Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

Enhancing the functional maturity of induced pluripotent stem cell-derived human hepatocytes by controlled presentation of cell-cell interactionsin vitro

(2015) Dustin R. Berger et al.   HEPATOLOGY

A Micropatterned Hepatocyte Coculture Model for Assessment of Liver Toxicity Using High-Content Imaging Analysis

(2014) O. Joseph Trask et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Toward predictive models for drug-induced liver injury in humans: are we there yet?

(2014) Minjun Chen et al.   Biomarkers in Medicine

Pluripotent stem cell-derived hepatocyte-like cells

(2014) R.E. Schwartz et al.   BIOTECHNOLOGY ADVANCES

CellNet: Network Biology Applied to Stem Cell Engineering

(2014) Patrick Cahan et al.   CELL

Human Induced Pluripotent Stem Cells in Hepatology

(2013) Sabine Gerbal-Chaloin et al.   AMERICAN JOURNAL OF PATHOLOGY

Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME

(2013) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

High-Content Assays for Hepatotoxicity Using Induced Pluripotent Stem Cell–Derived Cells

(2013) Oksana Sirenko et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

Physiologically relevant organs on chips

(2013) Kyungsuk Yum et al.   Biotechnology Journal

The Liver Toxicity Knowledge Base: A Systems Approach to a Complex End Point

(2013) M Chen et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Mechanisms of Drug-induced Liver Injury

(2013) Liyun Yuan et al.   Clinics in Liver Disease

Three-dimensional culture and cAMP signaling promote the maturation of human pluripotent stem cell-derived hepatocytes

(2013) S. Ogawa et al.   DEVELOPMENT

Long-Term Stability of Primary Rat Hepatocytes in Micropatterned Cocultures

(2013) Okechukwu Ukairo et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Vascularized and functional human liver from an iPSC-derived organ bud transplant

(2013) Takanori Takebe et al.   NATURE

Human induced pluripotent stem cells and their use in drug discovery for toxicity testing

(2013) Clay W Scott et al.   TOXICOLOGY LETTERS

Developing High-Fidelity Hepatotoxicity Models From Pluripotent Stem Cells

(2013) Claire N. Medine et al.   Stem Cells Translational Medicine

The promotion of hepatic maturation of human pluripotent stem cells in 3D co-culture using type I collagen and Swiss 3T3 cell sheets

(2012) Yasuhito Nagamoto et al.   BIOMATERIALS

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

(2012) Kazuo Takayama et al.   BIOMATERIALS

Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins

(2012) H. H. J. Gerets et al.   CELL BIOLOGY AND TOXICOLOGY

Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans

(2012) Salman R. Khetani et al.   TOXICOLOGICAL SCIENCES

Development of a Multiparametric Cell-based Protocol to Screen and Classify the Hepatotoxicity Potential of Drugs

(2012) Laia Tolosa et al.   TOXICOLOGICAL SCIENCES

Deconstructing the Drug Development Process: The New Face of Innovation

(2010) K I Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

(2010) W. W. Wang et al.   DRUG METABOLISM AND DISPOSITION

Oxygen-mediated enhancement of primary hepatocyte metabolism, functional polarization, gene expression, and drug clearance

(2009) S. Kidambi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical mechanisms in drug-induced liver injury: Certainties and doubts

(2009) Ignazio Grattagliano et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cellular Imaging Predictions of Clinical Drug-Induced Liver Injury

(2008) Jinghai J. Xu et al.   TOXICOLOGICAL SCIENCES