The Dynamics of DNA Methylation in Schizophrenia and Related Psychiatric Disorders

DNA Methylation Signatures in Development and Aging of the Human Prefrontal Cortex

(2012) Shusuke Numata et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Schizophrenia Genetics: Putting All the Pieces Together

(2012) Simon L. Girard et al.   Current Neurology and Neuroscience Reports

Schizophrenia genetics: progress, at last

(2012) Jennifer Gladys Mulle   CURRENT OPINION IN GENETICS & DEVELOPMENT

Cognitive Impairments in Schizophrenia and Schizoaffective Disorder

(2012) Minna Torniainen et al.   JOURNAL OF NERVOUS AND MENTAL DISEASE

Recognition and potential mechanisms for replication and erasure of cytosine hydroxymethylation

(2012) Hideharu Hashimoto et al.   NUCLEIC ACIDS RESEARCH

DNMT1 modulates gene expression without its catalytic activity partially through its interactions with histone-modifying enzymes

(2012) Eriko G. Clements et al.   NUCLEIC ACIDS RESEARCH

Cognitive endophenotypes of psychosis within dimension and diagnosis

(2012) Elena I. Ivleva et al.   PSYCHIATRY RESEARCH

Quantitative Sequencing of 5-Methylcytosine and 5-Hydroxymethylcytosine at Single-Base Resolution

(2012) M. J. Booth et al.   SCIENCE

The Genetic Architecture of Schizophrenia: New Mutations and Emerging Paradigms

(2011) Laura Rodriguez-Murillo et al.   Annual Review of Medicine

The presence of 5-hydroxymethylcytosine at the gene promoter and not in the gene body negatively regulates gene expression

(2011) Julia Robertson et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Targeting the nicotinic alpha7 acetylcholine receptor to enhance cognition in disease

(2011) Tanya L. Wallace et al.   BIOCHEMICAL PHARMACOLOGY

Thymine DNA Glycosylase Is Essential for Active DNA Demethylation by Linked Deamination-Base Excision Repair

(2011) Salvatore Cortellino et al.   CELL

Hydroxylation of 5-Methylcytosine by TET1 Promotes Active DNA Demethylation in the Adult Brain

(2011) Junjie U. Guo et al.   CELL

Mbd3/NURD Complex Regulates Expression of 5-Hydroxymethylcytosine Marked Genes in Embryonic Stem Cells

(2011) Ozlem Yildirim et al.   CELL

DNA Demethylation Dynamics

(2011) Nidhi Bhutani et al.   CELL

Regulation of chromatin by histone modifications

(2011) Andrew J Bannister et al.   CELL RESEARCH

The Role of Antipsychotics in Smoking and Smoking Cessation

(2011) Annette M. Matthews et al.   CNS DRUGS

DNA methylation: TET proteins—guardians of CpG islands?

(2011) Kristine Williams et al.   EMBO REPORTS

Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal CpG sequence coverage bias

(2011) Shalima S. Nair et al.   Epigenetics

Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation

(2011) H. Wu et al.   GENES & DEVELOPMENT

Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells

(2011) H. Wu et al.   GENES & DEVELOPMENT

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons

(2011) K. Iwamoto et al.   GENOME RESEARCH

Distinct DNA methylation changes highly correlated with chronological age in the human brain

(2011) Dena G. Hernandez et al.   HUMAN MOLECULAR GENETICS

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

(2011) Emma L. Dempster et al.   HUMAN MOLECULAR GENETICS

Effects of adjunct valproic acid on clinical symptoms and saccadic eye movements in schizophrenia

(2011) Abigail L. Larrison et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

DNA Methylation and Demethylation in Mammals

(2011) Zhao-xia Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Gadd45β is an inducible coactivator of transcription that facilitates rapid liver growth in mice

(2011) Jianmin Tian et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA methyltransferases1 (DNMT1) and 3a (DNMT3a) colocalize with GAD67-positive neurons in the GAD67-GFP mouse brain

(2011) Bashkim Kadriu et al.   JOURNAL OF COMPARATIVE NEUROLOGY

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells

(2011) Yufei Xu et al.   MOLECULAR CELL

Activation of Group II Metabotropic Glutamate Receptors Promotes DNA Demethylation in the Mouse Brain

(2011) F. Matrisciano et al.   MOLECULAR PHARMACOLOGY

5-Hydroxymethylcytosine: a new kid on the epigenetic block?

(2011) F. Matarese et al.   Molecular Systems Biology

TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity

(2011) Kristine Williams et al.   NATURE

Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells

(2011) William A. Pastor et al.   NATURE

Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation

(2011) Gabriella Ficz et al.   NATURE

Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells

(2011) Hao Wu et al.   NATURE

Exome sequencing supports a de novo mutational paradigm for schizophrenia

(2011) Bin Xu et al.   NATURE GENETICS

Increased exonic de novo mutation rate in individuals with schizophrenia

(2011) Simon L Girard et al.   NATURE GENETICS

Putting the DNA back into DNA methylation

(2011) Adrian Bird   NATURE GENETICS

Identification of genetic elements that autonomously determine DNA methylation states

(2011) Florian Lienert et al.   NATURE GENETICS

Sensitive and specific single-molecule sequencing of 5-hydroxymethylcytosine

(2011) Chun-Xiao Song et al.   NATURE METHODS

Neuronal activity modifies the DNA methylation landscape in the adult brain

(2011) Junjie U Guo et al.   NATURE NEUROSCIENCE

5-hmC–mediated epigenetic dynamics during postnatal neurodevelopment and aging

(2011) Keith E Szulwach et al.   NATURE NEUROSCIENCE

High Frequencies of De Novo CNVs in Bipolar Disorder and Schizophrenia

(2011) Dheeraj Malhotra et al.   NEURON

GABAergic interneuron origin of schizophrenia pathophysiology

(2011) Kazu Nakazawa et al.   NEUROPHARMACOLOGY

Mouse models of genetic effects on cognition: Relevance to schizophrenia

(2011) Francesco Papaleo et al.   NEUROPHARMACOLOGY

Selective α4β2 Nicotinic Acetylcholine Receptor Agonists Target Epigenetic Mechanisms in Cortical GABAergic Neurons

(2011) Ekrem Maloku et al.   NEUROPSYCHOPHARMACOLOGY

Growth Arrest and DNA-Damage-Inducible, Beta (GADD45b)-Mediated DNA Demethylation in Major Psychosis

(2011) David P Gavin et al.   NEUROPSYCHOPHARMACOLOGY

Pharmacological Activation of Group-II Metabotropic Glutamate Receptors Corrects a Schizophrenia-Like Phenotype Induced by Prenatal Stress in Mice

(2011) Francesco Matrisciano et al.   NEUROPSYCHOPHARMACOLOGY

Epigenetic Treatments for Cognitive Impairments

(2011) Jeremy J Day et al.   NEUROPSYCHOPHARMACOLOGY

Broad Epigenetic Signature of Maternal Care in the Brain of Adult Rats

(2011) Patrick O. McGowan et al.   PLoS One

Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1

(2011) Carina Frauer et al.   PLoS One

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

(2011) K. Takeshita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria

(2011) Lisa S. Shock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Folate supplementation in schizophrenia: A possible role for MTHFR genotype

(2011) Michele Hill et al.   SCHIZOPHRENIA RESEARCH

A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: The Schizo-Bipolar Scale

(2011) Matcheri S. Keshavan et al.   SCHIZOPHRENIA RESEARCH

Challenges of Analysing Gene-Environment Interactions in Mouse Models of Schizophrenia

(2011) Peter L. Oliver   TheScientificWorldJOURNAL

Neuronal Activity-Regulated Gene Transcription in Synapse Development and Cognitive Function

(2011) A. E. West et al.   Cold Spring Harbor Perspectives in Biology

Can the schizophrenia epigenome provide clues for the molecular basis of pathogenesis?

