Article
Biochemistry & Molecular Biology
Justine M. Webster, Michael S. Sagmeister, Chloe G. Fenton, Alex P. Seabright, Yu-Chiang Lai, Simon W. Jones, Andrew Filer, Mark S. Cooper, Gareth G. Lavery, Karim Raza, Ramon Langen, Rowan S. Hardy
Summary: Glucocorticoids are important anti-inflammatory therapies, but their use is limited due to metabolic adverse effects like muscle wasting. The enzyme 11 beta-HSD1 plays a role in modulating glucocorticoid responses in muscle. Knocking out 11 beta-HSD1 prevented muscle atrophy associated with glucocorticoid therapy in a model of chronic inflammation, suggesting a potential strategy to refine the safety of glucocorticoids.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Eva Kathrin Lamade, Ferdinand Hendlmeier, Stefan A. Wudy, Stephanie H. Witt, Marcella Rietschel, Michaela Coenen, Maria Gilles, Michael Deuschle
Summary: The study revealed time-specific alteration of fetoplacental 11 beta-HSD2 activity, peaking in the morning to protect fetus from maternal glucocorticoids. Acute affective or anxiety disorders were found to impact fetoplacental 11 beta-HSD2 activity.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Chloe G. Fenton, Ana Crastin, Claire S. Martin, Saicharan Suresh, Isabella Montagna, Bismah Hussain, Amy J. Naylor, Simon W. Jones, Morten S. Hansen, Caroline M. Gorvin, Maria Price, Andrew Filer, Mark S. Cooper, Gareth G. Lavery, Karim Raza, Rowan S. Hardy
Summary: This study reveals the critical role of 11 beta-HSD1 in inflammatory bone loss and its involvement in the anti-inflammatory effects of therapeutic glucocorticoids (GCs) in chronic inflammatory disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Rahul Singh, Vijay Kumar Bhardwaj, Pralay Das, Rituraj Purohit
Summary: Aminoarylbenzosuberene (AAB) molecules were analyzed in silico to develop potent inhibitors for 11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD1) protein. AAB4 molecule showed stronger interactions and binding affinity compared to the standard inhibitors.
CHEMICAL COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Hongguo Guan, Yiyan Wang, Huitao Li, Qiqi Zhu, Xiaoheng Li, Guang Liang, Ren-Shan Ge
Summary: WZS08 is a potent inhibitor of rat, mouse, and human 11 beta-hydroxysteroid dehydrogenase 1, effectively treating non-alcoholic fatty liver disease in mice by reducing liver fat content and improving liver morphology.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Callam T. Davidson, Eileen Miller, Morwenna Muir, John C. Dawson, Martin Lee, Stuart Aitken, Alan Serrels, Scott P. Webster, Natalie Z. M. Homer, Ruth Andrew, Valerie G. Brunton, Patrick W. F. Hadoke, Brian R. Walker
Summary: Glucocorticoids inhibit angiogenesis by activating the glucocorticoid receptor. The inhibition of glucocorticoid-activating enzyme 11 beta-HSD1 reduces tissue-specific glucocorticoid action and promotes angiogenesis in murine models of myocardial infarction. This study demonstrates that 11 beta-HSD1 inhibition increases SCC tumour growth, likely through suppression of inflammatory/immune cell signalling and extracellular matrix deposition.
Article
Medicine, Research & Experimental
Xueying Li, Wanhua Qiu, Lu Deng, Jingjing Lin, Wenting Huang, Yuchen Xu, Mulan Zhang, Nigel C. Jones, Runxuan Lin, Huiqin Xu, Li Lin, Peijun Li, Xinshi Wang
Summary: 11 beta-HSD1 participates in the pathogenesis of epilepsy and associated cognitive impairment by elevating neuronal excitability and contributing to apoptosis and hippocampal neuronal damage. Inhibition of 11 beta-HSD1 represents a promising strategy to treat epilepsy and cognitive comorbidity.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Eun-Nam Kim, Gil-Saeng Jeong
Summary: This study evaluated the effectiveness of the compound betulin in inhibiting periodontitis. The results showed that betulin inhibited the production of pro-inflammatory mediators and regulated the expression of osteogenic markers. Furthermore, betulin administration alleviated alveolar bone loss and periodontal inflammation in an animal model. Therefore, betulin has the potential to be a new treatment for periodontitis.
Article
Biotechnology & Applied Microbiology
Yang Yue, Fu Xu, JiaRong Zhang, Miao Zhao, FangFang Zhou
Summary: This study found that Sufentanil (SUF) enhances HTR8/SVneo cell proliferation by inhibiting miR-24-3p and promoting HSD11B2 expression. In patients with pre-eclampsia, miR-24-3p is increased while HSD1162 is inhibited, and miR-24-3p targets HSD11B2. Additionally, SUF restrains the progression of pre-eclampsia in vivo and in vitro by mediating the miR-24-3p/HSD11B2 axis.
Review
Medicine, General & Internal
Jonathan Seckl
Summary: 11 beta-HSDs are enzymes that convert active 11-hydroxy glucocorticoids to their inert 11-keto forms. 11 beta-HSD2 inactivates glucocorticoids and has important roles in the kidney and developing foetal brain. In contrast, 11 beta-HSD1 amplifies active glucocorticoid levels in the brain and is associated with age-related cognitive decline.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Medicine, General & Internal
Daria Kupczyk, Renata Studzinska, Renata Kolodziejska, Szymon Baumgart, Martyna Modrzejewska, Alina Wozniak
Summary: This paper discusses the role of glucocorticoids in the human body, their relationship with obesity, metabolic syndrome, and cardiovascular complications, and emphasizes the importance of selective inhibition of 11 beta-HSD1 in the treatment of these diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Nicola Wheelan, Jonathan R. Seckl, Joyce L. W. Yau
Summary: This study investigates how a deficiency of 11β-HSD1 and aging modulates fear conditioning and PTSD-like memory in mice. The results indicate that a deficiency of 11β-HSD1 protects young adult mice against amnesia for the conditioning context and hypermnesia for a salient tone, but only prevents contextual amnesia in aged mice.
PSYCHONEUROENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Beom Jun Kim, Noo Ri Lee, Chung Hyeok Lee, Young Bin Lee, Sung Jay Choe, Solam Lee, Hyun Jee Hwang, Eunjung Kim, Gareth G. Lavery, Kyong-Oh Shin, Kyungho Park, Eung Ho Choi
Summary: Increased expression of 11 beta-HSD1 in aged skin leads to elevated levels of active glucocorticoids, suppressing sebaceous lipid biosynthesis and causing impaired epidermal permeability barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jiangang Cao, Yawen Chen, Hui Wang
Summary: Basal glucocorticoid levels play a crucial role in regulating fetal development and determining future outcomes. Adverse prenatal environments have been found to result in abnormal maternal glucocorticoid levels during pregnancy. 11 beta-hydroxysteroid dehydrogenases (11 beta-HSDs), which are present in target organs of glucocorticoids and mineralocorticoids, are involved in fetal physiological and pathological development by activating or inactivating glucocorticoids. Several pathways can be affected by prenatal adverse environments, leading to abnormal local glucocorticoid levels, changes in fetal developmental programming and homeostasis, and increased susceptibility to various diseases after birth. This review provides a theoretical basis for the early prevention and treatment of fetal-originated diseases.
Article
Endocrinology & Metabolism
Mattia Albiero, Stefano Ciciliot, Anna Rodella, Ludovica Migliozzi, Francesco Ivan Amendolagine, Carlotta Boscaro, Gaia Zuccolotto, Antonio Rosato, Gian Paolo Fadini
Summary: Innate immune cells infiltrate and spread inflammatory signals in growing adipose tissue, leading to glucose intolerance and insulin resistance in distant tissues. Oncostatin M (OSM), a cytokine, is debated for its role in the metabolic consequences of overfeeding. Through this study, it was found that OSM is required during obesity development, as its concentrations are dynamically regulated during a high-fat diet. Osm(-/-) mice showed glucose intolerance, impaired muscle glucose uptake, and worsened liver inflammation and damage, demonstrating the importance of OSM in adapting to overfeeding.
