Article
Cardiac & Cardiovascular Systems
Ting-Ting Zhang, Qing-Qing Lei, Jie He, Xin Guan, Xin Zhang, Ying Huang, Zi-Yue Zhou, Rui-Xin Fan, Ting Wang, Chen-Xi Li, Jin-Yan Shang, Zhuo-Miao Lin, Wan-Li Peng, Li-Kai Xia, Yu-Ling He, Chuan-Ying Hong, Jing-Song Ou, Rui-Ping Pang, Xiao-Ping Fan, Hui Huang, Jia-Guo Zhou
Summary: This study reveals that Best3 mutation, which mainly acts in blood vessels, leads to aortic dissection by regulating the degradation of MEKK2/3, controlling smooth muscle cell phenotypic switch, and maintaining the structural integrity of the aorta. This provides a new therapeutic target for the treatment of aortic dissection.
Article
Peripheral Vascular Disease
Mohammad Shafid, Kumaravelu Jagavelu, Hina Iqbal, Pankaj Yadav, Debabrata Chanda, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: MK2 plays a significant role in pulmonary hypertension, and its inhibition may be a novel target for PH treatment. Inhibition of MK2 alleviated right ventricle pressure and hypertrophy in PH rats, improved cardiac function, reversed pulmonary vascular remodeling, and enhanced pulmonary vascular relaxation.
Review
Biochemistry & Molecular Biology
Hong-Beom Park, Kwang-Hyun Baek
Summary: This review summarizes the role and mechanisms of MAPK signaling pathways in cancer, as well as the functions of E3 ligases and DUBs targeting MAPK signaling components.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Immunology
Negar Farzam-kia, Ana Carmena Moratalla, Florent Lemaitre, Annie Levert, Sandra Da Cal, Clara Margarido, Yves Carpentier Solorio, Nathalie Arbour
Summary: GM-CSF induces differential responses in human monocytes and monocyte-derived macrophages, including changes in expression of immune mediators and surface markers. The ERK1/2 pathway plays a significant role in these effects.
IMMUNOLOGY LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Jin Hee Kim, In Gyoung Ju, Namkwon Kim, Eugene Huh, So-Ri Son, Joon Pyo Hong, Yujin Choi, Dae Sik Jang, Myung Sook Oh
Summary: This study aimed to investigate the anti-neuroinflammatory effects of yomogin, isolated from Artemisia iwayomogi. The results showed that yomogin suppressed neuroinflammatory factors and regulated the MAPK pathway, suggesting its potential as a therapeutic candidate for inflammation-mediated neurological diseases.
Article
Oncology
Junpeng Cui, Yang Ge, Wei Sun, Baolin Liu, Chaoliu Dai
Summary: This study investigated the expression and function of CgB in colonic neuroendocrine carcinoma (NEC). It was found that the expression of CgB was significantly upregulated in colonic NEC tissues and promoted cell invasion, migration, as well as epithelial mesenchymal transition (EMT) and stemness. Mechanistically, CgB overexpression activated p38 MAPK and ERK pathways. Overall, CgB contributes to the development of colonic NEC by activating p38 MAPK and ERK pathways.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Plant Sciences
Zahra Ayatollahi, Vaiva Kazanaviciute, Volodymyr Shubchynskyy, Kotryna Kvederaviciute, Manfred Schwanninger, Wilfried Rozhon, Michael Stumpe, Felix Mauch, Sebastian Bartels, Roman Ulm, Salma Balazadeh, Bernd Mueller-Roeber, Irute Meskiene, Alois Schweighofer
Summary: This study reveals the crucial role of different types of MAPK phosphatases in plant stress responses and the tight control of MAPK activities.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Cell Biology
Xiaochen Li, Xiaopei Cao, Hanqiu Zhao, Mingzhou Guo, Xiaoyu Fang, Ke Li, Lu Qin, Yuanzhou He, Xiansheng Liu
Summary: Hypoxia activates the Notch4-ERK/JNK/P38 MAPK signaling pathway to promote the proliferation, migration, and anti-apoptotic effects of LUAD cells. Notch4 plays a key role in the growth and metastasis of LUAD. Inhibitors of ERK, JNK, and P38 can partially reverse the effects of Notch4.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Food Science & Technology
Yue Zhao, Qingqing Jiang, Limin Guo, Daming Fan, Mingfu Wang, Yueliang Zhao
Summary: Glycidol is a food contaminant found in refined edible oils and various thermally processed foods, which induces cell cycle arrest, apoptosis, and autophagy in HUVECs. The toxicity effects of glycidol are mediated through activation of the ERK/JNK/p38 signaling pathways, and these effects can be attenuated by apigenin-7 (API-C8) through inhibition of the same pathways.
CURRENT RESEARCH IN FOOD SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Yoshiaki Soejima, Nahoko Iwata, Yasuhiro Nakano, Koichiro Yamamoto, Atsuhito Suyama, Takahiro Nada, Fumio Otsuka
Summary: The study examined the roles of Clock genes and BMP system in regulating gonadotropin secretion by GnRH using mouse L beta T2 cells. The results showed that LH beta mRNA expression in L beta T2 cells changed over time and was influenced by Bmal1 and Clock. ERK and BMPs were found to be involved in the regulation of LH beta mRNA expression at different stages after GnRH stimulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Geriatrics & Gerontology
Li Wei, Yupeng Du, Yirui Xie, Xiaopeng Yu, Hui Chen, Yunqing Qiu
Summary: The study revealed that hippocampal microglia are activated during poststroke depression (PSD), and LCN2 may regulate hippocampal microglial activation by the P38 MAPK pathway in the process of PSD.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Meijuan Meng, Xuerui Li, Ran Huo, Nana Ma, Guangjun Chang, Xiangzhen Shen
Summary: This experiment investigated the effects of a high-concentrate diet on mammary gland inflammation and mitochondrial damage in dairy cows. The results showed that the high-concentrate diet induced inflammation in the mammary gland, increased the concentration of Ca2+, upregulated the expression of inflammatory factors, and caused mitochondrial dysfunction via activation of the mitochondrial-associated signaling pathway.
JOURNAL OF DAIRY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Emma Marie Wilber Hepworth, Shanta D. Hinton
Summary: MAPK signaling pathways are crucial regulators of eukaryotic cell function, with kinases and phosphatases controlling the activation and inhibition of MAPK. Pseudoenzymes also play a significant role in regulating these pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Jun Yu, Yibo Wu, Hong Li, Hui Zhou, Cong Shen, Tingting Gao, Meng Lin, Xiuliang Dai, Jian Ou, Meiling Liu, Xiaoyan Huang, Bo Zheng, Fei Sun
Summary: The study identified BMI1 as a positive regulator of testosterone production, with the mechanism involving BMI1-mediated gene silencing to inhibit the p38 MAPK pathway and promote steroidogenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Matthaeus Metz, James O'Hare, Bob Cheng, Michelle Puchowicz, Christoph Buettner, Thomas Scherer
Summary: In this study, the role of brain insulin signaling in regulating lipolysis was further characterized. It was found that intact hypothalamic MAPK signaling is required for insulin to suppress adipose tissue lipolysis.
MOLECULAR METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Zahid Nawaz, Vikas Patil, Yashna Paul, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh, Kumaravel Somasundaram
Article
Multidisciplinary Sciences
Dinorah Friedmann-Morvinski, Rajesh Narasimamurthy, Yifeng Xia, Chad Myskiw, Yasushi Soda, Inder M. Verma
Article
Oncology
Zahid Nawaz, Vikas Patil, Sivaarumugam Thinagararjan, Soumya A. Rao, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh, Kumaravel Somasundaram
MOLECULAR ONCOLOGY
(2017)
Correction
Multidisciplinary Sciences
Lilach Agemy, Dinorah Friedmann-Morvinski, Venkata Ramana Kotamraju, Lise Roth, Kazuki N. Sugahara, Olivier M. Girard, Robert F. Mattrey, Inder M. Verma, Erkki Ruoslahti
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2014)
Article
Cell Biology
Rafi Mazor, Dinorah Friedmann-Morvinski, Tom Alsaigh, Oded Kleifeld, Erik B. Kistler, Liat Rousso-Noori, Cheng Huang, Joyce B. Li, Inder M. Verma, Geert W. Schmid-Schonbein
SCIENCE TRANSLATIONAL MEDICINE
(2018)
Article
Multidisciplinary Sciences
Zahid Nawaz, Vikas Patil, Anjali Arora, Alangar S. Hegde, Arimappamagan Arivazhagan, Vani Santosh, Kumaravel Somasundaram
SCIENTIFIC REPORTS
(2016)
Article
Chemistry, Multidisciplinary
Dnyaneshwar Kand, Lorena Pizarro, Inbar Angel, Adi Avni, Dinorah Friedmann-Morvinski, Roy Weinstain
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2019)
Article
Biochemistry & Molecular Biology
Inbar Angel, Ori Pilo Kerman, Liat Rousso-Noori, Dinorah Friedmann-Morvinski
Article
Biochemistry & Molecular Biology
Florian Schmidt, Bobby Ranjan, Quy Xiao Xuan Lin, Vaidehi Krishnan, Ignasius Joanito, Mohammad Amin Honardoost, Zahid Nawaz, Prasanna Nori Venkatesh, Joanna Tan, Nirmala Arul Rayan, Sin Tiong Ong, Shyam Prabhakar
Summary: The transcriptomic diversity of cell types in the human body can be analyzed in unprecedented detail using single cell technologies. Supervised clustering techniques, such as RCA2, show robustness to batch effects and data quality artifacts, providing a more accurate and stable method for defining cell types. RCA2 combines reference projection with graph-based clustering, offering new reference panels and a user-friendly framework for downstream analysis.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Multidisciplinary Sciences
Liat Rousso-Noori, Ignacio Mastandrea, Shauli Talmor, Tova Waks, Anat Globerson Levin, Maarja Haugas, Tambet Teesalu, Luis Alvarez-Vallina, Zelig Eshhar, Dinorah Friedmann-Morvinski
Summary: Chimeric antigen receptor (CAR) T cell therapy targeting p32 shows promising anti-tumor responses by specifically recognizing and eliminating glioma cells and tumor derived endothelial cells in preclinical models. This may serve as a therapeutic option for glioblastoma patients.