(2011) Hamid M Abdolmaleky et al.   Epigenomics

The structural basis for selective binding of non-methylated CpG islands by the CFP1 CXXC domain

(2011) Chao Xu et al.   Nature Communications

Integrating 5-Hydroxymethylcytosine into the Epigenomic Landscape of Human Embryonic Stem Cells

(2011) Keith E. Szulwach et al.   PLoS Genetics

5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells

(2011) Hume Stroud et al.   GENOME BIOLOGY

Loss of Reelin Expression in Breast Cancer Is Epigenetically Controlled and Associated with Poor Prognosis

(2010) Torsten Stein et al.   AMERICAN JOURNAL OF PATHOLOGY

Expression of Interneuron Markers in the Dorsolateral Prefrontal Cortex of the Developing Human and in Schizophrenia

(2010) Samantha J. Fung et al.   AMERICAN JOURNAL OF PSYCHIATRY

Reduced Expression of Reelin (RELN) Gene Is Associated With High Recurrence Rate of Hepatocellular Carcinoma

(2010) Yukiyasu Okamura et al.   ANNALS OF SURGICAL ONCOLOGY

Retardation of neurobehavioral development and reelin down-regulation regulated by further DNA methylation in the hippocampus of the rat pups are associated with maternal deprivation

(2010) Lina Qin et al.   BEHAVIOURAL BRAIN RESEARCH

Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain

(2010) Michael J. Morris et al.   BEHAVIOURAL PHARMACOLOGY

Epigenetic Studies of Psychosis: Current Findings, Methodological Approaches, and Implications for Postmortem Research

(2010) Ruth Pidsley et al.   BIOLOGICAL PSYCHIATRY

A Randomized Clinical Trial of MK-0777 for the Treatment of Cognitive Impairments in People with Schizophrenia

(2010) Robert W. Buchanan et al.   BIOLOGICAL PSYCHIATRY

Mouse behavioral endophenotypes for schizophrenia

(2010) Laura C. Amann et al.   BRAIN RESEARCH BULLETIN

DNA excision repair proteins and Gadd45 as molecular players for active DNA demethylation

(2010) Dengke K. Ma et al.   CELL CYCLE

TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine

(2010) Haikuo Zhang et al.   CELL RESEARCH

Depolarization induces downregulation of DNMT1 and DNMT3 in primary cortical cultures

(2010) Rajiv P. Sharma et al.   Epigenetics

From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia

(2010) Dennis R. Grayson et al.   Epigenetics

Valproate induces DNA demethylation in nuclear extracts from adult mouse brain

(2010) Erbo Dong et al.   Epigenetics

Cytidine deaminases: AIDing DNA demethylation?

(2010) E. L. Fritz et al.   GENES & DEVELOPMENT

Maternal Care and DNA Methylation of a Glutamic Acid Decarboxylase 1 Promoter in Rat Hippocampus

(2010) T.-Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Hyperhomocysteinemia does not affect global DNA methylation and nicotinamide N-methyltransferase expression in mice

(2010) Anna Bromberg et al.   JOURNAL OF PSYCHOPHARMACOLOGY

CpG Islands Recruit a Histone H3 Lysine 36 Demethylase

(2010) Neil P. Blackledge et al.   MOLECULAR CELL

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

(2010) John P. Thomson et al.   NATURE

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

(2010) Hsiao-Tuan Chao et al.   NATURE

Direct detection of DNA methylation during single-molecule, real-time sequencing

(2010) Benjamin A Flusberg et al.   NATURE METHODS

Analysis of the GAD1 promoter: Trans-acting factors and DNA methylation converge on the 5′ untranslated region