Meeting Abstract
Cardiac & Cardiovascular Systems
E. J. Batchen, R. V. Richardson, A. J. W. Thomson, C. M. Moran, G. A. Gray, K. E. Chapman
Meeting Abstract
Cardiac & Cardiovascular Systems
Kathryn Wilson, James Baily, Carl Tucker, Sharron Vass, Carmel Moran, Karen Chapman, John Mullins, Chris Kenyon, Patrick Hadoke, Martin Denvir
Article
Developmental Biology
Usua Laresgoiti, Marko Z. Nikolic, Chandrika Rao, Jane L. Brady, Rachel V. Richardson, Emma J. Batchen, Karen E. Chapman, Emma L. Rawlins
Article
Endocrinology & Metabolism
Christopher I. White, Maurits A. Jansen, Kieran McGregor, Katie J. Mylonas, Rachel V. Richardson, Adrian Thomson, Carmel M. Moran, Jonathan R. Seckl, Brian R. Walker, Karen E. Chapman, Gillian A. Gray
Article
Endocrinology & Metabolism
Agnes E. Coutinho, Tiina M. J. Kipari, Zhenguang Zhang, Cristina L. Esteves, Christopher D. Lucas, James S. Gilmour, Scott P. Webster, Brian R. Walker, Jeremy Hughes, John S. Savill, Jonathan R. Seckl, Adriano G. Rossi, Karen E. Chapman
Review
Endocrinology & Metabolism
Gillian A. Gray, Christopher I. White, Raphael F. P. Castellan, Sara J. McSweeney, Karen E. Chapman
JOURNAL OF MOLECULAR ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
J. Qiu, D. R. Dunbar, J. Noble, C. Cairns, R. Carter, V. Kelly, K. E. Chapman, J. R. Seckl, J. L. W. Yau
JOURNAL OF NEUROENDOCRINOLOGY
(2016)
Article
Pediatrics
Shuji Sai, Masaki Yamamoto, Rie Yamaguchi, Karen E. Chapman, Teruaki Hongo
Article
Multidisciplinary Sciences
Caitlin S. Wyrwoll, June Noble, Adrian Thomson, Dijana Tesic, Mark R. Miller, Eva A. Rog-Zielinska, Carmel M. Moran, Jonathan R. Seckl, Karen E. Chapman, Megan C. Holmes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Review
Immunology
Maria Emilia Solano, Megan C. Holmes, Paul R. Mittelstadt, Karen E. Chapman, Eva Tolosa
SEMINARS IN IMMUNOPATHOLOGY
(2016)
Review
Endocrinology & Metabolism
Rachel V. Richardson, Emma J. Batchen, Martin A. Denvir, Gillian A. Gray, Karen E. Chapman
TRENDS IN ENDOCRINOLOGY AND METABOLISM
(2016)
Article
Pharmacology & Pharmacy
Dongxing Zhu, Nabil A. Rashdan, Karen E. Chapman, Patrick W. F. Hadoke, Vicky E. MacRae
VASCULAR PHARMACOLOGY
(2016)
Article
Multidisciplinary Sciences
Leen Vandermosten, Thao-Thy Pham, Sofie Knoops, Charlotte De Geest, Natacha Lays, Kristof Van der Molen, Christopher J. Kenyon, Manu Verma, Karen E. Chapman, Frans Schuit, Karolien De Bosscher, Ghislain Opdenakker, Philippe E. Van den Steen
NATURE COMMUNICATIONS
(2018)
Editorial Material
Biochemistry & Molecular Biology
Karen E. Chapman
Article
Neurosciences
Jessica R. Ivy, Roderic N. Carter, Jin-Feng Zhao, Charlotte Buckley, Helena Urquijo, Eva A. Rog-Zielinska, Emma Panting, Lenka Hrabalkova, Cara Nicholson, Emma J. Agnew, Matthew W. Kemp, Nicholson N. Morton, Sarah J. Stock, Caitlin Wyrwoll, Ian G. Ganley, Karen E. Chapman
Summary: The late gestational increase in glucocorticoids helps in the maturation of the fetal heart, particularly in the switch from carbohydrate to fatty acid oxidation. Excessive use of exogenous glucocorticoids may interfere with normal fetal heart development and pose potential clinical risks.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)