The multiple facets of glucocorticoid action in rheumatoid arthritis

A Plant-Derived Ligand Favoring Monomeric Glucocorticoid Receptor Conformation with Impaired Transactivation Potential Attenuates Collagen-Induced Arthritis

(2014) P. Dewint et al.   JOURNAL OF IMMUNOLOGY

TH17 Cells Mediate Steroid-Resistant Airway Inflammation and Airway Hyperresponsiveness in Mice

(2014) L. McKinley et al.   JOURNAL OF IMMUNOLOGY

Dual-specificity phosphatase 1-null mice exhibit spontaneous osteolytic disease and enhanced inflammatory osteolysis in experimental arthritis

(2012) Youridies Vattakuzhi et al.   ARTHRITIS AND RHEUMATISM

Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass

(2012) Min Guan et al.   NATURE MEDICINE

Corticosterone selectively targets endo-cortical surfaces by an osteoblast-dependent mechanism

(2011) Holger Henneicke et al.   BONE

Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1

(2011) Eugénie Joanny et al.   BRITISH JOURNAL OF PHARMACOLOGY

MKP-1 Knockout Does not Prevent Glucocorticoid-Induced Bone Disease in Mice

(2011) Maria M. Conradie et al.   CALCIFIED TISSUE INTERNATIONAL

Widespread Negative Response Elements Mediate Direct Repression by Agonist- Liganded Glucocorticoid Receptor

(2011) Milan Surjit et al.   CELL

Extensive chromatin remodelling and establishment of transcription factor ‘hotspots’ during early adipogenesis

(2011) Rasmus Siersbaek et al.   EMBO JOURNAL

The Antagonists But Not Partial Agonists of Glucocorticoid Receptor Ligands Show Substantial Side Effect Dissociation

(2011) Xiao Hu et al.   ENDOCRINOLOGY

11β-Hydroxysteroid Dehydrogenase Type 1, But Not Type 2, Deficiency Worsens Acute Inflammation and Experimental Arthritis in Mice

(2011) Agnes E. Coutinho et al.   ENDOCRINOLOGY

An anti-inflammatory selective glucocorticoid receptor modulator preserves osteoblast differentiation

(2011) Alexander Rauch et al.   FASEB JOURNAL

Glucocorticoid dose determines osteocyte cell fate

(2011) Junjing Jia et al.   FASEB JOURNAL

Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

(2011) Anna Kleiman et al.   FASEB JOURNAL

Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes

(2011) N. A. S. Rao et al.   GENOME RESEARCH

Cre-Mediated Cell Ablation Contests Mast Cell Contribution in Models of Antibody- and T Cell-Mediated Autoimmunity

(2011) Thorsten B. Feyerabend et al.   IMMUNITY

Liposomal Encapsulation of Glucocorticoids Alters Their Mode of Action in the Treatment of Experimental Autoimmune Encephalomyelitis

(2011) Nils Schweingruber et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoids inhibit dendritic cell maturation induced by Toll-like receptor 7 and Toll-like receptor 8

(2011) Alexandre Larangé et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Transcription Factor AP1 Potentiates Chromatin Accessibility and Glucocorticoid Receptor Binding

(2011) Simon C. Biddie et al.   MOLECULAR CELL

Chromatin accessibility pre-determines glucocorticoid receptor binding patterns

(2011) Sam John et al.   NATURE GENETICS

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

The Pathogenesis of Rheumatoid Arthritis

(2011) Iain B. McInnes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Maps and legends: The quest for dissociated ligands of the glucocorticoid receptor

(2011) Andrew R. Clark et al.   PHARMACOLOGY & THERAPEUTICS

Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells

(2011) U. Baschant et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glucocorticoid receptor mutants: man-made tools for functional research

(2011) Ilse M. Beck et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

T helper 17 cell heterogeneity and pathogenicity in autoimmune disease

(2011) Kamran Ghoreschi et al.   TRENDS IN IMMUNOLOGY

Low-dose glucocorticoid therapy in rheumatoid arthritis: an obligatory therapy

(2010) Johannes W.J. Bijlsma et al.   Annals of the New York Academy of Sciences

Regulatory T cells control the transition from acute into chronic inflammation in glucose-6-phosphate isomerase-induced arthritis

(2010) O. Frey et al.   ANNALS OF THE RHEUMATIC DISEASES

Glucocorticoid-induced leucine zipper is an endogenous antiinflammatory mediator in arthritis

(2010) Elaine Beaulieu et al.   ARTHRITIS AND RHEUMATISM

Glucocorticoids Suppress Bone Formation by Attenuating Osteoblast Differentiation via the Monomeric Glucocorticoid Receptor

(2010) Alexander Rauch et al.   Cell Metabolism

Targeting inflammation using selective glucocorticoid receptor modulators

(2010) Karolien De Bosscher et al.   CURRENT OPINION IN PHARMACOLOGY

Dissociation of Osteogenic and Immunological Effects by the Selective Glucocorticoid Receptor Agonist, Compound A, in Human Bone Marrow Stromal Cells

(2010) Martina Rauner et al.   ENDOCRINOLOGY

Regulatory T Cells Protect from Local and Systemic Bone Destruction in Arthritis

(2010) M. M. Zaiss et al.   JOURNAL OF IMMUNOLOGY

The role of the glucocorticoid receptor in inflammation and immunity

(2010) Ulrike Baschant et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights

(2010) Agnes E. Coutinho et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis

(2010) Jos N. Hoes et al.   Nature Reviews Rheumatology

Differential mechanism of NF-κB inhibition by two glucocorticoid receptor modulators in rheumatoid arthritis synovial fibroblasts

(2009) Valerie Gossye et al.   ARTHRITIS AND RHEUMATISM

Prevention of glucocorticoid-induced bone loss in mice by inhibition of RANKL

(2009) Lorenz C. Hofbauer et al.   ARTHRITIS AND RHEUMATISM

Transgenic disruption of glucocorticoid signaling in mature osteoblasts and osteocytes attenuates K/BxN mouse serum-induced arthritis in vivo

(2009) Frank Buttgereit et al.   ARTHRITIS AND RHEUMATISM

1,25-dihydroxyvitamin D3modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis

(2009) E. M. Colin et al.   ARTHRITIS AND RHEUMATISM

Characterization of ZK 245186, a novel, selective glucocorticoid receptor agonist for the topical treatment of inflammatory skin diseases

(2009) H Schäcke et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glucocorticoid-induced leucine zipper (GILZ): a new important mediator of glucocorticoid action

(2009) Emira Ayroldi et al.   FASEB JOURNAL

Prednisolone Treatment Induces Tolerogenic Dendritic Cells and a Regulatory Milieu in Myasthenia Gravis Patients

(2009) C. Luther et al.   JOURNAL OF IMMUNOLOGY

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

The role of Dickkopf-1 in bone development, homeostasis, and disease

(2008) J. J. Pinzone et al.   BLOOD

BMP-2 vs. BMP-4 expression and activity in glucocorticoid-arrested MC3T3-E1 osteoblasts: Smad signaling, not alkaline phosphatase activity, predicts rescue of mineralization

(2008) Cynthia A. Luppen et al.   GROWTH FACTORS

Glucocorticoid chronotherapy in rheumatoid arthritis

(2008) Johannes WJ Bijlsma et al.   LANCET