(2010) Ying Chen et al.   NEUROPHARMACOLOGY

Epigenetic GABAergic targets in schizophrenia and bipolar disorder

(2010) A. Guidotti et al.   NEUROPHARMACOLOGY

DNA Methylation Regulates Cocaine-Induced Behavioral Sensitization in Mice

(2010) Kaili Anier et al.   NEUROPSYCHOPHARMACOLOGY

Neocortical RELN promoter methylation increases significantly after puberty

(2010) Carla Lintas et al.   NEUROREPORT

L-methionine decreases dendritic spine density in mouse frontal cortex

(2010) Patricia Tueting et al.   NEUROREPORT

Identification of preferential target sites for human DNA methyltransferases

(2010) Si Ho Choi et al.   NUCLEIC ACIDS RESEARCH

Chromatin methylation activity of Dnmt3a and Dnmt3a/3L is guided by interaction of the ADD domain with the histone H3 tail

(2010) Yingying Zhang et al.   NUCLEIC ACIDS RESEARCH

The treatment of cognitive impairment in schizophrenia

(2010) Donald C. Goff et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

De novo mutations in the gene encoding the synaptic scaffolding proteinSHANK3in patients ascertained for schizophrenia

(2010) Julie Gauthier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone modification levels are predictive for gene expression

(2010) R. Karlic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The environment and susceptibility to schizophrenia

(2010) Alan S. Brown   PROGRESS IN NEUROBIOLOGY

Evolution of neuropsychological dysfunction during the course of schizophrenia and bipolar disorder

(2010) K. E. Lewandowski et al.   PSYCHOLOGICAL MEDICINE

Prenatal stress: Role in psychotic and depressive diseases

(2010) Julie A. Markham et al.   PSYCHOPHARMACOLOGY

Maternal Infection and Schizophrenia: Implications for Prevention

(2010) A. S. Brown et al.   SCHIZOPHRENIA BULLETIN

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

Targeting the correct HDAC(s) to treat cognitive disorders

(2010) André Fischer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular coupling of DNA methylation and histone methylation

(2010) Hideharu Hashimoto et al.   Epigenomics

Epigenetic mechanisms in schizophrenia

(2009) Tania L. Roth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The Role of DNA Copy Number Variation in Schizophrenia

(2009) Gloria W.C. Tam et al.   BIOLOGICAL PSYCHIATRY

The current structural and functional understanding of APOBEC deaminases

(2009) Ronda Bransteitter et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Structural basis for recognition of H3K4 methylation status by the DNA methyltransferase 3A ATRX–DNMT3–DNMT3L domain

(2009) Junji Otani et al.   EMBO REPORTS

Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain

(2009) Karin Fellinger et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

CG dinucleotide periodicities recognized by the Dnmt3a–Dnmt3L complex are distinctive at retroelements and imprinted domains

(2009) Jacob L. Glass et al.   MAMMALIAN GENOME

Is There a Future for Histone Deacetylase Inhibitors in the Pharmacotherapy of Psychiatric Disorders?

(2009) D. R. Grayson et al.   MOLECULAR PHARMACOLOGY

HDAC2 negatively regulates memory formation and synaptic plasticity

(2009) Ji-Song Guan et al.   NATURE

The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores

(2009) Rafael A Irizarry et al.   NATURE GENETICS

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

Dynamic DNA methylation programs persistent adverse effects of early-life stress

(2009) Chris Murgatroyd et al.   NATURE NEUROSCIENCE

Shared genetics of bipolar disorder and schizophrenia

(2009) James B. Potash et al.   Nature Reviews Neurology

Epigenetic Profiling in Schizophrenia and Major Mental Disorders

(2009) Kazuya Iwamoto et al.   NEUROPSYCHOBIOLOGY

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars

(2009) Francine M. Benes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders

(2009) B. P. F. Rutten et al.   SCHIZOPHRENIA BULLETIN

Neurocognitive Dysfunction in Bipolar and Schizophrenia Spectrum Disorders Depends on History of Psychosis Rather Than Diagnostic Group

