Metformin targets c-MYC oncogene to prevent prostate cancer

Amplitude modulation of androgen signaling by c-MYC

(2013) M. Ni et al.   GENES & DEVELOPMENT

Metformin induces differentiation in acute promyelocytic leukemia by activating the MEK/ERK signaling pathway

(2012) Lei Huai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation

(2012) Arron Sikka et al.   CELL CYCLE

Metformin, an Antidiabetic Agent Reduces Growth of Cutaneous Squamous Cell Carcinoma by Targeting mTOR Signaling Pathway†

(2012) Sandeep C. Chaudhary et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Metformin enhances the antiproliferative and apoptotic effect of bicalutamide in prostate cancer

(2012) A J Colquhoun et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Therapeutic metformin/AMPK activation blocked lymphoma cell growth via inhibition of mTOR pathway and induction of autophagy

(2012) W-Y Shi et al.   Cell Death & Disease

Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC

(2012) Giovanni Blandino et al.   Nature Communications

Metformin Induces G1 Cell Cycle Arrest and Inhibits Cell Proliferation in Nasopharyngeal Carcinoma Cells

(2011) Li Zhao et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy

(2011) Jenny P. Nobes et al.   BJU INTERNATIONAL

Metformin and the Incidence of Prostate Cancer in Patients with Type 2 Diabetes

(2011) L. Azoulay et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Metformin, Independent of AMPK, Induces mTOR Inhibition and Cell-Cycle Arrest through REDD1

(2011) I. Ben Sahra et al.   CANCER RESEARCH

Phosphorylation Regulates c-Myc's Oncogenic Activity in the Mammary Gland

(2011) X. Wang et al.   CANCER RESEARCH

The antidiabetic drug metformin suppresses HER2 (erbB-2) oncoprotein overexpression via inhibition of the mTOR effector p70S6K1 in human breast carcinoma cells

(2011) Alejandro Vazquez-Martin et al.   CELL CYCLE

New Hormonal Therapies for Castration-Resistant Prostate Cancer

(2011) Elahe A. Mostaghel et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors

(2011) Nicola J. Clegg et al.   PLoS One

The combination of metformin and 2 deoxyglucose inhibits autophagy and induces AMPK-dependent apoptosis in prostate cancer cells

(2010) Issam Ben Sahra et al.   Autophagy

Cancer Statistics, 2010

(2010) A. Jemal et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

(2010) I. Ben Sahra et al.   CANCER RESEARCH

Inhibitory effects of megakaryocytic cells in prostate cancer skeletal metastasis

(2010) Xin Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

MYC Overexpression Induces Prostatic Intraepithelial Neoplasia and Loss of Nkx3.1 in Mouse Luminal Epithelial Cells

(2010) Tsuyoshi Iwata et al.   PLoS One

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

(2010) E. Kickstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities

(2009) C. V. Dang et al.   CLINICAL CANCER RESEARCH

The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc

(2009) Hugh K Arnold et al.   EMBO JOURNAL

Nuclear MYC protein overexpression is an early alteration in human prostate carcinogenesis

(2008) Bora Gurel et al.   MODERN PATHOLOGY

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE