Article
Neurosciences
Hristo Varbanov, Shaobo Jia, Gaga Kochlamazashvili, Subhrajit Bhattacharya, Manal Ali Buabeid, Mohamed El Tabbal, Hussam Hayani, Stoyan Stoyanov, Weilun Sun, Hauke Thiesler, Iris Roeckle, Herbert Hildebrandt, Oleg Senkov, Vishnu Suppiramaniam, Rita Gerardy-Schahn, Alexander Dityatev
Summary: Dysregulated cortical expression of NCAM and deficits of its associated polySia are found in Alzheimer's disease and schizophrenia. Acute enzymatic removal of polySia in the prefrontal cortex leads to increased transmission mediated by GluN1/GluN2B NMDARs, impaired LTP, and increased tonic currents. Treatment with polySia fragments or inhibition of GluN1/GluN2B receptors restores LTP and cognitive tasks in polySia-deficient mice and Alzheimer's disease models. The data highlight the crucial role of polySia-NCAM in balancing signaling through synaptic/extrasynaptic NMDARs and the therapeutic potential of polySia fragments.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Neurosciences
Joseph A. McQuail, Sofia Beas, Kyle B. Kelly, Caesar M. Hernandez, Jennifer L. Bizon, Charles J. Frazier
Summary: The study revealed that loss of NMDARs on interneurons in the PFC contributes to age-related impairment of cognitive flexibility, while a clear increase in AMPA/NMDA ratio in FSIs suggests a potential underlying mechanism for cognitive decline. These findings provide new insights into the neural mechanisms of cognitive decline.
Review
Neurosciences
Paul J. Banks, Zafar Bashir
Summary: This review focuses on the roles played by N-methyl-D-aspartate receptors (NMDARs) on pyramidal neurons in the medial prefrontal cortex, including their frequency-dependent effects on ongoing synaptic transmission, plasticity, and contribution to plasticity induced by synchronous activation of two separate inputs to the mPFC.
Review
Pharmacology & Pharmacy
Lily R. Aleksandrova, Anthony G. Phillips
Summary: The emerging therapeutic efficacy of ketamine and classical psychedelics for depression has sparked considerable interest in the mechanisms underlying neuroplasticity. Preclinical and clinical evidence suggests that these drugs induce synaptic, structural, and functional changes, particularly in pyramidal neurons in the prefrontal cortex, resulting in adaptive rewiring of pathological neurocircuitry.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Neurosciences
Huan Liu, Mei Tan, Boli Cheng, Si Wang, Lu Xiao, Jiang Zhu, Qionghui Wu, Xi Lai, Qian Zhang, Jie Chen, Tingyu Li
Summary: The study found that VPA affects the histone acetylation of ALDH1A1, leading to autism-like behavior and synaptic deficits. Administration of MS-275 and RA in VPA offspring partially reversed these effects.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Neurosciences
S. Murat Durakoglugil, R. Catherine Wasser, H. Connie Wong, Theresa Pohlkamp, Xunde Xian, Courtney Lane-Donovan, Katja Fritschle, Lea Naestle, Joachim Herz
Summary: Alzheimer's disease is characterized by the accumulation of Aβ plaques and neurofibrillary tangles, leading to synaptic dysfunction. Reelin protects synapses against Aβ toxicity through ApoE receptors. Experiments showed that Reelin modulates mGluR-LTD, potentially impacting memory consolidation or neurodegeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Paul J. Harrison, David M. Bannerman
Summary: The involvement of the glutamate system, particularly the NMDA receptor hypofunction, is considered to be part of the pathophysiology of schizophrenia. Recent data strongly implicate the gene GRIN2A, encoding the NR2A NMDA receptor subunit, in the development of schizophrenia. Both rare and common variants of this gene are associated with genetic risk for the disorder, and they are likely to result in reduced gene expression.
