Article
Neurosciences
B. Di Marco, P. Dell'Albani, S. D'Antoni, M. Spatuzza, C. M. Bonaccorso, S. A. Musumeci, F. Drago, B. Bardoni, M. V. Catania
Summary: The study found a novel modulatory role of mGlu5 receptor in SGs formation, providing new perspectives for understanding cellular response to stress in FXS pathophysiology.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Benjamin D. Auerbach, Senthilvelan Manohar, Kelly Radziwon, Richard Salvi
Summary: The study characterized auditory hypersensitivity in a Fmr1 knockout transgenic rat model of FX, revealing perceptual evidence of excessive loudness growth and altered integration of sound duration and bandwidth in Fmr1 KO rats. Antagonism of mGlu5 selectively and dose-dependently restored normal loudness growth in Fmr1 KO rats, suggesting a pharmacologic approach for alleviating sensory hypersensitivity associated with FX. Leveraging the tractable nature of the auditory system and unique behavioral advantages of rats, this study provides important insights into an understudied aspect of FX and ASD.
NEUROBIOLOGY OF DISEASE
(2021)
Article
Neurosciences
Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T. Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck
Summary: Aging is associated with decreased availability of mGluR5 in the brain, primarily due to tissue loss. This reduction in mGluR5 binding may provide insight into age-related molecular changes and their relationship with brain tissue loss.
Article
Neurosciences
Ruth C. Werthmann, Manuel Tzouros, Jens Lamerz, Angelique Augustin, Thorsten Fritzius, Luca Trovo, Michal Stawarski, Adi Raveh, Catherine Diener, Christophe Fischer, Martin Gassmann, Lothar Lindemann, Bernhard Bettler
Summary: Recent studies have shown that mGlu1 and mGlu5 form functional heterodimers in the brain, exhibiting symmetric signal transduction where both protomers need to reach an active conformation for full receptor activity. This highlights differences in the signaling transduction of heterodimeric mGluRs that influence allosteric modulation.
Article
Immunology
Kundian Guo, Xu Liu, Xue Gong, Aiqing Li, Yue Liu, Xingjie Li, Dong Zhou, Zhen Hong
Summary: This study described a case series of autoimmune encephalitis patients with mGluR5 antibodies from China. The clinical phenotype of anti-mGluR5 encephalitis in Chinese patients is similar, with behavioral/personality changes and cognitive disorders being the main manifestations. Most patients showed good responses to immunotherapy and had favorable clinical outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rohini Subrahmanyam, Deepanjali Dwivedi, Zubin Rashid, Katherine Bonnycastle, Michael A. Cousin, Sumantra Chattarji
Summary: This study reveals that FMRP represses spontaneous presynaptic SV fusion, while mGlu receptor activation increases this event, with reciprocal control likely mediated through their regulation of intrinsic neuronal excitability.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Immunology
Ya-Nan Zhang, Jing-Kai Fan, Li Gu, Hui-Min Yang, Shu-Qin Zhan, Hong Zhang
Summary: The research demonstrated that mGluR5 inhibits alpha-synuclein-induced microglia inflammation to protect against neurotoxicity, while alpha-synuclein promotes the degradation of mGluR5 through lysosomal pathway to accelerate neuroinflammation. This novel mechanism may serve as a potential therapeutic target for Parkinson's disease.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Li Luo, Le Yang, Kun Zhang, Shi-Meng Zhou, Yan Wang, Liu-Kun Yang, Bin Feng, Shui-Bing Liu, Yu-Mei Wu, Ming-Gao Zhao, Qi Yang
Summary: This study found that abnormal expression of caveolin-1 (Cav1) in Fragile X syndrome (FXS) patients leads to enhanced mGluR-dependent long-term depression (LTD) and further induces endocytosis of AMPA receptor. Massive cholesterol accumulation contributes to redundant caveolae formation, and alleviating FXS symptoms can be achieved by cholesterol depletion.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Cell Biology
Giselle Fernandes, Pradeep K. Mishra, Mohammad Sarfaraz Nawaz, Paul G. Donlin-Asp, Mohammed Mostafizur Rahman, Anupam Hazra, Sonal Kedia, Aiman Kayenaat, Dheeraj Songara, David J. A. Wyllie, Erin M. Schuman, Peter C. Kind, Sumantra Chattarji
Summary: In a rat model of Fragile X syndrome (FXS), it was observed that activation rather than inhibition of mGluRs in the basolateral amygdala reversed impairments in fear learning. Activation of presynaptic mGluR5 in the amygdala reversed deficient synaptic transmission and plasticity, restoring normal fear learning in FXS rats. This highlights the importance of considering circuit-specific differences in FXS pathophysiology when developing therapeutic strategies.