NATURE COMMUNICATIONS
(2021)
Article
Biology
Shreoshi Sengupta, Mainak Mondal, Kaval Reddy Prasasvi, Arani Mukherjee, Prerna Magod, Serge Urbach, Dinorah Friedmann-Morvinski, Philippe Marin, Kumaravel Somasundaram
Summary: Non-CSCs form the majority of the tumor, and DGC-secreted FMOD promotes glioma tumor angiogenesis and growth through paracrine signaling in endothelial cells.
Article
Genetics & Heredity
Ignasius Joanito, Pratyaksha Wirapati, Nancy Zhao, Zahid Nawaz, Grace Yeo, Fiona Lee, Christine L. P. Eng, Dominique Camat Macalinao, Merve Kahraman, Harini Srinivasan, Vairavan Lakshmanan, Sara Verbandt, Petros Tsantoulis, Nicole Gunn, Prasanna Nori Venkatesh, Zhong Wee Poh, Rahul Nahar, Hsueh Ling Janice Oh, Jia Min Loo, Shumei Chia, Lih Feng Cheow, Elsie Cheruba, Michael Thomas Wong, Lindsay Kua, Clarinda Chua, Andy Nguyen, Justin Golovan, Anna Gan, Wan-Jun Lim, Yu Amanda Guo, Choon Kong Yap, Brenda Tay, Yourae Hong, Dawn Qingqing Chong, Aik-Yong Chok, Woong-Yang Park, Shuting Han, Mei Huan Chang, Isaac Seow-En, Cherylin Fu, Ronnie Mathew, Ee-Lin Toh, Lewis Z. Hong, Anders Jacobsen Skanderup, Ramanuj DasGupta, Chin-Ann Johnny Ong, Kiat Hon Lim, Emile K. W. Tan, Si-Lin Koo, Wei Qiang Leow, Sabine Tejpar, Shyam Prabhakar, Iain Beehuat Tan
Summary: This study classifies tumor cells into two epithelial subtypes in colorectal cancer patients through single-cell transcriptomic analysis, and reveals differences in activation of pathways and metastasis based on epithelial subtype, microsatellite stability, and fibrosis. The findings improve tumor classification and provide a better understanding of colorectal cancer. The two identified subtypes are validated in a larger cohort through bulk transcriptomic analysis, demonstrating their stability and feasibility. Furthermore, this study defines the intrinsic epithelial axis of colorectal cancer and proposes a refined classification method based on intrinsic epithelial subtype, microsatellite instability status, and fibrosis.
Article
Oncology
Ori Mayer, Joshua Bugis, Daria Kozlova, Aviv Leemann, Shahar Mansur, Ilan Peerutin, Noga Mendelovich, Meital Mazin, Dinorah Friedmann-Morvinski, Noam Shomron
Summary: This study investigates the role of palladin in glioma tumors. The findings suggest that palladin is overexpressed in adult gliomas and is associated with a worse prognosis. These results indicate the potential use of palladin as a diagnostic and prognostic marker, as well as a therapeutic target for glioma tumors.
Article
Biochemical Research Methods
Ignacio Mastandrea, Divsha Sher, Prerna Magod, Dinorah Friedmann-Morvinski
Summary: This study presents a magnetic-bead-enrichment-based protocol for isolating and analyzing the immune fraction of mouse brain tumors, as well as characterizing the immune subtypes using FACS analysis.
Article
Multidisciplinary Sciences
Daniel Rosenblum, Anna Gutkin, Ranit Kedmi, Srinivas Ramishetti, Nuphar Veiga, Ashley M. Jacobi, Mollie S. Schubert, Dinorah Friedmann-Morvinski, Zvi R. Cohen, Mark A. Behlke, Judy Lieberman, Dan Peer