Regulation of tumor cell migration and invasion by the H19/let-7 axis is antagonized by metformin-induced DNA methylation

Long non-coding RNA H19 increases bladder cancer metastasis by associating with EZH2 and inhibiting E-cadherin expression

(2013) Ming Luo et al.   CANCER LETTERS

MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3

(2013) Bingtian Zhao et al.   CANCER LETTERS

HMGA2 Is a Driver of Tumor Metastasis

(2013) A. Morishita et al.   CANCER RESEARCH

Metformin targets c-MYC oncogene to prevent prostate cancer

(2013) Tunde Akinyeke et al.   CARCINOGENESIS

Meta-analysis of transcriptome reveals let-7b as an unfavorable prognostic biomarker and predicts molecular and clinical subclasses in high-grade serous ovarian carcinoma

(2013) Zhiqun Tang et al.   INTERNATIONAL JOURNAL OF CANCER

The Increasing Complexity of the Oncofetal H19 Gene Locus: Functional Dissection and Therapeutic Intervention

(2013) Imad Matouk et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential applications for biguanides in oncology

(2013) Michael Pollak   JOURNAL OF CLINICAL INVESTIGATION

Metformin Blocks Melanoma Invasion and Metastasis Development in AMPK/p53-Dependent Manner

(2013) M. Cerezo et al.   MOLECULAR CANCER THERAPEUTICS

The Imprinted H19 LncRNA Antagonizes Let-7 MicroRNAs

(2013) Amanda N. Kallen et al.   MOLECULAR CELL

Zbtb7a suppresses prostate cancer through repression of a Sox9-dependent pathway for cellular senescence bypass and tumor invasion

(2013) Guocan Wang et al.   NATURE GENETICS

miR-26a enhances miRNA biogenesis by targeting Lin28B and Zcchc11 to suppress tumor growth and metastasis

(2013) X Fu et al.   ONCOGENE

Stat3-coordinated Lin-28–let-7–HMGA2 and miR-200–ZEB1 circuits initiate and maintain oncostatin M-driven epithelial–mesenchymal transition

(2013) L Guo et al.   ONCOGENE

Metformin Downregulates the Insulin/IGF-I Signaling Pathway and Inhibits Different Uterine Serous Carcinoma (USC) Cells Proliferation and Migration in p53-Dependent or -Independent Manners

(2013) Rive Sarfstein et al.   PLoS One

Low Concentrations of Metformin Selectively Inhibit CD133+ Cell Proliferation in Pancreatic Cancer and Have Anticancer Action

(2013) Shanmiao Gou et al.   PLoS One

HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis

(2013) M. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Landscape of somatic single-nucleotide and copy-number mutations in uterine serous carcinoma

(2013) S. Zhao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metformin and Cancer Stem Cells: Old Drug, New Targets

(2012) F. Bednar et al.   Cancer Prevention Research

Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma

(2012) Ling Zhang et al.   CARCINOGENESIS

Lin28 regulates HER2 and promotes malignancy through multiple mechanisms

(2012) Chen Feng et al.   CELL CYCLE

Metformin selectively affects human glioblastoma tumor-initiating cell viability

(2012) Roberto Würth et al.   CELL CYCLE

Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?

(2012) Jessica L. Bell et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The let-7–Imp axis regulates ageing of the Drosophila testis stem-cell niche

(2012) Hila Toledano et al.   NATURE

The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

(2012) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

(2012) Dennis R Grayson et al.   NEUROPSYCHOPHARMACOLOGY

Constitutive proteasomal degradation of TWIST-1 in epithelial–ovarian cancer stem cells impacts differentiation and metastatic potential

(2012) G Yin et al.   ONCOGENE

Regulation of IMP3 by EGFR signaling and repression by ERβ: implications for triple-negative breast cancer

(2012) S Samanta et al.   ONCOGENE

How does Lin28 let-7 control development and disease?

(2012) James E. Thornton et al.   TRENDS IN CELL BIOLOGY

A mirror of two faces: Lin28 as a master regulator of both miRNA and mRNA

(2012) Yingqun Huang   Wiley Interdisciplinary Reviews-RNA

Metformin Inhibits Cell Proliferation, Migration and Invasion by Attenuating CSC Function Mediated by Deregulating miRNAs in Pancreatic Cancer Cells

(2011) B. Bao et al.   Cancer Prevention Research

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Pivotal Role of Reduced let-7g Expression in Breast Cancer Invasion and Metastasis

(2011) P. Qian et al.   CANCER RESEARCH

The Lin28/let-7 Axis Regulates Glucose Metabolism

(2011) Hao Zhu et al.   CELL

Signalling pathway for RKIP and Let-7 regulates and predicts metastatic breast cancer

(2011) Jieun Yun et al.   EMBO JOURNAL

Insulin Growth Factor-2 Binding Protein 3 (IGF2BP3) Is a Glioblastoma-specific Marker That Activates Phosphatidylinositol 3-Kinase/Mitogen-activated Protein Kinase (PI3K/MAPK) Pathways by Modulating IGF-2

(2011) Ramaswamy Suvasini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of microRNA let-7 and effect to HMGA2 in esophageal squamous cell carcinoma

(2011) Qing Liu et al.   MOLECULAR BIOLOGY REPORTS

Breast cancer genome-wide association studies: there is strength in numbers

(2011) D Fanale et al.   ONCOGENE

The H19 locus: Role of an imprinted non-coding RNA in growth and development

(2010) Anne Gabory et al.   BIOESSAYS

Let-7a regulation of insulin-like growth factors in breast cancer

(2010) Lingeng Lu et al.   BREAST CANCER RESEARCH AND TREATMENT

Metformin, Independent of AMPK, Inhibits mTORC1 in a Rag GTPase-Dependent Manner

(2010) Adem Kalender et al.   Cell Metabolism

Metformin Selectively Targets Cancer Stem Cells, and Acts Together with Chemotherapy to Block Tumor Growth and Prolong Remission

(2009) H. A. Hirsch et al.   CANCER RESEARCH

Oncofetal H19-derived miR-675 regulates tumor suppressor RB in human colorectal cancer

(2009) Wing Pui Tsang et al.   CARCINOGENESIS

Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7

(2009) Surabhi Dangi-Garimella et al.   EMBO JOURNAL

IMP3 is a novel biomarker for triple negative invasive mammary carcinoma associated with a more aggressive phenotype

(2009) Otto Walter et al.   HUMAN PATHOLOGY

Biomarkers for epithelial-mesenchymal transitions

(2009) Michael Zeisberg et al.   JOURNAL OF CLINICAL INVESTIGATION

let-7 regulates Dicer expression and constitutes a negative feedback loop

(2008) Shogo Tokumaru et al.   CARCINOGENESIS

RNA-binding protein insulin-like growth factor II mRNA-binding protein 3 expression promotes tumor invasion and predicts early recurrence and poor prognosis in hepatocellular carcinoma

(2008) Yung-Ming Jeng et al.   HEPATOLOGY

Transient cyclical methylation of promoter DNA

(2008) Sara Kangaspeska et al.   NATURE

A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence

(2008) J. J. Forman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The H19 locus acts in vivo as a tumor suppressor

(2008) T. Yoshimizu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The let-7 family of microRNAs

(2008) Sarah Roush et al.   TRENDS IN CELL BIOLOGY