Review
Behavioral Sciences
Sixian Chen, Haitao Ren, Fuhong Lin, Siyuan Fan, Yuze Cao, Weili Zhao, Hongzhi Guan
Summary: This study describes the clinical and radiological characteristics of anti-metabotropic glutamate receptor 5 (mGluR5) encephalitis. The main neurological symptoms in patients with anti-mGluR5 encephalitis were cognitive impairment, psychiatric or behavior problems, seizures, sleeping disorders, decreased consciousness, and movement disorders. Brain MRI was normal in some patients and limbic lobe lesions were observed in others. A subset of patients with anti-mGluR5 encephalitis had concomitant tumors. Immunotherapy led to significant improvements in most cases.
BRAIN AND BEHAVIOR
(2023)
Article
Biochemistry & Molecular Biology
Na Wang, Dan-Dan Wang, Xiaolin Hou, Xiumao Li, Ying Shen
Summary: Numb protein isoforms Numb-p72 and Numb-p65 exhibit distinct expression patterns in HEK293T cells, with Numb-p72 specifically binding to mGluR5 alpha and enhancing its membrane expression by inhibiting internalization. This indicates that a complete structure of Numb is necessary for binding to and modulating mGluR5 trafficking.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Medicine, General & Internal
Yu Zhang, Baorong Lian, Shiwei Yang, Xuming Huang, Yanxia Zhou, Liming Cao
Summary: A 29-year-old male patient developed reversible splenial lesion syndrome after receiving a SARS-CoV-2 vaccine, leading to a diagnosis of anti-mGluR5-related autoimmune encephalitis. Treatment with intravenous methylprednisolone pulse and gamma-globulin pulse therapies significantly improved the symptoms and resolved the lesion in the corpus callosum.
Article
Multidisciplinary Sciences
Ha Eun Kong, Junghwa Lim, Alexander Linsalata, Yunhee Kang, Indranil Malik, Emily G. Allen, Yiqu Cao, Lisa Shubeck, Rich Johnston, Yanting Huang, Yanghong Gu, Xiangxue Guo, Michael E. Zwick, Zhaohui Qin, Thomas S. Wingo, Jorge Juncos, David L. Nelson, Michael P. Epstein, David J. Cutler, Peter K. Todd, Stephanie L. Sherman, Stephen T. Warren, Peng Jin
Summary: This study identified Prosbeta5 (PSMB5) as a candidate genetic modifier for FXTAS using a Drosophila model. Knockdown of PSMB5 suppressed CGG-associated neurodegeneration in flies and cells. Additionally, an expression quantitative trait locus variant in PSMB5 was associated with delayed onset of FXTAS in human carriers. These findings suggest a therapeutic strategy for FXTAS by targeting PSMB5.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Serena Notartomaso, Nico Antenucci, Francesca Liberatore, Giada Mascio, Stefano Vito Boccadamo Pompili, Joan Font, Mariarosaria Scioli, Livio Luongo, Antonietta Arcella, Roberto Gradini, Amadeu Llebaria, Ferdinando Nicoletti
Summary: Breakthrough cancer pain (BTcP) is a sudden and transient exacerbation of pain in patients treated with opioid analgesics. Light-activated drugs offer a novel strategy for rapid pain control without systemic side effects. Activation of mGlu5 receptors in the thalamus with light-induced compounds showed analgesic effects in inflammatory and neuropathic pain models. This study demonstrates the potential use of optopharmacology in BTcP treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Clinical Neurology
Osama Khojah, Seraj Makkawi, Saeed Alghamdi