(2009) C. Simonsen et al.   SCHIZOPHRENIA BULLETIN

An upregulation of DNA-methyltransferase 1 and 3a expressed in telencephalic GABAergic neurons of schizophrenia patients is also detected in peripheral blood lymphocytes

(2009) A. Zhubi et al.   SCHIZOPHRENIA RESEARCH

Neuronal Activity-Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis

(2009) D. K. Ma et al.   SCIENCE

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

(2009) M. Tahiliani et al.   SCIENCE

The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain

(2009) S. Kriaucionis et al.   SCIENCE

One-carbon metabolism and schizophrenia: current challenges and future directions

(2009) M.O. Krebs et al.   TRENDS IN MOLECULAR MEDICINE

Antipsychotic subtypes can be characterized by differences in their ability to modify GABAergic promoter methylation

(2009) Erbo Dong et al.   Epigenomics

Epigenomic Profiling Reveals DNA-Methylation Changes Associated with Major Psychosis

(2008) Jonathan Mill et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Subunit-Selective Modulation of GABA Type A Receptor Neurotransmission and Cognition in Schizophrenia

(2008) David A. Lewis et al.   AMERICAN JOURNAL OF PSYCHIATRY

Epigenetics, DNA Methylation, and Chromatin Modifying Drugs

(2008) Moshe Szyf   Annual Review of Pharmacology and Toxicology

CXXC Domain of Human DNMT1 Is Essential for Enzymatic Activity

(2008) Mihika Pradhan et al.   BIOCHEMISTRY

The Colorful History of Active DNA Demethylation

(2008) Steen K.T. Ooi et al.   CELL

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

(2008) Kunal Rai et al.   CELL

GABAergic promoter hypermethylation as a model to study the neurochemistry of schizophrenia vulnerability

(2008) Erminio Costa et al.   Expert Review of Neurotherapeutics

Marking time: The dynamic role of chromatin and covalent modification in transcription

(2008) George Reid et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The effects of pH on DNA methylation state: In vitro and post-mortem brain studies

(2008) Carl Ernst et al.   JOURNAL OF NEUROSCIENCE METHODS

The Reelin and GAD67 Promoters Are Activated by Epigenetic Drugs That Facilitate the Disruption of Local Repressor Complexes

(2008) M. Kundakovic et al.   MOLECULAR PHARMACOLOGY

Cyclical DNA methylation of a transcriptionally active promoter

(2008) Raphaël Métivier et al.   NATURE

Transient cyclical methylation of promoter DNA

(2008) Sara Kangaspeska et al.   NATURE

The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation

(2008) Jing Wang et al.   NATURE GENETICS

Divalproex ER Combined with Olanzapine or Risperidone for Treatment of Acute Exacerbations of Schizophrenia

(2008) Daniel E Casey et al.   NEUROPSYCHOPHARMACOLOGY

The role of psychiatric disorders in the relationship between cigarette smoking and DSM-IV nicotine dependence among young adults

(2008) Lisa Dierker et al.   NICOTINE & TOBACCO RESEARCH

Tobacco use and cessation in psychiatric disorders: National Institute of Mental Health report

(2008) D. Ziedonis et al.   NICOTINE & TOBACCO RESEARCH

Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethylation

(2008) E. Dong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons

(2008) R. Satta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gene-Environment Interaction and Covariation in Schizophrenia: The Role of Obstetric Complications

(2008) V. A. Mittal et al.   SCHIZOPHRENIA BULLETIN

GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia

(2008) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

No association between global leukocyte DNA methylation and homocysteine levels in schizophrenia patients

(2008) A. Bromberg et al.   SCHIZOPHRENIA RESEARCH

Methylation Status of the Reelin Promoter Region in the Brain of Schizophrenic Patients

(2007) Mamoru Tochigi et al.   BIOLOGICAL PSYCHIATRY