MOLECULAR PSYCHIATRY
(2023)
Review
Neurosciences
Chieh-En Jane Tseng, Christopher J. McDougle, Jacob M. Hooker, Nicole R. Zurcher
Summary: The etiology of autism spectrum disorder (ASD) remains unknown, but gene-environment interactions, mediated through epigenetic mechanisms, are thought to be a key contributing factor. Prenatal environmental factors have been shown to be associated with both increased risk of ASD and altered histone deacetylases (HDACs) or acetylation levels. Alterations in histone acetylation, which lead to changes in gene transcription, may play a key role in ASD.
BIOLOGICAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Hikaru Koizumi, Taichi Hiraga, Leandro K. Oharomari, Toshiaki Hata, Takeru Shima, Jang Soo Yook, Masahiro Okamoto, Akihiro Mouri, Toshitaka Nabeshima, Hideaki Soya
Summary: Schizophrenia may be attributed to perinatal neurodevelopmental deficits and influenced by environmental factors. Hypofrontality and dysfunction in glutamatergic and dopaminergic neurons are known factors, while early enriched environment and low-intensity exercise training during adolescence may help prevent and ameliorate the disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Chen
Summary: The study found that the loss of GluN2A in adult mice elicits antidepressant-like responses without causing psychomimetic effects similar to ketamine. The antidepressant effects of ketamine and MK-801 are mediated by the suppression of GluN2A, not GluN2B. Additionally, these drugs increase the excitability of hippocampal neurons through GluN2A.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Tonghui Su, Yi Lu, Chaoying Fu, Yang Geng, Yelin Chen
Summary: This study demonstrates that the loss of GluN2A in adult mouse brains can elicit strong antidepressant-like responses without causing psychomimetic effects similar to Ketamine. The antidepressant effects of Ketamine and MK-801 are mainly mediated by the suppression of GluN2A rather than GluN2B.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Shao-Rui Chen, Hong Chen, Daozhong Jin, Hui-Lin Pan
Summary: Treatment with opioids not only inhibits nociceptive transmission but also elicits a rebound and persistent increase in primary afferent input to the spinal cord. Opioid-elicited long-term potentiation (LTP) from TRPV1-expressing primary afferents plays a major role in opioid-induced hyperalgesia and analgesic tolerance. The study found that opioid-elicited LTP occurs in VGluT2 neurons in the spinal dorsal horn, and not in VGAT neurons, with underlying signaling mechanisms.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Silvano R. Gefferie, Angelina Maric, Hanne Critelli, Sophie Gueden, Gerhard Kurlemann, Salome Kurth, Margherita Nosadini, Barbara Plecko, Maya Ringli, Kevin Rostasy, Stefano Sartori, Bernhard Schmitt, Agnese Suppiej, Patrick Van Bogaert, Flavia M. Wehrle, Reto Huber, Bigna K. Bolsterli
Summary: The plasticity of synaptic strength and density, critical for memory consolidation and learning, is strongly dependent on NMDAR function. A study on pediatric patients with anti-NMDAR encephalitis revealed alterations in sleep EEG markers for synaptic plasticity, indicating impaired synaptic plasticity in this unique human model of NMDAR deficiency.
Review
Medicine, Research & Experimental
Abdoh Taleb, Wen Lin, Xiang Xu, Gang Zhang, Qi-Gang Zhou, Muhammad Naveed, Fan Meng, Kohji Fukunaga, Feng Han
Summary: Autism spectrum disorder (ASD) is a mental disorder characterized by deficits in cognitive and communication abilities, with no effective cure available. Valproic acid (VPA) has been associated with increased risk of ASD in children and can lead to behavioral impairments and morphological changes in the brain. However, the exact mechanism of VPA exposure-induced ASD remains unclear.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Brittney Yegla, Asha Rani, Ashok Kumar
Summary: Age-associated decrease in NMDAR-mediated synaptic function contributes to cognitive impairments. Enhancing NMDAR function via increased SR expression in middle age rats improves learning and synaptic transmission. Prefrontal SR upregulation can improve visual discrimination and increase NMDAR activity.