Summary: This study aimed to systematically review reported cases of anti-mGluR1 encephalitis and summarize their clinical presentation, management, outcomes, and case reports. The study found that anti-mGluR1 encephalitis manifests as symptoms of cerebellar pathology, and early diagnosis with prompt initiation of immunotherapy is crucial for patient recovery.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Christiana Labermaier, Christine Kohl, Jakob Hartmann, Christian Devigny, Andre Altmann, Peter Weber, Janine Arloth, Carina Quast, Klaus V. Wagner, Sebastian H. Scharf, Ludwig Czibere, Regina Widner-Andrae, Julia Brenndoerfer, Rainer Landgraf, Felix Hausch, Ken A. Jones, Marianne B. Mueller, Manfred Uhr, Florian Holsboer, Elisabeth B. Binder, Mathias V. Schmidt
Article
Clinical Neurology
Sara Santarelli, Sylvie L. Lesuis, Xiao-Dong Wang, Klaus V. Wagner, Jakob Hartmann, Christiana Labermaier, Sebastian H. Scharf, Marianne B. Mueller, Florian Holsboer, Mathias V. Schmidt
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2014)
Article
Neurosciences
Xiao-Dong Wang, Gerhard Rammes, Igor Kraev, Miriam Wolf, Claudia Liebl, Sebastian H. Scharf, Courtney J. Rice, Wolfgang Wurst, Florian Holsboer, Jan M. Deussing, Tallie Z. Baram, Michael G. Stewart, Marianne B. Mueller, Mathias V. Schmidt
JOURNAL OF NEUROSCIENCE
(2011)
Article
Neurosciences
Xiao-Dong Wang, Yun-Ai Su, Klaus V. Wagner, Charilaos Avrabos, Sebastian H. Scharf, Jakob Hartmann, Miriam Wolf, Claudia Liebl, Claudia Kuehne, Wolfgang Wurst, Florian Holsboer, Matthias Eder, Jan M. Deussing, Marianne B. Mueller, Mathias V. Schmidt
NATURE NEUROSCIENCE
(2013)
Article
Neurosciences
Xiao-Dong Wang, Yuncai Chen, Miriam Wolf, Klaus V. Wagner, Claudia Liebl, Sebastian H. Scharf, Daniela Harbich, Bianca Mayer, Wolfgang Wurst, Florian Holsboer, Jan M. Deussing, Tallie Z. Baram, Marianne B. Mueller, Mathias V. Schmidt
NEUROBIOLOGY OF DISEASE
(2011)
Article
Neurosciences
Jakob Hartmann, Klaus V. Wagner, Claudia Liebl, Sebastian H. Scharf, Xiao-Dong Wang, Miriam Wolf, Felix Hausch, Theo Rein, Ulrike Schmidt, Chadi Touma, Joyce Cheung-Flynn, Marc B. Cox, David F. Smith, Florian Holsboer, Marianne B. Mueller, Mathias V. Schmidt
Article
Neurosciences
Sebastian H. Scharf, Vera Sterlemann, Claudia Liebl, Marianne B. Mueller, Mathias V. Schmidt
Article
Neurosciences
Klaus V. Wagner, Daria Marinescu, Jakob Hartmann, Xiao-Dong Wang, Christiana Labermaier, Sebastian H. Scharf, Claudia Liebl, Manfred Uhr, Florian Holsboer, Marianne B. Mueller, Mathias V. Schmidt
NEUROPSYCHOPHARMACOLOGY
(2012)
Article
Multidisciplinary Sciences
Sebastian H. Scharf, Claudia Liebl, Elisabeth B. Binder, Mathias V. Schmidt, Marianne B. Mueller
Article
Multidisciplinary Sciences
Mathias V. Schmidt, Jan-Philip Schuelke, Claudia Liebl, Michael Stiess, Charilaos Avrabos, Joerg Bock, Gabriela M. Wochnik, Heather A. Davies, Nicole Zimmermann, Sebastian H. Scharf, Dietrich Truembach, Wolfgang Wurst, Walter Zieglgaensberger, Christoph Turck, Florian Holsboer, Michael G. Stewart, Frank Bradke, Matthias Eder, Marianne B. Mueller, Theo Rein
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2011)
Article
Endocrinology & Metabolism
Klaus V. Wagner, Xiao-Dong Wang, Claudia Liebl, Sebastian H. Scharf, Marianne B. Mueller, Mathias V. Schmidt
PSYCHONEUROENDOCRINOLOGY
(2011)
Article
Endocrinology & Metabolism
Jakob Hartmann, Klaus V. Wagner, Nina Dedic, Dania Marinescu, Sebastian H. Scharf, Xiao-Dong Wang, Jan M. Deussing, Felix Hausch, Theo Rein, Ulrike Schmidt, Florian Holsboer, Marianne B. Mueller, Mathias V. Schmidt
PSYCHONEUROENDOCRINOLOGY
(2012)
Article
Endocrinology & Metabolism
Merce Masana, Yun-Ai Su, Claudia Liebl, Xiao-Dong Wang, Lara Jansen, Soeren Westerholz, Klaus V. Wagner, Christiana Labermaier, Sebastian H. Scharf, Sara Santarelli, Jakob Hartmann, Mathias V. Schmidt, Theo Rein, Marianne B. Mueller
PSYCHONEUROENDOCRINOLOGY
(2014)
Article
Psychiatry
Sebastian H. Scharf, Mathias V. Schmidt
CURRENT PSYCHIATRY REPORTS
(2012)