-Scully, Eszter Farkas, Oscar Herreras, Sergei A. Kirov, Michael Muller, Nikita Ollen-Bittle, Clemens Reiffurth, Omer Revah, R. Meldrum Robertson, C. William Shuttleworth, Ghanim Ullah, Jens P. Dreier
Summary: In this review, the mechanism and impact of spreading depolarization (SD) in the gray matter following blood flow loss are discussed. The initiation and propagation of SD are explored, along with the challenges and pitfalls in studying SD. The review concludes with a summary of the research direction and ongoing debates regarding SD.
NEUROCRITICAL CARE
(2022)
Article
Biochemistry & Molecular Biology
Laura Baroncelli, Stefanie Auel, Lena Rinne, Ann-Kathrin Schuster, Victoria Brand, Belinda Kempkes, Katharina Dietrich, Michael Mueller
Summary: Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the MECP2 gene. Antioxidant treatment has shown some therapeutic benefits, but long-term treatment may lose efficacy and worsen metabolic disturbances.
Article
Biology
Gocha Golubiani, Laura van Agen, Lia Tsverava, Revaz Solomonia, Michael Mueller
Summary: Rett syndrome is a genetic disorder primarily affecting female patients, characterized by deficits in brain functioning and development. The study found that mitochondrial dysfunction is one of the hallmarks of Rett syndrome, which may affect mitochondrial dynamics and oxidative phosphorylation. These findings contribute to our understanding of mitochondrial malfunction in Rett syndrome and provide insights for further translational medicine research.