Article
Neurosciences
Aurore Thomazeau, Clementine Bosch-Bouju, Olivier Manzoni, Sophie Laye
Article
Neurosciences
Henry G. S. Martin, Olivier Lassalle, Olivier J. Manzoni
Article
Biochemistry & Molecular Biology
Daniela Neuhofer, Olivier Lassalle, Olivier J. Manzoni
ACS CHEMICAL NEUROSCIENCE
(2018)
Correction
Neurosciences
Andrew F. Scheyer, Olivier J. Manzoni
Article
Biology
Anissa Bara, Antonia Manduca, Axel Bernabeu, Milene Borsoi, Michela Serviado, Olivier Lassalle, Michelle Murphy, Jim Wager-Miller, Ken Mackie, Anne-Laure Pelissier-Alicot, Viviana Trezza, Olivier J. Manzoni
Article
Behavioral Sciences
Milene Borsoi, Antonia Manduca, Anissa Bara, Olivier Lassalle, Anne-Laure Pelissier-Alicot, Olivier J. Manzoni
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2019)
Article
Neurosciences
Andrew F. Scheyer, Milene Borsoi, Jim Wager-Miller, Anne-Laure Pelissier-Alicot, Michelle N. Murphy, Ken Mackie, Olivier J. J. Manzoni
BIOLOGICAL PSYCHIATRY
(2020)
Article
Neurosciences
Yasmin L. Hurd, Olivier J. Manzoni, Mikhail Pletnikov, Francis S. Lee, Sagnik Bhattacharyya, Miriam Melis
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Marion A. Deroche, Olivier Lassalle, Laia Castell, Emmanuel Valjent, Olivier J. Manzoni
JOURNAL OF NEUROSCIENCE
(2020)
Review
Neurosciences
Andrew F. Scheyer, Miriam Melis, Viviana Trezza, Olivier J. J. Manzoni
TRENDS IN NEUROSCIENCES
(2019)
Article
Neurosciences
Andrew F. Scheyer, Milene Borsoi, Anne-Laure Pelissier-Alicot, Olivier J. J. Manzoni
NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Neurosciences
Andrew F. Scheyer, Milene Borsoi, Anne-Laure Pelissier-Alicot, Olivier J. J. Manzoni
Article
Multidisciplinary Sciences
Pauline Guily, Olivier Lassalle, Pascale Chavis, Olivier J. Manzoni
Summary: This study compared the morphology and function of basolateral amygdala (BLA) neurons in male and female rats during puberty and adulthood. The results showed that BLA neurons in adult males were more excitable than those in females. During puberty, male rats had smaller and shorter action potentials, while females had larger fast afterhyperpolarizations. Additionally, there were sex-specific differences in spine length, synaptic properties, and the developmental courses of long-term potentiation and depression.
Article
Psychiatry
Daniela Iezzi, Alba Caceres-Rodriguez, Pascale Chavis, Olivier J. J. Manzoni
Summary: This study evaluated the sex-dependent neonatal behavior of progeny exposed to CBD during gestation using behavioral approaches and deep learning analysis. The results showed that male pups gained more weight, while female pups emitted more high frequency calls compared to their control counterparts. There were also qualitative changes in syllabic USV repertoire and differences in homing behavior, with CBD-exposed females showing reduced motor and discriminatory abilities. These findings suggest a sexual divergence in the consequences of in utero CBD exposure on neonates, highlighting the need for further studies on the effects of perinatal CBD exposure.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Pharmacology & Pharmacy
Andrew F. Scheyer, Steven R. Laviolette, Anne-Laure Pelissier, Olivier J. J. Manzoni
Summary: The consumption of cannabis during adolescence presents scientific, medical, and economic challenges, due to changes in the social and political perception of the drug. With the wave of cannabis legalization, there is a need to educate the public about the potential risks and known dangers associated with both recreational and medical cannabis.
CANNABIS AND CANNABINOID RESEARCH
(2023)